6 - BIBLIOGRAFIA
Abi-Dargham A and Laruelle M (2005) Mechanisms of action of second generation antipsychoticdrugs in schizophrenia: insights from brain imaging studies. Eur psychiatry 20:15-27.
Ahlgren-Beckendorf JA and Levant B (2004) Signaling mechanisms of the D3 dopamine receptor. J Recept Signal Transduct Res 24:117-130.
Aihara K, Shimada J, Miwa T, Tottori K, Burris KD, Yocca FD et al (2004) The novel antipsychotic aripiprazole is a partial agonist at short and long isoforms of D2 receptors linked to the regulation of adenylyl cyclase activity
and prolactin release. Brain Res 1003-917.
Beom SR, Cheong D, Torres C, Caron MG, and Kim K-M (2004) Comparative studies of molecular mechanisms of dopamine D2 e D3
receptors for the activation of extracellular signal-regulated kinase. J Biol
Chem 279:28304- 28314.
Boeckler F and Gmeiner P (2006) The structural evolution of dopamine D3
receptor ligands: structure-activity relationships and selected neuropharmacological aspects. Pharmacol Ther 112:281-333.
Burstein ES, Ma J, Wong S, Gao Y, Pham E, Knapp AE, Nash NR, Olsson R, Davis RE, Hacksell U, et al. (2005) Intrinsic efficacy of antipsychotics at human D2, D3 e D4 dopamine receptors: identification of the clozapine
metabolite N-desmethylclozapine as a D2/D3 partial agonist. J Pharmacol
Cai G, Gurdal H, Smith C, Wang HY, and Friedman E (1999) Inverse agonist properties of dopaminergic antagonists at D1A receptor from GS
protein. Mol Pharmacol 56:989-996.
Clementi C. and Fumagalli G. (1999) Farmacologia generale e cellulare. UTET
Conklin BR, Farfel Z, Lustig KD, Julius D and Bourne HR (1993) Substitution of three aminoacids switches receptor specificity of Gq to that
of a Gi . Nature 363: 274-276.
Conklin BR, Herzmark P, Ishida S, VoynoYasenetskaya TA, Sun Y, Farfel Z and Bourne HR (1996) Carboxylterminal mutation of Gq and Gs that alter
the fidelity of receptor activation. Mol. Pharmacol. 50: 885-890.
Corsini GU, Maggio R and Vaglini F (2002) Molecular and cellular events regulating dopamine neuron survival. Handbook of Exp.Pharm. 154 (II),321-386
Cullen BR (1987) Use of eukaryotic expression technology in the functional analysis of cloned genes. Methods Enzymol. 152:684-704.
Cunningham Owens DC (1996) Adverse effects of antipsychotic agents: do newer agents offer advantages? Drugs 51:895-930.
Cussac D, Newman-Tancredi A, Pasteau V, and Millan MJ (1999) Human dopamine D3 receptors mediate mitogen-activated protein kinase
activation via a phosphatidylinositol 3-kinase and an atypical protein kinase C-dependent mechanism. Mol Pharmacol 56:1025-1030.
Cussac D, Pasteau V, and Millan MJ (2004) Characterisation of GS
activation by dopamine D1 receptors using an antibody capture assay:
antagonist properties of clozapine. Eur J Pharmacol 485:111-117.
Dean B and Scarr E (2004) Antipsychotic drugs: evolving mechanisms of action with improved therapeutic benefits. Curr Drug Targets 3:217-225.
Dubertret C, Gorwood P, Ades J, Feingold J, Schwartz JC, and Sokoloff P (1998) Meta-analysis of DRD3 gene and schizophrenia: ethnic heterogeneity and significant association in Caucasians. Am J Med Genet
81:318-322.
Dubuffet T, Newman-Tancredi A, Cussac D, Audinot V, Loutz A, Millan MJ, and Lavielle G (1999) Novel benzopyralon [3,4-c]pyrrole derivates as potent and selective dopamine D3 receptor antagonist. Bioorg Med Chem
Lett 9:2059-2064.
Everett PB and Senogles SE (2004) D3 dopamine receptor activates
phospholipase D through a pertussis toxin-insensitive pathway. Neurosci
Lett 371:34-39.
Fishburn CS, Belleli D, David C, Carmon S and Fuchs S (1993) A novel short isoform of the D3 dopamine receptor generated by alternative
splicing in the third cytoplasmic loop. J. Biol. Chem. 268: 5872-5878.
