Abramson R, Bhushan A, Dolci E, Tritton T. The structure of the multidrug resistance P-glycoprotein and its similarity to other proteins. Ann Rep Med Chem, 1989, 25:253–60.
Aiba S. Maturation of dendritic cells induced by cytokines and haptens. Tohoku J Exp Med, 1998, 184:159-72.
Albert ML, Sauter B, Bhardwaj N. Dendritic cells acquire antigen from apoptotic cells and induce class I-restricted CTLs. Nature, 1998, 392:86-9.
Allavena P, Piemonti L, Longoni D, Bernasconi S, Stoppacciaro A, Ruco L, Mantovani A. IL-10 prevents the differentiation of monocytes to dendritic cells but promotes their maturation to macrophages. Eur J Immunol, 1998, 28:359-69.
Allen SW, Mueller L, Williams SN, Quattrochi LC, Raucy J. The use of a high-volume screening procedure to assess the effects of dietary flavonoids on human cyp1a1 expression. Drug Metab Dispos, 2001, 29:1074-9.
Almand B, Clark JI, Nikitina E, van Beynen J, English NR, Knight SC, Carbone DP, Gabrilovich DI. Increased production of immature myeloid cells in cancer patients: a mechanism of immunosuppression in cancer. J Immunol, 2001, 166:678-89.
Almand B, Resser JR, Lindman B, Nadaf S, Clark JI, Kwon ED, Carbone DP, Gabrilovich DI. Clinical significance of defective dendritic cell differentiation in cancer. Clin Cancer Res, 2000, 6:1755-66.
Ambudkar SV, Dey S, Hrycyna CA, Ramachandra M, Pastan I, Gottesman MM. Biochemical, cellular and pharmacological aspects of the multidrug transporter. Ann Rev Pharmacol Toxicol, 1999, 39:361-98.
Anderson DM, Maraskovsky E, Billingsley WL, Dougall WC, Tometsko ME, Roux ER, Teepe MC, DuBose RF, Cosman D, Galibert L. A homologue of the TNF receptor and its ligand enhance T-cell growth and dendritic-cell function. Nature, 1997, 390, 6656:175-9.
Arancia G, Molinari A, Calcabrini A, Meschini S, Cianfriglia M. Intracellular P-glycoprotein in multidrug resistant tumor cells. Ital J Anat Embryol, 2001, 106:59-68.
Avendaño C, Menèndez JC. Inhibitors of multydrug resistance of antitumor agents (MDR). Curr Med Chem, 2002, 9:159-93.
Bain LJ, McLachlan JB, LeBlanc GA. Structure–activity relationships for xenobiotic transport substrates and inhibitory ligands of P-glycoprotein. Environ Health Perspect, 1997, 105:812–8.
Bakos E, Klein I, Welker E, Szabo K, Muller M, Sarkadi B, Varadi A. Characterization of the human multidrug resistance protein containing mutations in the ATP-binding cassette signature region. Biochem J, 1997, 323:777-83.
Banchereau J, Briere F, Caux C, Davoust J, Lebecque S, Liu YJ, Pulendran B, Palucka K. Immunobiology of dendritic cells. Annu Rev Immunol, 2000, 18:767-811. Banchereau J, Steinman RM. Dendritic cells and the control of immunity. Nature, 1998, 392:245-52.
Barret B. Medicinal properties of Echinacea: a critical review. Phytomedicine 10, 2003, 1:66-86.
Bauer R, Foster S. HPLC analysis of Echinacea simulata and E. paradoxa roots. Planta Medica, 1989, 55:637.
Bauer R, Hoheisel O, Stuhlfauth I, Wolf H. Extract of the Echinacea purpurea herb: an allopathic phytoimmunostimulant. Wien Med Wochenschr, 1999, 149:185-9. Bauer R, Wagner H. Echinacea species as potential immunostimulatory drugs. Economic and Medicinal Plant Research, Vol. 5, 1991.
Bauer R, Wagner H. New results in the analysis of Echinacea roots. Sci Pharm, 1996, 55:159-161.
Bauer R. Chemistry, analysis and immunological investigations of Echinacea phytopharmaceuticals. Immunomodulatory Agents from Plants, 1999, 41-88.
Bauer R. Plant immunostimulants in self-medication. Pharm Unserer Zeit, 1998, 27:144-57.
Bebawy M, Sze DM. Targeting P-glycoprotein for effective oral anti-cancer chemotherapeutics. Curr Cancer Drug Targets, 2008, 8:47-52.
Belkaid Y. Regulatory T cells and infection: a dangerous necessity. Nat Rev Immunol, 2007, 7:875-88.
Bell D, Young JW, Banchereau J. Dendritic cells. Adv Immunol, 1999, 72:255-324. Bellamy WT. P-glycoproteins and multidrug resistance. Annu Rev Pharmacol Toxicol, 1996, 36:161-83.
Bellone M, Iezzi G, Rovere P, Galati G, Ronchetti A, Protti MP, Davoust J, Rugarli C, Manfredi AA. Processing of engulfed apoptotic bodies yields T cell epitopes. J Immunol, 1997, 159:5391-9.
Bender A, Bui LK, Feldman MA, Larsson M, Bhardwaj N. Inactivated influenza virus, when presented on dendritic cells, elicits human CD8+ cytolytic T cell responses. J Exp Med, 1995, 182:1663-71.
Beuscher N, Bodinet C, Willigmann I, Egert D. Immune modulatig proprieties of root extracts of different Echinacea species. Z Phytother, 1995, 16:157-66.
Bhardwaj N, Bender A, Gonzalez N, Bui LK, Garrett MC, Steinman RM. Influenza virus-infected dendritic cells stimulate strong proliferative and cytolytic responses from human CD8+ T cells. J Clin Invest, 1994, 94:797-807.
Billiau A. BSF-2 is not just a differentiation factor. Nature, 1986, 324:415.
Binns E, Arnason J., Baum, BR.Taxonomic history and revision of the genus Echinacea. In: Miller, S. C., Yu, H. (eds) Echinacea. The genus Echinacea. CRC Press, Boca Raton, 2004.
Binns SE, Hudson J, Merali S, Arnason JT. Antiviral activity of characterized extracts from Echinacea spp. (Heliantheae: Asteraceae) against herpes simplex virus (HSV-I). Planta Medicam, 1995, 68:780-3.
Binns SE, Livesey JF, Arnason JT, Baum BR. Phytochemical variation in Echinacea from roots and flowerheads of wild and cultivated populations. Journal of Agriculture and Food Chemistry, 2002, 50:3673-87.
Binns SE, Baum BR, Arnason JT. A taxonomic revision of the genus Echinacea (Helianthae; Asteraceae) Syst Bot, 2002, 27:610–632.
Bisset NG. Herbal drugs and phytopharmaceuticals. Wichtl M (ed), German edition, 1994: 182-184.
Blumenthal M, Goldberg A, Gruenwald J, Hall J, Klein S, Riggins R, Rister M. German Commission E Monographs: Therapeutic Monographs on Medicinal Plants for Human Use. Austin, Texas: American Botanical Council, 1998.
Bodinet C, Beuscher N. Antiviral and immunological activity of glycoproteins from Echinacea purpurea radix. Planta Medica, 1991, 57:A33.
Bone K. Echinacea: what makes it work? Alt Med Rev, 1997, 2:87-93. Bone K. Echinacea: when should it be used? Alt Med Rev, 1997b, 2: 451-8.
Boni U, Patri G. Le Erbe: medicinali, aromatiche, cosmetiche. Gruppo Editoriale Fabbri Bompiani Sonzogno Etas S.p.A., Milano, 1976.
Borst P, Elferink RO Mammalian ABC transporters in health and disease. Ann Rev Biochem, 2002, 71:537-92.
Borst P, Evers R, Kool M, Wijnholds J. A family of drug transporters: the multidrug resistance-associated proteins. J Natl Cancer Inst, 2000, 92:1295-1302.
Bousso P, Robey E. Dynamics of CD8+ T cell priming by dendritic cells in intact
lymph nodes. Nat Immunol, 2003, 4:579-85.
Brown RD, Pope B, Murray A, Esdale W, Sze DM, Gibson J, Ho PJ, Hart D, Joshua D. Dendritic cells from patients with myeloma are numerically normal but functionally defective as they fail to up-regulate CD80 (B7-1) expression after huCD40LT stimulation because of inhibition by transforming growth factor-beta1 and interleukin-10. Blood, 2001, 98:2992–8.
Bruni A. Farmacognosia generale e applicata. Ed. Piccin Nuova Libreria S.p.A., 1999, 12:314-315.
Buelens C, Verhasselt V, De Groote D, Thielemans K, Goldman M, Willems F. Human dendritic cell responses to lipopolysaccharide and CD40 ligation are differentially regulated by interleukin-10. Eur J Immunol, 1997, 27:1848-52.
Burger RA, Torres AR, Warren RP, Caldwell VD, Hughes BG. Echinacea-induced cytokine production by human macrophages. Int J Immunopharmacol, 1997, 19:371-9.
Callen DF, Baker E, Simmers RN, Seshandri R, Roninson IB. Localization of the human multiple drug resistance gene, MDR1, to 7q21.1. Hum Genet, 1987, 77:142-4.
Cameron P, Pope M, Granelli-Piperno A, Steinman RM. Dendritic cells and the replication of HIV-1. J Leukoc Biol, 1996, 59:158-71.
Castro AF, Horton JK, Vanoye CG, Altenberg GA. Mechanism of inhibition of P-glycoprotein-mediated drug transport by protein kinase C blockers. Biochem Pharmacol, 1999, 58:1723-33.
