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SCIENTIFIC PROGRAM

CONGRESS PRESIDENTS:...

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Lorenzo Borgognoni, Division of Plastic and Reconstructive Surgery, Regional

Melanoma Referral Center and Melanoma & Skin Cancer Unit, S.M. Annunziata Hospital, Florence, Italy...

HOT TOPICS IN MELANOMA & NON-MELANOMA ^.

SKIN CANCER 2018

Florence, April 12 14 , 2018 Convitto della Calza

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With an unrestricted grant by

Under the Auspices of

SIDCO

Società Italiana di Dermatologia Chirurgica ed Oncologica

DCMTDIPARTIMENTO DI CHIRURGIA E MEDICINA TRASLAZIONALE

SIDeMaST

Società Italiana di Dermatologia

Dear Friends and Colleagues, It is a great pleasure to wel- come you in Florence to the 2018 edition of the ‘Hot Topics’ in Melanoma and Non- M e l a n o m a S k i n C a n c e r (NMSC). From the previous edition in 2015, great news have followed in the rapidly evolving field of cutaneuos oncology.

New, effective drugs have

been increasingly used in practice, and in the mean time the close integration among prevention, early diagnosis, surgical and medical therapies has become even more important in the fight against skin cancer.

During the Congress you will have the opportunity to hear state-of-the-art presentations given by leading experts in the field of skin cancer. Key opinion leaders in Melanoma and NMSC are invited to give an overview of the most recent advances in the pathogenesis, diagnosis, and treatment, and of the latest clinical trial results and new drugs development.

We are confident you all will appreciate the meeting, and look forward to welcoming you in Florence!

Lorenzo Borgognoni Nicola Pimpinelli

Borgognoni Lorenzo

Dept. Plastic and Reconstructive Surgery Melanoma & Skin Cancer Unit

AUSL Toscana Centro Florence, Italy

Pimpinelli Nicola

Div. Dermatology

Dept. Surgery and Translational Medicine University of Florence

Florence, Italy

Ayala Fabio

Dept. Dermatology

“Federico II” University Naples, Italy

Bagot Martine

Dept. Dermatology INSERM U976 Saint Louis Hospital Paris, France

Bassetto Franco

Dept. Plastic Reconstructive Surgery Padua University Hospital

Padua, Italy

Berti Emilio Francesco

Dept. Dermatology University of Milan Hospital Maggiore IRCCS Milan, Italy

Brambilla Lucia

Div. Dermatology Hospital Maggiore IRCCS Milan, Italy

Bray Freddie

Sect. Cancer Surveillance International Agency for Research on Cancer

Lyon, France

Brunetti Beniamino

Dept. Plastic and Reconstructive Surgery BioMedical Campus University

Rome, Italy

Calvieri Stefano

Dept. Dermatology

University of Rome “La Sapienza”

Rome, Italy

Calzavara Pinton Piergiacomo

Dept. Dermatology University of Brescia Brescia, Italy

Caracò Corrado

Dept. Melanoma and Skin tumours National Cancer Institute - IRCCS Naples, Italy

Cerroni Lorenzo

Dept. Dermatology University of Graz Graz, Austria

Chiarion Sileni Vanna

Melanoma and Esophageal Cancer Unit Veneto Cancer Institute - IRCCS Padua, Italy

Cordova Adriana

Dept. Plastic and Reconstructive Surgery University of Palermo

Palermo, Italy

Crocetti Emanuele

Epidemiology consultant

Dept. Surgery & Translational Medicine University of Florence

Florence, Italy

D'Aniello Carlo

Dept. Plastic and Reconstructive Surgery University of Siena

Siena, Italy

De Giorgi Vincenzo

Dermatology Unit AUSL Toscana Centro Florence, Italy

Del Vecchio Michele

Dept. Medical Oncology

National Cancer Institute - IRCCS Milan, Italy

Faculty

Di Giacomo Anna Maria

Medical Oncology and Immunotherapy Center for Immuno-Oncology

Siena University Hospital Siena, Italy

Fazio Maurizio

Div. Hematology/Oncology

Children`s Hospital-D. Farber Cancer Institute Boston, USA

Ferrara Gerardo

Pathologic Anatomy Unit Macerata Hospital Macerata, Italy

Ferrone Soldano

Department of Surgery Massachusetts General Hospital Harvard Medical School Boston, USA

