Kenneth B. Gordon Eric M. Ruderman Editors
Psoriasis and Psoriatic Arthritis
An Integrated Approach
Kenneth B. Gordon Eric M. Ruderman Editors
Psoriasis and
Psoriatic Arthritis
An Integrated Approach
With 47 Figures and 36 Tables
Kenneth B. Gordon, MD Division of Dermatology Loyola University
Stritch School of Medicine
2160 S. First Ave., Building 112, Room 342 Maywood, IL 60153
USA
Eric M. Ruderman, MD Division of Rheumatology Northwestern University Feinberg School of Medicine 675 N. St. Clair St.
Chicago, IL 60611 USA
Library of Congress Control Number: 2004113294 ISBN 3-540-21280-9 Springer Berlin Heidelberg New York
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Dermatologists and rheumatologists alike are confronted with patients suffering from both psoriasis and psoriatic arthritis, and are often asked to address the dis- ease with which they are least familiar. In our experience, proper care of either ail- ment requires a working knowledge of both. Working together to manage these pa- tients, we have found that the most effective treatments must account for all mani- festations of disease, whether skin or joint, and that this approach is the best way to ensure satisfied patients with the most unrestricted quality of life.
Our goal with this book is to bring current information about psoriasis and psor- iatic arthritis together in a form that is useful for a satisfactory understanding of the pathophysiology, clinical aspects, and therapy of both diseases. Ideally, the integrat- ed approach of this text will give specialists the necessary tools to work together ef- fectively in the same office or in consultation. While this type of coordinated care strikes us as the best approach, we recognize that all dermatologists and rheumatol- ogists will not have this luxury, and we hope this book will also serve as a useful re- view of those disease elements both within and outside the reader's own area of ex- pertise.
This book is dedicated to our families: Dafna, Danny, and Jake Gordon, and Stacey Empson and Lucy Ruderman. We thank them for their patience in helping us through this endeavor.
Kenneth B. Gordon, MD Eric M. Ruderman, MD December 2004
Preface
Contents
I Introduction . . . . 1 Kenneth B. Gordon, Eric M. Ruderman
II Genetics . . . . 3 A. Psoriasis . . . . 3
Mahreen Ameen, Jonathan N.W.N. Barker
B. Psoriatic Arthritis . . . . 12 Proton Rahman, Dafna D. Gladman
III Immunopathogenesis . . . . 23 A. Psoriasis . . . . 23
Brian K. Bonish, Brian J. Nickoloff
B. Psoriatic Arthritis . . . . 36 Jennifer Barton, Christopher T. Ritchlin
IV Epidemiology . . . . 47 A. Psoriasis . . . . 47
Christine C. Jacobson, Alexa B. Kimball
B. Psoriatic Arthritis . . . . 57 Dafna D. Gladman
V Clinical Presentation . . . . 67 A. Psoriasis . . . . 67
Jennifer Soung, Mark Lebwohl
B. Psoriatic Arthritis . . . . 73
Philip S. Helliwell
Contents VIII
VI Diagnostic Evaluation . . . . 83 A. Psoriasis . . . . 83
Bettina M. Prinz Vavricka, Joan Guitart
B. Psoriatic Arthritis . . . . 95 Soumya M. Reddy, Clifton O. Bingham III
VII Quality of Life . . . 109 A. Psoriasis . . . 109
Steven R. Feldman, Stephen R. Rapp
B. Psoriatic Arthritis . . . 118 Dafna D. Gladman
VIII Clinical Outcome Measurements . . . 125 A. Psoriasis . . . 125
Kenneth B. Gordon
B. Psoriatic Arthritis . . . 129 Soumya M. Reddy, Clifton O. Bingham III
IX Conventional Therapy . . . 133 A. Psoriasis . . . 133 1. Topical Therapy . . . 134
Rachel Quinby
2. Phototherapy . . . 145 Jennifer Dempsey, Michael Zanolli