Caux C, Dezutter-Dambuyant C, Schmitt D, Banchereau J. GM-CSF and TNF-a cooperate in the generation of dendritic Langerhans cells. Nature, 1992, 360:258– 61.
Caux C, Massacrier C, Vanbervliet B, Dubois B, de Saint-Vis B, Dezutter-Dambuyant C, Jacquet C, Schmitt D, Banchereau J. CD34+ hematopoietic
progenitors from human cord blood differentiate along two independent dendritic cell pathways in response to GM-CSF+TNFα: II Functional analysis. Blood, 1997, 90:1458–70.
Caux C, Massacrier C, Vanbervliet B, Dubois B, Van Kooten C, Durand I, Banchereau J. Activation of human dendritic cells through CD40 cross-linking. J Exp Med, 1994, 180:1263-72.
Caux C, Vanbervliet B, Massacrier C, Dezutter-Dambuyant C, de Saint-Vis B, Jacquet C, Yoneda K, Imamura S, Schmitt D, Banchereau J. CD34+ hematopoietic
progenitors from human cord blood differentiate along two independent dendritic cell pathways in response to GM-CSF+ TNFα. J Exp Med, 1996, 184:695–706.
Cella M, Engering A, Pinet V, Pieters J, Lanzavecchia A. Inflammatory stimuli induce accumulation of MHC class II complexes on dendritic cells. Nature, 1997, 388:782-7.
Cella M, Scheidegger D, Palmer-Lehmann K, Lane P, Lanzavecchia A, Alber G. Ligation of CD40 on dendritic cells triggers production of high levels of interleukin-12 and enhances T cell stimulatory capacity: T-T help via APC activation. J Exp Med, 1996, 184:747-52.
Chambers TC, Chalikonda I, Eilon G. Correlation of protein kinase C translocation, P-glycoprotein phosphorylation and reduced drug accumulation in multidrug resistant human KB cells. Biochem Biophys Res Commun, 1990, 169:253-9.
Chambers TC, Zheng B, Kuo JF. Regulation by phorbol ester and protein kinase C inhibitors, and by a protein phosphatase inhibitor (okadaic acid) of P-glycoprotein phosphorilation and relationship to drug accumaultion in multidrug-resistant human KB cells. Mol Pharmacol, 1992, 41:1008-15.
Chan LMS, Lowes S, Hirst BH. The ABCs of drug transport in intestine and liver: efflux proteins limiting drug absorption and bioavailability. Eur J Pharm Sci, 2004, 21:25-51.
Chaux P, Favre N, Martin M, Martin F. Tumor-infiltrating dendritic cells are defective in their antigen-presenting function and inducible B7 expression in rats. Int J Cancer, 1997, 72:619-24.
Cheminat A, Zawatzky R, Becker H, Brouillard R. Caffeoyl coniugates from Echinacea species: structure and biological activity. Phytochemistr, 1988, 27:2787-94.
Chicca A, Adinolfi B, Martinotti E, Fogli S, Breschi MC, Pellati F, Benvenuti S, Nieri P. Cytotoxic effects of Echinacea root hexanic extracts on human cancer cell lines. J Ethnopharmacol, 2007, 110:148-53.
Chithra P, Sajithal GB, Chandrakasan G. Influence of Aloe vera on the glycosaminoglycans in the matrix of healing dermal wounds in rats. J. Ethnopharmacol., 1998, 59:179-86.
Chomarat P, Banchereau J, Davoust J, Palucka AK. IL-6 switches the differentiation of monocytes from dendritic cells to macrophages. Nat Immunol, 2000, 1:510-4. Chong AS. Diverse multidrug resistance modification agents inhibit cytolitic activity of natural killer cells. Cancer Immunol Immunother, 1993, 36:133-9.
Ciolino HP, Yeh GC. Inhibition of aryl hydrocarbon-induced cytochrome P-450 1A1 enzyme activity and CYP1A1 expression by resveratrol. Mol Pharmacol, 1999, 56:760-7.
Clifford LJ, Nair MG, Rana J, Dewitt DL. Bioactivity of alkamides isolated from Echinacea purpurea. Phytomedicine, 2002, 9:249-53.
Coeugniet E, Kuhnast R. Recurrent candidiasis: adjuvant immunotherapy with different formulations of Echinacin®. Therapiewoche, 1986, 36:3352-58.
Coeugniet EG, Elek E. Immunomodulation with Viscum album and Echinacea purpurea extracts. Onkologie, 1987, 10:27-33.
Conseil G, Perz-Victoria JM, Jault JM, Ramarro F, Goffeau A, Hofmann J, Di Pietro A. Protein kinase C effectors bind to multidrug ABC transporter and inhibit their activity. Biochem, 2001, 40:2564–71.
Cordon-Cardo C, O'Brien JP, Boccia J, Casals D, Bertino JR, Melamed MR. Expression of the multidrug resistance gene product (P-glycoprotein) in human normal and tumor tissues. J Histochem Cytochem, 1990, 38:1277-87.
Crawford K, Gabuzda D, Pantazopoulos V, Xu J, Clement C, Reinherz E, Alper CA. Circulating CD2+ monocytes are dendritic cells. J Immunol 1999, 163:5920-8.
Croop JM, Raymond M, Haber D, Devault A, Arseci RJ, Gros P, Housman DE. The three mouse multidrug resistance (mdr) genes are expressed in a tissue specific manner in a normal mouse tissues. Mol Cell Biol, 1989; 9:1346-50.
Croop JM. Evolutionary relationships methods in enzymology. Meth Enzymol, 1998, 292:101–16.
Currier NL, Miller SC. Echinacea purpurea and melatonin augment natural-killer cells in leukemic mice and prolong life span. J Altern Complement Med, 2001, 7:241-51.
D’Amico A, Wu L. The early progenitors of mouse dendritic cells and plasmacytoid predendritic cells are within the bone marrow hemopoietic precursors expressing Flt3. J Exp Med, 2003, 198:293-303.
Dallal RM, Christakos P, Lee K, Egawa S, Son YI, Lotze MT. Paucity of dendritic cells in pancreatic cancer. Surgey, 2002, 131:135-8.
Dalod M, Salazar-Mather TP, Malmgaard L, Lewis C, Asselin-Paturel C, Brière F, Trinchieri G, Biron CA. Interferon alpha/beta and interleukin 12 responses to viral infections: pathways regulating dendritic cell cytokine expression in vivo. J Exp Med, 2002, 195:517-28.
De Smedt T, Van Mechelen M, De Becker G, Urbain J, Leo O, Moser M. Effect of interleukin-10 on dendritic cell maturation and function. Eur J Immunol, 1997, 27:1229-35.
Della Bella S, Gennaro M, Vaccari M, Ferraris C, Nicola S, Riva A, Clerici M, Greco M, Villa ML. Altered maturation of peripheral blood dendritic cells in patients with breast cancer. Br J Cancer, 2003, 89:1463-72.
Dey S, Ramachandra M, Pastan I, Gottesman MM, Ambudkar SV. Photoaffinity labeling of human P-glycoprotein: effect of modulator interaction and ATP hydrolysis on substrate binding. Meth Enzymol, 1998, 292:318-28.
Dieu MC, Vanbervliet B, Vicari A, Bridon JM, Oldham E, Aït-Yahia S, Brière F, Zlotnik A, Lebecque S, Caux C. Selective recruitment of immature and mature dendritic cells by distinct chemokines expressed in different anatomic sites. J Exp Med, 1998, 188:373-86.
Dong M, Ladavière L, Penin F, Deléage G, Baggetto LG. Secondary structure of P-glycoprotein investigated by circular dichroism and amino acid sequence analysis. Biochim Biophys Acta, 1998, 1371:317–34.
Dresser GK, McDonald W, Kim RB, Bailey DG. Evaluation of herbal products as potential inhibitors of MDR1. Clin Pharmacol Ther, 2004, 75: 79.
Dubois B, Vanbervliet B, Fayette J, Massacrier C, Van Kooten C, Brière F, Banchereau J, Caux C. Dendritic cells enhance growth and differentiation of CD40-activated B lymphocytes. J. Exp. Med, 1997, 185:941-51.
Duff Sloley B, Urichuk L, Tywin C, Coutts R, Pang PK, Shan JJ. Comparison of chemical components and antioxidant capacity of different Echinacea species. J Pharm Pharmacol, 2001, 53:849-57.
Duperrier K, Eljaafari A, Dezutter-Dambuyant C, Bardin C, Jacquet C, Yoneda, K, Schmitt D, Gebuhrer L, Rigal D. Distinct subsets of dendritic cells resembling dermal DCs can be generated in vitro from monocytes, in the presence of different serum supplements. J Immunol Methods, 2000, 238:119-31.
Ecker G, Huber M, Schmid D, Chiba P. The importance of a nitrogen atom in modulators of multidrug resistance. Mol Pharmacol, 1999, 56:791-6.
Elsasser-Belle U, Willenbacher W, Bartsch HH, Gallati H, Schulte-Monting J, von Kleist S. Cytokine production in leukocyte cultures during therapy with Echinacea extract. J. Clin. Lab. Anal, 1996, 10:441-5.
Esche C, Lokshin A, Shurin GV, Gastman BR, Rabinowich H, Watkins SC, Lotze MT, Shurin MR. Tumor’s other immune targets: dendritic cells. J Leukoc Biol, 1999, 66:336-44.
Facino RM, Carini M, Aldini G, Saibene L, Pietta P, Mauri P. Echinacoside and caffeoyl conjugates protect collagen from free radical-induced degradation: a potential use of Echinacea extracts in the prevention of skin photodamage. Planta Med, 1995, 61:510-14.
