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Capitolo 12 Agenti cardioprotettori

12.2 Cardioprotettori naturali

12.2.3 Aglio

L'aglio ha numerose proprietà curative fra le quali c'è quella relativa agli effetti benefici per il cuore,per la sua azione vasodilatatrice riduce naturalmente la pressione sanguigna e protegge da patologie cardiovascolari. I benefici dell'aglio sono legati ad una sostanza, il solfuro d'idrogeno (H2S). Sebbene non si

conoscono ancora i meccanismi molecolari che hanno a che fare con i processi di blocco del danno ossidativo a livello cellulare, si è constatato che il solfuro d'idrogeno rilassa i vasi e permette al sangue di fluire più facilmente.Inoltre, numerose ricerche hanno dimostrato che la pianta è utile anche nel rallentare la progressione dei tumori e nella cura di altre patologie.

Conclusioni

La cardiotossicità da farmaci rappresenta una grande limitazione per varie

strategie terapeutiche.Evidenti sono le varie patologie a livello del miocardio che possono insorgere in seguito a vari trattamenti farmacologici.Varie strategie cardioprotettive sono state adottate specialmente per quanto riguarda la classe dei farmaci antitumorali.La cardiotossicità da farmaci non è riconducibile

propriamente ad una specifica struttura molecolare,varie classi di farmaci agiscono con meccanismi molecolare propri,creando la tossicità a livello miocardico.Nell'ambito clinico è di fondamentale importanza la prevenzione a tale tossicità dal momento che non esistono precise cure

cardioprottetive.Operatori sanitari,infermieri,medici si occupano di affiancare alle cure farmacologiche un piano di prevenzione della cardiotossicità,che vada a valutare nel paziente ogni rischio cardiaco derivato da tali cure.Nella terapia antitumorale utilizzazioni di antracicline liposomiali,o agenti cardioprotettori come il Dexrazoxano hanno permesso di diminuire la cardiotossicità di questa classe di farmaci.Le principali strategie convenzionali di prevenzione al danno cardiaco sono l'elettrocardiogramma,l'ecocardiogramma,la risonanza magnetica cardiaca.Una valida alternativa diagnostica è sicuramente la valutazione dei marcatori biochimici di danno miocardico e di disfunzione

ventricolare,fondamentali nel riconoscimento precoce della cardiotossicità da chemioterapici.

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