May 2012
Volume 29
ISSN 1470-3947 (print) ISSN 1479-6848 (online)
ISSN 2046-0368 (CD-ROM)
Online version available at
www.endocrine-abstracts.org
15th International &
14th European Congress of
Endocrinology (ICE/ECE 2012)
5–9 May 2012, Florence, Italy
Endocrine
Abstracts
Endocrine
Abstracts
V
olume
29
Ma
y
2012
4/17/12 8:55:43 PMEndocrine Abstracts (ISSN 1470-3947) is published by BioScientifica, Euro House, 22 Apex Court, Woodlands, Bradley Stoke, Bristol BS32 4JT, UK.
Tel: +44 (0)1454-642240; Fax: +44 (0)1454-642201; E-mail: editorial@endocrinology.org;
Web: www.bioscientifica.com.
Subscriptions and requests for back issues should be addressed to Endocrine Abstracts, Portland Press, PO Box 32, Commerce Way, Whitehall Industrial Estate, Colchester CO2 8HP, UK. Tel: +44 (0)1206-796351; Fax: +44 (0)1206-799331.
Subscription rates 2012
Annual Single part
North & South America $382 $127 Rest of the World £191/ 287 £64/ 96 There are two regular issues per year plus occasional additional issues. Each issue is a separate volume.
Claims and communications
All claims or communications regarding issues lost or damaged in transit should be addressed to Portland Press in Colchester (see above for address). This applies to both institutional and personal subscribers. No claims can be entertained if they are later than 3 months after the date of despatch.
Disclaimer
The material contained in each issue of the journal has been prepared and written by named authors. Accordingly, neither the conference, BioScientifica Ltd nor their officers, employees or agents are responsible for the accuracy or otherwise of any abstracts or other articles and shall have no liability for any claims, damages or losses howsoever arising from the contents or any use to which they may be put by any person. It is not possible to guarantee that the abstracts printed in this issue will be presented at the conference.
Cover design by Rumba Graphic Design Ltd, Bristol, UK. Typeset by OKS Prepress Services, Chennai, India. Printed by Latimer Trend & Company Ltd, Plymouth, UK.
Printed on acid-free paper.
Copyright © 2012 by BioScientifica Ltd. This publication is copyright under the Berne Convention and the Universal Copyright convention. All rights reserved. Apart from any relaxations permitted under national copyright laws, no part of this publication may be reproduced, stored in a retrieval system or transmitted in any form or by any means without the prior
permission of the copyright owners save under a licence issued in the UK by the Copyright Licensing Agency.
Photocopying in the USA. Authorization to photocopy items for internal or personal use, or the internal or personal use of specific clients is granted by BioScientifica Ltd, provided that the appropriate fee is paid directly to Copyright Clearance Center, 222 Rosewood Drive, Danvers, MA 01923, USA, Tel: +1-978-750-8400. Prior to photocopying items for educational classroom use, please contact Copyright Clearance Center, Inc. at the address shown above.
Advertisements
Applications for advertisement space should be sent to Advertisement Department, BioScientifica Ltd, Euro House, 22 Apex Court, Woodlands, Bradley Stoke, Bristol-BS32 4JT, UK. Tel: +44 (0) 1454-642269;
Fax: +44 (0)1454-642201;
E-mail: advertising@endocrinology.org. Copy is required 6 weeks before publication date. Rates are available on request.
USA Postmaster: send address corrections to Endocrine
Abstracts, c/o Mercury International, 365 Blair Road, Avenel, New Jersey 07001. Periodicals postage is paid at Rahway New Jersey and at additional mailing offices. All despatches outside the UK are sent by air-speeded service.
Citing Endocrine Abstracts
When citing abstracts from this publication please include the names of the authors, year of publication, abstract title, name of this publication i.e. Endocrine
Abstracts, volume and abstract number: e.g. Stewart P 2001 A tale of two enzymes. Endocrine Abstracts 2 SP2.
