Evolutionary relationships and diversification of barhl genes within retinal cell lineages
17
0
0
Testo completo
(2) 6
(3) 8761 9
(4) 66856272 89 3 7
(5) 6 5. 6 79. 5 6 7 8 3 . 3 3 3 6 7. 8 .
(6) ! " 4 #8 9$%&'()*+,-.'/%0.1&23)0.'.435677899:;<6 55:==(62# 75983(2#=7<>7?57<@=77=;<6A57B21 # 95677C.
(7) · ¸ ¹º"%»¼½¾¿ÀÁ%ºÃÁÄ"#żÃÁ%ÁÆÅÇÈÉÉÊËËÌÍÎÈ ÌÏÏ'''»Ð¸ »¸ÏÉÎÑÉÒÇÉÎÓÏÉÉÏÍÎÈ. 012130453067481. 9
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`abcd)0._`abce8/0V41V1:1?>V)0.V1V+)U?.:/01)B1>[^0V1V+)U?._`abce8;*V0?V_`abcd8/> 1TU+1>>1./0V41+1V/0))0./>/5U?+V)0VW?+)5)3+/0131::>U13/W/3)V/?0[f1;+)W/>44)>V4+11_`abcU)+):?B>g_`abcdhdi _`abcdhe)0._`abce8;*VV41/+U+13/>1>U)V/?,V15U?+):+1V/0):1TU+1>>/?08)>Y1::)>V41/+W*03V/?0/>Z1V*0j0?Y0[ klmOnomRp1+1Y1U1+W?+51.)51V/3*:?*>1TU+1>>/?0U)VV1+03?5U)+/>?0?W)::j0?Y0_`abcW/>4U)+):?B>)0. .1>3+/;1.)0?X1:_`abcU)+):?B/051.)j)[q*+.1V)/:1.)0):Z>/>?Wr1;+)W/>4_`abcB1011TU+1>>/?0/0Y/:.VZU1 )0.5*V)0V+1V/0)>+1X1):1.V4)V?0:Z_`abcdhe)0._`abce)+1U+1>10V/0V41+1V/0)[s1):>?>4?Y1.V4)VV41>1VY? U)+):?B>)+11TU+1>>1./0./>V/03V01*+?0)::/01)B1>)0.)+1./WW1+10V:Z+1B*:)V1.;Z9V?4t8)j1Z+1V/0):,>U13/W/3 V+)0>3+/UV/?0W)3V?+[u/0)::Z8Y1W?*0.V4)VV41VY?+1V)/01.51.)j)W/>4_`abcU)+):?B>8_`abcd)0._`abce8)+1;?V4 1TU+1>>1./0V41+1V/0)8/0)U)VV1+0+15/0/>310V?Wr1;+)W/>4_`abcdhe)0._`abce+1>U13V/X1:Z[SZU1+W?+5/0B U4Z:?B101V/3)0.>Z0V10Z)0):Z>/>8Y1U+?X/.11X/.1031V4)V_`abc+1V/0):1TU+1>>/?0.?5)/0/>)0)031>V+): W1)V*+18U+?;);:Z:?>V/0V1V+)U?.>.*1V?W*03V/?0):+1.*0.)03Z[ vNPJnOmwNPmRu*03V/?0):./WW1+1031>)5?0B+1V)/01.U)+):?B>?Wj1Z+1V/0),>U13/W/3V+)0>3+/UV/?0W)3V?+>;1VY110 V1:1?>V>)0.V1V+)U?.>5/B4VU+?X/.1/5U?+V)0V3:*1>W?+*0.1+>V)0./0BV41/+U?V10V/):/5U)3V?0V41B101+)V/?0 ?W+1V/0):01*+?0):./X1+>/VZ[^0V+/B*/0B:Z8Y/V4/0V1:1?>V>8+1V10V/?0?Wr1;+)W/>4_`abcdhe)0./V>51.)j)?+V4?:?B _`abcd)UU1)+>V?3?++1:)V1Y/V4V41)3x*/>/V/?0?W./>V/03V>/B0)::/0B5134)0/>5>;ZV41VY?B101>Y/V4/0./>V/03V +1V/0):31:::/01)B1>[q*+W/0./0B>U+?X/.1)>V)+V/0BU?/0VW?+V41>V*.Z?W_`abcB1011X?:*V/?0/0+1:)V/?0V?V41 B101+)V/?0?W31::./X1+>/VZ/0V41X1+V1;+)V1+1V/0)[ yG z{F|}
(9) ~ ¡¢ £¤ ¥¢ ¦ C°?++1>U?0.1031g:*3/)[U?BB/±3?>[*0/,41/.1:;1+B[.1 7° ?0V+/;*V1.1x*)::Z 6°10V +1W?+q+B)0/>5):2V*./1>8²0/X1+>/VZ?Wp1/.1:;1+B8p1/.1:;1+B³´6@µ8 ¶1+5)0Z u*:::/>V?W)*V4?+/0W?+5)V/?0/>)X)/:);:1)VV4110.?WV41)+V/3:1. ¦§ ¨¨ ©ª«¦ £ ¬ ® ©¯«¦ ¡ ® . Ô@µ66234*45)341+1V):Õ:/310>11S/?<1.°10V+):(V.[\4/>/>)0qU109331>>)+V/3:1./>V+/;*V1.*0.1+V41V1+5>?WV41°+1)V/X1 °?55?0>9VV+/;*V/?0(/310>1Ö4VVUg]]3+1)V/X13?55?0>[?+B]:/310>1>];Z]@[µ×8Y4/34U1+5/V>*0+1>V+/3V1.*>18./>V+/;*V/?08)0. +1U+?.*3V/?0/0)0Z51./*58U+?X/.1.V41?+/B/0):Y?+j/>U+?U1+:Z3/V1.[.
(10) |}~~}~ ~ ¡¢£¤}¥¦}£§¨©. 01232456736839 16
(11) 24563 572656 16
(12) 24563 43 2456593
(13) 149 36 16
(14) 24566 5 16
(15) 24563 43 2456597 422 36
(16) 7293 16
(17) 2456 2. 62. 393 5 771 16
(18) 24563 432456 2 9 59 38846
(19) 50 42252 8. 50 623 6 6 259!232 73 759 36 59032456"# 6 75 2 $%&'( 304 . 6
(20) 5846 2 50 5 5 29367
(21) 942456 3
(22) 2597)39 *368 )39 3 . 675625 . 9 77 846059 59. 775 9 346 85034675 2
(23) 6293 6 9517772 0 3683 39243 9 8168362 16
(24) 24567466 193 71 2.
