NEUROBEHAVIORAL EFFECTS IN ADOLESCENTS EXPOSED TO METALS

Abstract # Abstraur # #23 10:s NEUROBEHAVIORAL E F F E D S

IN

ADOLESCENTS EXPOSED TO

METALS.

R. Ltic.chinil, N. J. Zimrneman'. E. Albinil, S. Michelenil, S. Zonil, F. Taglianil, C. Ntlrdoni'. Ci. Parr~nello~. F. Donna'. R. Ferril, Z. Annalisa'. B. Laura' and E. Bonrrmpil. 10ccuparional Health, Umversily of Bwscia Italy, Brescia lbly, Themistry Lahoraiwy for Technologies, University of Brescla, Brewla, Ilaly. 'School of Health Sciences, Purdue Un~veaity,West Lafayette. IN and 'Statistics and Biometry, Univers~ry nf Brescia, Brescia. Italy.

#26 9:20 OVARIAN TOXICITY-ANAMMY,

PATHOPHYSIOLOCY, AND THE

ILLUSION

OF SLhlPLIClTY. M. Miruh3,. mzer, G n t o n , fl. #27 10:00 OVARLAN TOXICITY INDUCED

BY

PHARMACEUTICALS A N D CHEMICALS. A.

S.

Faqi. Toxicology, MPI Research, Mattawan, MI.

#?tc

L O : N

OVOTOXICLTY

CAUSED

BY

4VINYLCYCLOHEXENE DIEPOXLDE: MECHANISTIC

INSIGHTS.

P Hoyrr. University of Anmna, Tucson, AZ.

#24 11:28 NEUROLNFLAMMATION, SEVERE A I R #29 11:20 COLLABOWATIVE WORK

ON

EVAI.UA'IION POLLUTION AND CHILDREN. L Caldtron- OF OVARIAN TOXICITY

BY

REPEATED

Gm~duenss','. L. Gonzalez-Gonzalez'. A.

DOSE

A N D FERTILITY STUDIES

lN

D'Angiulli!

and

H. Medina-Conha'. 'The Universrly of Monlana, Missuula. MT. 'Psychology Carleton University, Ottawa ON. Canndd and 'Institute ~ a c i o n a l - d e Pediatria. Mcxico City, Mexico. Sponsor: J, Antoninr.

Monday Mordag, March 8 9:15 AM lo

12:M

NOON Ballrwm

B

Symwium

Session:

Ovarian

Toxicity:

Current

Concepts

in

Toxicology,

Patholosy,

and

Mechanisms

Chauprson(s): William J. Brurt, Bmrk Scientific Consulung, U C , Monfgumry HIlage, MD, and Ali Faqi, MPI Research. Matrawan,

MI.

Sponsor:

R e p d u c l i v e and Developmental T o x i c o l ~ SpecMty Section

Endorsed by:

Regulatory and Sdety Evaluation SpecLalty Section

Repmdudw and Developmental Toximlogy Specialty Section Wo~nen In Todcdqq Speclal Intereat Cmup

The ovary is responsible for the dlffcrenr~ation and release of a mature m y t e for fertilization and for orynlhes~rlng and secreting hormones that arc cssentiill for follicle developmenl, eblroua cyclicity. and maintenance of thc r e p r d u c t i v e lract and its function. Reproduclive toxzcity studies arc lmportant components of the regulatory approval of drugs and chemi- cals. The identification c~f ovanan toxicity and determination of I& cause q u i r e s familiarity wirh ovanan anatomy, physiology. relattonships with other components of the female reproductive tract, and h e neuroedocrine regulation of the eslrous cycle. A ~nechanistic approach at the morpha- logic, biochemical, dnd moiecuiar level demonstrate that various faclors are involved in ovarian toxicity. Therefore, our f w u s will be on the basic concepts of ovarian anatomy, histopathology, and ptential mechanisms of toxicity. We will hegin by discussing the rlnponvnct of assessing fertilily that uullzes 8 cornhination of methds includrng <valuation of eslrous cycle length, icnility endpoints, and ovarian weights. Recent collaborative work suggesls a I-week d e n t study may be sufficient to elucidnte the effer of p h m x e u l i c a l s m ovarian function and its impact on thc revised ICH M3 will be prewnled. Aener interpretation of drug induced ovanan roucity will be highlighted as fertility effects in d e n t s , especially when sexes are treatad do not often distlnpuiah betu+een male or female tndlalwl effects. A rncchanislic model of ovanar, ~ U K I C I ~ Y o r 4-vinylcycloheaene d i e p x i d r provides an understanding vC the putsntlal risk o f human e a w u r e to envi- mr~tiiental ovarian toxicants and E r e a m ~nsight of toxicants on rcprductive health In women will also he d ~ u s s e d .

825 9:15 OVARIAN TOXICITY: CURRENT

CONCEPTS

IN

T O X I C O I f i Y , PATHOLOGY, AND MECHANISMS. W. 1. Rmrkl, A. Fnqrq, M. Mirsky', P H o y d and A. Sanbulssho'. 'Brock Sc~cntific Consulting. Montgomely Villagr. MD. 'MPI Research, Mattawan, MI, 3 w ~ r , Groton. CT+ 'University of Arizona. Tucson, AZ and 'Dalichl- Sankyo, Fuhurt~i Shizuoka. Japan.

FEMALE RATS. A. Sambuissho. VAIICHI SANKYO CO., LTD., Fukuwi, Shizuoka, Japan. Sponsor: W Bmck.

Monday Morning, March 8 9:15 AM t~ l2:M

N O O N

Ballroom G

Symposium Session:

Silica

and

A s k ~ t o s

Immunotoxicity:

Mechanisms

to Fibrosis, Autoimmunity,

and

Modified lhmor

Rmistance

Chuirpc*llon(s): Andrij Holian, Unrver~ity c$Montana, Mi.~soula.