Freedman SB, Patel S, Marwood R, Emms F, Seabrook GR, Knowles MR and McAllister G (1994) Expression and pharmacological characterization of the human D3 dopamine receptor. J. Pharmacol. Exp. Ther. 268:
Griffon N, Pilon C, Sautel F, Schwartz JC, and Sokoloff P (1997) Two intracellular signalling pathways for the dopamine D3 receptor: opposite
and synergistic interactions with cyclic AMP. J Neurochem 68:1-9.
Gurevich EV, Bordelon Y, Shapiro RM, Arnold SE, Gur RE, and Joyce JN (1997) Mesolimbic dopamine D3 receptor and use of antipsychotics in
patient with schizophrenia: a post-mortem study. Arch Gen Psychiatry
54:225-232.
Hall DA and Strange PG (1999) Comparison of the ability of dopamine receptor agonists to inhibit Forskolin-stimulated adenosine 3’5’-cyclic monophosphate (cAMP) accumulation via D2L (long isoform) and D3
receptors expressed in Chinese hamster ovary (CHO) cells. Biochem
Pharmacol 58:285-289.
Heidbreder CA, Gardner EL, Xi ZX, Thanos PK, Mugnaini M, Hagan JJ, and Ashby CR (2005) The role of central dopamine D3 receptors in drug
addition: a review of pharmacological evidence. Brain Res Rev 49:77-105.
Jonsson EG, Flyckt L, Burgert E, Crocq MA, Forslund K, Mattila-Evenden M, Rylander G, Asbert M, Nimgaonkar VL, Edman G, et al. (2003) Dopamine D3 receptor gene Ser9Gly variant and schizophrenia:
association study and meta-analysis. Psychiatr Genet 13:1-12.
Josselyn SA, Miller R, and Beninger RJ (1997) Behavioral effects of clozapine and dopamine receptor subtypes. Neurosci Biobehav Rev
21:531-558.
Joyce JN (2001) Dopamine D3 receptors as a therapeutic target for
Joyce JN and Millan R (2005) Dopamine D3 receptor antagonists as
therapeutic agents. Drug Discov Today 10:917-925.
Kapur S and Mamo D (2003) Half a century of antipsychotics and still a central role for dopamine D2 receptors. Prog Neuropsychopharmacol Biol
Psychiatry 27:1081-1090.
Kozell LB, Macida CA, Neve RL and Neve KA (1994) Chimeric D1/D2
dopamine receptors. Distinct determinants of selective efficacy, potency and signal trasduction. J. Biol. Chem. 269:30299-30306.
Landwehrmeyer B, Mengod G and Palacios JM (1992) Dopamine D3
receptor mRNA and binding sites in human brain. Mol. Brain Res. 18: 187-192.
Lane JR, Powney B, Wise A, Rees S, and Milligan G (2007) Protean agonism at the dopamine D2 receptor:
S-3-(3-hydroxyphenyl)-N-propylpiperidine is an agonist for activation of Go1 but an
antagonist/inverse agonist for Gi1, Gi2 and Gi3. Mol Pharmacol
71:1349-1359.
Laszy J, Laszlovszky I, and Gyrtyan I (2005) Dopamine D3 receptor
antagonists improve the learning performance in memory-impaired rats.
Psychopharmacology 179:567-575.
Lee SP, O’Dowd BF, and George SR (2003) Homo- and hetero-oligomerization of G protein-couple receptors. Life Sci 74:173-180.
Lieberman JL, Stroup TS, McEvoy JP, Swartz MS, Rosenheck RA, Perkins DO, Keefe RSE, Davis SM, Davis CE, Lebowitz BD, et al. (2005) Effectiveness of antipsychotic drugs in patients with chronic schizophrenia.
Maggio R, Barbier P, Colelli A, Salvadori F, DeMontis G and Corsini GU (1999) G protein linked receptors: pharmacological evidence for the formation of heterodimers. J. Pharmacol. Exp. Ther. 291: 251-257.
Maggio R, Scarselli M, Novi F, Milan MJ, and Corsini GU (2003) Potent activation of dopamine D3/D2 heterodimers by the antiparkinsonian agents,
S32504, pramipexole and ropinirole. J Neurochem 87:631-641.
MarcusMM, Jardemark KE, Wadenberg ML, Langlois X, Hertel P, and Svensson TH (2005) Combined α2- and D2/3 receptor blockage enhances
cortical glutamatergic transmission and reverses cognitive impairment in the rat. Int J Neuropsychopharmacol 8:315-327.