Fan D, Beltran PJ, O'Brian CA. Reversal of multidrug resistance. In: J.A. Kellen, Editor, Reversal of Multidrug Resistance in Cancer, 1994:93-125.
Fayette J, Dubois B, Vandenabeele S, Bridon JM, Vanbervliet B, Durand I, Banchereau J, Caux C, Brière F. Human dendritic cells skew isotype switching of CD40-activated naive B cells towards IgA1 and IgA2. J Exp Med, 1997, 185:1909– 18.
Flannery MA. From Rudbeckia to Echinacea: The emergence of the purple cone flower in modern therapeutics. Pharmacy in History, 1999, 41:52-69.
Fogli S, Nieri P, Chicca A, Adinolfi B, Mariotti V, Iacopetti P, Breschi MC, Pellegrini S. Cannabinoid derivatives induce cell death in pancreatic MIA PaCa-2 cells via a receptor-independent mechanism. FEBS Lett, 2006, 580:1733-9.
Förstermann U, Gath I, Schwarz P, Closs EI, Kleinert H. Isoforms of nitric oxide synthase. Properties, cellular distribution and expressional control. Biochem Pharmacol, 1995, 50:1321-32.
Foster S. Echinacea: The Purple Coneflowers. American Botanical Council, 1996. Frank MH, Denton MD, Alexander SI, Khoury SJ, Sayegh MH, Briscoe DM. Specific MDR1 P-glycoprotein blockade inhibits human alloimmune T cell activation in vitro. J Immunol, 2001;166:2451-9.
Frézard F, Pereira E, Quidu P, Priebe W, Garnier-Suillerot A. P-glycoprotein preferentially effluxes compounds containing free basic versus charged amine. Eur J Biochem, 2001, 268:1561–7.
Fujii S, Liu K, Smith C, Bonito AJ, Steinman RM. The linkage of innate to adaptive immunity via maturing dendritic cells in vivo requires CD40 ligation in addition to antigen presentation and CD80/86 costimulation. J Exp Med, 2004, 199:1607-18. Gabrilovich D. Mechanism and functional significance of tumor-induced dendritic-cell defects. Nature Rev Immunol, 2004, 4:941-52.
Gabrilovich DI, Chen HL, Girgis KR, Cunningham HT, Meny GM, Nadaf S, Kavanaugh D, Carbone DP. Production of vascular endothelial growth factor by human tumors inhibits the functional maturation of dendritic cells. Nat Med, 1996, 2:1096-103.
Gabrilovich DI, Ciernik IF, Carbone D. Dendritic cells in antitumor immune responses. I. Defective antigen presentation in tumor-bearing hosts. Cell Immunol, 1996b, 170:101–10.
Gaisbauer M, Schleich T, Stickl HA, Wilczek I. The effect of Echinacea purpurea Moench on phagocytosis in granulocytes measured by chemiluminescence. Arzneimittelforschung, 1990, 40:594-8.
Gallo M, Koren G. Can herbal products be used safely during pregnancy? Focus on Echinacea. Can Fam Physician, 2001, 47:1727-8.
Gan XH, Zhang L, Heber D, Bonavida B. Mechanism of activation of human peripheral blood NK cells at the single cell level by Echinacea water soluble extracts: recruitment of lymphocyte-target conjugates and killer cells and activation of programming for lysis. Int Immunopharmacol, 2003, 3:811-24.
Garrigos M, Mir LM, Orlowski S. Competitive and non-competitive inhibition of the multidrug-resistance-associated P-glycoprotein ATPase: further experimental evidence for a multisite model. Eur J Biochem, 1997, 244:664-73.
Gertsch J, Schoop R, Kuenzle U, Suter A. Echinacea alkylamides modulate TNF-alpha gene expression via cannabinoid receptor CB2 and multiple signal transduction pathways. FEBS Lett, 2004, 577:563-9.
Ghiara O, Boraschi D, Nencioni L, Ghezzi P, Tagliabue A. Enhancement of in vivo immune response by tumor necrosis factor. J Immunol, 1987, 139:3676-9.
Ghiringhelli F, Puig PE, Roux S, Parcellier A, Schmitt E, Solary E, Kroemer G, Martin F, Chauffert B, Zitvogel L. Tumor cells convert immature myeloid dendritic cells into TGF-β-secreting cells inducing CD4+CD25+ regulatory T cell proliferation. J Exp Med, 2005, 202:919-29.
Giusti E. Echinacea. In Botanica, chimica, farmacologia e terapia. Erboristeria Domani, 1992: 64-67.
Goel V, Chang C, Slama JV, Barton R, Bauer R, Gahler R, Basu TK. Alkylamides of Echinacea purpurea stimulate alveolar macrophage function in normal rats. Int Immunopharmacol, 2002, 2:381-7.
Gonda R, Tomoda M, Ohara N, Takada K. Arabinogalactan core structure and immunological activities of ukorian C, and acidic polysaccharide from the rhizome of Curcuma long. Biol. Pharm. Bull., 1993, 16: 235-8.
Gottesmann MM e Pastan I. Biochemistry of multidrug resistance mediated by the multidrug transporter. Annu Rev Biochem, 1993, 62:385-427.
Granelli-Piperno A, Pope M, Inaba K, Steinman RM. Proc Natl Acad Sci, 1995, 92:10944-8
Granucci F, Vizzardelli C, Pavelka N, Feau S, Persico M, Virzi E, Rescigno M, Moro G, Ricciardi-Castagnoli P. Inducible IL-2 production by dendritic cells revealed by global gene expression analysis. Nat Immunol, 2001, 2:882-8.
Grimm W, Müller HH. A randomized controlled trial of the effect of fluid extract of Echinacea purpurea on the incidence and severity of colds and respiratory infections. Am J Med, 1999, 106:138-43.
Grohmann U, Fioretti MC, Bianchi R, Belladonna ML, Avroldi E, Surace D, Silla S, Puccetti P. Dendritic cells, inteleukin-12 and CD4+ lymphocytes in the initiation of
class-I restricted reactivity to a tumor/self peptide. Crit Rev Immunol, 1998, 18:87-98.
Gupta S. Preferential expression and activity of multidrug resistance gene-1 product (P-glycoprotein, a functionally active efflux pump, in human CD8+ T cells: a role in cytotoxic effector finction. J Clin Immunol, 1992, 12:451-8.
Hafkemeyer P, Dey S, Ambudkar SV, Hrycyna CA, Pastan I, Gottesman MM. Contribution to substrate specificity and transport of nonconserved residues in transmembrane domain 12 of human P-glycoprotein. Biochemistry, 1998, 37:16400-9.
Harborne JB. Nature, distribution and function of plant flavonoids. Prog. Clin. Biol. Res., 1986, 213:15-24.
Hauer J, Anderer FA. Mechanism of stimulation of human natural killer cytotoxicity by arabinogalactan from Larix occidentalis. Cancer Immunol Immunother, 1993, 36:237-44.
Hawiger D, Inaba K, Dorsett Y, Guo M, Mahnke K, Rivera M, Ravetch JV, Steinman RM, Nussenzweig MC. Dendritic cells induce peripheral T cell unresponsiveness under steady state conditions in vivo. J Exp Med, 2001, 194:769-79.
Hellum BH, Nilsen OG. In vitro inhibition of CYP3A4 metabolism and P-glycoprotein-mediated transport by trade herbal products. Basic Clin Pharmacol Toxicol, 2008, 102:466-75.
Hertz CJ, Kiertscher SM, Godowski PJ, Bouis DA, Norgard MV, Roth MD, Modlin RL. Microbial lipopeptides stimulate dendritic cell maturation via Toll-like receptor 2. J Immunol, 2001, 166:2444-50.
Hinz B, Woelkart K, Bauer R. Alkamides from Echinacea inhibit cyclooxygenase-2 activity in human neuroglioma cells. Biochem Biophys Res Commun, 2007, 360:441-6.
Hirata N, Yanagawa Y, Iwabuchi, Onoé K. Selective regulation of interleukin-10 production via Janus kinase pathway in murine conventional dendritic cells. Cell Immunol, 2009, doi:10.1016/j.cellimm.2009.03.006.
Hobbs AJ, Higgs A, Moncada S. Inhibition of nitric oxide synthase as a potential therapeutic target. Annu Rev Pharmacol Toxicol, 1999, 39:191-220.
Hoffman TK, Muller-Berghaus J, Ferris RJ, Johnson JT, Storkus WJ, Whiteside TL. Alterations in the frequency of dendritic cell subsets in the peripheral circulation of patients with squamous cell carcinomas of the head and neck. Clin Cancer Res, 2002, 8:1787–93.
Hrycyna CA, Ramachandra M, Ambudkar SV, Ko YH, Pedersen PL, Pastan I, Gottesman MM. Mechanism of action of human P-glycoprotein ATPase activity. Photochemical cleavage during a catalytic transition state using orthovanadate reveals cross-talk between the two ATP sites. J Biol Chem, 1998, 3:16631-4.
Hrycyna CA, Ramachandra M, Germann UA, Cheng PW, Pastan I, Gottesman MM. Both ATP sites of human P-glycoprotein are essential but not symmetric. Biochemistry, 1999, 38:13887-99.
Hu C, Kitts DD. Studies on the antioxidant activity of Echinacea root extract. J Agric Food Chem, 2000, 48:1466-72.
Hudaib M, Fiori J, Bellardi MG, Rubies-Autonell C, Cavrini V. GC-MS analysis of the lipophilic principles of Echinacea purpurea and evaluation of cucumber mosaic cucumovirus (CMV) infection. J Pharm Biomed Anal, 2002, 29:1053-60.