M Z

and T k m i Otsuki, Katvasaki Metfical Srhr)ul. Kumshiki, Japan. sponsor:

lmmunotoximlog). Spedalty Section

hhalatioi and Rpsplretory Spedalty Section

Mechanisms Swcidty Seciion

Occuptlonal kl d l i c H&(h Spcialty Section

Fffwtr of s i l i c a l a s k s t o ~ on local and sysiemic untnune system componcnls are very important in the cascade of event5 In a host that evolve over [he course of time from lhe point of initial exposure to the ultimate onset of long f i b m i s (i.e., s~hcosis, asbestosis), malipnanl t u m m (I e.. lung cancer, n m thelioma), or autoimmune disorders (c.g., systemic sclerosis, rheumatoid arthritrs-Xaplan tyndrome). In particular, mechanisms used by Immune competent cells to pmesrs the entrained silica or asbestos may affect induc- tion of these pathologies. With regard to asbestos specifically, lhere may also be a reduction in lwal/general antl-tumor immune responses lhar strver to amplify its own carcinogenic potential in siru. We will beg~n with an up-to- date overview of emerginp iopics in the held of silicalasbestos toxicology that can, in rum, serve ac a b a w to understand mechanistic interpretations that link development of pneumoconioses lo fibmr~c diseases, autoimmu- mty, and cancer. To better understand thebe i a u r s the latcst findings on the roles thai particle recognition, innarnrnasolne formation, cytokine-driven inflammatron. or immune dysfunction have io eventual induction of fibrosis, altered autolmmuni~y, andlor modified tumor resistance in ~ilicdaskstwtos- exposed hosts. I r is anticipated that with an enhanced unders~xnding u i h e molecular pathologicah mechanisms underlying the immunotoxicalogic effects of silicdasbestos, researchers in many fields (including immunnlogy, immunotomcology, pulmonary biology and medicine, occupational medi- cine) will be better abte to d e v e l q t h s r a ~ u t i c tools for the prevcntlon. mitigation, o r treatment of debilirnnng diseases induced by these agenls.

a311 9: 15 SILICA AM) ASBESMS

IMMUNOTOXICITY: MECHANISMS

TO

FIBROSIS, AUTOIMMVWITI: A N D

MODWIED TUMOR

RESISTANCE.

A. Hnlthn. Un~vemity of Montana, Missoub. MT

print Submitted on August 05, 10:42 FM for sol2010 Roof CONTROL ID: 689240

CONTACT (NAME ONLY): Roberto Lucchini Abstract Details

PRESENTATION TYPE: Inuted Presentation

KEYWORDS: children, neumbehauoral chenges, manganese and lead. DATElTlME LAST MODIFIED: August 5,2M)9,10:42 PM

DATElTIME SUBMITTED: August 5,2009,10:42 PM

Abstract

TITLE: NEUROBEHAVIORAL EFFECTS IN ADOLESCENTS EXPOSED TO METALS

AUTHORS (LAST NAME FIRST NAME): Lucchini. ~obertol; Bmmerman, Neil J.~; Albini, Elisa I ; Micheletti, ~erena'; Zoni, silual; Tagliani, ~iorellal; Nardoni, ~hiara'; Paninello, ~ i o v a n n i ~ ; Donna, ~ i l i ~ p o l ; Feni, ~obertal; Annalisa, zacco2; Laura, ~ o r ~ e s e ~ ; Bontempi, ~ l z a ~

SPONSOR NAME: James Antonini

INSTITUTIONS (ALL): 1. Occupational Health, Uniersity of Brescia, Italy, Brescia, Italy. 2. Chemistry Laboratory for Technologies, Uniersity of Brescia, Brescia, Italy.

3. School of Health Sciences, Purdue Uniersity, West Lafayette, IN, USA. 4. Statistics and Biometry, Uniersity of Brescia, Brescia, Italy.

ABSTRACT BODY: Background: Increased parkinsonism was o b s e d in Valcamonica, a valley in the Italian

Alps. Prevalence was higher in the ucinities offemalloy plants and associated to the manganese l e d in deposited dust. The aim ofthis study was to assess motor and cogniti* functions in adolescents in the exposed area.

~ e t h c d s : Metals were measured in PMIO airbome particles collected with 24-hours personal samplers. SamDles were analvzed with Total Rdection X-Rav Fluorescence. Soil was analvzed at surface and 10cm depth. ~dolescentiof 11-13 years old were recruited thmugh the local school system for neumbehauoral

examination. Various biomarkers were collected for metal analysis.

Results: A total of 303 children residing in the exposed area and a reference area participated in the study. Amage airborne manganese was 57.79 nglm3 (n.86, range 1.24-516.70) in Valcamonica and 22.45 ngIm3

(n.11, range 5.30-36.59) in the reference area. Lead, imn, zinc and chmmium also showed significantly higher le*ls. Manganese results were significantly higher also at the surface and at 10 cm depth of soil and in salad. Children in the exposed area showed impairment of motor coordination and d o u r identification associated with airborne manganese at multivariate analysis. Blood lead was inersely associated with IQ, but

only in the metal exposed area ofvalcamonica.

Conclusion: Enumnmental exposure to manganese in adolescents is related to deficit in motor and olfactory

functions whereas concomitant lead exposure is related to decrease of IQ.

Acknowledgement: This work was partially supported by the EU thmugh its Sixth Framework Programme for RTD (contract no FOOD-CT-2006- 016253). It reRects only the authors'uews. The Eumpesn Community is not IiaMe for any use that may be made of the information contained therein.

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