(25) 48 624204 93245636871943 +,-5. 9 $%&'(.0 0 973 3925 1641 9 77 8462. 9 2463/0"163924
(26) 1 39)39 47336 92 932 9 1 32595 2 7
(27) 4 4
(28) 3245636871943 5 237368 45376**"759
(29) 8 9 774565 )39 462 0517. 9 246395052 72 84 9 624324565
(30) 46 9 4
(31) 303
(32) 946
(33) 7322. 67 5 45 3936889 9
(34) 7 *:"288424563 363 7475 )39 61 9 2463771 727232)39 373
(35) 9424
(36) 3 95 46 522371 2. 8 2 9046324563684645371943 6"# ;<=>?@A )39 5925 5 9 4517 630 8B *37 . 6 75625 . 9 77 8464537368469 71024 23 9
(37) 1975973682595052 45384 9 62432456856 729 30 5 2 CDC29367
(38) 942456 3
(39) 259225/**" E4 ;<=>?@A0517 93236810363 56
(40) 5 5 $%&'(F368$%&'(. 3
(41) 93 473729. $%&'( 393 5 75774 81 253 192 9 650 81 4
(42) 32456. 622322. 5727168 9 6281946 5 124563 2 92. 7 42 950 2 2 29358 46 3 * *"G62 37475 952 467 1 6
(43) 3 4 60 62368 5 6 24
(44) 363 74742 37 . 671 72 8232255 2 7 5925 5 7 56 252 $%&'(F393 5 9516504632 8$%&'(FHF368 $%&'(FH.4 2 2498 56 7252 $%&'(. 951 ,* "16
(45) 5629372250517 368;<=>?@A3 29. $%&'(7. 025 . 9 77 8 52462 9346368462. 9 2463* "160 83!3 47I&JKL%A(%ML?<A56 56. $%&'(37 . 68 7
(46) 94 875 39>($%&'(- 37 856 5 6 24
(47) 363 747>($%&'(37 . 6
(48) 172 9 8252. $%&'(F 9515 393 5 7,* *"#5 2059 4674 27 46252. 5 124565 $%&'(393 5 7429 7
(49) 2259 2 463 84 9 62432456 255!383623 5 2 93 47 3680 83!3058 772 0725 9 5903
(50) 509 674.
(51) 5039324 363 7475 $%&'( 6. 9 7745637
(52) 50 39 8252 56 462 29358")8 234 8L=ALM@ 9484 32456363 747
(53) 56 490 8232$%&'(FH.368$%&'(. 39. 9 77 8462 93 479 2463 12652$%&'(FHF"2 0 24
(54) 1 517467
(55) 24565 $%&'(FH.368$%&'(.29367
(56) 942 847294 124564684
(57) 32 72324 $%&'(.3 397259
(58) 3 421 32 2. 9 774565 42703003 436368;<=>?@A
(59) 5162 93922 732452 0593 9 77456322 965 $%&'(FH.476569 8168362252325 $%&'(.71 7246 232$%&'(FH.04 23. 5 86569 8168362 42 9 7
(60) 225$%&'(.462 9 2463"162 9 7246 3. ª«£¬. 8 2
(61) 2 8232$%&'(FH.7573 9 39 567 25. 9 774564
(62) 474 5 9 346 422. 9 7 74565 2 %M>'N 6 8 039
(63) 3246 2 567 25 453 6 747"7192 9059 3 758 7
(64) 94 36 $%&'( 393 5 460 83!34
(65) 37 856952 463 4 60 62
(66) 51 8 3774 6 8252 )39 951")
(67) 503946 2. 9 774565 0 83!3$%&'(F368$%&'(. 5168 2322 39 52 9 77 8462 9 2463463322 96 9 04647
(68) 625 93 47$%&'(FH.368$%&'(.9 7
(69) 24 "# 7 9 71 27
(70) 50 46 842 5 6 24
(71) 368 762 6363 74771 72232$%&'(9 2463 9 77456 850346473636
(72) 7293 3219 23237 . 67
(73) 4 4
(74) 3 572462 2935895 3 81 25 16
(75) 24563 9 816836
(76) 5 546 2 81 4
(77) 3245671 0 623245639384 0 ". OPQRSTQ. UVWXYZ[\]^_`abcdeYfg^_`abehWijfkj^_`abcdchYXV VlmXV\\Vg[fg[\j[fnj\mYj[kojVpmkXYqgkpY[f\kZj]V gVrVqkm[fsXVj[fY. 16 4 25 2 847246
(78) 2 9 774565 $%&'(F368$%&'(. 462 2 293589 2463 340 832
(79) 394 46 2 9 2463. 9 7745685034677366 8 3
(80) 5 2 29. 393 5 725 2 192 94674 2462535774 6569 8168362 16
(81) 24565 $%&'(393 5 7462 93 479 2463"E. 9 590 8L=ALM@ 94843245656 0 9573284 9 62 8. 50 623 723 77239246 9502 46646 5 9 2 463 84 9 62432456395168:5197572 924 432456 1624 /: "#9367
(82) 94275 $%&'(.39 8 2
(83) 2 846 2 9 246337 39 37+ 74 19 *)"22247723 057245373682 497223739 596*+"t%&'(.2936 7
(84) 942739 464243 5
(85) 3 4 8463
(86) 7462
(87) 6293 9 246336871 7 1 62 9 77 8462 5 9 2463 74 19 *23463322 96032
(88) 46 2 3 5 23 6 747"22: 9 774563 3970572 9 7294
(89) 2 8 252 466 93925 2 1uD74 19 *v368 32 95642. 2 687252 53D74 19 *3w")/: 9 77456 4703462346 846 522 1uD3682 453 3 98323 652756"162 9 7246 29367
(90) 94275 $%&'(FH. 9. 8 2
(91) 2 8462 9 24633 9 3832 0: 74 19 *x" #47723
(92) 599 75687252 3!5 453 6 747" y404 39 25$%&'(.427 9 7745647464243 9 7294
(93) 2 8 252
(94) 6293 9 246336871 7 1 62 79 3872 05 93 36885973 74 19 *xz"C5. 9247 9 7 74563 397 39 9 7294
(95) 2 8252 453 3 974 19. *zD368*836842 32 9
(96) 50 79 7294
(97) 2 8252
(98) 4 4 39039 463 56 38{+: 74 19 *7"16
(99) 56 2937265 48 62 9 774565 $%&'(FHF37 5168462. 9 2463323 723 7363 83 251 29367
(100) 9427
(101) 51 8
(102) 39 8 2
(103) 2 8462 934674 19 *51"#47 5 7 932456
(104) 56 4907232 93 47$%&'(FHF472. 5925 5 5 52 9 92 932 $%&'(F-4
(105) 9 6. 9 5168 9 77 8462 9 24635 2 29358/0".
(106) \]^_^`a]^bcdefghijklmngoepnqfrsipngntsuvwwx66yz{v ^||}y~~h`b]b|ca h]`~w{wuw{~ww~z{v. abzw. 0123456789
(107)
(108) 88 !
