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Pediatrics in Greece

Thermisia, Greece

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Introduction

George P. Chrousos, MD

Professor and Chairman First Department of Pediatrics

(Founded 1855)

Athens University Medical School

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Doctor and Patient

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WESTERN MEDICINE

ANCIENT GREEK MEDICINE (< 500 BCE)

Asklepios- The Asklepeia as Healing Places CLASSIC GREEK MEDICINE (500- 200 BCE)

Hippocrates- Evidence based-Medicine HELLENISTIC MEDICINE (200 BCE-400 CE)

Erasistratos, Herophilos, Galen, Aretaeos, Soranos BYZANTINE (EASTERN ROMAN) MEDICINE (400-1400 CE)

First modern hospital in Constantinople (430 CE) MODERN MEDICINE (1400- present)

Judaic-Arabic Medicine

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Medication= Pharma-con, Pharma-cy Pharmaco-poieia, Pharmaco-logy

Pharma or Varma from the Greek Varao= I knock or hit the demon

causing the disease

Target Therapy= Knocks out the defective substance, ie. gene, protein,

enzyme etc.

(8)

Σιτία, ποτά, ύπνος και αφροδίσια, πάντα ταύτα µέτρια. Το δε περισσόν νούσων ποιεί

Food, drink, sleep and sex, all these

should be in moderation. Excess causes disease

Pythagoras

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A BASIC PRINCIPLE OF NATURE

Balance Equilibrium

Harmony

Counteracting Reestablishing Disturbing

Forces

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General Stress Syndrome Diseases of Adaptation Disturbing

Forces

Harmony Equilibrium

Balance Isonomia

Counteracting Reestablishing

Forces II

II II

Stressors Homeostasis Adaptive Responses (Physical,

Emotional)

Specific Nonspecific

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Hippocrates of Cos

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”The three branches of Medicine are Physics, Surgery and Dietetics "

Hippocrates

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«Παχέες ταχυθάνατοι µάλλον των ισχνών»

“Obese people die earlier than thin ones”

Hippocrates

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Mentor and Mentee

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Aristotle of Stageira

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The constituents of Man:

Physis, Ethos, Logos

Aristotle

(384-322 BCE)

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«Συµπάσχει η ψυχή τω σώµατι νοσούντι και τεµνοµένω, το δε σώµα τη ψυχή»

“The soul suffers when the body is diseased or traumatized, while the body suffers when the soul is ailing”

Aristotle

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BASIC CONCEPTS

Pythagoras The brain is the site of the intellect (580-489 BCE)

Alkmaion Health is the equipose of opposing forces: isonomia (c. 500 BCE)

Hippocrates A harmonious balance of the elements and qualities of life (460-375 BCE) is health- Dysharmony is disease

Νούσων φύσεις ιητροί =Vis medicatrix naturae

Stress-induced hypogonadism, male sterility from orchitis Obesity as a health problem

Aristotle Embryology, ovariotomy, semen (384-322 BCE)

Soranos Menarche, menstrual disorders, eating disorders, anorexia nervosa (98-138 CE)

Galen The hypophysis or pituitary gland (129-201 CE)

Aretaeus Diabetes mellitus vs. insipidus, seminarche

(c. 200 CE) Major depression

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Hippocrates as a Church Figure

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Νοσοκοµείο Παίδων η Αγία Σοφία

CHILDRENS’ HOSPITAL AGHIA SOPHIA

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“ The improvement of our children’s health depends on research and the provision of

care requires a culture that constantly asks and questions”

A. Aynsley-Green, Arch. Dis. Child. 78: 101, 1998

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70-75

Life Expectancy (1998)

75-80

65-70

60-65

55-60

under 55

NA

(39)

Homo erectus Homo sapiens Homo fatuous

---5 miilion y--- 150.000 y--- 10.000 y

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TRADITION versus

GLOBALISATION

The case of the Greek diet

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"Let food be thy medicine and

medicine be thy food"

Hippocrates

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'Positive health requires a knowledge of man's primary constitution (which today we call genetics) and of the powers of various foods, both those natural to them and

those resulting from human skill (today's processed food). But eating alone is not enough for health. There must also be exercise, of which the effects must likewise

be known. The combination of these two things makes regimen, when proper attention is given to the season of

the year, the changes of the winds, the age of the individual and the situation of his home. If there is any

deficiency in food or exercise the body will fall sick.'

Hippocrates 480 BC

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That as you ought not to attempt to cure the eyes without the head, or the head without the body, so neither ought you to attempt to cure the body without the soul; and this, he said (Socrates), is the reason why the cure of many diseases is unknown to the physicians of Hellas, because they are ignorant of the whole, which ought to the studied also; for the part can never be well unless the whole is well.

Plato

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STRESS AS A CONCEPT

Pythagoras The intellect is based in the brain (580-489 BC)

Alkmaion Health is the equipose of opposing forces isonomia (c. 500 BC)

EmpedoclesMatter consists of essential elements and qualities in (500-430 BC) opposition or alliance to one another

Hippocrates A harmonious balance of the elements and qualities of life (460-375 BC) is health- Dysharmony is disease

Νούσων φύσεις ιητροί =Vis medicatrix naturae

Epicurus Ataraxia (imperturbability of mind) as a superior pleasure (341-270 BC)

Thomas Sydenham Symptoms and signs of a disease arise also from the reaction of the (AD 1624-1689 patients system

Claude Bernard The milieu interieur (1813-1878)

