15/12/2016
1
S1P1 S1P2
S1P S1PR Sph p-SphK1 S1P
p-SphK1
SpnS2
S1P1 S1P3
S1P1 S1P2 S1P3 S1P4
S1P2 S1P3 S1P5
Gq Gi/0
G12/13
PLC AC
PI3K Rho p-SphK1
Intracellular actions
Ceramide-induced APOPTOSIS
TRAF2 PKCδ
MITOCHONDRIA (PHB2)
MIGRATION PLC
Ca2+ PKC
AC
cAMP RAS
ERK
PI3K AKT RAC
Rho
CYTOSKELETON PROLIFERATION
SURVIVAL TRAF2
NFkB
MIGRATION NEURAL COMMUNICATION CYTOSKELETON
REMODELING
PROLIFERATION INFLAMMATION