Accelerated Partial Breast Irradiation

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David E. Wazer · Douglas W. Arthur · Frank A. Vicini (Eds.)

Accelerated Partial Breast Irradiation

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David E. Wazer · Douglas W. Arthur · Frank A. Vicini (Eds.)

Accelerated Partial Breast Irradiation

Techniques and Clinical Implementation

With 125 Figures and 42 Tables

123

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Library of Congress Control Number: 2005937527

ISBN-10 3-540-28202-5 Springer Berlin Heidelberg New York ISBN-13 978-3-540-28202-0 Springer Berlin Heidelberg New York

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Printed on acid-free paper 21/3100/YL 5 4 3 2 1 0 David E. Wazer

Department of Radiation Oncology Tufts-New England Medical Center Tufts University School of Medicine 750 Washington Street

Boston, MA 02111 USA

Douglas W. Arthur

Department of Radiation Oncology Virginia Commonwealth University Medical Center

Medical College Virginia Campus 401 College St

Richmond, VA 23298-0058 USA

Frank A. Vicini

Department of Radiation Oncology William Beaumont Hospital 3577 W. Thirteen Mile Road, Ste. 210 Royal Oak, MI 48073

USA

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Contents

1 Accelerated Partial Breast Irradiation: History, Rationale, and Controversies . . . 1 Thomas A. Buchholz

and Eric A. Strom

2 Who is a Candidate for Accelerated Partial Breast

Irradiation? . . . . 17 Douglas W. Arthur, Frank A.

Vicini and David E. Wazer

3 Pathologic Anatomy of Early- Stage Breast Cancer and its Relevance to Accelerated Partial Breast Irradiation:

Deﬁning the Target . . . . 31 Shruti Jolly, Larry L. Kestin, Neal S. Goldstein and Frank A. Vicini

4 Physics of Partial Breast Irradiation: Coping with the New Requirements of the NSABP B39/RTOG 0413

Protocol . . . . 41 Gregory K. Edmundson

5 The Radiobiology of Accelerated Partial Breast

Irradiation . . . . 55 Simon N. Powell

6 Surgical Considerations for Accelerated Partial Breast

Irradiation . . . . 69 Henry M. Kuerer

7 The Virginia Commonwealth University (VCU) Technique of Interstitial Brachytherapy . . . . 79 Laurie W. Cuttino and

Douglas W. Arthur

8 The William Beaumont Hospital Technique of

Interstitial Brachytherapy . . . . 91 Peter Y. Chen and

Greg Edmundson

9 Brachytherapy Techniques:

the University of Wisconsin/

Arizona Approach . . . 105 Robert R. Kuske

10 The MammoSite Technique for Accelerated Partial Breast

Irradiation . . . 129 Martin E. Keisch and

Frank A. Vicini

11 3D Conformal External Beam Technique . . . 143 Yasmin Hasan and

Frank A. Vicini

12 Intraoperative Radiotherapy:

a Precise Approach for Partial Breast Irradiation . . . 163 Jayant S. Vaidya

13 Quality Assurance for Breast Brachytherapy . . . 179 Bruce Thomadsen

and Rupak Das

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Contents VI

14 New and Novel Treatment Delivery Techniques for Accelerated Partial Breast

Irradiation . . . 197 Mark J. Rivard, Alphonse G.

Taghian and David E. Wazer

15 Overview of North American Trials . . . 207 Rakesh R. Patel

16 An Overview of European Clinical Trials of Accelerated Partial Breast Irradiation . . . . 227 Csaba Polgár, Tibor Major,

Vratislav Strnad, Peter Niehoff, Oliver J. Ott and György Kovács

17 Normal Tissue Toxicity after Accelerated Partial Breast

Irradiation . . . 247 David E. Wazer

18 Future Directions: Phase III Cooperative Group Trials . . . . 263 Joseph R. Kelley and

Douglas W. Arthur

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List of Contributors

Douglas W. Arthur

Department of Radiation Oncology, Virginia Commonwealth University Medical Center,