(109) "8#$%
(110) $$8
(111) $
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
(113) yz{|{}~z{ { }¡z¢~£ z }¤¥¦. §~¨ ©ª. 012345567879
(114) 8
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`aLP%"/)&#",)-='JXJF'-(9%"=.+=&&/+%"=.K $)-#(9)/$�-9$&)M$&%bF/)"!&,(=?#->"*M$%OK: %&>&=&<&0c3\B\d4@52M$&#-=:%-('""#(%&;#$&'" "(("#$-=0&)[ Q*00")"#$-$&# #>&,(":E"')-0(%-#* %,>-#^_b+RWa-#* ($)-#("#$=?"./)"(("* #)"$#-= /)"9,)(&)(0-$"*$&'"9&>">-#=?[ Q(:',$-=(&%&)+ E&#$-=:/%&$&)"9"/$&)-#*(/"909(,'/&/,=-$&#(&0 MQ(^_O:R_:RRaLGHIJ/")0&)>"*;$%12345786+Q?Oe# )"*K-#*2C\4]+GHPQF#<)""#K(%&;($%-$-$NW%/0 $)-#(9)/$(&0'&$%<"#"(9&+=&9-=E"#$%"9"#$)-=)"$#FG<,)"NM+QKLM$VW%/0:2C\4]$)-#(9)/$(($-)$$&'" *&;#)"<,=-$"* #$%">-$,)"[ Q(&0$%"9"#$)-=)"$#FG<,)"NZ:GK:;%="12345786"./)"((&# (>-#$-#"* #$%(-)"-FG<,)"NS+GKLM$$%(($-<":;"'"<#$& &'(")!"-9&+=&9-=E-$&#&012345786;$%2C\4];$%# $%"Qfg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h";-!";%="2C\4]<"$()"($)9$"*$&$%"Qfg F(""VO%/0-#*OW%/0 #G<,)"VG+i-#*Vj+k )"(/"9$!"=?KLM$-==($-<"(-#-=?E"*:123456-#*2C\4] "./)"((&#(-//"-)>&($=?>,$,-==?".9=,(!"F".->/="( -)"%<%=<%$"*;$%-($")(h( #G<,)"VH+i:Y+kK:. -))&;(#G<,)"VS+Z:-#*VY+kKLP%")"0&)":#9&#+ $)-($;$%12345786:$%"9&>/=">"#$-)?"./)"((&#&0 123456-#*2C\4](,<<"($(-)"9/)&9-=#"<-$!")"<,=-+ $&#'"$;""#$%"("$;&<"#"(LP&0,)$%") #!"($<-$" $%(-(/"9$@Al@l\:;"$&&h$%"-*!-#$-<"&0$%" 2C\4]+m+>,$-#$">')?&(F52n3@CoKLH#$%"2C\4]+m+)"$#[ Q(0-=$&".$$%"9"==9?9="-#*$&*00")"#$-$"-()"(,=$&0-=&((+&0+0,#9$&#>,$-$&#;$%#$%"2C\4] <"#"^_paLT"$"($"*%&;2C\4]=&((+&0+0,#9$&#-#* $%")"0&)"=-9h&0[ Q*00")"#$-$&#-00"9$$%""./)"(+ (&#&012345786-#*123456FG<,)"OKLqAB@CD%?')*E-+ $&# &# ">')?&(-$VW%/0(%&;($%-$12345786 $)-#(9)/$(-)"9&>/="$"=?> ((#< #$%" QX&0$%" 2C\4]+m+)"$#-FG<,)"OZ+GK:;%="123456"./)"((&# ( )"$-#"* #$%(>,$-#$)"$#-FG<,)"OM+UKLP%" "./)"((&#&0'&$%12345/-)-=&<(#&$%")')-#-)"-(: (,9%-($%"$"9$,>-#*$%")%&>'9=/(:(#&$-00"9$"* '?M$&%b=&((FG<,)"OQ+S-#*O +JKLP%,(:12345786 -//"-)($&'"(,($-#"*'?2C\4];%="123456&#("$&0 "./)"((&#-//"-)(#*"/"#*"#$C\4]LH$)">-#($& '"*">&#($)-$"*;%"$%")-#"<-$!"0""*'-9h #$")-9+ $&#".($('"$;""#123456-#*2C\4]L r486966787987s4
(116) 23768t4u. M($(9&>>&#=?-99"/$"*$%-$-==$"="&($(,#*");"#$ &#"0,)$%"))&,#*&0T S:;";-#$"*$&$"($;%"$%") &$%")$"="&($(%-!"-=(&)"$-#"*>&)"$%-#$;&12345-#* %&;$%")"./)"((&# #$%")"$#-"!&=!"*LP%">"*-h0(% (-;"==+"($-'=(%"*>&*"=(?($">-#* ($%")"0&)" !")?(,$-'="0&)-9&>/-)(&#;$%E"')-0(%^RNaLI&0-): &#"12345%-('""#*"(9)'"* #$%">"*-h-0(%F\512345: ^_VaKv'-("*&#/%?=&<"#"$9-#-=?((\512345%-('""# 9=,($")"*;$%#$%"U-)%=_<)&,/&0/-)-=&<(F\512345^`aKL H#$")"($#<=?:\5123457 (-=(&"./)"(("* #$%")"$#--#* #/-)$9,=-)#$%"*"!"=&/#< QX^_VaLH#&)*")$&*"#+ $0?&$%")/,$-$!"12345/-)-=&<(:;"/")0&)>"*-UXMIP ("-)9%-<-#($$%">"*-h-<"#&>"FZ#(ZfUX["="-("Ow: ("">"$%&*(K,(#<E"')-0(%U-)%=/)&$"#(-(x,")"(L T"9&,=* *"#$0?-("9&#*>">'")&0$%">"*-h-12345 0-> =?	%)&>&(&>"VLU?/")0&)> #<->,=$/=" ("x,"#9"-=<#>"#$&0U-)%=/)&$"#(:$%"#";=?*"#$0"* >"*-h-U-)%=;-(-((<#"*$&$%"U-)%=R<)&,/FG<,)"`KL P%"#";=?*"#$0"*U-)%=>"*-h-/)&$"#%-(-#-(/-)-+ <#")"(*,"#($"-*&0-#-=-##"-$/&($&#_O:-#-(/-)+ $9-9*9)"(*,"#($"-*&0-<=,$-> 9-9*-$/&($&#NV -(;"==-(-#-=-##"#($"-*&0(")#"-$/&($&#NwF%<%+ =<%$"*'?-($")(h( #G<,)"`QKLP%"%&>"&'&. ("x,"#9"(&0!")$"')-$"U-)%=*00")-$$%"("/&($&#(-#* 9="-)=?*!*"$%"<"#"(#$%"$;&>"#$&#"*<)&,/(LP%" GHX*&>-#()"/)"("#$-#&$%")("$&0%<%=?9&#(")!"* >&$0(^b:w:_R:_V:RVaLk#=?&#"&0$%"GHX*&>-#(:GHXR: 9-#'"0&,#* #'&$%>"*-h-U-)%=_-#*U-)%=RFG<,)".