Huls M, Russel GMF, Masereeuw R. The role of ABC transporters in tissue defense and organ regeneration. JPET, 2008, DOI:10.1124.
Hansen TS, Nilsen OG. Echinacea purpurea and P-glyciprotein drug transport in Caco-2 cells. Phytother Res, 2009, 23:86-91.
Hurlbert D. Endangered Echinacea: What threat, which species, and where? UpS Newsletter, 1999, 4-6.
Inaba K, Inaba M, Naito M, Steinman RM. Dendritic cell progenitors phagocytose particulates, including bacillus Calmette-Guerin organisms, and sensitize mice to mycobacterial antigens in vivo. J Exp Med, 1993,178:479-88.
Jiang W, Swiggard WJ, Heufler C, Peng M, Mirza A, Steinman RM, Nussenzweig MC. The receptor DEC-205 expressed by dendritic cells and thymic epithelial cells is involved in antigen processing. Nature, 1995, 375:151-5.
Johnstone RW, Ruefli AA, Smyth MJ. Multiple physiological functions for multidrug transporter P-glycoprotein? Trends Biochem Sci, 2000, 25:1–6.
Jodoin J, Demeule M, Beliveau R. Inhibition of the multidrug resistance P-glycoprotein activity by green tea polyphenols. Biochim Biophys Acta, 2002, 30, 1542:149-59.
Jodoin J, Demeule M, Fenart L, Cecchelli R, Farmer S, Linton KJ, Higgins CF, Beliveau R. P-glycoprotein in blood-brain barrier endothelial cells: interaction and oligomerization with caveolins. J Neurochem, 2003, 87:1010-23.
Jones PM, George AM. A new structural model for P-glycoprotein. J Membrane Biol, 1998, 166:133–47.
Jonuleit H, Schmitt E, Schuler G, Knop J, Enk AH. Induction of interleukin 10-producing, nonproliferating CD4(+) T cells with regulatory properties by repetitive stimulation with allogeneic immature human dendritic cells. J Exp Med, 2000, 192:1213-22
Jordens R, Thompson A, Amons R, Koning F. Human dendritic cells shed a functional, soluble form of the mannose receptor. Int Immunol, 1999, 11:1775-80. Kaliński P, Hilkens CM, Wierenga EA, Kapsenberg ML. T-cell priming by type-1 and type-2 polarized dendritic cells: the concept of a third signal. Immunol Today, 1999, 20:561-7.
Kapsenberg ML, Kalinski P. The concept of type 1 and type 2 antigen-presenting cells. Immunol Lett, 1999, 69:5-6.
Karsunky H, Merad M, Cozzio A, Weissman IL, Manz MG. Flt3 ligand regulates dendritic cell development from Flt3+ lymphoid and myeloid-committed progenitors
to Flt3+ dendritic cells in vivo. J Exp Med, 2003, 198:305-13.
Katz SI, Tamaki K, Sachs DH. Epidermal Langerhans cells are derived from cells originating in bone marrow. Nature, 1979, 282:324-6.
Kelly GS. 'Brittle' diabetes. J R Coll Gen Pract, 1989, 39:260.
Kemp DE, Franco KN. Possible leukopenia associated with long-term use of echinacea. J Am Board Fam Pract, 2002, 15:417-9.
Kiertscher SM, Luo J, Dubinett SM, Roth MD. Tumors promote altered maturation and early apoptosis of monocyte-derived dendritic cells. J Immunol, 2000, 164: 1269-76.
Kiessling R, Petranyi G, Klein G, Wigzel H. Genetic variation of in vitro cytolytic activity and in vivo rejection potential of non-immunized semi-syngeneic mice against a mouse lymphoma line. Int J Cancer, 1975, 15:933-40.
Klimecki WT, Futscher BW, Grogan TM, Dalton WS. P-Glycoprotein expression and function in circulating blood cells from normal volunteers. Blood, 1994, 83:2451-8. Koch F, Stanzl U, Jennewein P, Janke K, Heufler C, Kämpgen E, Romani N, Schuler G. High level IL-12 production by murine dendritic cells: upregulation via MHC class II and CD40 molecules and downregulation by IL-4 and IL-10. J Exp Med, 1996, 184:741-6.
Laasonen M, Harmia-Pulkkinen T, Simard CL, Michiels E, Rasanen M, Vuorela H. Fast identification of Echinacea purpurea dried roots using near-infrared spectroscopy. Anal Chem, 2002, 74:2493-9.
Leier I, Jedlitschky G, Buccholtz U Cole SP, Deeley RG, Keppler D. The MRP gene encodes an ATP-dependent export pump for leukotriene C4 and structurally related conjugates. J Biol Chem, 1994, 269:27804-10.
Lenahan C, Avigan D. Dendritic cell defects in patients with cancer: mechanisms and significance. Breast cancer Res, 2006, 8:101.
León B, López-Bravo M, Ardavín C. Monocyte-derived dendritic cells formed at the infection site control the induction of protective T helper 1 responses against Leishmania. Immunity, 2007, 26:519-31.
Lersch C, Zeuner M, Bauer A, Siemens M, Hart R, Drescher M, Fink U, Dancygier H, Classen M. Nonspecific immunostimulation with low doses of cyclophosphamide (LDCY), thymostimulin, and Echinacea purpurea extracts (echinacin) in patients with far advanced colorectal cancers: preliminary results. Cancer Invest, 1992, 10:343-8. Li Q, Grover AC, Donald EJ, Carr A, Yu J, Whitfield J, Nelson M, Takeshita N, Chang AE. Simultaneous targeting of CD3 on T cells and CD40 on B or dendritic cells augments the antitumor reactivity of tumor-primed lymph node cells. J Immunol, 2005, 175:1424-32.
Lin CL, Suri RM, Rahdon RA, Austyn JM, Roake JA. Dendritic cell chemotaxis and transendothelial migration are induced by distinct chemokines and are regulated on maturation. Eur J Immunol, 1998, 28:4114-22.
Lindquist RL, Shakhar G, Dudziak D, Wardemann H, Eisenreich T, Dustin ML, Nussenzweig MC. Visualizing dendritic cell networks in vivo. Nat Immunol, 2004, 5: 1243-50.
Litman T, Zeuthen T, Skovssgard T, Stein WD. Structure–activity relationships of P-glycoprotein interacting drugs: kinetic characterization of their effects on ATP-ase activity. Biochim Biophys Acta – Mol Bases Disease, 1997, 1361:159–68.
Liu K, Waskow C, Liu X, Yao K, Hoh J, Nussenzweig M. Origin of dendritic cells in peripheral lymphoid organs of mice. Nat Immunol, 2007, 8:578-83.
Liu YJ, Kanzler H, Soumelis V, Gilliet M. Dendritic cell lineage, plasticity and cross-regulation. Nat Immunol, 2001, 2:585-9.
Lohamann-Matthes ML, Wagner H. Macrophage activaction by plant polysaccharides. Z Phytother, 1989, 10:52-59.
Lohmann-Matthes ML, Wagner H. Macrophage activation by the polysaccharide arabinogalactan isolated from plant cell cultures of Echinacea purpurea. Journal of National Cancer Institute, 1989, 81:669-75.
Loo TW, Bartlett MC, Clarke DW. Substrate-induced conformational changes in the transmembrane segments of human P-glycoprotein. Direct evidence for the substrate-induced fit mechanism for drug binding. J Biol Chem, 2003, 278:13603-6. LooTW, Clarke DM. Identification of residues in the drug-binding site of human P-glycoptotein. Analysis of transmembrane segment 11 by cysteine-scanning mutagenesis and inhibition by dibromobimane. J Biol Chem, 1999, 274:35388-92. Loo TW, Clarke DM. Membrane topology of a cysteine-less mutant of human p-glycoprotein. J Biol Chem, 1995, 270:843-8.
Loo TW, Clarke DM. Molecular dissection of the human multidrug resistance P-glycoprotein. Biochem Cell Biol, 1999, 77:11–23.
Lotzová E, Savary CA. Pyrimidinones: inducers of NK cell activity and antitumor immunity. Comp Immunol Microbiol Infect Dis, 1986, 2-3:185-91.
Luettig B, Steinmuller C, Gifford GE, Wagner H Lohmann ML. Macrophage activation by the polysaccharide arabinogalactan isolated from plant cell cultures of Echinacea purpurea. J. Natl. Cancer Inst., 1989, 81:669-675.
Luo X, Tarbell KV, Yang H, Pothoven K, Bailey SL, Ding R, Steinman RM, Suthanthiran M. Dendritic cells with TGF-beta1 differentiate naive CD4+CD25- T cells into islet-protective Foxp3+ regulatory T cells. Proc Natl Acad Sci, 2007,
104:2821-6.
Martin C, Berridge G, Higgins CF, Mistry P, Charlton P, Callaghan R. Communication between multiple drug binding sites on P-glycoprotein. Mol Pharmacol, 2000, 58:624-32.
Matsunaga H, Katano M, Saita T, Yamamoto H, Mori M. Potentiation of cytotoxicity of mitomycin C by a polyacetylenic alcohol, panaxytriol. Cancer Chemother Pharmacol, 1994, 33: 291-7.
Matsunaga H, Katano M, Yamamoto H, Fujito H, Mori M, Takata K. Cytotoxic activity of polyacetylene compounds in Panax ginseng C. A. Meyer. Chem Pharm Bull, 1990, 38:3480-2.
Maurer D, Fiebiger E, Reininger B, Ebner C, Petzelbauer P, Shi GP, Chapman HA, Stingl G. Fc epsilon receptor I on dendritic cells delivers IgE-bound multivalent antigens into a cathepsin S-dependent pathway of MHC class II presentation. J Immunol, 1998, 161:2731-9.