Medical College Virginia Campus, 401 College Street

Richmond, VA 23298 USA

Thomas A. Buchholz

Department of Radiation Oncology, The University of Texas

M. D. Anderson Cancer Center, 1515 Holcombe Blvd., Unit 1202, Houston, TX 77030, USA

Peter Y. Chen

Department of Radiation Oncology, William Beaumont Hospital, 3601 W. 13 Mile Road, Royal Oak, MI 48073, USA

Laurie W. Cuttino

Department of Radiation Oncology, Virginia Commonwealth University, Richmond, VA 23298, USA

Rupak Das

Department of Human Oncology, University of Wisconsin, K4/B100 Clinical Sciences Center, Madison, WI 53792, USA

Gregory K. Edmundson Cytyc Surgical Products, P.O. Box 944, Rough and Ready, CA 95975, USA

Neal S. Goldstein

Department of Anatomic Pathology, William Beaumont Hospital, 3601 West Thirteen Mile Road, Royal Oak, MI 48073, USA

Yasmin Hasan

William Beaumont Hospital, 3601 West Thirteen Mile Road, Royal Oak, MI 48073-6769, USA

Shruti Jolly

Department of Radiation Oncology, William Beaumont Hospital, 3601 West Thirteen Mile Road, Royal Oak, MI 48073, USA

Martin E. Keisch Mt. Sinai Medical Center, 4300 Alton Road, Blum Bldg, Miami Beach, FL 33140, USA

Joseph R. Kelley

Department of Radiation Oncology, Virginia Commonwealth University Medical Center,

Medical College Virginia Campus, 401 College Street

Richmond, VA 23298 USA

Larry L. Kestin

Department of Radiation Oncology, William Beaumont Hospital, 3601 West Thirteen Mile Road, Royal Oak, MI 48073, USA

Henry M. Kuerer

Department of Surgical Oncology, The University of Texas,

M. D. Anderson Cancer Center, Box 444, 1515 Holcombe Boulevard, Houston, TX 77030, USA

Robert R. Kuske Jr.

Arizona Oncology Services, 8994 E Desert Cove Avenue, Ste. 100, Scottsdale, AZ 85260, USA

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List of Contributors VIII

Tibor Major

Department of Radiotherapy, National Institute of Oncology, Ráth Gy. u. 7-9.,

Budapest 1122, Hungary

Peter Niehoff

Department of Radiation Oncology, University Hospital Schleswig-Holstein Campus Kiel, Arnold-Heller Str. 9, 24105 Kiel, Germany

Oliver J. Ott

Department of Radiation Oncology, University Hospital Erlangen, Universitätsstr. 27,

91054 Erlangen, Germany

Rakesh R. Patel

Department of Human Oncology, University of Wisconsin, 600 Highland Avenue K4/B100, Madison, WI 53792, USA

Csaba Polgár

Department of Radiotherapy, National Institute of Oncology, Ráth Gy. u. 7-9.,

Budapest 1122, Hungary

Simon N. Powell

Department of Radiation Oncology, Washington University School of Medicine, 4511 Forest Park,

St. Louis, MO 63108, USA

Mark J. Rivard

Department of Radiation Oncology, Tufts-New England Medical Center, 750 Washington Street,

Boston, MA 02111, USA

Vratislav Strnad

Department of Radiation Oncology, University Hospital Erlangen, Universitätsstr. 27,

91054 Erlangen, Germany

Eric A. Strom

Department of Radiation Oncology, The University of Texas

M. D. Anderson Cancer Center, 1515 Holcombe Blvd.,

Houston, TX 77030, USA

Alphonse G. Taghian

Department of Radiation Oncology, Massachusetts General Hospital, Harvard Medical School, 55 Fruit Street,

Bruce Thomadsen

Departments of Medical Physics and Human Oncology,

University of Wisconsin, 1530 Medical Sciences Center, Madison, WI 53706, USA

Jayant S. Vaidya

Department of Surgery and Molecular Oncology,

University of Dundee, Level 6,

Ninewells Hospital and Medical School, Dundee DD1 9SY, UK

Frank A. Vicini

Department of Radiation Oncology, William Beaumont Hospital, 3577 W. Thirteen Mile Road, Ste. 210, Royal Oak, MI 48073, USA

David E. Wazer

Department of Radiation Oncology, Tufts-New England Medical Center, Tufts University School of Medicine, 750 Washington Street,