CURRICULUM VITAE Rosaria Villano
[email protected] [email protected]
STUDI
Università degli Studi di Salerno
Marzo 2003: Dottorato di Ricerca in Chimica (Novembre 1999 - Novembre 2002).
Tesi: Nuove metodologie nel campo della sintesi asimmetrica: formazione di legami C-C mediata da complessi chirali di metalli di transizione (supervisors:
Prof. A. Scettri, Dr.ssa A. Soriente)
Campo di ricerca: Formazione di legami C-C – Catalisi asimmetrica – Effetti non lineari ed autoinduzione in reazioni organiche.
Università degli Studi di Salerno
Maggio 2000: Abilitazione all’esercizio della professione di Chimico.
Università degli Studi di Salerno
Novembre 1999: Laurea in Chimica, votazione 110/110.
Tesi: Studio mediante spettri di dicroismo circolare della configurazione assoluta di sesterterpeni marini antiinfiammatori (supervisors: Prof. G. Sodano, Dr.ssa A.
Soriente)
Campo di ricerca: Sintesi multi-steps – Catalisi asimmetrica – Dicroismo Circolare.
ESPERIENZA PROFESSIONALE
Ruolo attuale: Ricercatore, CNR, Istituto di Chimica Biomolecolare – Pozzuoli (NA), da Ottobre 2017 a tutt’oggi.
Indirizzo: Istituto di Chimica Biomolecolare – CNR Ex Comprensorio Olivetti
via Campi Flegrei 34 80078 Pozzuoli (NA)
Ruolo precedente: Ricercatore, CNR, Istituto di Chimica Biomolecolare – UOS di Sassari, da Gennaio 2008 a Ottobre 2017.
Indirizzo: Istituto di Chimica Biomolecolare - CNR Trav. La Crucca 3, Reg. Baldinca
07100 Sassari
Esperienze precedenti: Assegnista di Ricerca, Facoltà di Scienze Matematiche, Fisiche e Naturali, Dipartimento di Chimica, Università degli Studi di Salerno, da Novembre 2002 a Novembre 2007.
Cultore della materia, Facoltà di Scienze Matematiche, Fisiche e Naturali,
Dipartimento di Chimica, Università di Salerno, da Ottobre 2006 a Ottobre 2011.
Indirizzo: Dipartimento di Chimica - Università degli Studi di Salerno via Ponte don Melillo
84084 Fisciano (SA)
INTERESSI DI RICERCA
Nuove metodologie di reazione in Chimica Organica, Catalisi, Green Chemistry, Effetti non lineari ed autoinduzione in reazioni asimmetriche, Sintesi Organica, Chiralità, Structure-Activity
Relationship.
PUBBLICAZIONI
1. A. Soriente, A. Crispino, M. De Rosa, S. De Rosa, A. Scettri, G. Scognamiglio, R. Villano, G. Sodano
“Stereochemistry of antiinflammatory marine sesterterpenes”
Eur. J. Org. Chem. 2000, 6, 947.
2. A. Soriente, M. De Rosa, R. Villano, A. Scettri
“Enantioselective Aldol Condensation of 1,3-bis-(trimethylsilyloxy)-1-methoxy-buta-1,3- diene Promoted by Chiral Ti(IV)/BINOL Complex”
Tetrahedron: Asymmetry 2000, 11, 2255.
3. A. Soriente, M. De Rosa, M. Stanzione, R. Villano, A. Scettri
“An efficient asymmetric aldol reaction of Chan’s diene promoted by chiral Ti(IV)-BINOL complex”
Tetrahedron: Asymmetry 2001, 12, 959.
4. R. Villano, M. De Rosa, C. Salerno, A. Soriente, A. Scettri
“Nonlinear effects and auto-induction in the asymmetric aldol condensation of synthetic equivalents of acetoacetic esters”
Tetrahedron: Asymmetry 2002, 13, 1949.