(117) [\]^]_`\]abcdefghijklmfndompeqrhomfmsrtuvvwxxyz{u ]||}y~~g_a\a|b` g\_~v{vtv{~vv~z{u. `av. 0123456789
(118) 98
(119)
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
(121) cdefeghdeijklmnopqrstunvlwuxmyzpwunu{z|}~~} e ogidijhodg~~|~~~}. hi~. 0123456789
(122) 98
(123)
(124) 88 !"#$% &!'()*+,*-./01-23*+0245*674241-1+25./5123+.*,1895:*04:953;3<1; =324>?@ABCDEFGHI.+;JH3+51;K.+;?LMANFOHP.+;QH3+7511+K.+2301+01RSGT5*910(F)HU.+;VK81571*,51;.+;7511+-4.++1/0(S6-/13 =15102.3+1;=324IGWVF9/61K(X31=30,5*+2./3+.//T3-26510H.+2153*530./=.:02*2412*T(Y2.710.+./:<1;.513+;3-.21;(FIZ[\ZUK I*=+5176/.23*+*,>?@ABCDE3+241-1+25./5123+.30;1/.:1;=324510T1-22*241*+1*,?LMAN962*]15/.TT3+73+241-3/3.5:8.573+./<*+1 F4374/37421;=324=432195.-^120)_`K(a4321.55*=04374/37422=*-1//0=41519*24>?@ABCDE.+;?LMAN.511bT51001;(FU.+;VK241=4321 95.-^1203+;3-.21241)_`=4151>?@ABCDE.+;?LMAN1bT51003*+./=.:0*]15/.T(.
(125) ¯°±²±³´°±µ¶·¸¹º»¼½¾¿ÀÁºÂ¸ÃÁĹÅƼÃÁºÁÇÆÈÉÊÊËÌÌÍÎÏÉ ±ÐÐÑÍÒÒÓÓÓ»ÔÕÖ³µ×°µØж´Ù»°Ö³ÒÊÏÚÊÛÈÊÏÜÒÊÊÒÎÏÉ. 0123456789
(126)
(127)
(128) 79 7 7 78
(129) 7
(130) 772
(131) 7 7 9 9 !"#$%&3 '(3 ') 7 7 7 79 79*+9 ,451 72 77
(132)
(133) 3
(134) 7 -9 78
(135) 9 7 7 .$/&!&0$1/2$3 &/4#$!56&7% $8&92
(136)
(137) 8 :3;1<6
(138) 5.$/&!&0$1/2$3
(139) 3 &/4#$!56&7% $8&93
(140) 79
(141)
(142) 79 792
(143) 7 7 9 7 7
(144) 7 9 7
(145) : 8=>?
(146) 77 3
(147) 7 56
(148) 3
(149) 7 9 7 79 2
(150)
(151) 8 -9 : 7 7
(152) 3
(153) ) 7956
(154) 9 2
(155) 7 3
(156) (7 3
(157) )
(158) 7
(159)
(160) 777 7
(161) 7 2 79 @ 8 7
(162) 7
(163) . Ý´ÞµÚÖßÊà. 7
(164) 7 5A9. 9
(165) . 7
(166) : : 8
(167) 3
(168) ( 7 7
(169) . 7 3
(170) ( 7 9
(171) : 8
(172) 3
(173) (5)
(174) : 8 7
(175) 7 3
(176) ( 795 =
(177) 79
(178) 77
(179) @ 7 78 :7
(180) B& #%C B& #%D
(181) : $/!$5E
(182) : 729 7: . 8 8 7 @ : >F1 * G
(183) 7 45G B& #%C 7: @
(184) )HI(J2)HK56
(185) 7 7 7. 7 7)L MN
(186) 8 : 8
(187) 2
(188) &5#O @ 7P?Q88 7: I)M2)0K5; 72 @ 7 @ 7
(189)
(190) 7 P?Q I(JK5= 879
(191) MN2
(192) B& #%C @
(193) ?Q;:9 : . RSTUVWXYZ[\]^_][Z`^ab^cdefgehijk\`lmlnodlZcZ_pqrstuocmqhvswxyz{|z}~}z{ z}{ ~ {~z| z ~yz{{ {~{ ~yz{{ ~{{ ¡¢ zx } ~{ £¡¤zz{ {~~ x¥| z{~{~¢} ~{ z ~~zz¢x£¦§~{ ¦¨©~ zz}z¦z}~~z{ z|z ¡{}~z z|ª¢ z{z~{x¦«~{ ¦¨~ ¬{}~~~}{}ª¢ { z x£~{ ®~ ~{|~ ~{§«~{¨ ¢}x.
(194) £¤¥¦¥§¨¤¥©ª«¬®¯°±²³´µ®¶¬·µ¸¹º°·µ®µ»º¼½¾¾¿ÀÀÁÂý ¥ÄÄÅÁÆÆÇÇǯÈÉʧ©Ë¤©ÌĪ¨Í¯¤Ê§Æ¾Ãξϼ¾ÃÐƾ¾ÆÂý. ѨҩÐÊÓ¾Ô. Z[\]^_`abcA@??d=>=eIJKLMcfAfg=D?d>Fh@JijLklmlA@Fd>fnopqrstuvwxsyzqu{vw|}zq|vwy~ytu~yq }w xyzuzurw}vunx~zq}~}wzxyu}sx~{xwuyxzxuwy}wyz}qu}rn urwuzzy}yz xvzuyquwuyxn~}wzxyux~xuwxyuxquuu}squu {x~wq}{vy yrzwzq}y¡qx urwuzzy}}sv}q x~ wu{xyz qx¡u~yquzuvwxyxwuxzn¢qyuxww}yy~y xuz urwuzzy}y quwuyxqy qyz{yzzy¡y{xzn. 0123456789 50 3
(195) 5 53 49845 39 67453 54 5 368
(196)
(197) 5 9659 2
(198)
(199) 5 45 13981 94 1 50123456789 50 3
(200) 5 53 49845 39 3 !509"9#$%&'3
(201) 51
(202) 54
(203) 930
(204) 5!509"9() *+ 88 413685 4550 3
(205) 5 53 49845 39 6745, - 965./!509"9() *0 493 4 93 505 5 50 138 3
(206) 5,12 6745-2
(207) 85!509"9() *+ 88 413685 4550 3 1
(208)
(209) 53,4930
(210) 5 3354 94 15
(211) 564 674578
(212) 7
(213) 55 45 13 01!9 315
(214) 5!509"9() *09 594954 ! 894 1.
(215) 9 15
(216) 5:5495
(217) () *0;+9 1
(218) 493 4 93 5 517309545948 3
(219) 53,493094595411395 54 45 4 50 1
(220) 5,12,1395458
(221) 5!509"95 45 1315() *+455! 85
(222) 5135154950514:5495
(223) () *+9 1
(224) 93 551730 413685 4550 3
(225) 5 649303,473 889 5 96515059581 !53 . 0 954653 515
(226) 5 2107 8 9 506535PQ 3 5
(227) 5 585 1 493
(228) 73054253 9R37
(229) 9 0 031 9555 1
(230) 54 954 549 5255 5. 15 30 2181 51459
(231) () * 6535 35
(232) 2
(233)
(234) 217805 89 3
(235) 5 4553 515 21 () *0 949816 3:5495
(236) 7 138135 94981621780
(237) 995 55345 9 350 3!509"981574
(238) 54 395 69 5.
(239)
(240) 1
(241) 5 25 1! 9450
(242) 581 15() *6535 930811"505146535
(243) 9 945 1354950 33 53.
(244) 9 553 41 150
(245) 9 6535
(246) 9 89 ! 14 93 4185 3059581 !53 945744173050
(247) 6
(248) 8 1354950585 !53 930981
(249) 12
(250) 6
(251) 8 135495065353 53 #$S&T "7 95 98589149 5013
(252) 5
(253) 6
(254) 8 1354950 3 53 5 2553
(255) 5
(256) 7!93930:5495
(257) 94
(258) 8U81 .
