New oncological approach and innovation in Radiation Oncology
Alba Fiorentino
Chief, Radiation Oncology
General Regional Hospital “F. Miulli”
Acquaviva delle fonti (BA)
Italy
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RADIOTERAPIA STEREOTASSICA Hyper Arc
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Local control by BED using a cutoff of 72Gy. One year local control was 90% compared to 57%, in favor of higher biologic dose Local control based on pretreatment SUV. Local control at one year was 92%
compared to 67%, in favor of lesions with less avidity.
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Metastatic breast cancer
Small molecule inhibitors
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Metastatic breast cancer
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Small molecule inhibitors : CDK 4/6
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Small molecule inhibitors : CDK 4/6
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Treatment with palbociclib before and during 5 daily fractions of irradiation exacerbates GI-ARS in mice [7]. Lee C.L.,Int J Radiat Oncol Biol Phys 2018.
We administered conformal radiotherapy of 30 Gy in 10 fractions, over 2 weeks. She experienced grade 1 diarrhoea during treatment with Palbo-RT. Three days after radiotherapy completion, she experienced left abdominal pain, bloating and bloody diarrhoea and was diagnosed with grade 3 colitis (CTCTE v4.0). Colonoscopy revealed erosion and angiectasis of the descending colon (Fig.
1D); therefore, acute radiation-induced enterocolitis was diagnosed.