Margolese HC, Chouinard G, Kolivakis TT, Beauclair L, Miller R, and Annable L (2005) Tardive dyskinesia in the era of typical and atypical antipsychotics: II.Incidence and management strategies in patient with schizophrenia . Can J Psychiatry 50:703-714.
McCue RE, Waheed R, Urcuyo L, Orendain G, Joseph MD, Charles R, and Hasan SM (2006) Comparative effectiveness of second-generation antipsychotics and haloperidol in acute schizophrenia. Br J Psychiatry
189:433-440.
McGowan S, Lawrence AD, Sales T, Quested D, and Grasby P (2004) Presynaptic dopaminergic dysfunction in schizophrenia. Arch Gen
Psychiatry 61:134-142.
Meltzer HY (2004) Cognitive factors in schizophrenia : auses impact and treatment. CNS Spectr 9:15-24.
Millan MJ (2003) The neurobiology and control of anxious states. Prog
Neurobiol 70:83-244.
Millan MJ, Cussac D, Gobert A, Lejeune F, Rivet JM, Mnnoury la Cour C, Newman-Tancredi A, and Peglion JL (2004a) S32504, a novel naphtoxazine agonist at dopamine D3/D2 receptors : I. Cellular,
electrophysiological and neurochemical profile in comparison with ropinirole. J Pharmacol Exp Ther 309:903-920.
Millan MJ, Di Cara B, Dekeyne A, Panayi F, De Groote L, Sicard D, Cistarelli L, Billiras R, and Gobert A (2007a) Selective blockade of dopamine D3 versus D2 receptors enhances frontocortical cholinergic
transmission and social memory in rats: a parallel neurochemical and behavioural analysis. J Neurochem 100:1047-106.
Millan MJ, Gobert A, Newman-Tancredi A, Lejeune F, Cussac D, Rivet JM, Audinot V, Dubuffet T, and Lavielle G (2000b) S33084, a novel, potent, selective, and competitive antagonist at dopamine D3-receptors: I.
Receptorial, electrophysiological and neurochemical profile compared with GR18,231 and L741,626. J Pharmacol Exp Ther 293:1048-1062.
Millan MJ, Seguin L, Gobert A, Cussac D, and Brocco M (2004b) The role of dopamine D3 compared with D2 receptors in the control of locomotor
activity: a combined behavioural and neurochemnical analysis with novel, selective antagonists in rats. Psychopharmacology 174:341-357.
Millan MJ, Svenningsson P, Ashby CR Jr, Hill M, Egeland M, Dekeyne A, Brocco M, Di Cara B, Lejeune F, Thomasson N, et al. (2007b) S33138 [N- [4-[2-[(3aS,9bR)-8-cyano-1,3a,4,9b-tetrahydro[1]benzopyrano[3,4-c]pyrrol-2(3H)-yl)-ethyl]phenylacetamide], a preferential dopamine D3 versus D2
electrophysiological and behavioural characterization in vivo. J Pharmacol
Ext Ther 324:600-611.
Monti JM and Monti D (2005) Sleep disturbance in schizophrenia . Int Rev
Psychiatry 17:247-253.
Neve KA, Seamans JK, and Trantham-Davidson H (2004) Dopamine receptor signalling. J Recept Signal Transduct Res 24:165-205.
Newman-Tancredi A, Cussac D, Audinot V, Nicolas JP, De Ceuninck F, Boutin JA, and Millan MJ (2002) Differential actions of antiparkinson agents at multiple classes of monoaminergic receptor: II. Agonist and antagonist properties at subtypes of dopamine D2-like receptor and α1/α2-
adrenoceptor. J Pharmacol Ext Ther 303:805-814.
Newman-Tancredi A, Cussac D, Audinot V, Pasteau V, Gavaudan S, and Millan MJ (1999) G protein activation by human dopamine D3 receptors in
high-expressing Chinese hamster ovary cells: a guanosine-5’-O-(3-[35S]thio)-triphosphate binding and antibody study. Mol Pharmacol 55:564-574.
Novi F, Millan MJ, Corsini GU, and Maggio R (2007) Partial agonist actions of aripiprazole and the candidate antipsychotics, S33592, bifeprunox, N-desmethylclozapine and preclamol, at dopamine D2L
receptors are modified by co-transfection of D3 receptors: potential role of
heterodimer formation. J Neurochem 102:1410-1424.
