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Intracellular actions

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15/12/2016

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S1P1 S1P2

S1P S1PR Sph p-SphK1 S1P

p-SphK1

SpnS2

S1P1 S1P3

S1P1 S1P2 S1P3 S1P4

S1P2 S1P3 S1P5

Gq Gi/0

G12/13

PLC AC

PI3K Rho p-SphK1

Intracellular actions

Ceramide-induced APOPTOSIS

TRAF2 PKCδ

MITOCHONDRIA (PHB2)

MIGRATION PLC

Ca2+ PKC

AC

cAMP RAS

ERK

PI3K AKT RAC

Rho

CYTOSKELETON PROLIFERATION

SURVIVAL TRAF2

NFkB

MIGRATION NEURAL COMMUNICATION CYTOSKELETON

REMODELING

PROLIFERATION INFLAMMATION

Nuclear actions

HDAC Receptor-mediated

intracellular actions

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