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ZEISS AngioPlex OCT Angiography Overview

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(1)

ZEISS AngioPlex OCT Angiography Overview

California, 2015-09-02

ZEISS OCT Angiography

(2)

ZEISS AngioPlex

Ultra-clear visualization of microvascular blood flow using non-invasive

OCT angiography

(3)

3 2015-09-02

Carl Zeiss Meditec, AngioPlex from Zeiss, Retina Business Sector

AngioPlex OCT Angiography from ZEISS

new

non-invasive

microvasculature imaging technology

AngioPlex OCT Angiography allows visualization of both perfused

vasculature and vascular abnormalities of the retina without the need

of contrast.

(4)

AngioPlex OCT Angiography from ZEISS

AngioPlex Technology detects motion of scattering particles such as red-blood cells within sequential OCT B-scans performed repeatedly at the same location of the retina.

B-scan y 0

y 2 y 3 y 1

y

Fast axis x

AngioPlex Technology

AngioPlex Maps consist of reconstruction of the perfused microvasculature within the retina and choroid.

AngioPlex Maps

(5)

5 2015-09-02

Carl Zeiss Meditec, AngioPlex from Zeiss, Retina Business Sector

AngioPlex Maps

Superficial Retina Map

Visualization of blood flow in superficial retina.

Deep Retina Map

Visualization of blood flow in deep retina.

Avascular Retina Map

Avascular region of the retina in healthy eyes.

Allows for detection of abnormal vascular growth.

AngioPlex Maps consists of a 2D representation of retinal the vasculature of a particular region of interest.

1

2

3

(6)

AngioPlex Color Depth Map

Superficial Retina Deep Retina Avascular Retina

Color Depth Retina Map

The color depth map combines superficial, deep and avascular retina

maps and allows for depth visualization of retinal blood flow.

(7)

7 2015-09-02

Carl Zeiss Meditec, AngioPlex from Zeiss, Retina Business Sector

AngioPlex OCT Angiography from ZEISS Potential clinical applications

AngioPlex can potentially be used to detect vascular structures, such as:

 Areas of CNV in AMD

 Neovascularization in Mactel

 Micro-aneurysms and ischemia in DR

 Occlusions and abnormalities in CRVO and BRVO cases

 Abnormalities of optic nerve vasculature

(8)

OCT enface (3x3) OCT Fundus LSO

Clinical case #1: Wet AMD with CNV 64y Male, OS

Courtesy of Prof. Philip Rosenfeld, Bascom Palmer Eye Institute, Miami, FL

(9)

9 2015-09-02

Carl Zeiss Meditec, AngioPlex from Zeiss, Retina Business Sector

OCT Enface

Superficial Retina AngioPlex - CIRRUS

OCT Angiography Superficial Retina

Clinical case #1: Wet AMD with CNV 64y Male, OS

Courtesy of Prof. Philip Rosenfeld, Bascom Palmer Eye Institute, Miami, FL

(10)

A n g io Pl e x m a p s : C N V le s io n Su p e rfi c ia l R e ti n a

Clinical case #1: Wet AMD with CNV 64y Male, OS

Courtesy of Prof. Philip Rosenfeld, Bascom Palmer Eye Institute, Miami, FL

(11)

11 2015-09-02

Carl Zeiss Meditec, AngioPlex from Zeiss, Retina Business Sector

CNV lesion

Courtesy of Prof. Philip Rosenfeld, BPEI, Miami

Zeiss SD-OCT prototype (investigational device, 510k pending)

CIRRUS OCT Angiography Superficial Retina

CIRRUS OCT Angiography Map through CNV Lesion

Clinical case #1: Wet AMD with CNV 64y Male, OS

Courtesy of Prof. Philip Rosenfeld, Bascom Palmer Eye Institute, Miami, FL

(12)

Clinical case #2: MacTel Type 2 56y Female, OD

Fluorescein Angiogram 00:37

Courtesy of Prof. Philip Rosenfeld, Bascom Palmer Eye Institute, Miami, FL

(13)

13 2015-09-02

Carl Zeiss Meditec, AngioPlex from Zeiss, Retina Business Sector

Fluorescein Angiogram 00:37

AngioPlex Map Color Depth Retina

Clinical case #2: MacTel Type 2 56y Female, OD

Comparison between Fluorescein Angiography and AngioPlex

Courtesy of Prof. Philip Rosenfeld, Bascom Palmer Eye Institute, Miami, FL

(14)