(259) 9 ! 6
(260) 5 530 1
(261) 5456789 1485958#$S&149 !145 305
(262) 9398 25750900 1398 5851 5 5 1 9"5 3 19 173 3 53 135499 132
(263) 3.
(264) 5549 0859189 365
(265) 5 5#$&R5594
(266) 50514 6535
(267) 9 945 33 53 5 2553:5495
(268) "859 " <=>?@AB@CD@>@?E>F@>EG@FH@@>IJKLMD@>@? N9
(269) 545 3985 45 1301!9 3 55381 13515 !509"9VW)XY930
(270) 7!9393051730
(271) 9 514 1
(272).
(273) 5() *07 8 9 514
(274) 9 5539 O7 45095 54 () *+930() *0
(275) 5 135499 1315
(276) 581 7 954.
(277) ¡¢£¢¤¥¦¦§¨¨©ª«¥ ¬¬©®®¯¯¯°±²³´¬µ²®¦«¶¦·¤¦«¸®¦¦®ª«¥. ¹º»²¼¦½. =>?@ABCDEFGHIFJKJLEJMNJOFHPMQJMGRSTOUVFIURGJHMKWXYZ[\]^\__Y`abZ[cYdZ_bZef\ga]fhi]Ye\bZ[a]\[fYjZWXYZ[\Z[d[[\kd\Zl\[ Ycef\cdZlebYZah_Y`abZ[a]\bZ]\_m]aln\e[opqrst_Y`abZub[i]\[\ZebZahh^\]e\m]ae\[mde`\_anaWogqrst_Y`abZvb[[fa]\_m\ej\\Zahh ^\]e\m]ae\[wmdelaZYZhxm\ia]ebahhxahbyZ\_jbefz{|}~WoXqY`\Y_Y`abZolYZ[\]^\_pmbZ_bZy`YebcqWphhga]fhvi]Ye\bZ[fa^\aZ a[ia]eblalb_]\[b_d\aeiY[bebYZ waZahaZbZ\bZ[e\a_Yc[\]bZ\aeiY[bebYZaZ_aZa[ia]aybZ\]\[b_d\bZ[e\a_YcahaZbZ\aeiY[bebYZu oa[e\]b[n[qWf\mhd\malny]YdZ_]\i]\[\Ze[ef\ghY[d`v[lY]\fbyf[b`bha]beb\[a]\bZ_a]nmhd\jfbh\hYj\][b`bha]beb\[a]\bZ_blae\_bZhbyfe mhd\W. 012034560758959 5
(278) 192 9 9691 29 951 5 6159 5729
(279) 19609. 1 94759
(280) 1960
(281)
(282) 16159714 128 05 5
(283) 5760 96986159 469
(284) 3 4871 09
(285) 09 9!"#$%&1 5 6
(286) 59 0855 5 '860552 576029 8859
(287) 192 !"#$%&1909 94759
(288) 59 4871 0 0855. 5 ()08!"#$%&*+1 ,8 96-9
(289) .)08 !"#$%&*&1 ,8 96-9
(290)
(291) 0855 5 )08 95!"#$% 94759
(292) -9
(293) .)08!"#$%&1 ,8. 96-01 98151 5 61 608 657/019 65 6 9
(294) 01201206 60660 59
(295)
(296) !"#$%& ,85231, 6
(297) 654 59 82
(298) 19 96959 085. 5 5 0 495 6
(299) 8192256159 58!"#$%+. 954 82 118,6689029 8859
(300) 192 !"#$%+5909 0855 5 94759
(301)
(302) 1 6814. 6
(303) 46965 0855 5 019 4871 09
(304)
(305) 3564319456065 6 , 1 5959
(306) ,1. 657!"#$%+0 498619
(307) 07 6606759
(308) 608585829 6068 59 82
(309) 196018,5 16159 9120458 57!"#$%+195 1606
(310) 1
(311) 956 59619 !"#$%+) 4871 0 0855 5.3
(312) 0855 5 4- 22 6 60660 0855 582159 8,8 96
(313) ,1 6
(314) 82159 606
(315) 1
(316) 9568619 59
(317) !"#$%+ ,85205 5759!"#$%+ 5,0 49 59 1. 69654 82
(318) 19560865 6 , 1 0 567#"89 :8;9
(319) 7208 60!"#$%&5 6502 9
(320) 8259
(321) 1778962951 8889296 <9
(322)
(323) 319.
(324) tuvwvxyuvz{|}~ }~ vxzuz{yux ¡. ¢y£z¤¥. /0123456789:;<=<>?@>A<<:BCDA797:E:9:;FGDF<H:=IA:><?=F<JK<=@<EK9>?LD9?;=E<=>MNOPQRSTUVUWXYWZUU[\]XV^_XZU`aZSbWPU b_RWXORU]U^_UVYU\RXTVbUVW_]XVTWPUVUXTPcS_ZdeSXVXVT\RTSZXWPbfXSghMf\ZPRiYR_]WUZX]YSRS_ZU`XVRXTPWcR_Ujf\ZPRkYR_]WUZXV`\ZlcR_UM g\bU]ZUR\WU`WSmUcZ\aX]P\V`bU`\l\]U^_UVYU]\ZUPXTPRXTPWU`XVcSR`MnPUV_bcUZ]XV`XY\WUWPUO\Z\RST]V_bcUZ]aSZU\YP]OUYXU]MgS`U o\R_U]ZUOZU]UVWcSSW]WZ\O]_OOSZWpcSSW]WZ\OqirrrsM. 01234565789
(325) 9 9 9
(326) 43 9
(327) 9 99 899 9 9 9
(328) 9 9
(329) !"99 #
(330) 9$% &9&98 9
(331) 9. 9 9 9
(332)
(333) 943
(334) !99 99 '() 99 99&
(335) . 9 *
(336) 9 9
(337) ! 9 +,- !9 99!9 9 9
(338) ! 99. 9 9.