O’Hara CM, Tang L, Taussig R, Todd RD, and O’Malley KL (1996) Dopamine D2L receptor couples to G i2 and G i3 but not G i1, leading to
the inhibiton of adenylate cyclase in transfected cell lines. J Pharmacol
Pacher P and Kecskemeti V (2004) Cardiovascular side effects of new antidepressants and antipsychotics: new drugs, old concerns? Curr
Pharmaceutical Design 10: 2463-2475.
Palczewski K et al. (2000) Crystal structure of rhodopsin: a G protein coupled receptor. Science 28:739-745.
Park PS, Filipek S, Wells JW, Palczewski K (2004) Oligomerization of G protein coupled receptors: past, present, and future. Biochemistry 43: 15643-15656.
Reavill C, Taylor SG, Wood MD, Ashmeade T, Austin NE, Avenell KY, Boyfield I, Branch CL, Cilia J, Coldwell MC, et al. (2000) Pharmacological actions of a novel, high-affinity, and selective human dopamine D3
receptor antagonist, SB-277011-A. J Pharmacol Exp Ther 294:1154-1165.
Richtand NM, Woods SC, Berger SP, and Strakowski SM (2001) D3
dopamine receptor, behavioural sensitization, and psychosis. Neurosci
Biobehav Rev 25:427-443.
Robinson SW and Caron MG (1997) Selective inhibition of adenylate cyclase type V by dopamine D3 receptor. Mol Pharmacol 52:508-514.
Scarselli M, Armogida M, Chiacchio S, DeMontis MG, Colzi A, Corsini GU and Maggio R (2000) Reconstitution of functional dopamine D2S receptor
by coexpression of amino and carboxyl terminal receptor fragments. Eur.
J. Pharmacol. 397: 291-296.
Scarselli M, Novi F, Schallmach E, Lin R, Baragli A, Colzi A et al (2001). D2/D3 dopamine receptor heterodimers exhibit unique functional
Shapiro DA, Renock S, Arrington E, Chiodo LA, Liu LX, Sibley DR, Roth BL, and Mailman R (2003) Aripiprazole, a novel atypical antipsychotic drug with a unique and robust pharmacology. Neuropsychopharmacology
28:1400-1411.
Sokoloff P, Diaz J, Le Foll B, Guillin O, Leriche L, Bezard E, and Gross C (2006) The dopamine D3 receptor: a therapeutic target for the treatment of
neuropsychiatric disorders. CNS Neurol Disorders Drug Targets 5:25-43.
Surmeier DJ, Eberwine CJ, Wilson Y, Cao A, Stefani A, and Kitai ST (1992) Dopamine receptor subtypes colocalize in rat stiatonigral neurons.
Proc Natl Acad Sci U S A 89:10176-10182.
Tang L, Todd RD, O'Malley KL (1994) Dopamine D2 and D3 receptors
inhibit dopamine release. J.Pharm.Exp.Ther. 268:495-502.
Tauscher J, Hussan T, Agid O, Verhoeff NP, Wilson AA, Houle S, Remington G, Zipursky RB, and Kapur S (2004) Equivalent occupancy of dopamine D1 and D2 receptors with clozapine: differentiation from other
atypical antipsychotics. Am J Psychiatry 161:1620-1625.
Urban JD, Clarke WP, von Zastrow M, Nichols DE, Kobilka B, Weinstein H, Javitch JA, Roth BL, Christopoulos A, Sexton PM, et al. (2007a) Functional selectivity and classical concepts of quantitative pharmacology.
J Pharmacol Ext Ther 320:1-13.
Vanhauwe JFM, Ercken M, Van de Wiel D, Jurzak M, and Leysen JE (2000) Effect of recent and reference antipsychotic agents at human dopamine D2 and D3 receptor signalling in Chinese hamster ovary cells.
Van Tol HHM, Bunzow JR, Guan HG, Sunhara RK, Seeman P, Niznik H and Civelli O (1991) Cloning of the gene for a human dopamine D4
receptor with high affinity for the antipsychotic clozapine. Nature 350: 610-614.
Werkman TR, Glennon JC, Wadman WJ, and McCreary AC (2006) Dopamine receptor pharmacology: interactions with serotonin receptors and significance for the aetiology and treatment of schizophrenia. CNS
Neurol Targets Neurol Disord 5:3-23.
Zhang LJ, Lachowicz JE and Sibley DR (1994) The D2S and D2L dopamine
receptor isoforms are differentially regulated in Chinese Hamster Ovary cells. Mol. Pharmacol. 45: 878-889.