5. A. Massa, R. Acocella, M. De Rosa, A. Soriente, R. Villano, A. Scettri
“Mo(CO)6-catalyzed oxidation of furan derivatives to E- and Z-enediones by cumyl hydroperoxide”
Tetrahedron Letters 2003, 44, 835.
6. M. De Rosa, L. Palombi, M.R. Acocella, M. Fruilo, R. Villano, A. Soriente, A. Scettri
“An easy approach to chiral Michael adducts by Eu+3-catalyzed conjugate addition”
Chirality 2003, 15, 579.
7. M. De Rosa, R. Acocella, R. Villano, A. Soriente, A. Scettri
“Ti(IV)/BINOL catalyzed asymmetric aldol reaction of a masked acetoacetic ester:
pronounced influence of catalyst concentration on nonlinear effects”
Tetrahedron Letters 2003, 44, 6087.
8. M. De Rosa, R. Acocella, R. Villano, A. Soriente, A. Scettri
“A convenient catalytic procedure for the highly enantioselective aldol condensation of Osilyldienolate”
Tetrahedron: Asymmetry 2003, 14, 2499.
9. A. Soriente, M. De Rosa, R. Villano, A. Scettri
“Recent advances in asymmetric aldol reaction of masked acetoacetic esters promoted by Ti(IV)/BINOL Complex. A new methodology, non linear effects and autoinduction”
Current Organic Chemistry 2004, 8, 993.
10. R. Villano, M.R. Acocella, M. De Rosa, A. Soriente, A. Scettri
“Pronounced Asymmetric Amplification in the Aldol Condensation of Chan’s Diene Promoted by Ti(IV)/BINOL Complex”
Tetrahedron: Asymmetry 2004, 15, 2421.
11. R. Villano, A. Scettri
“Neutral Lewis Bases as Activators of Molecular Sieves in the Coniugate Addition of 1,3- Dicarbonyl Compounds”
Synthesis 2005, No. 5, 757.
12. M.R. Acocella, M. De Rosa, A. Massa, L. Palombi, R. Villano, A. Scettri
“Silicon tetrachloride in organic synthesis: new applications for the vinylogous aldol reaction”
Tetrahedron 2005, 61, 4091.
13. M.R. Acocella, A. Massa, L. Palombi, R. Villano, A. Scettri
“Solvent-free Mukaiyama aldol reaction of O-silyl dienolates catalyzed by benzoic acid.”
Tetrahedron Letters 2005, 46, 6141.
14. M. De Rosa, M. Lamberti, C. Pellecchia, A. Scettri, R. Villano and A. Soriente
“An efficient solvent free catalytic oxidation of sulfides to sulfoxides with hydrogen peroxide catalyzed by a binaphthyl-bridged Schiff base titanium complex”
Tetrahedron Letters 2006, 47, 7233.
15. A. Scettri, M.R. Acocella, L. Palombi, C. Scalera, R. Villano, A. Massa
“Diastereo- and enantioselective synthesis of trans-2,3-disubstituted-2,3-dihydropyran-4- one derivatives”
Advanced Synthesis & Catalysis 2006, 348, 2229.
16. L. Palombi, M.R. Acocella, N. Celenta, A. Massa, R. Villano, A. Scettri
“Highly enantioselective vinylogous addition of 2-trimethylsilyloxyfuran to aldehydes promoted by the SiCl4/chiral Lewis base system”
Tetrahedron: Asymmetry 2006, 17, 3300.
17. R. Villano, M.R. Acocella, A. Massa, L. Palombi, A. Scettri
“A new procedure for the enantioselective vinylogous aldol reaction of Chan’s diene .”
Tetrahedron: Asymmetry 2006, 17, 3332.
18. R. Villano, M.R. Acocella, A. Massa, L. Palombi, A. Scettri
“Enantioselective vinylogous aldol reaction of Chan’s diene catalyzed by hydrogenbonding”
Tetrahedron Letters 2007, 48, 891.