Mazza G, Cottrell T. Volatile components of roots, stems, leaves, and flowers of Echinacea species. J Agric and Food Chem, 1999, 47:3081-5.
Mc Dougall B, King PJ, Wu BW, Hostomsky Z, Reinecke MG, Robinson WE Jr. Dicaffeoylquinic and dicaffeoyltartaric acids are selective inhibitors of human immunodeficiency virus type 1 integrase. Antimicrob Agents Chemother, 1998, 42:140-6.
McGregor RL. The taxonomy of the genus Echinacea (Compositae). University of Kansas Science Bullettin, 1968, 48:113-42
McGuirk P, Mills KH. Pathogen-specific regulatory T cells provide a shift in the Th1/Th2 paradigm in immunity to infectoius diseases. Trends Immunol, 2002, 23:450-5.
Meijerman I, Beijnen JH, Schellens JH. Herb-drug interactions in oncology: focus on mechanisms of induction. Oncologist, 2006, 11:742-52.
Melchart D, Linde K, Worku F, Sarkady L, Holzmann M, Jurcic K, Wagner H. Results of five randomized studies on the immunomodulatory activity of preparations of Echinacea. J Altern Complement Med, 1995,1:145-6.
Melchart D, Wattner E, Brandmaier KL, Lerosch R. Echinacea root extracts for the prevention of upper respiratory tract infections. Arch Family Med, 1998, 7:541-5. Mellman I, Steinman RM. Dendritic cells: specialized and regulated antigen processing machines. Cell, 2001, 106:255-8.
Menetrier-Caux C, Montmain G, Dieu MC, Bain C, Favrot MC, Caux C, Blay JY. Inhibition of the differentiation of dendritic cells from CD34+ progenitors by tumor
cells: role of interleukin-6 and macrophage colonystimulating factor. Blood, 1998, 92:4778-91.
Menetrier-Caux C, Thomachot MC, Alberti L, Montmain G, Blay JY. IL-4 prevents the blockade of dendritic cell differentiation induced by tumor cells. Cancer Res, 2001, 61:3096-104.
Mengs U, Clare CB, Poiley JA. Toxicity of Echinacea purpurea. Acute, subacute and genotoxicity studies. Arzneimittelforschung, 1991, 41:1076-81.
Miller SC. Echinacea: a Miracle Herb against Aging and Cancer? Evidence In vivo in Mice. Evid Based Complement Alternat Med, 2005, 2:309–14.
Mizutani T, Masatoshi M, Nakai E, Furumiya K, Togawa H, Nakamura Y, Kawai Y, Nakahira K, Shinkay S, Takahashi K. Genuine Functions of P-Glycoprotein (ABCB1). Curr Drug Metab, 2008, 9:167-174.
Moll H, Fuchs H, Blank C, Röllinghoff M. Langerhans cells transport Leishmania major from the infected skin to the draining lymph node for presentation to antigen-specific T cells. Eur J Immunol, 1993, 23:1595-601.
Monti P, Leone BE, Zerbi A, Balzano G, Cainarca S, Sordi V, Pontillo M, Percalli A, Di Carlo V, Allavena P, Piemonti L. Tumor-derived MUC1 mucins interact with differentiating monocytes and induce IL-10high IL-12low regulatory dendritic cell. J Immunol, 2004, 172:7341-9.
Morazzoni P, Cristoni A, Di Pierro F, Avanzini C, Ravarino D, Stornello S, Zucca M, Musso T. In vitro and in vivo immune stimulating effects of a new standardized Echinacea angustifolia root extract (Polinacea). Fitoterapia, 2005, 76:401-11.
Morelli AE, Zahorchak AF, Larregina AT, Colvin BL, Logar AJ, Takayama T, Falo LD, Thomson AW. Cytokine production by mouse myeloid dendritic cells in relation to differentiation and terminal maturation induced by lipopolysaccharide or CD40 ligation. Blood, 2001, 98:1512-23.
Moser M, Murphy KM. Dendritic cell regulation of TH1-TH2 development. Nat Immunol, 2000, 1:199-205.
Mucci I, Legitimo A, Compagnino M, Consolini R, Metelli MR, Scatena F. The methodological approach for the generation of human dendritic cells from monocytes affects the maturation state of the resultant dendritic cells. Biologicals, 2009, in press (DOI: 10.1016/j.biologicals.2009.05.004).
Mullins RJ, Heddle R. Adverse reactions associated with echinacea: the Australian experience. Ann Allergy Asthma. Immunol, 2002, 88:42-51.
Muzio M, Bosisio D, Polentarutti N, D'amico G, Stoppacciaro A, Mancinelli R, van't Veer C, Penton-Rol G, Ruco LP, Allavena P, Mantovani A. Differential expression and regulation of toll-like receptors (TLR) in human leukocytes: selective expression of TLR3 in dendritic cells. J Immunol, 2000, 164:5998-6004.
Nagayama H, Sato K, Kawasaki H, Enomoto M, Morimoto C, Tadokoro K, Juji T, Asano S, Takahashi TA. IL-12 responsiveness and expression of IL-12 receptor in human peripheral blood monocyte-derived dendritic cells. J Immunol, 2000, 165:59-66.
Nestle FO, Burg G, Fah J, Wrone-Smith T, Nickoloff BJ. Human sunlight-induced basal-cell-carcinoma-associated dendritic cells are deficient in T cell co-stimulatory molecules and are impaired as antigen-presenting cells. Am J Pathol, 1997, 150:641-51.
Neumann M, Fries H, Scheicher C, Keikavoussi P, Kolb-Mäurer A, Bröcker E, Serfling E, Kämpgen E. Differential expression of Rel/NF-kappaB and octamer factors is a hallmark of the generation and maturation of dendritic cells. Blood, 2000, 95:277-85.
Nguyen H, Zhang S, Morris ME. Effect of flavonoids on MRP1-mediated transport in Panc-1 cells. J Pharm Sci, 2000, 92:250-7.
Niess JH, Reinecker HC. Lamina propria dendritic cells in the physiology and pathology of the gastrointestinal tract. Curr Opin Gastroenterol, 2000, 21:687-91. Nijman HW, Kleijmeer MJ, Ossevoort MA, Oorschot VM, Vierboom MP, van de Keur M, Kenemans P, Kast WM, Geuze HJ, Melief CJ. Antigen capture and major histocompatibility class II compartments of freshly isolated and cultured human blood dendritic cells. J Exp Med, 1995, 182:163-74.
Nooter K, Herweijer H. Multidrug resistance (mdr) genes in human cancer. Br J Cancer, 1991, 63:663-9.
Novak N, Haberstok J, Geiger E, Bieber T. Dendritic cells in allergy. Allergy, 1999, 54:792-803.
O’Garra A, Vieira P. Th1 cells control themselves by producing interleukin-10. Nat Rev Immunol, 2007, 7:425-8.
Okasala O, Salo T, Tammi R, Hakkinen L, Jalkkanen M, Inki P, Larjava H. Expression of proteoglycans and hyaluronan during wound healing. J. Histochem. Cytochem., 1995, 43:125-135.
Ohnishi A, Matsuo H, Yamada S, Takanaga H, Morimoto S, Shoyama Y, Ohtani H, Sawada Y. Effect of furanocoumarin derivatives in grapefruit juice on the uptake of vinblastine by Caco-2 cells and on the activity of cytochrome P450 3A4. Br J Pharmacol, 2000, 130:1369-77.
Osterberg T, Norinder U. Theoretical calculation and prediction of P-glycoprotein-interacting drugs using MolSurf parameterization and PI. Statistics. Eur J Pharm Sci, 2000, 10:295-303.
Oyama T, Ran S, Ishida T, Nadaf S, Kerr L, Carbone DP, Gabrilovich DI. Vascular endothelial growth factor affects dendritic cell maturation through the inhibition of nuclear factor-Kappa B activation in hemopoietic progenitor cells. J Immunol, 1998, 160:1224-32.
Palucka KA, Taquet N, Sanchez-Chapuis F, Gluckman JC. Dendritic cells as the terminal stage of monocyte differentiation. J Immunol, 1998, 160:4587-95.
Parnham MJ Sodium cromoglycate and nedocromil sodium in the therapy of asthma, a critical comparison. Pulm Pharmacol 1996, 9:95-105.
Pellati F, Calò S, Benvenuti S, Adinolfi B, Nieri P, Melegari M. Isolation and structure elucidation of cytotoxic polyacetylenes and polyenes from Echinacea pallida. Phytochemistry, 2006, 67:1359-64
Pendse SS, Behjati S, Schatton T, Izawa A, Sayegh MH, Frank MH. P-Glycoprotein functions as a differentiation switch in antigen presenting cell maturation. Am J Transplan, 2006, 6:2884-93.
Percival SS. Commentary. Use of Echinacea in Medicine. Biochem Pharmacol, 2000, 60:155-158.
Perrotta C, Falcone S, Capobianco A, Camporeale A, Sciorati C, De Palma C, Pisconti A, Rovere-Querini P, Bellone M, Manfredi AA, Clementi E. Nitric oxide confers therapeutic activity to dendritic cells in a mouse model of melanoma. Cancer Res, 2004, 64:3767-71.
Perry NB, Burgess EJ, Glennie VA. Echinacea standardition:analytical methods for phenolic coumponds and typical levels in medicinal species. J Agric Food Chem, 2001, 49:1702-6.