Endocrine Abstracts
(www.endocrine-abstracts.org)
d:g2 \dA ) !2
! j
g_bA e
jLY dA d!\gd!_ $ jOY gpA!d
gdQ A gJ d:g2 \dg_gQ
r js
L E e ! j8 _g Ad2A8 !_
YA !) !2 A A b! ^A: ) YA ) !2 b! ^\dQ !dA_ A_A2A: ) YA p gQ !bbA Q!d\\dQ gbb\AA j gQ !bbA Q!d\\dQ gbb\AA
! \d A\d2^A8 A b!d Y!\
Gj.G !Yb b! ! Y\dQ[YdQ Y!dQ YA \ A!_ d: A! d!\J \ gY\ g Ad gdAd)A Q ! ^ 2_A!d b) \Y \Y!_ ! \! _A\!^\ Ad g__A _A Y\_\ppA g2Y! : g !!dg A\b __ A!d[! ^ !Jb!d !_:\ \ !Q !d gb\]d Y \\!d !) QA A Ab gb_\dgd AA !\dA !\bg g\_!\dAd ) !2 ! ^\dQ !dA_ ):A_[!Y\b Qp :!b^\ A b!d _A\!^\ AA2A __g_\g A b!d b! ! Qp d:A gd A A:Ad !!: Qp !:\ gb!d\! ! !_Ad! !_ !:\d !d2A A2^A A_Q\b A !Qd! !d2A A2Y_A\d A b!d
\A b! YA AYA _!d:
gA_!A g__A _A g ! g A! !_ g gd[Y!g J !d2A g2! g !_ g2Y! : !d2A g\__gd A_Q\b g_g g Q\Qdgd A_Q\b !\d! _gAd\! \d^b!dd YA AYA _!d: \Ad Adb! ^ ^g _g!^ Ap)_\2 !_\! !pg !_ !!dg p!\d !A__!dg !_ Y!dgd !d2A Y \\d[!\ A !d2A _!gd gYAd ggpA g gd! !_ !!d\ !bA \A A_Q\b A _g2^ A_Q\b d!\J d2!d !_\! d! AA2A _\A\ !_ )! ^A :gQ!d ^A !d!2Y A b!d
AA_:A YA AYA _!d:
A_:[!bAd Adb! ^ A gdA !_ g__\d A:Ad g \ !_ Q!g_! !_ \A 2b!d A:Ad _\d)g Q Adb! ^ !!d A A!_!d: !Yg_ Adb! ^ gb!d __ ^A g ^A g8 Ad Y!d\Ab\ A)A g ! d:A gY!ddgd A:Ad !:\gQ_ ^A !_! AA2A [ !Jb!d YA AYA _!d: A_A\b ^A \A_ \dAb!d :_! g_!d: !2 g\ !d2A !Y_g !d2A !_\2 A )\!
!b)A YA AYA _!d:
! QA !d2A
! )A Q Adb! ^
! g! _g!^ Ap)_\2
AAdY! : !d2A
Ad:A YA AYA _!d:
A\d^\ A:\2!_ d\A \
\p YA AYA _!d: _!Y!d! :Q!A zA p!\d !ddA__\ !_ !dA g !_ ! 2g22\ !_ ! \g\ !_ ! _!d: !\ AdA:A\ !_ 2g b!2^ !_\! 2A!d !_\! \_A\2 g_!d: \d!b\8 !p!d \Y!_ d:\! \!Q A:Ad gd!d! p!\d gA^\_:A Adb! ^ \A2Y_!Q A b!d pg2YA !_ gA QAdAd Adb! ^ !2Y^A A b!d
AAA YA AYA _!d:
_g=2^\dQA A b!d
g_Ad Adb! ^
\d^_A A b!d
!:A\ !_
!
A\d2^A YA AYA _!d:
g)_A:g p!\d g!^ A b!d gA\d !Y\d ^A !d\A)!d p!\d 2YdA\:A A b!d \bgd\ !_ ^Qg b\Y A:Ad gdbA ^A !A_ !d2A !__! A b!d !) QA A b!d b\d^g! A2Y Ap)_\2 !)! \d !d2A AbA_^g![ ^2Y\A _Q! \! \__b!dd gd\! gb_\dgd gpp! \ \d_!d: g p !_\! g2!dg !_ !\dA d_Y\! 2\ ^A !\:! g\_!\dAd \d_!d: A)) p!\d
\A \Qd! YA AYA _!d:
\_:\dQ \__\!b [ \ YA AYA _!d: \_:\ ^A gdQ b^ ^A !)_\AdA \Y!d\! !A__\ !_
YA !d: g_: _\^A g Y!d^ YA j pgdg 7
g_: pgdg
_\ \__
pAd
g! \
^!