19. L. Palombi, M.R. Acocella, R. Villano, A. Scettri
“Eu(OTf)3-catalyzed oxidation of 5-alkylidene-4,5-dihydrofurans: a new approach to functionalized furylhydroperoxides.”
Catalysis Communications 2007, 8, 1655.
20. R. Villano, M.R. Acocella, A. Massa, L. Palombi, A. Scettri
“A convenient approach to d-amino-b-ketoesters by vinylogous Mannich reaction of masked acetoacetates.”
Tetrahedron 2007, 63, 12317.
21. R. Villano, A. Massa, L. Palombi, A. Scettri
“[2,2-dimethyl-4-methylene-4H-1,3-dioxin-6-yl)oxy]trimethyl-silane.”
e-EROS Encyclopedia of Reagents for Organic Synthesis by John Wiley & Sons 2008 (Article Online Posting Date: March 14, 2008) DOI: 10.1002/047084289X.rn00789
22. L. Palombi, C. Bocchino,T. Caruso, R. Villano, A. Scettri
“Electro- and acid-catalysis in tetrafluoroborate-based ionic liquid: new alternative routes for the oxidation of sulfides with UHP”
Tetrahedron Letters 2008, 49, 5611.
23. L. Palombi, C. Bocchino,T. Caruso, R. Villano, A. Scettri
“Cathodic C–H electro-activation in ionic liquid: An improved electrochemical method for the conjugate addition of 1,3-dicarbonyl compounds”
Catalysis Communications 2008, 10, 321.
24. A. Scettri, A. Massa, L. Palombi, R. Villano, M.R. Acocella
“Organocatalytic asymmetric aza-Michael addition of aniline to chalcones under solventfree conditions”
Tetrahedron: Asymmetry 2008, 19, 2149.
25. A. Massa, M.R. Acocella, V. De Sio, R. Villano, A. Scettri
“A catalytic asymmetric allylation of aldehydes with allyl trichlorosilane activated by a chiral tetradentate bis-sulfoxide”
Tetrahedron: Asymmetry 2009, 20, 202.
26. A. Massa, V. De Sio, R. Villano, M.R. Acocella, L. Palombi, G. Sellitto, A. Peduto, R.
Filona, P. De Capraris, A. Scettri
“A new approach to di- and tetrasubstituted 2,3-dihydropyridin-4(1H)-ones through aza- Diels-Alder reaction promoted by silicon tetrachloride”
Synthesis 2009, 643.
27. R. Villano, M.R. Acocella, A. Massa, L. Palombi, A. Scettri
“Solvent-free asymmetric vinylogous aldol reaction of Chan's diene with aromatic aldehydes catalyzed by hydrogen bonding”
Tetrahedron 2009, 65, 5571.
28. A. Scettri, R. Villano, M.R. Acocella
“Asymmetric Friedel-Crafts Alkylation of Indole with Chalcones Catalyzed by Chiral Phosphoric Acids”
Molecules 2009, 14, 3030.
29. A. Scettri, V. De Sio, R. Villano, M.R. Acocella
“Solvent-Free Organocatalytic Mukaiyama-Michael Addition of 2-Trimethylsilyloxy Furan to Nitroalkenes Catalyzed by Brønsted Acids”
Synlett 2009, 2629.
30. V. De Sio, M. R. Acocella, R. Villano, A. Scettri
“New chiral imino- and amino-sulfoxides as activators of allyl trichlorosilane in the asymmetric allylation of aldehydes”
Tetrahedron: Asymmetry 2010, 21, 1432.
31. A. Scettri, V. De Sio, R. Villano, P. Manzo, M. R. Acocella
“Solvent-free Mukaiyama and Mukaiyama–Michael vinylogous reactions of a dioxinonederived
silyl enol ether promoted by Lewis bases”
Tetrahedron Letters 2010, 51, 3658.