Walter Cannon Homeostasis

(1871-1945) Bodily responses to emotions Fight or flight (or freeze) reaction

Hans Selye The general adaptation syndrome(the stress syndrome) (1907-1982) Diseases of adaptation

Distress vs. eustress

(54)

STRESS AS A CONCEPT

Empedocles Matter consists of essential elements and qualities in (500-430 BC) opposition or alliance to one another

Hippocrates A harmonious balance of the elements and qualities of life (460-375 BC) is health-Dysharmony is disease

Νούσων φύσεις ιητροί =Vis medicatrix naturae

Epicurus Ataraxia (imperturbability of mind) as a superior pleasure (341-270 BC)

Thomas Sydenham Symptoms and signs of a disease arise also from the reaction of the (AD 1624-1689 patients system

Claude Bernard The milieu interieur (1813-1878)

Walter Cannon Homeostasis

(1871-1945) Bodily responses to emotions Fight or flight (or freeze) reaction

Hans Selye The general adaptation syndrome(the stress syndrome) (1907-1982) Diseases of adaptation

Distress vs. eustress

(55)

STRESS AS A CONCEPT

Pythagoras The intellect is based in the brain (580-489 BC)

Alkmaion Health is the equipose of opposing forces:

isonomia (c. 500 BC)

Empedocles Matter consists of essential elements and qualities in (500-430 BC) opposition or alliance to one another

Hippocrates A harmonious balance of the elements and qualities of life

(460-375 BC) is health- Dysharmony is disease

Νούσων φύσεις ιητροί =Vis medicatrix naturae

Epicurus Ataraxia (imperturbability of mind) as a superior pleasure

(341-270 BC)

(56)

92 Successful Inventions

1900: portable camera

1900: paper clip

1902: dog biscuits

1902: teddy bear

1902: vacuum cleaner

1903: safety razor

1907: baking powder

1908: model T ford,(first mass- produced car)

1910: electric stove

1910: washing machine (with crank)

1912: luminous advertising

1912:vitamins discovered

1913:zipper

1914: bra

1916: tennis shoes

1916:loudspeaker

1919:electric toaster

1920: paper handkerchiefs

1920: sliced bead

1921: insulin

1921: band-aids

1928:peanut butter

1926: refrigerator

1928: adhesive tape

1928: penicillin

1928: ready-made baby food

1928: air conditioning

1929: TV set

1930: transparent tape

1930: flashlight

• 1931:Alkaseltzer

• 1931: hair colour to use at home

• 1931: electric shaver

• 1931: stereo amplifier

• 1931: tampons

• 1931:tape record ( invented by AEG, Germany)

• 1931:LP record

• 1933:laundry powder

• 1935:colour film

• 1935: garbage disposal

• 1937: electric blender

• 1938: Teflon

• 1938: photocopier

• 1939: nylon stockings

• 1937: jet-propelled aircraft

• 1940: electric kettle

• 1941: elastic

• 1941: wrinkle-free textiles

• 1942:cake mixes

• 1944: ballpoint pen

• 1946: Tupperware

• 1946: electric washing machine

• 1947: instamatic camera

• 1947: microwave oven

• 1948: electric guitar

• 1949: disposable diapers

• 1950: cortisol

• 1951: first home computer

• 1953: colour TV

• 1953: cling film

• 1954: domestic dishwasher

Inventions are made every day, but not all of them meet with the

Inventions are made every day, but not all of them meet with the same sweeping success as the following : same sweeping success as the following :

•1954: Domestic dishwasher

•1954: Frozen food

•1955: Vaccine for polio

•1955: Transistor radio

•1956: Correction fluid

•1957: Frisbee

•1958: Hula Hoop

•1959: Barbie doll

•1960: Pantyhose

•1960: Tylenol (painkiller)

•1960: The Pill

•1961: Soft contact lenses

•1963: Cassette recorder

•1963: Canned Coca-Cola

•1963: Touch-dial telephone

•1963: Metal tennis racket

•1964: Fax machine

•1969: Quartz wristwatch

•1970: Skateboard

•1972: Pocket calculator

•1973: Food processor

•1973: Cellular phone

•1978: Snowboard

•1979: Walkman

•1980: Pacman, the first video game

•1980: Post-its

•1980: Inline Skates

•1980: CD

•1981: Goretex

•1984: Macintosh computer

•1988: Prozac

•1993: Internet Navigator

Sources: "Bild Zeitung"/" The people's Almanac Presents the 20th Century"

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Depression is ancient:

Aretaeus of Capadocia (150-200 AD):

“The patients are dull or stern:

dejected or unreasonably torpid,

without any manifest cause…”

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«Παχέες ταχυθάνατοι µάλλον των ισχνών»

“Obese people die earlier than thin ones”

Hippocrates

(60)

Target Therapy= Specifically directed against the defective substance, ie. gene,

protein, enzyme, etc. correcting loss of

function or excess function

(61)
(62)

Load

Elastic region

Deformation Plastic region Yield point

Fracture point

Load deformation

curve

(63)

«Σιτία, ποτά, ύπνος και αφροδίσια, πάντα

ταύτα µέτρια. Το δε περισσόν νούσων ποιεί»

“Food, drink, sleep and sex, all these

should be in moderation. Excess causes disease”

Pythagoras

(64)

Pyramid of Progress

Therapeutic Agent Works

Clinical Trial

Clinical Relevant Preclinical Trials Phase I Animal Trials Focused In Vitro/

In Vivo Studies Basic

Sciences

(65)

Target Therapy= Specifically directed against the defective substance, ie. gene,

protein, enzyme, etc. correcting loss of

function or excess function

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