(339) ¡¢¡£¤ ¡¥¦§¨©ª«¬®¯°±ª²¨³±´©µ¶¬³±ª±·¶¸¹ºº»¼¼½¾¿¹ ¡ÀÀÁ½ÂÂÃÃëÄÅÆ£¥Ç ¥ÈÀ¦¤É« ƣº¿ÊºË¸º¿ÌººÂ¾¿¹. RSTUVWXYZ[\\]^_Y`aa[Z_\^bac[d[e`f`ghijkl`_eghijkm ]_ac[Z[a]_`nopqrstuvwxryzqp{|zyzwqwyv}sp~wsswqpr zqvvwxvyzwvyzwqwss pqwss o s}yvrw}rwqpwn}ywqvpqvrypyzwypnqwrrvp}p~ wss qwryqvywypyzwvtvsqsq|v}stp}wvr zv|ztv|zywxvyztsqswyrv}s}xvyzstspyywtv}wv} nzwxzvywpyywtv}wv}vsywryzw|s}|tvp}wtttswqv}}wq }{twsqtswqp{}sqn. 012345366378509 81 4
(340) 81694 199 1 193 638 45343 6934389
(341) 9934183132 694 09 81 138634732. 842 1989 66902
(342) 3488639 9734934 936 73988 85868 !"#$%!"#$& 12 !"#$'(20398 )*+3731969 98 044323843933 3431 38734, 934 936- 6 6 1 8194 69 9."/0/1#2$!34398 3 44313648 5
(343) 486348 9 123 205 9 81 1 936 358 0659 6 98 863 05 9 813934 9343 7333181384984801268)*+ 13 45
(344) 734934 93378509 8138439365 98939353869648 9389346 32734934 936 12 0443195
(345) 93 869 235
(346) 39327 3 69 9934334398789:;<04 12 16 43 816 69319 9935 99347 3 6939 42 4 588012 1=34 6 8695 >35
(347) 84 1 93248 93 22 9 81 5480128853318 3205 9 819 9. ͤΥººÆϺÐ. 4>32934 63893538696 122 2189 3 98934734, 934 93679?;- 6
(348) 8936 6 6 1 433 319 993 99 9 1 6 52309348698 3660 663 6@0 49 12 8A06815
(349) 813 !"#$58 06 805238012
(350) 3B C-63 4 D48 9 663 05 9 818138052 660 3 9 9 559353869 681 3 2 953 699433
(351) 33731 804 4 5868 !"#$68 38 3435869)3 80129 9 1=34 689 !"#$' 12 !"#$&E' 43 3A436632 193237358 1439 1 F!"#$&E&5 >38934 734934 93 !"#$&8 8586 61893A436632 193 439 1 343 693 32 > !"#$& 12 !"#$' 4389 3A436632 193439 1 1 6 5 4 6 81 6 !"#$&E' 12 !"#$' 1=34 690660369 19 9 32 > !"#$& 6 6 5 42
(352) 1 894 16 4 9 81 54305 , 9 81 6=34 6 !"#$&E'* 7319 993 !"#$3A436, 6 81 193439 1 6 1 1 3694 53 90439 9 6 543 2
(353) 436319 1."/0/1#2$!93 869 46 81 8063A5 1 , 9 8184 !"#$&313378509 81 69 9 96439 1 53A436, 6 81 6 19 132 9 19393538695 13 309 6 5869 1GHI/1J6 12 56-343 934 9 19353, 869693=34 6 !"#$&E& 5685869 96439 1 53A436, 6 8148 5
(354) 20398 432012 1901 9 81 9 !"#$&E' 12435 A32378509 81 4
(355) 4366043 1 9658 06- 6 1 304934 550694 932 193 8193A9893KHL"!/M/I !"#$& 4 586-36363@031 3628815
(356) 4363 53 4, 9 58465 93 454893 16 1293438439386 9 816 1 939433 433A 5023248 939353869 45? 506934 )3 73 55329365 963@031 36KHL"!/M/I3 45? 123 45?9 12934893 19 9 5069346 9 193935, 3869480 3 45??51 8194 693 45 4893 1 63@031 36 43 44 132 1 8443681231 3 993378, 509 8189363 36 5393439 1 53A4366 818 3 45 6331 81634732948080993 1 5> 1, 28 - 6 80523435 93298 136 101 9 8184 4305 9 818 45? 4 5869 9532982 7346 9 81 12 168 3 636439319 814 9349 158668 205 , 93N184901 935
(357) 9809 366983A4366 81 184, 9 8184KHL"!/M/I 1269 >53 >1804934
(358) 8936 68193435 9 816 801 9 81 12 8
(359) 10 34 13 23 515 13 9936386347 9 8168042I02LJ
(360) 4 2 = , 9 81 1 5
(361) 6 66036969 993=34 6 !"#$'3A436, 6 81 99341 58635
(362) 4363 5369 98 !"#$'849858 1 8934734934 936 129343843 95
(363) 4853 193 6 3130481 55 13 36-3 80633 459 >36 49 1 9363 9 81893 O6 125 934 63 968P*O 904 9 8178?:;D01 9 81 53A34 3196 55313 36, 6 4
(364) 9893699 6
(365) 8936 6 1=34 659 56843 16 98323 81694 9323934933A4366 818 !"#$' 9 193*OB 643694 932982 65 32 O684P*O6 8489 123934 498 !"#$'3A4366 81 93 2331231981!L/#Q5 >3 18934734934 93678; 693 3A4366 818!L/#Q 12 !"#$' 43 8695
(366) 8 53 31, 9 4
(367) 804
(368) 8936 6 69 9 !"#$'94 16 4 9 81 5.
(369) GHIJIKLHIMNOPQRSTUVWXYRZP[Y\Q]^T[YRY_^`abbcddefga IhhiejjkkkSlmnKMoHMphNLqSHnKjbgrbs`bgtjbbjfga. uLvMb`nwbx. 0123456789 98
(370) 9 99
(371) !"#"$"#%&!'()"*$+%!!,)*(-./01)* 2#%*34'5!%6)$ %*7#'7%8%9'!'+"#:%!'7 %*7*')( 5"2!)*(('*'$9); +"*$'!<'7$,*;'*,)7'*;)6)'7=%+ ('*')$!':!'$'*;'7)*%7)66'!'*;+"&"2!%$%*%!!"9$"9)*();$"!)'*;%;)"* "*;'+!"#"$"#'>')( 5"2!)*(('*'$;%;%!')*$,*;'*,%!'$"9*9); %$+'#%;)+)*7)+%;)"*"6;')!7)$;%*+'?9 )+ )$*";)*$+%&' =@%+;&"+%;)"*%*762&&*%#'"6'%+ ('*'+%*5'6"2*7)*;' 77);)"*%&6)&'ABC%5&'A D "#:%!)$"*"6('*'7)$;!)52;)"*)*;';'*&"+)6"! 6"2!;'&'"$;$:'+)'$%*7 2#%*E,*;'*)+('*'$%!'6"2*7');'!)*;'5%!&A(!"2:"!;'5%!&F(!"2:.