Perry NB, Van Klink JW, Burrgess EJ, Parmenter GA. Alkamide levels in Echinacea purpurea (L.) Moench: a rapid analytical method revealing differences among roots, rhizomes, stems, leaves and flowers. Planta Med., 1997, 63:58-62.
Pierre P, Turley SJ, Gatti E, Hull M, Meltzer J, Mirza A, Inaba K, Steinman RM, Mellman I. Developmental regulation of MHC class II transport in mouse dendritic cells. Nature, 388:787-92.
Pilarski L, Paine D, McElhaney J, Cass CE, Belch AR. Multidrag transporter P-Glycoprotein 170 as a differentiation antigen on normal human lymphocyties and thhymocities: modulation with differentiation stage and during aging. Amer Journ of Hemat, 1995, 49:323-35.
Piqueras B, Connolly J, Freitas H, Palucka AK, Banchereau J. Upon viral exposure, myeloid and plasmacytoid dendritic cells produce 3 waves of distinct chemokines to recruit immune effectors. Blood, 2006, 107:2613-8.
Pulendran B. Variegation of the immune response with dendritic cells and pathogen recognition receptors. J Immunol, 2005, 174:2457-65.
Raduner S, Majewska A, Chen JZ, Xie XQ, Hamon J, Faller B, Altmann KH, Gertsch J. Alkylamides from Echinacea are a new class of cannabinomimetics. Cannabinoid type 2 receptor-dependent and -independent immunomodulatory effects. J Biol Chem, 2006, 281:14192-206.
Raggers RJ, Vogels I, van Meer G. Multidrug-resistance P-glycoprotein (MDR1) secretes platelet-activating factor. Biochem J, 2001; 357:859-65.
Raghu G, Park SW, Roninson IN, Mechetner EB. Monoclonal antibodies against P-glycoprotein, an MDR1 gene product, inhibit interleukin-2 release from PHA-activated lymphocytes. Exp Haematol, 1996, 24:1258-64.
Randolph GJ, Baelieu S, Pope M, Sugarawa I, Hoffman L, Steinman R, Muller WA. A physiologic function of p-glycoprotein (MDR-1) during the migration of dendritic cells from skin via afferent lymphatic vessels. Proc Nat Acad Sci, 1998, 95:6924-6929.
Randolph RK, Gellenbeck K, Stonebrook K, Brovelli E, Qian Y, Bankaitis-Davis D, Cheronis J Regulation of human immune gene expression as influenced by a commercial blended Echinacea product: preliminary studies. Exp Biol Med, 2003, 228:1051-6.
Ranges GE, Zlotnick A, Esperik T, Dinarello CA, Cerami A, Palladino MA Jr. Tumor necrosis factor α/cachectin is a growth factor for thymocytes: synergistic interactions with other cytokines. J Exp Med, 1988, 167:1472-8.
Ranieri E. Dall’immunità al cancro: una questione di doppia identità. Giornale Italiano di nefrologia, 2005, 2:140-51.
Raso GM, Pacilio M, Di Carlo G, Esposito E, Pinto L, Meli R. In-vivo and in-vitro anti-inflammatory effect of Echinacea purpurea and Hypericum perforatum. J. Pharm. Pharmacol., 2002, 54:1379-83.
Razina TG, Lopatina KA, Zueva AM, Gur'ev AM, Krylova SG, Amosova EN. Effect of Echinacea purpurea tincture and its polysaccharide complex on the efficacy of cytostatic therapy of transferred tumors. Eksp Klin Farmakol, 2007, 70:33-5.
Reddy A, Sapp M, Feldman M, Subklewe M, Bhardwaj N. A monocyte conditioned medium is more effective than defined cytokines in mediating the terminal maturation of human dendritic cells. Blood, 1997, 90:3640–6.
Regnault A, Lankar D, Lacabanne V, Rodriguez A, Théry C, Rescigno M, Saito T, Verbeek S, Bonnerot C, Ricciardi-Castagnoli P, Amigorena S. Fcgamma receptor-mediated induction of dendritic cell maturation and major histocompatibility complex class I-restricted antigen presentation after immune complex internalization. J Exp Med, 1999, 189:371-80.
Reid G, Wielinga P, Zelcer N, van der Heijden I, Kuil A, de Haas M, Wijnholds J, Borst P. The human multidrug resistance protein MRP4 functions as a prostaglandin efflux transporter and is inhibited by non steroidal antiinflammatory drugs. Proc Natl Acad Sci USA, 2003, 100: 9200-49.
Reis e Sousa C, Hieny S, Scharton-Kersten T, Jankovic D, Charest H, Germain RN, Sher A. In vivo microbial stimulation induces rapid CD40 ligand-independent production of interleukin 12 by dendritic cells and their redistribution to T cell areas. J Exp Med, 1997, 186:1819-29.
Rescigno M, Granucci F, Citterio S, Foti M, Ricciardi-Castagnoli P. Coordinated events during bacteria-induced DC maturation. Immunol Today, 1999, 20:200-3. Rescigno M, Martino M, Sutherland CL, Gold MR, Ricciardi-Castagnoli P. Dendritic cell survival and maturation are regulated by different signaling pathways. J Exp Med, 1998, 188:2175-80.
Rininger JA, Kickner S, Chigurupati P, McLean A, Franck Z. Immunopharmacological activity of Echinacea preparations following simulated digestion on murine macrophages and human peripheral blood mononuclear cells. J Leukoc Biol, 2000, 68:503-10.
Robinson Jr WE, Reinecke ME, Abdel-Malek S, Jia Q, Chow SA. Inhibitors of HIV-1 replication that inhibit HIV integrase. Proc Nat Acad Sci, 1996, 93:6326-31.
Roesler J, Emmendorffer A, Stenmuller C, Luettig B, Wagner H, Lohmann-Matthes MLJ. Application of purified polysaccharides from cell cultures of the plant Echinacea purpurea to test subjects mediates activation of phagocyte system. J Immunopharmacol, 1991, 13:931-94.
Roesler J, Steinmuller C, Kiderlen A, Emmendorffer A, Wagner H, Lohmann-Matthes ML. Application of purifed polysaccharides from cell cultures of plant Echinacea purpurea to mice mediates protection against systemic infections with Listeria monocytogenes and Candida albicans. Int. J. Immunopharmacol., 1991b, 13: 27-37.
Romani N Reider D, Heuer M, Ebner S, Kämpgen E, Eibl B, Niederwieser D, Schuler G. Generation of mature dendritic cells from human blood: An improved
method with special regard to clinical applicability. J Immunol Meth, 1996, 196:137-51.
Romiti N, Pellati F, Nieri P, Benvenuti S, Andolfi B, Chieli E. P-glycoprotein inhibitory activity of lipophilic constituents of Echinacea pallida roots ina ahuman proximal tubular cell line. Planta Med, 2008, 74:264-6.
Ronchetti A, Rovere P, Iezzi G, Galati G, Heltai S, Protti MP, Garancini , Manfredi AA, Rugarli C, Bellone M. Immunogenicity of apoptotic cells in vivo: role of antigen load, antigen-presenting cells, and cytokines. J Immunol, 1999, 163:130-6.
Roninson IB. Molecular and cellular biology oh multidrug resistance in tumor cells. New York, NY, Plenum, 1991.
Rosemberg SA. Shedding light on immunotherapy for cancer. N Engl J Med, 2004, 350:1461-3.
Rosenberg MF, Callaghan R, Ford RC, Higgins CF. Structure of the multidrug resistance P-glycoprotein to 2.5 nm resolution determined by electron microscopy and image analysis. J Biol Chem, 1997, 272:10685–94.
Rovere P, Sabbadini MG, Vallinoto C, Fascio U, Zimmermann VS, Bondanza A, Ricciardi-Castagnoli P, Manfredi AA. Delayed clearance of apoptotic lymphoma cells allows cross-presentation of intracellular antigens by mature dendritic cells. J Leukoc Biol, 1999, 66:345-9.
Rovere P, Vallinoto C, Bondanza A, Crosti MC, Rescigno M, Ricciardi-Castagnoli P, Rugarli C, Manfedi AA. Bystander apoptosis triggers dendritic cell maturation and antigen-presenting function. J Immunol, 1998, 161:4467-71.
Rutella S, Danese S, Leone G. Tolerogenic dendritic cells: cytokine modulation comes of age. Blood, 2006, 108:1435-40.
Sadzuka Y, Sugiyama T, Sawanishi H, Miyamoto K. Enhanced efficacy of 1-methyl-3-propyl-7-butylxanthine on the antitumor activity of doxorubicin against doxorubicin-resistant P388 leukemia. Cancer Lett, 1999, 138:5-11.
Sallusto F, Lanzavecchia A. Dendritic cells use macropinocytosis and the mannose receptor to concentrate antigen to the MHC class II compartment. Downregulation by cytokines and bacterial products. J Exp Med, 1995, 182:389–400.
Sallusto F, Lanzavecchia A. Efficient presentation of soluble antigen by cultured human dendritic cells is maintained by granulocyte/macrophage colony-stimulating factor plus interleukin 4 and downregulated by tumor necrosis factor α. J Exp Med, 1994, 179:1109–18.
Sallusto F, Lanzavecchia A. Understanding dendritic cell and T-lymphocyte traffic through the analysis of chemokine receptor expression. Immunol Rev, 2000, 177:134-40.
