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NUOVI DATI

Lucia Mentuccia

UOC Oncologia ASL Frosinone

SESSIONE: BREAST

(2)

Early Breast Cancer

• Integrating PI3K and CDK 4-6 inhibitors in the neoadjuvant treatment of ER + EBC LORELEI STUDY & NEOPAL STUDY

• Dual endocrine blockade as adjuvant therapy in ER+ EBC GEICAM 2006-10 TRIAL

• Escalating adjuvant therapy in HER2+ EBC EXTENET TRIAL

(3)

Early Breast Cancer

• Integrating PI3K and CDK 4-6 inhibitors in the neoadjuvant treatment of ER + EBC LORELEI STUDY & NEOPAL STUDY

• Dual endocrine blockade as adjuvant therapy in ER+ EBC GEICAM 2006-10 TRIAL

• Escalating adjuvant therapy in HER2+ EBC EXTENET TRIAL

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Early Breast Cancer

• Integrating PI3K and CDK 4-6 inhibitors in the neoadjuvant treatment of ER + EBC LORELEI STUDY & NEOPAL STUDY

• Dual endocrine blockade as adjuvant therapy in ER+ EBC GEICAM 2006-10 TRIAL

• Escalating adjuvant therapy in HER2+ EBC EXTENET TRIAL

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(23)
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Median FU =6.3 yrs

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Median FU =6.3 yrs

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Early Breast Cancer

• Integrating PI3K and CDK 4-6 inhibitors in the neoadjuvant treatment of ER + EBC LORELEI STUDY & NEOPAL STUDY

• Dual endocrine blockade as adjuvant therapy in ER+ EBC GEICAM 2006-10 TRIAL

• Escalating adjuvant therapy in HER2+ EBC EXTENET TRIAL

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(30)
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Metastatic Breast Cancer

• Predicting immunogenenicity in breast cancer KEYNOTE - 086 STUDY

• Consistent benefit across studies –class effect of CDK4/6 inhibitors MONARCH 3 TRIAL

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Metastatic Breast Cancer

• Predicting immunogenenicity in breast cancer KEYNOTE - 086 STUDY

• Consistent benefit across studies –class effect of CDK4/6 inhibitors MONARCH 3 TRIAL

(38)
(39)
(40)
(41)
(42)
(43)
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Metastatic Breast Cancer

Predicting immunogenenicity in breast cancer KEYNOTE - 086 STUDY

• Consistent benefit across studies –class effect of CDK4/6 inhibitors MONARCH 3 TRIAL

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(46)
(47)
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