KA
gdA pgdg
A ^\d _bA
YA pgdg $ Y\)\g
jLY dA d!\gd!_ $ jOY gpA!d gdQ A gJ d:g2 \dg_gQ r js
d:g2 \dA ) !2 rjs g_ e
j A2 A! \! \g2\Ad\K2! :
g gA A_7 xOO rsjOLO OO
pA g !7 xOO rsjOLO O
gg:_!d: [b!\_7 \2A[A2Aj()\g2\Ad\K2!u2gb
!:_A g^A \g_ O8
A) \A7 u\2A[A2Aju2gb
A2 A! \! gd!27 d: A! !\
g gA A_7 xOO rsjOLO OO
pA g !7 xOO rsjOLO O
gg:_!d: [b!\_7 \dJg(A g[Ad:gug Q
!:_A g^A A) \A7 uAA[Yg bgdAug Q
\g_ O8
YA bA \2!d g2\!\gd gJ _\d\2!_
d:g2 \dg_gQ\
_A\gd
\g2\Ad\K2! :
\gAd:g [!)g !g d\ A:\2\d! !uu
Y\dAA A:\2!_ g2\!\gd
\!g \d
d:g2 \dA gddA2\gd
d:g2 \dA :2!\gd d2
gpA!d g2\A gJ d:g2 \dg_gQ
Y! b!
gd! g_gQdA b)
A:\AzA
A 2g:\!
YgAd\ Y! b!2A\2!_ d2
g !^!d
u ! QA
!_\b!A \2 gpA :
!d:g dA d!\gd!_
A gdg bpg\!
g2\A Jg d:g2 \dg_gQ
YA d:g2 \dA g2\A
YA bgKYA 2\Ad\K2
\ gY! b!
jLY dA d!\gd!_ $ jOY gpA!d gdQ A gJ d:g2 \dg_gQ r js
d:g2 \dA ) !2 rjs g_ e
: Ad!_ !\2 u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u juj E ju !_A Ap g:2\gd u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u jOuj E jOu Y g\: !\2 u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u jLuj E jLu Ab!_A Ap g:2\gd _\d\2!_ u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u juj E ju \!)AA !\2 u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u juj E ju !A:\! \2 d:g2 \dg_gQ u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u jBuj E jBu ! :\g!2_! d:g2 \dg_gQ u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u jeuj E jeu u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u j E B
: Ad!_ 2g A u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u j Ejj : Ad!_ bA:__! u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u jjO EjB gdA $ Agpg g\ u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u je EjeL !_2\b $ \!b\d bA!)g_\b u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u je EB ! :\g!2_! d:g2 \dg_gQ !d: \p\: A!)g_\b u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u e E Ojuj _\d\2!_ 2!A Apg [ \\! : Ad!_ u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u O Eee _\d\2!_ 2!A Apg [ Y g\:YA u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u O EOB AA_gpbAd!_ Ad:g2 \dg_gQ u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u OBj EOeB \!)AA u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u Oee EO d:g2 \dA \ pg u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u O E d:g2 \dA bg !d: dAgp_!\! u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u EBBO Ab!_A Ap g:2\gd u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u BBL EeB gY Yg bgdA !\ [ )!\2 u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u eBOE j !_A Ap g:2\gd u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u j E je A gAd:g2 \dg_gQ u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u j E jjL 2_A! A2Apg !d: \Qd!_ !d:2\gd u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u jjL E jje )A\ u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u jj E jB !A:\! \2 Ad:g2 \dg_gQ u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u jBO E j \\! [ !\2 u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u jj E j \\! [ _\d\2!_ u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u jj E jLOuj A g\: bA!)g_\b x !2\gd u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u jLO E jLj Y g\: rdgd[2!d2A s u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u jL E jOe Y g\: 2!d2A u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u u jL E jBL
