OCCUPATIONAL RISKS FOR LUNG CANCER IN THE POPULATIONBASED CASE-CONTROL STUDY “ENVIRONMENTAL AND GENETIC
LUNG CANCER ETIOLOGY” (EAGLE) STUDY
CONSONNI D.(1), BERTAZZI P.A.(1), PESATORI A.C.(1), COLOMBI A.(1), CORNO M.(1), RUBAGOTTI M.(1), CAPORASO N.(2), LANDI M.T.(2) Ospedale Maggiore Policlinico, Mangiagalli e Regina Elena and
University of Milan - Milano - Italy (1)
Division of Cancer Epidemiology and Genetics, NCI/NIH/DHHS, Bethesda - Bethesda - United States (2)
[ID 1931]
A population-based case-control study sponsored by the NCI has been conducted in Lombardy, Northern Italy, in collaboration with the University of Milan and 14 hospitals. Over 2,000 lung cancer cases, diagnosed in April 2002-February 2005, and 2,000 randomly selected population controls (frequency-matched to cases by area, gender, age) were enrolled.
Participation rates were 85% (cases) and 72% (controls). The subjects consented to conduct a computer-assisted personal interview (CAPI), and to fill-in a self-administered questionnaire; biospecimens were collected from all participants and pathological material (tissue blocks and slides as well as fresh frozen tissue in a subset of surgical cases) from cases. Data cleaning is in progress. We performed analyses of occupational lung cancer occupations on 3,972 subjects with CAPI: 1962 confirmed lung cancer cases (1,556 males, 406 females); 2,008 controls (1,554/454). Jobs were coded according to standard classifications and then classified as known (List A) or suspected (List B) to entail exposure to lung carcinogens.
We used logistic regression to compute odds ratios (ORs) and 95%
confidence intervals (95%CI), adjusted for area, age, consumption of other types of tobacco, number of jobs held; cigarette smoking was modeled using different covariates: ever smoker status; years since quitting;
cumulative pack-years, treated in different ways (continuous without or with quadratic/cubic components, categorical). Among males, 156 cases (10%) and 98 controls (8.1%) reported having worked in List A jobs: the ORs ranged from 1.3 (0.94-1.8) to 1.4 (1.0-1.9), depending on how packyears were considered; the excess was manly due to jobs in nonferrous
metal basic industries (51 cases, 31 controls; ORs 1.5 to 1.7). Risk for List B jobs was not increased. In conclusion, among men, we found a 30- 40% elevated lung cancer risk for occupations with a known carcinogenic potential; the corresponding population attributable fraction was around 2.5% (95%CI 0-4.8%).
