Correction to: Assessment of intratumor immune-microenvironment in colorectal cancers with extranodal extension of nodal metastases

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Fassan et al. Cancer Cell Int (2019) 19:244 https://doi.org/10.1186/s12935-019-0966-z

CORRECTION

Correction to: Assessment of intratumor

immune-microenvironment in colorectal

cancers with extranodal extension of nodal

metastases

Matteo Fassan

1*†

_{, Luca Vianello}

1†

_{, Diana Sacchi}

1†

_{, Giuseppe N. Fanelli}

1

_{, Giada Munari}

1

_{, Marco Scarpa}

2

_,

Rocco Cappellesso

1

_{, Fotios Loupakis}

3

_{, Cristiano Lanza}

1

_{, Roberta Salmaso}

1

_{, Claudia Mescoli}

1

_{, Nicola Valeri}

4,5

_,

Marco Agostini

2,6,7

_{, Edoardo D’Angelo}

2

_{, Sara Lonardi}

3

_{, Salvatore Pucciarelli}

4

_{, Nicola Veronese}

8,11

_,

Claudio Luchini

9

_{and Massimo Rugge}

1,10

© The Author(s) 2019. This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/ publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

Correction to: Cancer Cell Int (2018) 18:131

https ://doi.org/10.1186/s1293 5-018-0634-8

Following publication of the original article [

1 ], it has

been brought to our attention that an incorrect

Seque-nom MassArray trace and an incorrect Seque-nomenclature

Open Access

Cancer Cell International

*Correspondence: matteo.fassan@unipd.it

†_{Matteo Fassan, Luca Vianello and Diana Sacchi contributed equally to}

this work

1_{Surgical Pathology & Cytopathology Unit, Department of Medicine}

(DIMED), University of Padua, via Gabelli 61, 35121 Padua, Italy Full list of author information is available at the end of the article

were used to represent the PIK3CA p.E545A mutation in

Fig. 2b. The correct Fig.

2 b is shown in this erratum. The

authors apologize for the confusion.

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Page 2 of 2 Fassan et al. Cancer Cell Int (2019) 19:244

Author details

1_{Surgical Pathology & Cytopathology Unit, Department of Medicine (DIMED),}

University of Padua, via Gabelli 61, 35121 Padua, Italy. 2_{Department of Surgical}

Oncology and Gastroenterology (DiSCOG), University of Padua, Padua, PD, Italy. 3_{Unit of Oncology 1, Department of Clinical and Experimental Oncology,}

Istituto Oncologico Veneto, IOV-IRCCS, Padua, PD, Italy. 4_{Division of Molecular}

Pathology, The Institute of Cancer Research, Sutton, London, UK. 5_Department

of Medicine, The Royal Marsden NHS Trust, Sutton, London, UK. 6

Nanoin-spired Biomedicine Laboratory, Institute of Pediatric Research, Fondazione Città della Speranza, Padua, PD, Italy. 7_{Department of Nanomedicine, The}

Methodist Hospital Research Institute, Houston, TX, USA. 8_{National Research}

Council, Neuroscience Institute, Aging Branch, Padua, PD, Italy. 9_Department

of Diagnostics and Public Health, Section of Pathology, University and Hospital Trust of Verona, Verona, VR, Italy. 10_{Veneto Cancer Registry, Padua, PD, Italy.} 11_{National Institute of Gastroenterology-Research Hospital, IRCCS “S. de Bellis”,}

70013 Castellana Grotte, BA, Italy.

Reference

1. Fassan M, Vianello L, Sacchi D, Fanelli GN, Munari G, Scarpa M, Cappel-lesso R, Loupakis F, Lanza C, Salmaso R, Mescoli C, Valeri N, Agostini M, D’Angelo E, Lonardi S, Pucciarelli S, Veronese N, Luchini C, Rugge M. Assessment of intratumor immune-microenvironment in colorectal cancers with extranodal extension of nodal metastases. Cancer Cell Int. 2018;18:131. https ://doi.org/10.1186/s1293 5-018-0634-8.

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BRAF c.1799T>A (p.V600E)

#1

#2

#3

#4

#5

#6

#7

#8

#9

#10 #11 #12 #13 #14 #15

TP53 (p.I195F) PIK3CA (p.E542K) KRAS (p.Q61H) BRAF (p.V600E) BRAF (p.V600E) APC (p.E1309*) TP53 (p.R273H) APC (p.R876*) PIK3CA (p.E545A) BRAF (p.V600E) TP53 (p.C242Y) KRAS (p.A146T) (p.R306*)TP53 TP53 (p.R306*) NRAS (p.Q61L) APC (p.R805*) BRAF (p.V600E) APC (p.E1306*) NRAS (p.G12D) TP53 (p.R196*) BRAF (p.V600E) APC (p.E1397*) TP53 (p.C242Y) TP53 (p.E298*) APC (p.E1353*) None TP53 (p.I195F) PIK3CA (p.E542K) KRAS (p.Q61H) NRAS (p.G12D) BRAF (p.V600E) BRAF (p.V600E) APC (p.E1309*) TP53 (p.R273H) APC (p.R876*) PIK3CA (p.E545A) BRAF (p.V600E) TP53 (p.C242Y) KRAS (p.A146T) PIK3CA (p.E545K) TP53 (p.R306*) TP53 (p.R306*) NRAS (p.Q61L) APC (p.R805*) BRAF (p.V600E) APC (p.E1306*) NRAS (p.G12D) TP53 (p.R196*) BRAF (p.V600E) APC (p.E1397*) TP53 (p.C242Y) TP53 (p.E298*) APC (p.E1353*) KRAS (p.A146T) TP53 (p.I195F) PIK3CA (p.E542K) KRAS (p.Q61H) BRAF (p.V600E) BRAF (p.V600E) APC (p.E1309*) PIK3CA (p.E545A) BRAF (p.V600E) TP53 (p.C242Y) KRAS (p.A146T) (p.R306*)TP53 None TP53 (p.R306*) NRAS (p.Q61L) APC (p.R805*) BRAF (p.V600E) APC (p.E1306*) NRAS (p.G12D) TP53 (p.R196*) BRAF (p.V600E) APC (p.E1397*) TP53 (p.C242Y) TP53 (p.E298*) APC (p.E1353*)

KRAS c.436G>A (p.A146T)

PIK3CA c.1634A>C (p.E545A)

a

b

NRAS c.35G>A (p.G12D)

Fig. 2 a Mutational profiling of the 15 cases profiled through a hotspot multigene mutational custom panel, including 164 hotspot regions of

AKT1, APC, BRAF, CTNNB1, KIT, KRAS, NRAS, PDGFRA, PIK3CA, PTEN and TP53 genes. In red are the samples showing a different mutational landscape

in comparison to the other matched samples (scale bars = 100 µm). b Representative Sequenom MassArray output profiles for KRAS c.436G> A (p.A146T), PIK3CA c.1634A>C (p.E545A), BRAF c1799T>A (p.V600E) and NRAS c.35G>A (p.G12D) mutations. On the right the correspondent Sanger chromatogram

The original article can be found online at https ://doi.org/10.1186/s1293 5-018-0634-8.