32. R. Villano, M. R. Acocella, V. De Sio, A. Scettri
“1-Naphthyl-TADDOL/Emim BF4: A new catalytic system for the asymmetric addition of Chan’s diene to aromatic aldehydes”
Cent. Eur. J. Chem. 2010, 8, 1172.
33. R. Villano, M. R. Acocella, A. Scettri
“Synthesis of multifunctionalized building blocks via vinylogous addition of Chan’s diene to carbonyl and carbonyl-related electrophiles, mediated by molecular iodine”
Tetrahedron 2011, 67, 2768.
34. A. Scettri, R. Villano, P. Manzo, M. R. Acocella
“Mukaiyama-Michael vinylogous additions to nitroalkenes under solvent-free conditions”.
Cent. Eur. J. Chem. 2012, 10, 47.
35. A. Ligresti, R. Villano, M. Allarà, I. Ujvàry, V. Di Marzo
“Kavalactones and the endocannabinoid system: the plant-derived yangonin is a novel CB1 receptor ligand”
Pharmacological Research 2012, 66, 163.
36. M.R. Acocella, R. Villano, C. Costabile, A. Scettri.
“Vinylogous Aldol Reaction of a Silyloxydiene Promoted by Sulfoxides, as Lewis Bases:
1,4–asymmetric Induction Mediated by a Remote Methylsulfinyl Group”
Curr. Org. Chem. 2013, 17, 886.
37. R. Villano, M.R. Acocella, A. Scettri.
“Fe3O4 nanoparticles/ethyl acetoacetate system for the efficient catalytic oxidation of aldehydes to carboxylic acids”
Tetrahedron Letters 2014, 55, 2442.
38. R. Villano.
“Chapter 24: Alcohols, Phenols and Carboxylic Acids as Asymmetric Organocatalysts” in Sustainable Catalysis: Without Metals or Other Endangered Elements, Part 2, 2016, 406-433 DOI:10.1039/9781782626435-00406 (Print publication date: 16 Nov 2015; Copyright: 2016) – Series: RSC Green Chemistry, Edited by Michael North, Published by the Royal Society of Chemistry.
39. R. Villano, M.R. Acocella, A. Scettri.
“Influence of a remote sulfinyl group on L-proline-catalyzed direct asymmetric aldol addition of acetone”.
Tetrahedron 2016, 72, 5414-5419.
40. R. Villano, M.R. Acocella, G. Guerra.
“Oxidized Carbon Black as Catalyst for the Enamine Formation in Solvent-Free Conditions: A Green Strategy to Build the Benzodiazepine Scaffold”.
ChemistrySelect 2017, 2, 10559-10564.
41. P. Peluso, V. Mamane, R. Dallocchio, A. Dessì, R. Villano, D. Sanna, E. Aubert, P. Pale, S.
Cossu.
“Polysaccharide-based chiral stationary phases as halogen bond acceptors: A novel strategy for detection of stereoselective σ-hole bonds in solution”.
Journal of Separation Science 2018, 41, 1247-1256.
