2
... 12
... 14
... 18
... 19
... 21
... 26
... 28
... 32
... 34
... 37
... 39
... 41
... 42
... 43
... 45
... 49
... 50
... 59
... 59
... 59
3
... 67
... 68
... 68
... 73
... 75
... 76
... 78
... 79
... 81
... 84
... 87
Β
Β ... 89 Β91
4
... 95
... 97
... 98
... 101
... 105
107 ... 109
... 109
... 110
... 110
... 111
... 111
... 113
5
6 β
β
β
β
β
7
8
9 β
α β
β
β
10
11
12 β
β
β γ
β
13 β
β β
ε
ε ε
β ε
β
14
ε β
β
β
β
β
β β
β β
β
15 β
β β
β
γ
β
β β
β
16 β
β
β
α β
α β
β
α γ
β
α
α β
γ
γ β
β
β
β
17
α β β
β β
γ β
18
19
20
21
22
23
α
24 β
β
β
25
26
α
27
28
29
30
31
32
β
33 β
β
β
β β
β β
β
34 ε
β
β
β
ɣ
β
35 β
β
β β
β β
β
β
β
β β
β
36
β
37
38 α
β
39 ɣ
ɣ
40 β
β ɣ
β α
β
α
α
β
41 β
β
42 α
α
β
β
43
α β
44 α
β
45
46 β
β
47
48
49
50
51
52
53 β
β
β β
γ
α β α
β α
β
54
55
56
β
57
58
59
60
61
62
63
64
β
65
66
67
β β
β
β ββ
68
69
70
α β
71
72
73
74
75
76
77
78
79
80
81
82
83 β
β
β
β β
WT
CAP2 KO 0
10 20 30 40 50
O.D. Amyloid Beta1-42 (pg/ml) / concentration
**
84
85
86
87
88
89
β
β
β β
β β
β
β β
β
β β
β
β
β
β β
β
β
90 β
β
β
β
β
β
β β
91
β β
β β
β β β
β β
β β
β β β β β β
β
β
β β
β
β β
β β
β
β
β
β
92 β
β
β β
β
β β β
β β
β β β
β
β β
93
β β
β β
β β β
β
β β
β β β
β
β
β
β
β
β
94
β
β
β
95
96
97
98
99
100
101
102
103
β
104
105 β
β
β
106
107
108
109
β
110
111
112
113 α
α
β
114
α α
α
115
116 β
β
β α
117
β
118 β
β