Sallusto F, Palermo B, Lenig D, Miettinen M, Matikainen S, Julkunen I, Forster R, Burgstahler R, Lipp M, Lanzavecchia A. Distinct patterns and kinetics of chemokine production regulate dendritic cell function. Eur J Immunol, 1999, 29 5:1617-25. Sallusto F, Schaerli P, Loetscher P, Schaniel C, Lenig D, Mackay CR, Qin S, Lanzavecchia A. Rapid and coordinated switch in chemokine receptor expression during dendritic cell maturation. Eur J Immunol, 1998, 28:2760-9
Salmon SE, Grogan TM, Miller T, Scheper R, Dalton WS. Prediction of doxorubicin resistance in vitro in myeloma, lymphoma, and breast cancer by P-glycoprotein staining. J Natl Cancer Inst, 1989, 81:696-701.
Scambia G, Ranelletti FO, Panici PB, De Vincenzo R, Bonanno G, Ferrandina G, Piantelli M, Bussa S, Rumi C, Cianfriglia M, et al. Quercetin potentiates the effect of adriamycin in a multidrug-resistant MCF-7 human breast-cancer cell line: P-glycoprotein as a possible target. Cancer Chemother Pharmacol, 1994, 34:459-64. Schaniel C, Sallusto F, Sideras P, Melchers F, Rolink AG (1999) A novel CC chemokine ABCD-1, produced by dendritic cells and activated B cells, exclusively attracts activated T lymphocytes. Curr Top Microbiol Immunol. (246):95-101
Scharma RC, Inoue S, Roitelman J, Schimke RT, Simoni RD. Peptide transport by the multidrug resistance pomp. J Biol Chem, 1992, 267:5731-4.
Scheffer GL, Wijngaard PL, Flens MJ, Izquierdo MA, Slovak ML, Pinedo HM, Meijer CJ, Clevers HC, Scheper RJ. The drug resistance-related protein LRP is the human major vault protein. Nat Med, 1995, 1:578-82.
Schmidt T, Ziske C, Marten A, Endres S, Tiemann K, Schmitz V, Gorschlüter M, Schneider C, Sauerbruch T, Schmidt-Wolf IG. Intratumoral immunization with tumor RNA-pulsed dendritic cells confers antitumor immunity in a C57BL/6 pancreatic murine tumor model. Cancer Res, 2003, 63:8962-7.
Schoneberger D. Influence of the immunostimulating effects of the pressed juice of Echinacea purpurea on the duration and intensity of the common cold: results of a double-blind clinical trial. Forum Immunol., 1992, 2: 18-22.
Schwarz E, Metzeler J, Diedrich JP, Freudenstein J, Bode C, Bode JC. Oral administration of freshly expressed juice of Echinacea purpurea herbs fail to stimulate the nonspecific immune response in healthy young men: resultes of a double-blind, placebo-controlled crossover study. J Immunother, 2002, 25: 413-420. Schwarz E, Parlesak A, Henneicke-von Zepelin HH, Bode JC, Bode C. Effect of oral administration of freshly pressed juice of Echinacea purpurea on the number of various subpopulations of B- and T-lymphocytes in healthy volunteers: results of a double-blind, placebo-controlled cross-over study. Phytomedicine, 2005, 12:625-31. See DM, Broumand N, Sahl L, Tilles JG. In vitro effects of echinacea and ginseng on natural killer and antibody-dependent cell cytotoxicity in healthy subjects and chronic fatigue syndrome or acquired immunodeficiency syndrome patients. Immunopharmacology, 1997, 35:229-35.
Seelig A, Blatter XL, Wohnsland F. Substrate recognition by P-glycoprotein and the multidrug resistance-associated protein MRP1: a comparison. Int J Clin Pharmacol Ther, 2000, 38:111–21.
Seelig A, Landwojtowicz E. Structure-activity relationship of P-glycoprotein substrates and modifiers. Eur J Pharm Sci, 2000, 12:1-40.
Seelig A. A general pattern for substrate recognition by P-glycoprotein. Eur J Biochem, 1998, 251:252-61.
Seelig A. How does p-glycoprotein recognize its substrates? Int J Clin Pharmacol Ther, 1998, 36:50–4.
Shakhar G, Lindquist RL, Skokos D, Dudziak D, Huang JH, Nussenzweig MC, Dustin ML Stable T cell-dendritic cell interactions precede the development of both tolerance and immunity in vivo. Nat Immunol, 2005, 6:707-14.
Shapiro AB, Ling V. The mechanism of ATdependent multidrug transport by P-glycoprotein. Acta Physiol Scand Suppl, 1998, 643:227-34.
Shapiro AB, Fox K, Lam P, Ling V. Stimulation of P-glycoprotein-mediated drug transport by prazosin and progesterone. Evidence for a third drug-binding site. Eur J Biochem, 1999, 259:841-50.
Sharom FJ, Yu X, Chu JW, Doige CA. Characterization of the ATPase activity of P-glycoprotein from multidrug-resistant Chinese hamster ovary cells. Biochem J, 1995, 308:381-90.
Sharp R. Echinacea a danger to asthmatics. MLO - Med Lab Obs, 1997, 1:81-7. Shimizi N, Tomaia M, Gonda R, Kanari M, Takanashi N. The major pectic arabinogalactan having activity on the reticuloendothelial system from the roots and rhizomes of Saposhnikovia divaricata. Chem Pharm Bull, 1989, 37:1329-32.
Shortman K, Naik SH. Steady-state and inflammatory dendritic-cell development. Nat Rev Immunol, 2007, 7:19-30.
Skach WR, Calayag MC, Lingappa VR. Evidence for an alterate model of human P-glycoprotein structure and biogenesis. J Biol Chem, 1993, 268:6903-8.
Smyth MJ e Trapani JA. Granzymes: exogenous proteinases that induces target cell apoptosis. Immunol Today, 1995, 16:202-6.
Soon SL, Crawford RI. Recurrent erythema nodosum associated with Echinacea herbal therapy. Amer J Dermat, 2001, 44:298-9.
Sozzani S, Allavena P, D'Amico G, Luini W, Bianchi G, Kataura M, Imai T, Yoshie O, Bonecchi R, Mantovani A. Differential regulation of chemokine receptors during dendritic cell maturation: a model for their trafficking properties. J Immunol, 1998, 161:1083-6.
Sparreboom A, Chen H, Acharya MR, Senderowicz AM, Messmann RA, Kuwabara T, Venzon DJ, Murgo AJ, Headlee D, Sausville EA, Figg WD. Effects of alpha1-acid glycoprotein on the clinical pharmacokinetics of 7-hydroxystaurosporine. Clin Cancer Res, 2004, 10:6840-6.
Speroni E, Covoni P, Guizzardi S, Renzulli C, Guerra MC. Anti-inflammatory and cicatrizing activity of Echinacea pallida Nutt root extract. J. Ethnopharmacol., 2002, 79:265-72.
Spignoli G, Mercati V, Boncompagni E. Guida bibliografica ai più noti fitoterapici, Aboca, 1999: 90.
Spörri R, Reis e Sousa C. Inflammatory mediators are insufficient for full dendritic cell activation and promote expansion of CD4+ T cell populations lacking helper function. Nat Immunol, 2005, 6:163-70.
Stein GM, Edlund U, Pfüller U, Büssing A, Schietzel M. Influence of polysaccharides from Viscum album L. on human lymphocytes, monocytes and granulocytes in vitro. Anticancer Res , 1999, 19:3907-14.
Steinman RM, Pack M, Inaba K. Dendritic cells in the T-cell areas of lymphoid organs. Immunol Rev, 1997, 156:25-37.
Steinman RM. The control of immunity and tolerance by dendritic cell. Pathol Biol (Paris), 2003, 51:59-60.
Steinmüller C, Roesler J, Gröttrup E, Franke G, Wagner H, Lohmann-Matthes ML. Polysaccharides isolated from plant cell cultures of Echinacea purpurea enhance the resistance of immunosuppressed mice against systemic infections with Candida albicans and Listeria monocytogenes. Int J Immunopharmacol 1993, 15:605-14. Stevens A, Lowe J, Anatomia Patologica, 2001. Elsevier.
Stevenson LM, Matthias A, Banbury L, Penman KG, Bone KM, Leach DL, Lehmann RP. Modulation of macrophage immune responses by Echinacea. Molecules, 2005, 10:1279-85.
Stimpel M, Proksch A, Wagner H, Lohmann-Matthes ML. Macrophage activation and induction of macrophage cytotoxicity by purified polysaccharide fractions from the plant Echinacea purpurea. Infect Immun 46:845-9.
Stockwin LH, McGonagle D, Martin IG, Blair GE. Dendritic cells: immunological sentinels with a central role in health and disease. Immunol Cell Biol, 2000, 78:91-102.
Stoll A, Renz J, Brack A. Isolation and constitution of Echinacoside, a glycoside from the roots of Echinacea angustifolia. Helv. Chim. Acta., 1997, 33:1877-93.
Strobl H, Knapp W. TGF-β1 regulation of dendritic cells. Microbes Infect, 1999, 1:1283-90.
Strunk D, Egger C, Leitner G, Hanau D, Stingl G. A skin homing molecule defines the Langerhans cells progenitor in human peripheral blood. J Exp Med, 1997, 185:1131-6.
Stuppner H. Dissertation. Ludwig-Maximillians-Universität, Munich, 1985. Citato in: Bauer R, Wagner H. Echinacea species as potential immunostimulatory drugs. In: Economic and Medicinal Plant Research. Ed. Wagner H, Farnsworth NR, London: Academic Press Limited, 1991, 5: 253-321.
Subbaramaiah K, Dannenberg AJ. Cyclooxygenase 2: a molecular target for cancer prevention and treatment. Trends Pharmacol Sci, 2002, 2:96-102.
Sun J, He ZG, Cheng G, Wang SJ, Hao XH, Zou MJ. Multidrug resistance P-glycoprotein: crucial significance in drug disposition and interaction. Med Sci Monit, 2004, 10:5-14.