Fimiani Michele

Dept. Dermatology University of Siena Siena, Italy

Gelli Riccardo

Dept. Plastic and Reconstructive Surgery Melanoma & Skin Cancer Unit

AUSL Toscana Centro Florence, Italy

Gerlini Gianni

Dept. Plastic and Reconstructive Surgery Melanoma & Skin Cancer Unit

AUSL Toscana Centro Florence, Italy

Grandi Vieri

Division Dermatology

Dept. Surgery and Translational Medicine University of Florence

Florence, Italy

Kim Youn Hee

Cutaneous Lymphoma Clinic/Program Stanford Cancer Institute

Stanford University Medical School Stanford, USA

Leoncini Lorenzo

Dept. Human Pathology and Oncology Pathologic Anatomy Unit

University of Siena Siena, Italy

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Luzzatto Lucio

Haematology Unit

Muhimbili University of Health and Allied Sciences (MUHAS)

Dar-es-Salaam, Tanzania

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Maio Michele

Medical Oncology and Immunotherapy Center for Immuno-Oncology

Siena University Hospital Siena, Italy

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Mandalà Mario

Dept. Oncology and Haematology Clinical Research Unit

Papa Giovanni XXIII Hospital Bergamo, Italy

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Marconcini Riccardo

Dept. Oncology University of Pisa Santa Chiara Hospital Pisa, Italy

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Massi Daniela

Dept. Pathology, Histopathology and Molecular Diagnostics

Careggi Hospital University of Florence Florence, Italy

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Maurichi Andrea

Dept. Melanoma and Sarcoma Surgery National Cancer Institute - IRCCS Milan, Italy

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Micali Giuseppe

Dept. Dermatology University of Catania Catania, Italy

Mini Enrico

Medical Oncology Careggi Hospital University of Florence Florence, Italy

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Moretti Silvia

Div. Dermatology

Dept. Surgery and Translational Medicine University of Florence

Florence, Italy

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Mozzillo Nicola

Dept. Melanoma and Soft Tissue Surgery National Cancer Institute - IRCCS Naples, Italy

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Naldi Luigi

Dermatology Unit AULSS8 Berica

San Bortolo Hospital Vicenza GISED

Bergamo and Vicenza, Italy

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Offidani Anna Maria

Dept. Dermatology Ospedali Riuniti

Marche Polytechnical University Ancona, Italy

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Palmieri Giuseppe

Cancer Genetics Unit

Institute of Biomolecular Chemistry (ICB) National Research Council (CNR) Sassari, Italy

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Parodi Aurora

Dept. Dermatology University of Genua San Martino Hospital Genua, Italy

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Paulli Marco

Dept. Pathologic Anatomy San Matteo Hospital - IRCCS Pavia, Italy

Persichetti Paolo

Dept. Plastic and Reconstructive Surgery Campus Bio-Medico University

Rome, Italy -

Piaserico Stefano

Dept. Medicine (DIMED) University of Padua Padua, Italy -

Pino Simona

Dept. Medical Oncology AUSL Toscana Centro Florence, Italy -

Pileri Alessandro

Div. Dermatology

Dept. Internal Medicine, Aging and Nephrology University of Bologna

Bologna, Italy -

Pileri Stefano

Haematopathology Unit European Institute of Oncology Milan, Italy

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Pizzichetta Maria Antonietta

Prevention and Early Melanoma Diagnosis Dept. Medical Oncology

National Cancer Institute Aviano, Italy

Pusceddu Sara

Dept. Medical Oncology, Gastro-Entero- Pancreatic and neuroendocrine Unit National Cancer Institute - IRCCS Milan, Italy