(372) ¡¡¢££¤¤¤¥¦§¨©¡ ª§£ «¬ ££ . 0123402356362789 3680
(373) 83 3688686259257 27810630280125 3
(374) 7280253636136
(375) 0231 0 !275 80125 27027048886 756 250459 028022788"86 85#$ 36%803 7 &'()*78 2336
(376) 15 88620!8"8 3565+, 06 270285 848. 88/3
(377) 8015 0278 52 068
(378) 0234888018288627825
(379) 868 26288 236
(380) ! 33 020 !8"1 36
(381) 8"8 356 5036 7048886560 53635 573 082886 278755 5
(382) +,4 06
(383) 868 &56)26273 2!0 68
(384) 02348880170 886 7562551182886278 2535 573 0
(385) 868 27
(386)
(387) 8 236
(388) 278156 8402356 5060618 20 8028*788"8 3565 36278 %803 7+, -7878236002097080 258820368 36238232 0228658"8 3563 7328250 278 86 ./3
(389) 8(:1;5 29 5602273 20
(390) 8 81583 018362788 2348$ <.73173 84535#$ &'=)1>73173
(391) 720115625278 510 3%023565 8"8 35636273 5036*7 5186202058 6?25438683278328"1 8 843@ 8618 568
(392) 02348880182886+, -06 36%803 72615620 225 ABA 8562702 AB 3 8"8 836278%803 782360C3 @ 36
(393) ! 273 8"8 356511 680 !36 !61756!327 2785685+, -06278848 58625#$ C33@ 0 !8562702278800 A 0235@2850 8"8 3563 8363 1862570270 8868435 ! 8 1385+, -8"8 3563627880082360 836
(394) 3 282812802 20
(395) 86(0681536
(396) 8 23128 25278 ;D02 20
(397) 859@5(&6E)*73 5 8402356278 52 2787!5278 3 5156 848!6031 582360 3680
(398) 8 8133102356365273 7F236 G02 80 2327 8 81225+, -06
(399) 868 *7 825273 8"288 33 032!82886 AB 06+, -8"8 @ 35632736278#$ 3680
(400) 8 323 0 55 3 82702 :07 '66123568108860623278 81225278 56859257060 278858 5 23627828205 3680
(401) 826 3
(402) 725273 3623
(403) 36
(404) 7!5278 3 323 8 48!36288 236
(405) 250 7023 2788203686123565 278%803 7 AB 36278#$ 3680
(406) 806368 0@ 235625+, - 928061736
(407) 5278820%5061 08 3625525@ 258 068285 258 020688 310235636H ,7 I,J K LM 4,NI+M 8252788"3 28618525:0 0125 3627832 !2702080 825886062 26527836 812 170 H ,I,J K 44IIMOP4,7 J M MI5PJKILM KQM 56 !568:0106856 .8 2 5*:<9C*R 8017126278 3685278828@ 5 258 02 80 2568565S$3255 018858 2783 85278
(408) 60275 258 .T084828028 1S8 0 82702858273 835536286 8
(409) 865880@ 06
(410) 886227880 56 !568:07 0 81063636 278
(411) 8658 8U8618 5V 4W K,I+,LQ , KXM .0735" 15YK,4IZKN4[K. 80 U328 2 5. ® ¯§°±. *:<9C*R 80171$536
(412) 27836278845 23560! 28802 80 225:07 15 85636848! 8138 8 55802*78 85 8402356 03 82783623
(413) 36
(414) 7!5278 3 2702:07 0125 7048845 483615 8"32! 5523560 25278845 436
(415) 348 32!582360 006
(416) 8@ 86206705831752581825@834818 2!8 &55)26 0! 5 2!5438 068"0 856 75820368
(417) 86800 5
(418) 3
(419) 727048845 4836156@ 23236
(420) 25278 813310235653 2361218 @ 3680
(421) 8 36 2784828028823609 0
(422) 8 10 8060 ! 3 527861@ 23560 3 3102356 5278388618 3682360 8!206@ 1323560125 8288628 85 2 0652784828028 3 78 25 81 028278562785 85 3102356 8286235636278845 235654828028 0658 8@ 13310 !36
(423) 8!8845 2356. \]^_`abc]^b 26 0!528 85 21503 565:07 5275 5
(424) 73
(425) 7 3
(426) 72 388618 368"8 35602286 3273682@ 360 18 5 02356 068
(427) 036
(428) 92578
(429) 02356:! 8"286 34815 @ 8138 060 ! 3 5278 513278 8 388618 15 8 368253886230 8 8123488 @ 8d73 8278 51 8036 68845 23560! 156 203628 752702278 A 51 03 !845 48 2788! 8036
(430) 256123560 388618 32736 A 00 5
(431) 15 @ 8138 060 ! 3 5438 36 3
(432) 72 56 75820368
(433) 86800 5
(434) 3
(435) 727048845 48368 0@ 2356253 2361218 @ 3680
(436) 8 36278482802882360 efgh]ib jklmnkopl :8836
(437) 063 36
(438) 5%803 75 58 20605@ 2515 &50)D803 78!5 8828028327 9990(q'@r786! @6@*73580.r*s13683 028
(439) 0 2 0235625848623
(440) 862502356;800 8!5 888236t#; 83 156203636
(441) '
(442) u R0 59
(443) u v 09
(444) u 0 6w6x606'E5
(445) u ;
(446) C0wx63683563%8028 yzmk{llz|zp}poz. 9 3 70875 8362783 7013 32!55 05025! 73170 3 2011536
(447) 25278 510 0630 8 08 2060 .*38 172%
(448) 8 82%''' 9 ' R'10636 01150618327t5806s63560630 8 08
(449) 38@ 368 *78013 32!3 68278 843 3565278 510 88 8620234852780630 8 080
(450) 861!R50630 8"83862 88858t!5 5800.~ [7 KI +KJMI106%803 7.H4K, M K,188 8 8"1 348 !02 20
(451) 8 35257021736
(452) .652156 3880 0630 011536
(453) 25$806 006t58066356 8
(454) 02356 1D803 7068008803 806 036203680 8 1388435 !&6E)*785 536
(455) 2036 88 85%803 78!5 d3 2!8S2vu 9:0658008!5 d278 03 2!8 2036G.