3. Systemic Retinoids . . . 158 Milan J. Anadkat, Michael P. Heffernan
4. Methotrexate and Cyclosporine . . . 172 Jennifer C. Cather, Alan Menter
B. Psoriatic Arthritis . . . 185
Christopher G. Jackson, Daniel O. Clegg
Contents IX
X Biologic Therapy . . . 193 A. Psoriasis . . . 193 1. Anti-T-Cell Agents . . . 193
Richard G.B. Langley, Christa L. Doherty, Scott J. Murray
2. TNF Antagonist Therapy . . . 208 Bruce E. Strober . . . . B. Psoriatic Arthritis . . . 223
1. TNF α Inhibitors in Psoriatic Arthritis . . . 223 Philip J. Mease
2. Other Biologic Therapy . . . 234 Ja Huen Jung, Zuhre Tutuncu, Arthur F. Kavanaugh
XI Synthesis and Conclusion . . . 245 Kenneth B. Gordon, Eric M. Ruderman
Subject Index . . . 251
List of Contributors
Mahreen Ameen
St. Johns Institute of Dermatology St. Thomas’ Hospital
London UK
Milan J. Anadkat, MD Division of Dermatology
Washington University School of Medicine St. Louis, MO
USA
Jonathan N.W.N. Barker, MD St. Johns Institute of Dermatology St. Thomas' Hospital
London UK
Jennifer Barton, MD
University of Rochester Medical Center Rochester, NY
USA
Clifton O. Bingham, MD Johns Hopkins University Baltimore, MD
USA
Brian K. Bonish, MD
Loyola University of Chicago Medical Center
Skin Disease Research Laboratory Cardinal Bernardin Cancer Center Maywood, IL
USA
Jennifer C. Cather, MD
University of Texas Southwestern Medical School Dallas
Dallas, TX USA
Daniel O. Clegg, MD Division of Rheumatology University of Utah Medical Center Salt Lake City, UT
USA
Jennifer Dempsey, MD
Vanderbilt University Medical School Dermatology Consultants
Nashville, TN USA
Christa L. Doherty, BSc (Hons) QEII Health Sciences Centre Halifax, Nova Scotia Canada
Steven R. Feldman, MD, PhD
Wake Forest University School of Medicine Medical Center Boulevard
Winston-Salem, NC USA
Dafna D. Gladman, MD FRCPC Center for Prognosis Studies Toronto Hospital Western Division Toronto, ON
Canada
List of Contributors XII
Kenneth B. Gordon, MD Division of Dermatology Loyola University
Stritch School of Medicine Maywood, IL
USA
Joan Guitart, MD Northwestern University Department of Dermatology Chicago, IL
USA
Michael P. Heffernan, MD Division of Dermatology
Washington University School of Medicine St. Louis, MO
USA
Philip Helliwell, MD
Academic Unit of Musculoskeletal Disease University of Leeds
Leeds UK
Christopher Jackson, MD Division of Rheumatology University of Utah Medical Center Salt Lake City, UT
USA
Christine C. Jacobson, AB Department of Dermatology
Stanford University School of Medicine Stanford, CA
USA
Ja Huen Jung, MD UCSD
Rheumatology Division Department of Medicine La Jolla, CA
USA
Arthur F. Kavanaugh, MD UCSD
Rheumatology Division Department of Medicine La Jolla, CA
USA
Alexa Kimball, MD, MPH
Dermatology Clinical Studies Unit Massachusetts General and Brigham and Women’s Hospitals
Boston, MA USA
Richard G.B. Langley, MD, FRCPC QEII Health Sciences Centre Halifax, Nova Scotia Canada
Mark Lebwohl, MD, FACP Department of Dermatology The Mt. Sinai Medical Center New York, NY
USA
Philip J. Mease, MD
Seattle Rheumatology Associates University of Washington Seattle, WA
USA
M. Alan Menter
Division of Dermatology
Baylor University Medical Center
University of Texas Southwestern Medical School Dallas
Dallas, TX USA
Scott J. Murray, MD, FRCPC QEII Health Sciences Centre Halifax, Nova Scotia Canada
Brian J. Nickoloff, MD, PhD Loyola University Medical Center Maywood, IL
USA
Bettina M. Prinz Vavricka, MD Department of Dermatology University Hospital Zurich Zurich
Switzerland
List of Contributors XIII