Quaglino Pietro

Dept. Dermatology San Lazzaro Hospital Univerisity of Turin Turin, Italy

Queirolo Paola

Dept. Medical Oncology San Martino Hospital

National Cancer Institute (IST) Genua, Italy

Rossi Carlo Riccardo

Surgical Oncology Unit Veneto Cancer Institute Padua, Italy

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Rupoli Serena

Div. Hematology Ospedali Riuniti

Marche Polytechnical University Ancona, Italy

Santucci Marco

Div. Pathologic Anatomy

Dept Surgery and Translational Medicine University of Florence

Florence, Italy

Schadendorf Dirk

Dept. Dermatology

Comprehensive Cancer Center Essen University Hospital Essen, Germany

Sestini Serena

Dept. Plastic and Reconstructive Surgery Melanoma & Skin Cancer Unit

AUSL Toscana Centro Florence, Italy

Simonacci Marco

Dept. Dermatology Macerata Hospital Macerata, Italy

Simontacchi Gabriele

Div. Radiotherapy University of Florence Florence, Italy

Sondak Vernon Keith

Dept. Cutaneous Oncology Lee Moffitt Cancer Center Tampa, USA

Stanganelli Ignazio

Div. Dermatology University of Parma Dermatologic Oncology

IRST – IRCCS

Parma and Meldola, Italy

Testori Alessandro

General Surgery

EORTC Melanoma Group Milan, Italy

Vermeer Maarten H.

Dept. Dermatology

Leiden University Medical Center (LUMC) Leiden, The Netherlands

Zichichi Leonardo

Dept. Dermatology S. Antonio. Abate Hospital Trapani, Italy

Zinzani Pier Luigi

Inst. Hematology “L. e A. Seràgnoli”

University of Bologna Bologna, Italy

Registration

Symposium I: POSTER PRESENTATIONS

Chairs: G. Gerlini (Florence, Italy), S. Sestini (Florence, Italy)

 S. Mancini (Cesena, Italy): Incidence and mortality of melanoma in Europe - the ECIS tool

 S. Mancini (Cesena, Italy): Malignant melanoma incidence trends:

preliminary results of age-period-cohort analysis in Romagna, region of Italy

 S. Mancini (Cesena, Italy): Melanoma survival according to Cox model versus classification and regression trees analysis: a registry-based study

 G. Bagnoni (Livorno, Italy): Epidemiology of melanoma in Livorno between 2006 and 2016 and evaluation of risk factors for the positivity of lymph nodes in pT1b-pT3 groups

 A. Ravaioli (Ravenna, Italy): What has changed for thin melanoma moving from TNM 7th to TNM 8th?

 E. Antoniazzi (Bologna, Italy) Animal-type Melanoma. A case report

 H. Kocic (Nis, Serbia): Multiple blue-black lesions on the face of the 58- year old patient.

 C. Mazzatenta (Lucca, Italy): Imiquimod treatment of lentigo maligna melanoma

 C. Ottanelli (Florence, Italy): Predective prognostic value of lactate dehydrogenase (LDH) variations during treatment in advanced (stage IIIc-IV) melanoma: preliminary results of a monocentric observational study

 S. Gunnella (Florence, Italy): Target Therapy with Dabrafenib e Trametinib

"beyond progression" associated with electrochemotherapy (ECT) and Zoledronic Acid in a patient with BRAF mutated metastatic melanoma.

 R. Colucci (Florence, Italy): Bacterial and fungal gut microbiota composition in melanoma patients: preliminary results

 S. Peppicelli (Florence, Italy): Aspects of Melanoma cells adapted to a chronic acidosis relevant for therapy

 A. Biagioni (Florence, Italy): uPAR gene knockout mediated by CRISPR/Cas9 in Melanoma: a pivotal role for a "sociable" receptor

 J. Ruzzolini (Florence, Italy): Oleuropein potentiates the cytotoxic activity of Dacarbazine against melanoma cells

 F. Margheri (Florence, Italy): uPA/uPAR system activation drives a glycolytic phenotype in melanoma cells

 E. Andreucci (Florence, Italy): Carbonic anhydrase IX targeting in melanoma treatment: the role of acidic tumor microenvironment.