COMUNICAZIONI A CONGRESSO
1. A. Soriente, M. De Rosa, R. Villano, A. Scettri
“Enantioselective Aldol Condensation of Masked Acetoacetic Esteres to Aldehydes mediated by Chiral Ti(IV)/BINOL Complex”
Second Franco-Italian Symposium, Strasbourg-France 24-25 November 2000. (Poster)
2. M. De Rosa, A. Soriente, R. Villano, C. Salerno, A. Scettri
“Nonlinear Effects in Aldol Condensations Catalyzed by BINOL-Ti complexes”
IASOC - Ischia Advanced School of Organic Chemistry - 10th session, Ischia (Na) 21-26 September 2002. (Poster)
3. M.R. Acocella, M. De Rosa, R. Villano, A. Soriente, A. Scettri
“Concentration-dependent nonlinear effects in enantioselective aldol condensations catalyzed by Ti(IV)/BINOL complex”
XXI Congresso SCI, Torino 22-27 Giugno 2003. (Poster)
4. M.R. Acocella, M. De Rosa, R. Villano, A. Soriente, A. Scettri
“Concentration-dependent nonlinear effects in enantioselective aldol condensations
catalyzed by Ti(IV)/BINOL complex”
The 2003 Younger European Chemists’ Conference, Grenoble 26-29 Agosto 2003. (Poster)
5. A. Soriente, M. Fruilo, C. Gaeta, R. Villano, P. Neri
“Calixarene/Ti(IV) complexes as active catalysts in aldol reaction”
Fourth Franco-Italian Symposium, Annecy-France 5-9 May 2004. (Poster)
6. R. Villano, M.R. Acocella, M. De Rosa, A. Soriente, A. Scettri
“Enantioselective aldol condensation of Chan’s diene: pronounced influence of catalyst concentration on nonlinear effects”
Fourth Franco-Italian Symposium, Annecy-France 5-9 May 2004. (Oral communication)
7. R. Villano, M.R. Acocella, A. Massa, L. Palombi, A. Scettri
“Strategie per la sintesi di d-idrossi-b-chetoesteri attraverso reazione di addizione viniloga del diene di Chan”
SardiniaChem 2008, Sassari 30 Maggio 2008. (Oral communication)
8. E. Fenude, R. Villano
“Studio sintetico e caratteristiche conformazionali di peptidi di interesse biomedico”
SardiniaChem 2008, Sassari 30 Maggio 2008. (Poster)
9. R. Villano, M. R. Acocella, V. De Sio, A. Scettri
“Nuove metodologie organocatalitiche per la sintesi di d-idrossi-b-chetoesteri”
SardiniaChem 2010, Cagliari 31 Maggio 2010. (Poster)
10. R. Villano, M. R. Acocella, V. De Sio, A. Scettri
“Efficient synthesis of multifunctionalized scaffolds via vinylogous addition of Chan’s diene to carbonyl and carbonyl-related electrophiles, mediated by molecular iodine”
IASOC 2010, Ischia (Napoli) 25-30 Settembre 2010. (Poster)
11. R. Villano
“Formazione di legami C-C mediante addizione aldolica viniloga: un felice connubio tra stereoselezione e semplicità di processo”
Workshop “Recenti sviluppi in Chimica Organica: aspetti sintetici e biologici”, Università degli Studi di Salerno, Campus di Fisciano 20 Febbraio 2012. (Comunicazione orale su invito).
12. I. Ujváry, A. Ligresti, R. Villano, M. Allarà, V. Di Marzo
“Yangonin, a kavalactone from Piper methysticum, is a novel CB1 receptor ligand”
22nd Annual Symposium of the International Cannabinoid Research Society, Freiburg (Germany) 22–27 luglio 2012 (Comunicazione orale). O45
13. R. Villano
“Efficient and environmentally friendly methodologies for the synthesis of multifuncionalized scaffolds” II Convegno dell’Istituto di Chimica Biomolecolare CNR, Area della Ricerca di Sassari, 8-9 Ottobre 2015. (Comunicazione orale). OC7.
14. R. Villano, M. R. Acocella, A. Scettri
“Influence of a remote sulfinyl group on L-proline-catalyzed direct asymmetric aldol addition of acetone” III Convegno dell’Istituto di Chimica Biomolecolare CNR, Catania, 28-30 Settembre 2016. (Poster). P13.
15. R. Villano, M. R. Acocella, G. Guerra
“Carbon nanomaterials as efficient catalysts for organic reactions” Conferenza di Dipartimento DSCTM-CNR 2018, Assisi, 24-26 Settembre 2018. (Poster). Premio miglior poster DSCTM-CNR YIA2018, Area strategica: Chimica Verde. Atti ISBN 978 88 8080 339 3