Svensson M, Stockinger B, Wick MJ. Bone marrow-derived dendritic cells can process bacteria for MHC-I and MHC-II presentation to T cells. J Immunol, 1997, 158:4229-36.
Szabolcs P Avigan D, Gezelter S, Ciocon DH, Moore MA, Steinman RM, Young JW. Dendritic cells and macrophages can mature independently from a human bone marrow-derived, post-CFU intermediate. Blood, 87:4520–30.
Tarbell KV, Petit L, Zuo X, Toy P, Luo X, Mqadmi A, Yang H, Suthanthiran M, Mojsov S, Steinman RM. Dendritic cell-expanded, islet-specific CD4+ CD25+ CD62L+ regulatory T cells restore normoglycemia in diabetic NOD mice. J Exp Med, 2004, 204:191-201.
Teodori E, Dei S, Scapecchi S, Gualtieri F. The medicinal chemistry of multidrug resistance (MDR) reversing drugs. Il farmaco, 2002, 57:385-415.
Thiebaut F, Tsuruo T, Hamada H, Gottesman MM, Pastan I, Willingham MC. Cellular localization of the multidrug resistance gene product P-glycoprotein in normal human tissues. Proc Natl Acad Sci USA, 1987, 84:7735-8.
Thomas H, Coley HM. Overcoming multidrug resistance in cancer: an update on the clinical strategy of inhibiting p-glycoprotein. Cancer Control, 2003, 10:159-65.
Thoma-Uszynski S, Kiertscher SM, Ochoa MT, Bouis DA, Norgard MV, Miyake K, Godowski PJ, Roth MD, Modlin RL. Activation of toll-like receptor 2 on human dendritic cells triggers induction of IL-12, but not IL-10. J Immunol, 2000, 165:3804-10.
Tragni E, Galli CL, Tubaro A, Del Negro P, Della Loggia R. Anti-infiammatory activity of E. angustifolia fraction separated on the basis of molecolar weight. Pharmacol. Res. Commun., 1988, 20:87-90.
Tragni E, Tubaro A, Melis S, Galli CL. Evidance from two classic irritation test for anti-infiammatory action of a natural extract, Echinacina B. Food Chem. Toxicol., 1985, 23: 317-319.
Trombetta ES, Mellman I (2005) Cell biology of antigen processing in vitro and in vivo. Annu Rev Immunol. 23:975-1028.
Troy A, Davidson P, Atkinson C, Hart D. Phenotypic characteristics of dendritic cell infiltrate in prostate cancer. J Urol, 1998, 160: 214–9.
Troy AJ, Summers KL, Davidson PJ, Atkinson CH, Hart DN. Minimal recruitment and activation of dendritic cells withing renal cell carcinoma. Clin Cancer Res, 1998, 4:585–93.
Tsuruo T, Iida H, Tsukagoshi S, Sakurai Y. Overcoming of vincristine resistance in P388 leukemia in vivo and in vitro through enhanced cytotoxicity of vincristine and vinblastine by verapamil. Cancer Res, 1981, 41:1967–72.
Tsuruo T, Naito M, Tomida A, Fujita N, Mashima T, Sakamoto H, Haga N. Molecular targeting therapy of cancer: drug resistance, apoptosis and survival signal. Cancer Sci, 2003,94:15-21.
Ueda K, Taguchi Y, Morishima M. How does P-glycoprotein recognise its substrates? Sem Cancer Biol, 1997, 8:151-9.
Ueda K, Yoshida A, Amachi T. Recent progress in P-glycoprotein research. AntiCancer Drug Des, 1999, 14:115–21.
Van de Ven R, C de Jong M, Reurs WA, Schoonderwoerd AJN, Jansen Gerrit, Hooijberg J, Scheffer GL, D de Gruijl T, Scheper R. Dendritic cells multidrag resistance protein 1 (abcc1) transporter activity for differentiation. J Immun, 2006, 1176:5191-9.
Van de Ven R, Scheffer, G, Reurs WA, Lindenberhg J, R Orlemans, Gerrit J, Gillet JP, Glaslow J, Pereboev A, Curiel D, Rik J, Scheper, T. De Gruijl. A role for multidrag resistence protein 4 (MRP4,ABCC4) in human dendritic cell migration. Blood, 2008, 8:47-52.
Varol C, Landsman L, Fogg DK, Greenshtein L, Gildor B, Margalit R, Kalchenko V, Geissmann F, Jung S (2007) Monocytes give rise to mucosal, but not splenic, conventional dendritic cells. J Exp Med. 204:171-80
Vicari AP, Caux C, Trinchieri G. Tumor escape from immune surveillance through dendritic cell inactivation. Semin Cancer Biol, 2002, 12:33-42.
Vieira PL, de Jong EC, Wierenga EA, Kapsenberg ML, Kaliński P. Development of Th1-inducing capacity in myeloid dendritic cells requires environmental instruction. J Immunol. 164 :4507-12
Vomel T. Der einfluss eines pflanzelischen Immunostimulans auf die Phagozytose von Erythozyten durch das retikulohistozytare System der isoliert pergundierten Rattenleeber. Arzneimittelforschung, 1983, 35:1437-1439.
Wacker A, Hilbig W. Virus inhibition by Echinacea purpurea. Planta Med., 1978,33:89-102.
Wagner H, Heeg K, Hardt C. Cross-linking of T-cell receptors is insufficient to induce IL-2 responsiveness (activation) in resting Lyt-2+ T cells. IL-4 or RIF are essential as second signal. Ann NY Acad Sci, 1988, 532:128-35
Wagner H, Jurcic K. Immunologic of plant combination preparations. In-vitro and in-vivo studies on the stimulation of Phagocytosis. Arzneimittelforschung, 1991, 41: 1072-1076.
Wagner H. Phytomedicine research in Germany. Environ Health Perspect, 1999, 107:779-81.
Wang CY, Chiao MT, Yen PJ, Huang WC, Hou CC, Chien SC, Yeh KC, Yang WC, Shyur LF, Yang NS. Modulatory effects of Echinacea purpurea extracts on human dendritic cells: a cell- and gene-based study. Genomics, 2006, 88:801-8.
Wang G, Pincheira R, Zhang JT. Dissection of drug-binding-induced conformational changes in P-glycoprotein. Eur J Biochem, 1998, 255:383–90.
Wang Y, Marsden PA (1995) Nitric oxide synthases: gene structure and regulation. Adv Pharmacol 34:71-90.
Wichtl M. (ed.) Herbal drugs and phytopharmaceuticals. A handbook for practice on a scientific basis, 3rd edn. Medpharm, 2008.
Winzler C, Rovere P, Rescigno M, Granucci F, Penna G, Adorini L, Zimmermann VS, Davoust J, Ricciardi-Castagnoli P (1997) Maturation stages of mouse dendritic cells in growth factor-dependent long-term cultures. J Exp Med. 185 (2):317-28. Wong BR, Josien R, Lee SY, Sauter B, Li HL, Steinman RM, Choi Y TRANCE (tumor necrosis factor [TNF]-related activation-induced cytokine), a new TNF family member predominantly expressed in T cells, is a dendritic cell-specific survival factor. J Exp Med., 1997, 186:2075-80.
Xie QW, Kashiwabara Y, Nathan C. Role of transcription factor NF-kappa B/Rel in induction of nitric oxide synthase. J Biol Chem, 1994, 269:4705-8.
Yanagihara S, Komura E, Nagafune J, Watarai H, Yamaguchi Y. EBI1/CCR7 is a new member of dendritic cell chemokine receptor that is up-regulated upon maturation. J Immunol, 1998, 161:3096-102.
Yoneyama H, Matsuno K, Toda E, Nishiwaki T, Matsuo N, Nakano A, Narumi S, Lu B, Gerard C, Ishikawa S, Matsushima K. Plasmacytoid DCs help lymph node DCs to induce anti-HSV CTLs. J Exp Med, 2002, 202:425-35.
Young JW, Szabolcs P, Moore MAS. Identification of dendritic cell colony-forming units among normal CD4+ bone marrow progenitors that are expanded by c-kit-ligand and yield pure dendritic cell colonies in the presence of granulocyte/macrophage colony-stimulating factor and tumor necrosis factor α. J. Exp. Med, 1994, 182:1111–20.
Young JW. Dendritic cells: expansion and differentiation with hematopoietic growth factors. Curr Opin Hematol, 2001, 6:135-44.
Yu P, Lee Y, Liu W, Chin RK, Wang J, Wang Y, Schietinger A, Philip M, Schreiber H, Fu YX. Priming of naive T cells inside tumors leads to eradication of established tumors. Nat Immunol, 2004, 5:141-9.
Zamora JM, Pearce HL, Beck WT. Physical-chemical properties shared by compounds that modulate multidrug resistance in human leukemic cells. Mol Pharmacol, 1988, 33:454-62.
Zhang JT, Duthie M, Ling V. Membrane topology of the N-terminal half of the hamster P-glycoprotein molecole. J Biol Chem, 1993, 268:15101-10.
Zhang JT, Ling V. Study of membrane orientation and glycosylated extracellular loops of mouse P-glycoprotein by in vitro translation, J Biol Chem, 1991, 266:18224-32.
Zheleznova EE, Markham P, Edgar R, Bibi E, Neyfakh AA, Brennan RG. A structure-based mechanism for drug binding by multidrug transporters. Trends Biochem Sci, 2000, 25:3943.
Zhu BT. A novel hypothesis for the mechanism of action of p-glycoprotein as a multidrug transporter. Mol Carcinogenesis, 1999, 25:1-13.