 I. Lastrucci (Florence, Italy): Treatment and outcome of basal cell carcinoma in the setting of dermato-oncology clinic

 A. M. D'Erme (Livorno, Italy): Use of vismodegib in advanced basal cell carcinoma: the experience of Livorno

2.30 pm - 3.30 pm 3.30 pm - 5.30 pm

Thursday - April 12 , 2018

 A. Lamberti (Siena, Italy): Vismodegib: a useful treatment for Gorlin-Goltz Syndrome

 I. Lastrucci (Florence, Italy): Dermatofibrosarcoma Protuberans secondary to a tattoo? Case report and review of literature.

 A. M. D'Erme (Livorno, Italy): A clinical, dermoscopic and histological challenge: the pigmented mammary Paget’s disease

 P. Vitiello (Naples, Italy): Diffuse large B cell lymphoma "non-germinal centre type". A case report

 S. Gunnella (Florence, Italy): Primary cutaneous CD8+ CD30+

lymphoproliferative disorder in patient with CD4 acquired immunodeficiency

 I. Lastrucci (Florence, Italy): Indolent CD8-positive lymphoid proliferation of acral sites

Symposium II «UGO BOTTONI»

SELECTED ORAL COMMUNICATIONS

 E. N. Gangemi (Torino, Italy): Complex reconstruction in dermatosurgery:

our experience

 R. Villani (Bologna, Italy): Reconstruction of upper palpebral fissure

 G. Damiani (Milan, Italy): Squamous cell carcinoma of the scalp and its treatment. Role of radiation therapy

 D. Russo (Naples, Italy): Role of carbonic anidrase IX in the neoplastic progression of basal cell carcinoma

 A. Pileri (Bologna, Italy): Primary cutaneous Rosai-Dorfmann Disease:

diagnostic and therapeutic aspects

 V. Grandi (London, United Kingdom): T-cell receptor CDR3 region deep sequencing with padlock probes as a diagnostic tool in T-cell

malignancies

 F. Bianchini (Florence, Italy): Selective targeting of melanoma cells and efficient cellular internalization using RGD-functionalized gold

 M. Colombino (Sassari, Italy): Sinonasal mucosal melanomas from the Southern Italian population are mutated in the BRAF gene

 A. Laurenzana (Florence, Italy): Therapeutic strategies to overcome Vemurafenib acquired resistance in melanoma cells

OPENING PLENARY LECTURE

Chairs: L. Borgognoni (Florence, Italy), N. Pimpinelli (Florence, Italy)

Causative factors and chance events in the pathogenesis of cancer

Welcome reception

7.00 pm - 7.30 pm

7.30 pm

Welcome address Keynote Lecture

Chair: N. Pimpinelli (Florence, Italy)

Pathogenesis of NMSC and influence on treatment

Chairs: P.G. Calzavara-Pinton (Brescia, Italy), F. Ayala (Naples, Italy)

Session 1

Non-Melanoma Skin Cancer (NMSC): pathogenesis, diagnosis and topical treatment

Chairs: P.G. Calzavara-Pinton (Brescia, Italy), F. Ayala (Naples, Italy) 1. Risk of post-transplantation NMSC: an update

L. Naldi (Bergamo and Vicenza, Italy)

2. The role of nicotinamide in kidney transplant recipients A. Parodi (Genua, Italy)

3. Topical treatment of NMSC: the evolving scenario L. Zichichi (Trapani, Italy)

4. PhotoDynamic Therapy of NMSC: new approaches and indications

S. Piaserico (Padua, Italy) 5. Treatment algorithm in NMSC G. Micali (Catania, Italy) 6. Discussion

Coffee break

Keynote Lecture

Chair: L. Borgognoni (Florence, Italy)

Checkpoint blockade in NMSC

Session 2

NMSC: surgical and systemic treatment

Chairs: M. Fimiani (Siena, Italy), R. Gelli (Florence, Italy)

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1. Defining high risk NMSC M. Simonacci (Macerata, Italy)

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2. Reconstructive surgery of NMSC F. Bassetto (Padua, Italy)

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3. Perforator flaps for skin cancer reconstruction of the head B. Brunetti (Rome, Italy), P. Persichetti (Rome, Italy)