jO
!_A gJ ApA!A: [Q\:A: KdA[dAA:_A !p\ !\gd r[s \d YA Jg__g[p gJ Y g\: dg:_A7 YA gY rg:Ad! g_gQ gJ YA Y g\:s
jL
YA g2\!\gd )AAAd Y g\: 2! 2\dgb! !d: !Y\bgg Y g\:\\7 \ A!__ !Y\bgg Y g\:\\ \d2 A!A YA \^ gJ Y g\: 2!d2A { j
_\d\2gp!Yg_gQ\2!_ 2Y! !2A \\2 gJ p!\Ad \Y Y g\: p!p\__! b\2 g2! 2\dgb!7 p A_\b\d! A_
,
j
\JJA Ad\!A: 2! 2\dgb! \d :Ab) \gQAdA\2 Y g\: _A\gd
, jLY dA d!\gd!_ $ jOY gpA!d gdQ A gJ d:g2 \dg_gQ r js
jLY dA d!\gd!_ $ jOY gpA!d gdQ A gJ d:g2 \dg_gQ r js g)\dgd8 Bu g)\dgd8 ju g)\dgd8 jOB g)\gd8 jBuO $ jOO g)_A:g8 jBj8 jBL8 Ou $ Buj g2!8 jBj g2!8 jj g2! g: @"QA8 jOB g22\g8 j g2Y!8 Lj g2Y!8 e $ g2YA8 jLO8 jLe8
jBj $ Oe g2Y\ !8 jj8 jOB8 jLOe8 j8 jO8 jB8 jj $ jB g2^b!d[ AAd)A Q8 Buj
g:QA 8 Oe $ ej g:\Ad8 jB g:\gdg!8 je g: @"QA8 BL g: @"QA g: @"QA8 jBLL g: @"QA[gb@"dQA8 jj g: @"QA[!d2YA8 j g: \QA8 jB $ BB g: \QA8 Oj g: \QA8 ee g: \QA8 jjO8 jj $ BO g: \QA8 jB $ eB g: \QA8 jj g: \QA8 jOL $ g: \QA Y\dA!8 jBL g: \QA g: \QA8 g: \QA !d2YA8 O g: \QA[Y!2g"d8 ej g: \QA[g_\d!8 jB gA)8 jj
gAJ8 u $ jLLe gA_JAb!8 jO gAbb_A 8 ju gQ!dg\28 jLL gQA 8 O gQA 8 jO gQA 8 j8 jB $ j gQQAd8 j gQg^\8 jLeB8 jj $ jO gYAd^gY_8 eej $ ee
gYbA 8 BjO $ ee g\A 8 jj g]d\2 ! A^8 je g]g8 jee $ L g]g[! \dA8 j g^!d:!8 juL g_:!"d8 jeO g_\b8 jj g_\d^\8 jLee gb!"d8 jOO $ jOL gb!Qdg_\8 je gb!Qdg_\8 j gb!d8 jjL gb!d8 jL gb!dA__g8 ee gb!dg8 jjO8 j $ L gb!dg8 j $ L gb!dg8 jB gb!dg^\8 jj gbA\8 jLB8 jeL $ jBe gbA g[dg8 jLjO gbA g[\8 jjB gb\]d8 jO gb\]d8 B $ Oee gbbA_8 jO gd2A__!8 B gd2A g[! \d8 jj gd2YA\8 B gd2Y\8 O gd222\8 jB gzA8 Oe g !g8 jj g8 jBj g!_A8 jBO g!\8 O g!g8 BjB g2!8 jj gA8 B $ e gA__\d\8 B gAdJA_:8 jBuO gAd^ !d8 jjj $ jOL gAd!_:8 O gA 8 ee g_gdg^!8 e $ e g8 B g8 L $ Lu g!g8 gA\8 ju8 BBL $ e g\8 jOuj $ Be g\8 jjB $ jB g\8 je8 B $ Bj g\8 B g\8 jLeO g\8 jOje $ B gb!dd8 j gbA\A_g!8 jj gb8 j ggb!d8 B g!8 je gA__!8 gY8 jOO g:\A 8 Oeu g=:_8 jLu g\ !8 e $ Lj g8 Lj $ L gY\d^!!8 jLjL $ B gY^g8 O !dg8 Le !8 jB8 jO $ BB )\!_A :A ! \gQ_\g8 j )\d8 8 O $ BL )\dJA_:8 OuL $ jO )\dg8 jBe8 jOBO $ L )\g8 BB )\g[_b!d!8 )\g[!\d8 jee 2Y!_!8 j $ jj :g\2Y8 BL :\d^!8 jLuL A:!8 jOB JK__\8 jB JKd8 juj $ jOO QQ\A g8 jO QYggpY8 BB \ :A :!d!8 j8 B $ BB \ :A !!8 jBj \8 u \[!!dA8 jOuj \[! 2A__!d8 jBj \[\dg8 jjB $ jee __8 e
d^_A8 jjOe $ O !^8 jjO !_Ad^g8 O 2\2!8 L g8 ee g8 j g8 eO AbgQ_8 j 8 jj d\A^\8 BjO 8 j =AQQA 8 =d^g Q8 L !8 j AY!]\8 \28 jL !8 B [\__!dA!8 LLO !d8 jB )A Q8 B )\2^!8 B :A"d8 Lu ^!8 jBje !"d2YA8 jOL !"d2YA8 j !"d2YA g) \dg8 j !"d2YA[! @"d8 LLO !"d2YA[!2YA2g8 L !!:8 jj8 j8 jB8 jL $ u !!:8 jjL $ Lj !!:]\!d8 jj !)!8 L !)!\d\8 B !)!8 uO !))!QY\!d8 Ouj !))!8 jOe !)A2^\AdA8 je !)\dg8 e !)g_8 jO !)gg8 LjB8 L $ e !)8 j !22g8 !22g8 B !2A :gA8 jj !2Y:A8 u $ LB !:\^8 Oe !:g_8 ee !: \8 !AQA 8 jOL !A^\8 LB !Ad^g8 jBj !A8 Luj !J !dA^8 j !J !g8 L !J\Q8 jLBB !Q!d8 jLB !QQ\g g8 Be !Q^!d8 jL