Clinical case #2: MacTel Type 2 56y Female, OD

AngioPlex Maps

Superficial Retina Deep Retina Avascular Retina

AngioPlex maps highlight regions of abnormal vasculature within the retina

Color depth Retina

Courtesy of Prof. Philip Rosenfeld, Bascom Palmer Eye Institute, Miami, FL

(15)

15 2015-09-02

Carl Zeiss Meditec, AngioPlex from Zeiss, Retina Business Sector

Superficial Retina Avascular Retina

Retina

Superficial Retina Avascular Retina

Retina

=

=

Deep Retina

Deep Retina

OS OD

AngioPlex Maps

Clinical case #2: MacTel Type 2 56y Female, OU

Courtesy of Prof. Philip Rosenfeld, Bascom Palmer Eye Institute, Miami, FL

(16)

Fluorescein Angiogram Early phase

Clinical case #3: PDR 57y Male, OS

Courtesy of Dr. Scott Lee, East Bay Retina Consultants, Oakland, CA

(17)

17 2015-09-02

Carl Zeiss Meditec, AngioPlex from Zeiss, Retina Business Sector

Courtesy of Dr. Scott Lee, East Bay Retina Consultants, Oakland, CA

Clinical case #3: PDR 57y Male, OS

Comparison between Fluorescein Angiography and AngioPlex

Fluorescein Angiogram 00:37

AngioPlex Map

Color Depth Retina

(18)

Superficial Retina Deep Retina Avascular Retina

Courtesy of Dr. Scott Lee, East Bay Retina Consultants, Oakland, CA

Clinical case #3: PDR 57y Male, OS

AngioPlex maps highlight regions of abnormal vasculature (micro-aneurysm, ischemia) within the retina

AngioPlex Maps

Color depth Retina

(19)

19 2015-09-02

Carl Zeiss Meditec, AngioPlex from Zeiss, Retina Business Sector

Clinical case #4: DR with NVE 37y Male, OD

Fluorescein Angiogram Early phase

Courtesy of Dr. Soraya Rofagha, East Bay Retina Consultants, Oakland, CA

(20)

Clinical case #4: DR with NVE 37y Male, OD

Comparison between Fluorescein Angiography and AngioPlex

Fluorescein Angiogram 34s

AngioPlex Map overlay on OCT Fundus LSO Full Retina

Courtesy of Dr. Soraya Rofagha, East Bay Retina Consultants, Oakland, CA

(21)

21 2015-09-02

Carl Zeiss Meditec, AngioPlex from Zeiss, Retina Business Sector

Clinical case #4: DR with NVE 37y Male, OD

Courtesy of Dr. Soraya Rofagha, East Bay Retina Consultants, Oakland, CA

AngioPlex Maps

AngioPlex maps highlight regions of

abnormal vasculature in the vitreous

(22)

Courtesy of Dr. Soraya Rofagha, East Bay Retina Consultants, Oakland, CA

Clinical case #5: BRVO 44y Female, OS

Fluorescein Angiogram Late phase

(23)

23 2015-09-02

Carl Zeiss Meditec, AngioPlex from Zeiss, Retina Business Sector

Comparison between Fluorescein Angiography and AngioPlex

Fluorescein Angiogram 10 mins

AngioPlex Map Color Depth Retina

Clinical case #5: BRVO 44y Female, OS

Courtesy of Dr. Soraya Rofagha, East Bay Retina Consultants, Oakland, CA

(24)

Superficial Retina Deep Retina Avascular Retina

Clinical case #5: BRVO 44y Female, OS

AngioPlex maps identify regions of

abnormal vasculature (micro-aneurysm, ischemia) within the retina

AngioPlex Maps

Color depth Retina

Courtesy of Dr. Soraya Rofagha, East Bay Retina Consultants, Oakland, CA

(25)

25 2015-09-02

Carl Zeiss Meditec, AngioPlex from Zeiss, Retina Business Sector

AngioPlex OCT Angiography from ZEISS

new

non-invasive

microvasculature imaging technology

CIRRUS AngioPlex OCT Angiography allows visualization of both

perfused vasculature and vascular abnormalities of the retina without

the need of contrast.

(26)

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Abbreviations: ONH = optic nerve head; SVP = superficial vascular plexus; DVP = deep vascular plexus; IS = inferior sector; FAZ = foveal avascular zone; SN = superior nasal quadrant;