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4. Merkel cell carcinoma: new insights in surgical and systemic treatment

A. Maurichi (Milan, Italy), S. Pusceddu (Milan, Italy)

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5. Systemic treatment of Kaposi’s sarcoma: when and how L. Brambilla (Milan, Italy)

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6. Discussion 8.30 am - 8.45 am

8.45 am - 9.15 am

9.15 am - 10.45 am

10.45am-11.00am 11.00am-11.30am

11.30am-1.00pm

Friday - April 13 , 2018

Opening secretariat

Keynote Lecture

Diagnosis of cutaneous lymphoma: tools and rules

Session 3

Cutaneous Lymphoma: update in diagnosis and pathogenesis

M. Santucci (Florence, Italy)

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2. Cutaneous B-Cell Lymphoma M. Paulli (Pavia, Italy)

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3. Rare entities of cutaneous lymphoma E. Berti (Milan, Italy)

Keynote Lecture

Chair: E. Berti (Milan, Italy)

Pathogenesis of cutaneous lymphoma: focus on the most clinically relevant issues

M.H. Vermeer (Leiden, The Netherlands)

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4. Cellular microenvironment and progression of Mycosis Fungoides A. Pileri (Bologna and Florence, Italy)

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Coffee Break

Keynote Lecture

Chair: N. Pimpinelli (Florence, Italy)

Treatment of cutaneous lymphoma: a stage-based algorithm

Session 4

Cutaneous Lymphoma: current treatment and evolving trends

1. Skin-directed treatment in cutaneous T-cell lymphoma M. Bagot (Paris, France)

2. Phototherapy of early Mycosis Fungoides: the position of the Cutaneous Lymphoma Task Force of the Italian Lymphoma Foundation

V. Grandi (Florence, Italy)

3. Total skin electron beam radiotherapy of cutaneous T-cell lymphoma: improving efficacy while reducing toxicity G. Simontacchi (Florence, Italy)

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4. Patterns of care in advanced cutaneous T-cell lymphoma P. Quaglino (Turin, Italy)

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5. Discussion 2.00pm-2.30pm

2.30pm-4.00pm

4.15pm-4.45pm

4.45pm-6.00pm 4.00pm-4.15pm

Opening secretariat Keynote Lecture

Chair: E. Crocetti (Florence, Italy)

Worldwide Cancer Registry data on Melanoma and NMSC:

incidence, mortality and trends

Session 5

Epidemiology, Screening and Diagnosis of Cutaneous Melanoma

1. Skin cancer screening and secondary prevention campaigns E. Crocetti (Florence, Italy)

2. Dermoscopy, confocal reflectance microscopy and sequential follow-up of pigmented lesions

I. Stanganelli (Parma and Meldola, Italy)

3. Dermoscopic diagnosis of amelanotic/hypomelanotic melanoma M.A. Pizzichetta (Aviano, Italy)

4. Genetic markers of prognostic outcome G. Palmieri (Sassari, Italy)

5. Fishing for answers in precision melanoma medicine M. Fazio (Boston, USA)

6. Discussion

Coffee break Keynote Lecture

Chair: L. Borgognoni (Florence, Italy)

Surgery, sentinel node biopsy and lymphadenectomy in melanoma:

evolution of a new treatment paradigm

Session 6

Surgery of Melanoma: update of an evergreen

Chairs: C. Caracò (Naples, Italy), A. Cordova (Palermo, Italy)

1. The importance of quality control program in melanoma treatment C.R. Rossi (Padua, Italy)

2. Sentinel biopsy in thick melanoma: is it worthwhile?

S. Sestini (Florence, Italy)

3. The role of surgery in advanced melanoma: when alone, when combined, when useless ?

N. Mozzillo (Naples, Italy)

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4. Melanocytic tumors of uncertain biologic potential: what are they, and how to manage ?

