albumin-heme 1, 194 anemia 217
artificial blood 169, 267
artificial oxygen carriers 252, 259
blood substitute 1, 22, 38, 62, 127, 135, 186, 229
cardioplegia 221 cell signaling 76 chemical property 267 clinical efficacy 267 clinical trial 53, 267 cytochrome P450 221
deformability 205
electrophoresis 205 endothelial cell 76 energy metabolism 221 erythrocyte 186
— substitutes 217
extracorporeal perfusion 169 extravasation 176
fluid resuscitation 259
fluorocarbon emulsion stabilization 237
fluorocarbon/hydrocarbon diblock 237
HBOC 127 hemodilution 259
hemoglobin (Hb) 22, 38, 53, 127, 186
— -based oxygen carrier 76, 176
— -raffimer 53
— -vesicles 1, 135 hemorrhage 217
human serum albumin 194
inhalation therapy 34 interfacial tension 237
liposome 135 liver 169
microbubbles 217 microcapsules 205 microcirculation 62 molecular diffusion 237
nanocapsules 22 nanotechnology 22 nitric oxide (NO) 127
Key Word Index
279
280 Key Word Index
— scavenging 176 nitrosyl hemoglobin 186 normothermic perfusion 169
Ostwald ripening 237 oxygen-binding ability 194 oxygen carriers 1, 229 oxygen delivery 70 oxygen gradients 62 oxygen therapeutic 1, 53 oxygen transport 38, 135, 217
p50 38 PEG 38
perfluorocarbon microemulsions 229 perfluorochemicals 221
polyelectrolytes 205 polyhemoglobin 22 preclinical assessment 267 prehospital care 259
radicals 76
recombinant hemoglobin 127 red blood cell 22, 135, 186, 259
— substitute 194 rejuvenation 186 repeat dose 53
selective pulmonary vasodilator 34 shock 252
stroke 62
synthetic hemoprotein 194
tissue oxygenation 70 toxicity 76
transurethral resection of the prostate 259
trauma 252
vasoconstriction 176
vessel wall oxygen consumption 70
zero-link polymers 62
