Recent Results
in Cancer Research 166
Managing Editors
P.M. Schlag, Berlin H.-J. Senn, St. Gallen
Associate Editors
P. Kleihues, Lyon F. Stiefel, Lausanne B. Groner, Frankfurt A. Wallgren, Gteborg
Founding Editors
P. Rentchnik, Geneva
H.-J. Senn · R. Morant (Eds.)
Tumor Prevention and Genetics III
With 29 Figures and 44 Tables
Professor Dr. Hans-Jrg Senn Dr. Rudolf Morant
Zentrum fr Tumordiagnostik und Prvention Rorschacherstrasse 150
9006 St. Gallen, Switzerland
Indexed in Current Contents and Index Medicus ISSN 0080-0015
ISBN 3-540-22228-6 Springer Berlin Heidelberg New York
Library of Congress Control Number: 2004110715
This work is subject to copyright. All rights are reserved, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilm or in any other way, and storage in data banks. Duplication of this publication or parts thereof is permitted only under the provision of the German Copyright Law of September 9, 1965, in its current version, and permission for use must always be obtained from Springer-Verlag. Violations are liable for prosecution under the German Copyright Law.
Springer is a part of Springer Science+Business Media springeronline.com
Springer-Verlag Berlin Heidelberg 2005 Printed in Germany
The use of designations, trademarks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant pro- tective laws and regulations and therefore free for general use.
Product liability: The publisher can not guarantee the accuracy of any information about dosage and application contained in this book. In every individual case the user must check such information by consulting the relevant literature.
Editor: Dr. Ute Heilmann, Heidelberg, Germany
Desk editor: Drthe Mennecke-Bhler, Heidelberg, Germany Production editor: Ingrid Haas, Heidelberg, Germany Typesetting: Strtz GmbH, Wrzburg, Germany Printing: Krips, Meppel, The Netherlands
Binding: Litges & Dopf GmbH, Heppenheim, Germany
Cover-design: design & production GmbH, Heidelberg, Germany Cover printing: Stolinski GmbH, Malsch, Germany
Printed on acid-free paper 21/3150/ih – 5 4 3 2 1 0
Contents
Lifestyle and Medical Approaches to Cancer Prevention . . . . 1 Peter Greenwald
Application of Genetics to the Prevention of Colorectal Cancer . . . . 17 John L. Hopper
Genetics and Prevention of Oesophageal Adenocarcinoma . . . . 35 Rebecca C. Fitzgerald
Preclinical Models Relevant to Diet, Exercise, and Cancer Risk . . . . 47 R. James Barnard, William J. Aronson
Individualizing Interventions for Cancer Prevention . . . . 63 Michael Pollak
Can Animal Models Help Us Select Specific Compounds
for Cancer Prevention Trials? . . . . 71 Ernest T. Hawk, Asad Umar, Ronald A. Lubet,
Levy Kopelovich, Jaye L. Viner
Problems with Using Biomarkers as Surrogate End Points for Cancer:
A Cautionary Tale . . . . 89 Arthur Schatzkin
Can a Marker Be a Surrogate for Development of Cancer,
and Would We Know It if It Exists? . . . . 99 William B. Armstrong, Thomas H. Taylor,
Frank L. Meyskens
How Should We Move the Field of Chemopreventive Agent Development Forward in a Productive Manner? . . . . 113
Frank Louis Meyskens, Eva Szabo
VI Contents The Problems with Risk Selection; Scientific and Psychosocial Aspects . . . 125
Anne-Rene Hartman
Chemoprevention of Lung Cancer . . . . 145 Stphane Vignot, Jean-Philippe Spano, Sylvie Lantuejoul, Fabrice Andr, Thierry Le Chevalier, Jean-Charles Soria
Anti-nicotine Vaccination: Where Are We? . . . . 167 T. Cerny
Primary Prevention of Colorectal Cancer: Lifestyle, Nutrition, Exercise . . . . 177 Mara Elena Martnez
Chemoprevention of Colorectal Cancer: Ready for Routine Use? . . . . 213 Nadir Arber, Bernard Levin
Screening of Colorectal Cancer: Progress and Problems . . . . 231 Sidney J. Winawer
The Role of Endogenous Hormones in the Etiology and Prevention
of Breast Cancer: The Epidemiological Evidence . . . . 245 Paola Muti
Innovative Agents in Cancer Prevention . . . . 257 Margaret M. Manson, Peter B. Farmer, Andreas Gescher,
William P. Steward
The IARC Commitment to Cancer Prevention:
The Example of Papillomavirus and Cervical Cancer . . . . 277 Silvia Franceschi
Health Economics in the Genomic Age . . . . 299 Thomas D. Szucs
Screening for Cancer: Are Resources Being Used Wisely? . . . . 315 Robert M. Kaplan