(456) ¡¢£¡¤¥¦£¡¡§¦¨©ªª«¬¬®¯© °°±²²³³³´µ¶·¸°¹¶²ª¯ºª»¨ª¯¼²ªª²®¯©. 012345467849 7 639 4
(457) 951 7773. !"#$ ! %&' % '" ()*+,- #'' ." '/ .! .0%12 $ . '3!' & " .' (4454***45444*544,. 6 ! ' (*5454445**445*54*54,. !' . "'.' /"!7.8" 9:;<=>:?(@2AB+C5D88E@!@FGC6H,I*$%#' %".' '"!J'6 %$%# !KHL*E7! %EMHL*ED! %ENDL*E8 'O"##" .$D%$%# ! ' & #' ML*I5P 12-)"#$ ! !3! ."-5'#' E'%3 '" ! "Q ' NDL*I5& )*+".3% !%#" .' " *+RR5B)B56 % "(R6' " ,.! P3 % .3!' 5N.A)M" " !I5& ! P3 % &! !3 ' . " & @FGCS4 G0JTUKQ7VI W93 X19Y 8Z[\Z]^_`4 4a7849. A' # &"# - "3 bcdbef&$'.'g '"";<=>: ! !%' ."3 ! 6'"3!#$. !%' .'SQVE" & g '!& $"!.'SQ7VE" & .0 $"!I +'"" ! & # ## . ' &.' "/' '-h5)(+"%& #' .A%' % ,Ii$'.'g '" ' & & " !%' .""6 ' & MHL*jML*I '-1R4' $ '".$%"3# . "#0#' &"!& ! (+"%& F"# %3# G'"%& '%#!,.2G5-G*R)(+"%& F"# %3#G'"%& '%#!, !3! ."!' #. % '"Ik" & kRAi "g '!& $"!E ".''% '"! #' . " & &".. !%' .'SQVE!!3 ! .$A & l'%& ' (33#'!& .,I@ $"! !& . ' & 7m#5$ '. A' # #''% '"(5A,!"#3 '" .'%3 . ' &kR5*'5AIR%3 '" ' & & ;<=>:?" !"Q '3 !E'%3 '" ' & & <e9>n" !"8 '3 !I@ $"! & 0 ' & .0"##"##" ' ! !Ik". % '" .! '' " & '! ! " !E $"! !& .Ho7 ' ' &525(I7F 5'!iNIHEI7HF 2*#EI7p5 D,E'%3 . ' &7piDBD'525 "D '. !& . 'Ho7 'I@ $"! #"%0 .'52G(Dp1R4G#"%0'525,"7& +5 . .!'%3 . ' & '-1' "/' '-)B1 k !.'#3 .7J7'52GIk"!' #. % '"Ek#3" !% '(kR5*,E*$' Q(*$Q,"*$' H (*$H,k#3""&" 5$ '. $) 0'@# !3! .I @ $"! & '%3 .'7o8qEM-1' '.'-D& $#'."#(1)R,'525"6 ' & 8L*. !& .! 6 # ' !'525 & / .$I@ $"! ! ' . ' &2G5jG*R) "3 .'Np4#$% "# " '%"!%" !#'. !. ' . ' & C '% 1FHGE7/"D/'"r % '6 !EC '%*1H '%"!%" % .C '%k' * 7INI7!" I 1"3# #3" !% $"! "3 .'7o7H #!!" " .'!& !'7IHp#" # ' "! I *""%#! %0! 0 3!' & C '%A)H%""%# '%"!%" ED/ ' !'""r % '6 .C '% #'% '"A3' (CA,!" IkR5* ! /%' . . ½¾ª¯¶¿ªÀ. 8 $ "#! E*$Q$ & HM i #'3 2 "#! E*$H MQQ $i #'3 -2 ".1)R $hs#! I@ '!!'" !! ! . H-HH " kR5*EMH-N "*$QEMH- "*$H. 8-H "1)RI@ '!!'"%& #! ' . ! P3 '##$ "6"'.# .- &"3 &" & "#3" !% !' #!I)'% 3 ! "% !! .3!' & " !"3% !" R T6 !'"7I8Q.." )&" "!&"*AQI. t_39
(458) 8467 73_u4u. )" '! P3 % ! " ' ." @!@FGC4 " G" ! (6H, 3!' 5GCA52 " " ! %&" & g '!&" '! P3 % "G&#D. GI7E ! % '6 #$E '! & " '%12" & 3! .! %' ! "%& %0 & ' ' $" & " ." '! P3 % !I5& "##" ' " '! P3 % ! 3! .Jv<cb9 =w=b9 GI7 (%% !!'" 3 @2A1+)7M778xv<cb9=w=b9GID(%%I2"I @2A1+)H78NQ,v<cb9=w=b9G&#D(%%I2"I @2A1+)KQ8QM,y9z9d<{bwcdG+iC7(%%I 2"I@2A)DMQM7,y9z9d<{bwcdG+iCD(%%I 2"I@2A)QHK8N8,|fdzfd}f:fdG+iC7(%%I 2"I@2AFhA)HQ78Nx|fdzfd}f:fdG+iCD (%%I2"I@2AFhA)8H,~wc9{fde=9{b}<:bd (%%I2"I@2A@5)7QND,~wc9{fde=9{b }<:bd&#D(%%I2"I@2A@5)H7N88,<dew=9d ewfd <}f:w<efd G (@2A4*)DQKN8, <dew=9dewfd<}f:w<efdG&#D(@2A4*)HNQ, we=<99ccb=9 b=bbdG&#D(@2A52R)7MNM7, we=<99ccb=9 b=bbdGI7(@2A52R)7Q, we=<99ccb=9 b=bbdGID(@2A52R)7NK, we=<99ccb=9 b=bbdGIQ(@2A52R)NQ, <bff=f;=b{wdG(@2A5+h)7Q8NN,<b ff=f;=b{wdG&#D(@2A5+h)QDHNH,=b<d :<eb{wdG(%%I2"I@2AB+C)7H8H,b9c< d< bcbG&#(@2A*As)7KD7K,v=9d9{>b:< zw:<c9<dew=G7(%%I2"IkGN8D8,v=9d9{>b:< zw:<c9<dew=GD(%%I2"IkGN8D8Q,A P3 % ! " ' ." 2 '"#* "G'" %&"#" $q! (2*GR,4 G0. ! (+ # ! 7N,J~wc9{fd:<w bd G(%%I2"I4788H7I7,~wc9{fd:<w bdG&#D (%%I2"I2)7DD7I7,<:z9d<:<=G(%%I 2"I2)77MN7I7,=<c}>b9de9z<:9=b<wG ()DHKMQK7I7,I5& " '! P3 % "=b<d :<eb{wdG&#D !" ' ." !# ' & ! P3 % .%12%#" 3!' & @/)A$"#' !# ""#" A '!!R! ' 3 "G'"'" '%!(ARG,I #' " & ! P3 % ! !".3% .3!' FhA*C@"#' & @3" G'"'" '%!R! ' 3 (@GR,SQHVI&$#" '% !!! # .3!' G'"2T"#' &$#" $I " ' 7"" ! ! .3!' T" !-5$#"-5&" " '/I5&'!.'! % ! .# "' & '!%#' . " ##!3' .".
(459) Ø¡·©·±»¡· ³ À §«¦¦Ô!!¥Ûá« ·®®¥77äääÀ²¢°± ¤¡ ª®³»µÀ¡°±7¦áý¦ñ§¦áÉ7¦¦7Ûá«. 0123456718197
(460) 80 7 667
(461) 76
(462) 61854 7 5. 4767
(463) 46
(464) 768 13 871
(465) 50. 719 45 8 517013 !"#$"!%"%&!'('. )512171241061945 8 768
(466) 248 54967 760* 40*+,-./010248 2 4*4 5 012345 3 6 8693684 8 74100
(467) 568215 4818 19. 106 317661819 4019 7 8 7 47 8 7 450 68473 06 7
(468) 768 4874567 4447. 7 4509
(469) 80618848745675 47 9 :;17661848 6 86319 8 7 5 31 70 24604340015 68 1 6515 548 156 846188<6
(470) 5 =811704 : 4>40317661819 40 8 048 91
Documenti correlati
Lo ricorda la ver- sione profana (xli), dove la distruzione della morte con la morte è even- to tanto laico quanto eroico, percepito come l’unico che può condurre al naturale esito
The threshold 0.5 is the closest to the Task 1 partition, with a similar percentage of HS (16.90%), while lower thresholds allow for much higher percent- ages of tweets classified
In opposition to other theories of the mind in which the subject and the environment are considered to be separate entities, enaction claims that the study of the action and
Figure 3 shows the evolution of the uncertainties in the background prediction, before the fit to the invariant mass distribution described in section 8 , as a function of m γγ in
After addressing MIT’s Moral Machine and its criticisms, we will present a way in which we could use artificial intelligence to solve moral dilemmas such as the trolley problem 4 ,
Number of consensus regulatory elements and corresponding fraction of the human genome covered for CONREL global consensus regions computed using both narrow and broad peak data and
Rosenberg et al., “Comput- erized analysis of enhancement kinetics for preoperative lymph node staging in rectal cancer using dynamic contrast- enhanced magnetic resonance