A. Maurichi (Milan, Italy)

5. The AJCC melanoma staging system 8th edition: what changed in clinical practice ?

8.30am-9.00am

9.00am-10.30am

10.30am-11.00am 11.00am-11.30am

11.30am-1.00pm

Saturday - April 14 , 2018

Lunch

Keynote Lecture

Chair: S. Moretti (Florence, Italy)

B7-H3, an attractive target of antibody based immunotherapy of solid tumors

S. Ferrone (Boston, USA)

Session 7

Medical treatment of advanced melanoma:

a rapidly changing scenario

Chairs: E. Mini (Florence, Italy), S. Pino (Florence, Italy), R. Marconcini (Pisa, Italy)

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1. Molecular testing in melanoma: an update D. Massi (Florence, Italy)

2. Update in adjuvant melanoma treatments and trials P. Queirolo (Genua, Italy)

3. Adjuvant melanoma treatment with beta-blockers: facts and future directions

V. De Giorgi (Florence, Italy)

4. Target therapy of melanoma: where are we today ? M. Del Vecchio (Milan, Italy)

5. Immunotherapy: from a concept to a well-established reality A.M. Di Giacomo, M. Maio (Siena, Italy)

6. Immunomodulating properties of target therapies M. Mandalà (Bergamo, Italy)

7. Stable complete response after target or immune therapy in stage IV: stop or continue treatment?

V. Chiarion-Sileni (Padua, Italy)

8. Electrochemotherapy: indications, results and lessons from biology G. Gerlini (Florence, Italy)

9. Discussion

Closing remarks, free Communications & Poster Awards

2.00pm-2.30pm

2.30pm-4.45pm

4.45pm

1.00pm-2.00pm

General information

Meeting venue

The venue for the Meeting will be

CONVITTO DELLA CALZA, Piazza della calza nr. 6 – Florence, Italy Room PONTE VECCHIO

Secretariat during the Meeting

The Secretariat will be open at the following times:

Thursday, April 12 , from 1.30 p.m. to 7.30 p.m.

Friday, April 13 , from 7.30 a.m. to 6.00 p.m.

Saturday, April 14 from 7.30 a.m. to 5.00 p.m.

Official language

The official language of the Meeting will be English.

Simultaneous translation will not be provided.

Italian ECM Accreditation

The Event entitled HOT TOPICS IN MELANOMA & NON-MELANOMA SKIN CANCER 2018 has been accredited by the Italian Ministry of Health for 13,3 ECM credits (Event number: 215872; Provider number: 322).

The specialities and disciplines (only for Italian participants) able to apply for Italian ECM credits are:

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Biologo;

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Infermiere;

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Medico Chirurgo, nelle Discipline di: Dermatologia e Venereologia; Ematologia;

Oncologia; Genetica Medica; Radioterapia; Chirurgia Generale; Chirurgia Maxillo-Facciale; Chirurgia Plastica e Ricostruttiva; Otorino-laringoiatria;

Anatomia Patologica, Medicina Nucleare, Radiodiagnostica; Cure Palliative;

Epidemiologia.

The ECM certificate will be available for Italian participants after completing the evaluation test as well as 90% of attendance of the entire congress.

Italian participants will be asked to record attendance each day.

Registration

The Meeting is free to attend. Please confirm the participation to the Organizing Secretariat:

Via J. Melani, 19/23 – 59016 Poggio a Caiano (PO)

Tel. 055 8797796 – 8777875 Fax 055 8797843 [email protected]

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Sede Legale ed Operativa: Via Aurora, 39 – 00187 Roma Tel. 06 48906436 – 42012177 Fax 06 4821566

Provider ECM n. 322

Technical facilities

Facilities will be available for computer presentations and overhead projections. A business center with PC (Powerpoint for Windows) will be available for check and preview of presentations. It is essential that speakers take their presentation to the business center at least one hour before the session starts.

The center will be open at the following times:

Thursday, April 12 , from 1.30 p.m. to 7.30 p.m.

Friday, April 13 , from 7.30 a.m. to 6.00 p.m.

Saturday, April 14 from 7.30 a.m. to 5.00 p.m.

Lunches and coffee breaks

Lunches and coffee breaks will be served in the Meeting area.

Fondazione Internazionale Menarini Symposia n. 381