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Effect of MGO accumulation on vascular function in mouse experimental models in vitro and in vivo.

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Academic year: 2021

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Figure 1: Molecular  pathways activated chronic hyperglycemia. (Schalkwijk and  Stehouwer 2005)
Figure 2. Pathways involved in MGO formation and detoxification. MGO is generated as  a byproduct of glycolysis
Figure  3. The Glyoxalase System. Glyoxalase system is formed by two enzymes.  Glyoxalase 1 catalyzes the conversion the MGO-GSH hemi-thioacetal to the thioester  S-D-lactoyglutahione
Figure  4. Sources of methylglyoxal (MGO) accumulation contributing to  vascular  dysfunction
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Author(s) トッリーニ, アルド; TOLLINI, Aldo. Citation 人文学研究所報,