DEVELOPMENT OF ELECTROCHEMICAL BIOMEMS FOR TNFalpha DETECTION IN SALIVA: APPLICATION TO HEART FAILURE.

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State of Art

Chapter 1:

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

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Electrochemical

Chapter 2:

Characterization

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𝐶 = 𝐶(𝑥, 𝑡)

0 ≤ 𝑥 ≤ ∞

𝐽

₀

(𝑥, 𝑡) = −𝐷

₀𝑑𝐶0(𝑥,𝑡) 𝑑𝑥 𝑑𝐶0(𝑥,𝑡) 𝑑𝑡

= 𝐷

0 𝑑2𝐶0(𝑥,𝑡) 𝑑𝑥2

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√−1

⍵

𝑗

⍵

𝑍(𝑗⍵) =

𝑈(𝑗⍵) 𝐼(𝑗⍵)

= 𝑍

𝑟𝑒

(𝑗⍵) + 𝑗𝑍

𝑖𝑚

(⍵);

⍵ = 2𝜋𝑓

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𝛿

𝐶

_𝑑

=

𝜀𝑑𝐴

𝛿

;

𝜀

𝑑

= 𝜀

0

𝜀

𝑝

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𝐶𝑃𝐸 = 𝐴

−1

(𝑗𝜔)

−𝑛

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𝜔 → ∞

𝑅

_𝑆

+ 𝑅

_𝑐𝑡

𝜔

0

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R = 8,31 J 𝑚𝑜𝑙

−1

_𝐾

−1

𝐹 = 9,65 × 10

4

A

𝑐𝑚

−2

𝑚𝑜𝑙 𝑐𝑚

−3

𝑅

𝑐𝑡

= 𝑅𝑇(𝑛𝐹𝐼

0

)

−1

𝐼

₀

= 𝑛𝐹𝐴𝑘

_𝑐𝑡

[𝑆]

𝑗

⍵



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BioMEMS

Chapter 3:

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Experimental Section

Chapter 4:

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 𝐸

_𝑖

= 0,300 𝑉 𝑣𝑠. 𝑅𝑒𝑓



𝑑𝐸 𝑑𝑡

= 80 𝑚𝑉 𝑠

⁄

 𝐸

₁

= 0,300 𝑉 𝑣𝑠. 𝑅𝑒𝑓

 𝐸

₂

= −0,910 𝑉 𝑣𝑠. 𝑅𝑒𝑓

 𝑛

_𝑐

= 4 𝑡𝑖𝑚𝑒 (𝑠)

 𝑀𝑒𝑎𝑠𝑢𝑟𝑒 < 𝐼 > 𝑜𝑣𝑒𝑟 𝑡ℎ𝑒 𝑙𝑎𝑠𝑡 50% 𝑜𝑓 𝑡ℎ𝑒 𝑠𝑡𝑒𝑝 𝑑𝑢𝑟𝑎𝑡𝑖𝑜𝑛

 𝑅𝑒𝑐𝑜𝑟𝑑 < 𝐼 > 𝑎𝑣𝑒𝑟𝑎𝑔𝑒𝑑 𝑜𝑣𝑒𝑟 𝑵 = 10 𝑣𝑜𝑙𝑡𝑎𝑔𝑒 𝑠𝑡𝑒𝑝𝑠

 𝐸 𝑅𝑎𝑛𝑔𝑒 = [−2,5 𝑉 ÷ 2,5 𝑉]

 𝐵𝑎𝑛𝑑𝑤𝑖𝑑𝑡ℎ = 4

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

𝐸 = 0,128 𝑉 𝑣𝑠. 𝑅𝑒𝑓

 𝑓

_𝑖

= 200 𝐾𝐻𝑧

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

𝑁

_𝑎

= 1 𝑚𝑒𝑎𝑠𝑢𝑟𝑒(𝑠)𝑝𝑒𝑟 𝑓𝑟𝑒𝑞𝑢𝑒𝑛𝑐𝑦

 𝑛

𝑐

= 200

 𝐸 𝑅𝑎𝑛𝑔𝑒 = [−5𝑉 ; 5𝑉]

 𝐵𝑎𝑛𝑑𝑤𝑖𝑑𝑡ℎ = 4

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±

[(𝑅 − 𝑅

)/𝑅

]

R

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∆𝑅 𝑅𝐴𝑏

=

𝑅𝐴𝑔−𝑅𝐴𝑏

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Annex

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