ANEMIA IN THE ELDERLY

ANEMIA IN THE ELDERLY

ANEMIA IN THE ELDERLY

edited by

Lodovico Balducci, MD

Professor of Oncology and Medicine University of South Florida College of Medicine Program Leader, Senior Adult Oncology Program H. Lee Moffitt Cancer Center & Research Institute

Tampa, FL, USA

William B. Ershler, MD

Deputy Clinical Director

National Institute on Aging Intramural Research Program National Institutes of Health

Harbor Hospital, NM 545 Baltimore, MD, USA

John M. Bennett, MD

Professor of Medicine

Laboratory Medicine and Pathology James P. Wilmot Cancer Center University of Rochester Medical Center

Rochester, NY, USA

Lodovico Balducci, MD William B. Ershler, MD

University of South Florida National Institute on Aging Intramural

College of Medicine Research Program

H. Lee Moffitt Cancer Center Harbor Hospital

Tampa, FL, USA Baltimore, MD, USA

John M. Bennett, MD

James P. Wilmot Cancer Center University of Rochester

Medical Center Rochester, NY, USA Anemia in the Elderly

Library of Congress Control Number: 2006939207

ISBN-13: 978-0-387-49505-7 e-ISBN-13: 978-0-387-49506-4 Printed on acid-free paper.

© 2007 Springer Science + Business Media, LLC

All rights reserved. This work may not be translated or copied in whole or in part without the written permission of the publisher (Springer Science + Business Media, LLC, 233 Spring Street, New York, NY 10013, USA), except for brief excerpts in connection with reviews or scholarly analysis. Use in connection with any form of information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed is forbidden.

The use in this publication of trade names, trademarks, service marks, and similar terms, even if they are not identified as such, is not to be taken as an expression of opinion as to whether or not they are subject to proprietary rights.

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Contributors vii

Chapter 1: Stem Cell Aging: Potential Effects on Health and Mortality Erin Oakley, Alison Miller, Amanda Waterstrat, Carol Swiderski,

Ying Liang, and Gary Van Zant 1

Chapter 2: Anemia and Aging or Anemia of Aging?

Lodovico Balducci and Matti Aapro 21

Chapter 3: B

and Iron Deficiency in the Elderly

John W. Adamson 39

Chapter 4: The Anemia of Chronic Inflammation

John W. Adamson 51

Chapter 5: Anemia due to Chronic Kidney Disease in the Elderly

Jeffrey S. Berns 61

Chapter 6: Anemia in Long-Term Care

Andrew S. Artz and Miriam Rodin 75

Chapter 7: Myelodysplastic Syndromes and Aplastic Anemia:

Pathologic and Immunologic Implications

John M. Bennett 93

Chapter 8: Anemia and Cancer

Kaaron Benson, Lodovico Balducci, and Matti Aapro 99

Contents

vi Contents

Chapter 9: Erythropoietin Deficiency and Late-Life Anemia

Bindu Kanapuru, Andrew S. Artz, and William B. Ershler 115

Chapter 10: Anemia and Physical Health Decline in Old Age

Brenda WJH Penninx 129

Subject Index 141

Matti Aapro, MD Clinique Genolier Geneve

John W. Adamson, MD Division of Hematology Department of Medicine Medical College of Wisconsin Medical Services

Blood Center of Wisconsin Milwaukee, WI

Andrew S. Artz, MD, MS

University of Chicago Pritzker School of Medicine Department of Medicine

Section of Hematology/Oncology and Section of Geriatrics Chicago, IL 60637

Lodovico Balducci, MD

Professor of Oncology and Medicine

University of South Florida College of Medicine Chief Division of Geriatric Oncology

H. Lee Moffitt Cancer Center and Research Institute Tampa, FL, USA

John M. Bennett, MD

Professor of Medicine, Emeritus James P. Wilmot Cancer Center

University of Rochester Medical Center Rochester, NY

Contributors

Kaaron Benson, MD

Associate Professor of Oncology and Pathology University of South Florida College of Medicine Chief Blood Services

H. Lee Moffitt Cancer Center and Research Institute Tampa, FL, USA

Jeffrey S. Berns, MD

Professor of Medicine and Pediatrics

University of Pennsylvania School of Medicine Hospital of the University of Pennsylvania Philadelphia, PA, USA

William B. Ershler, MD

Senior Investigator and Deputy Director Clinical Research Branch, NIA

Harbor Hospital

National Institute of Health Baltimore, MD, USA

Bindu Kanapuru, MD Clinical Research Branch National Institute on Aging Baltimore, MD

Ying Liang, PhD

Departments of Internal Medicine and Physiology Markey Cancer Center

University of Kentucky Lexington, KY, USA

Alison Miller, PhD

Departments of Internal Medicine and Physiology Markey Cancer Center

University of Kentucky Lexington, KY, USA

Erin Oakley, PhD

Departments of Internal Medicine and Physiology Markey Cancer Center

University of Kentucky Lexington, KY, USA

viii Contributors

Brenda WJH Penninx, PhD

EMGO Institute/Department of Psychiatry VU University Medical Center

Amsterdam, The Netherlands

Miriam Rodin, MD, PhD

University of Chicago Pritzker School of Medicine Department of Medicine

Section of Hematology/Oncology and Section of Geriatrics Chicago, IL 60637

Carol Swiderski, MS

Departments of Internal Medicine and Physiology Markey Cancer Center

University of Kentucky Lexington, KY, USA

Gary Van Zant, PhD

Departments of Internal Medicine and Physiology Markey Cancer Center

University of Kentucky Lexington, KY, USA

Amanda Waterstrat, PhD

Departments of Internal Medicine and Physiology Markey Cancer Center

University of Kentucky Lexington, KY, USA

Contributors ix