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3.4 Analisi statistiche

6. TABELLE E FIGURE

Figura 1 -Diagramma di dispersione dei livelli plasmatici di BDNF nei pazienti con

Figura 2 -Diagramma di dispersione dei livelli plasmatici di BDNF nei pazienti con

Figura 3-Diagramma di dispersione dei livelli plasmatici di BDNF nei pazienti con

diagnosi di PTSD, che hanno esperito il trauma meno o più di un anno prima dalla

Tabella 1-Caratteristiche socio-demografiche e cliniche dei pazienti con diagnosi di

PTSD (P) e dei soggetti di controllo (SC).

PTSD (n = 18) SC (n = 18) N N Genere Uomini Donne 6 12 7 11 Stato civile Single Sposato/a o convivente Separato/a o divorziato/a Vedovo/a 5 9 2 2 9 7 2 - Livello di istruzione >8 anni. 15 14 Situazione lavorativa

Impiegati a tempo pieno/part time Studenti Disoccupati Pensionati 7 6 3 2 9 4 4 1

Trauma indice (LEC)

-Morte improvvisa e inaspettata di una persona cara -Violenza fisica o sessuale

- malattia o ferita minacciosa per la vita - Incidente grave 6 3 4 5 NA NA NA NA

Età (anni, media±DS) 42.1±12.5 38.8±12.1 Impact of Event Scale

Punteggio totale Sintomi intrusivi Sintomi di evitamento 37.57±14.18 19.00±6.87 18.57±6.93 NA NA NA

Tabella 2-Punteggi medi±DS nei domini del TALS-SR nei 18 pazienti con diagnosi di PTSD. PTSD DOMINI Media±DS I - Eventi di Perdita 3.77±1.87

II - Reazione agli Eventi di Perdita 7.51±5.52

III - Eventi Potenzialmente

Traumatici 5.25±3.08

IV - Reazione alla Perdita o agli Eventi

Potenzialmente Traumatici 10.57±3.51

V - Rievocazione 5.45±2.35

VI - Evitamento e Ottundimento delle

Emozioni 6.15±2.72

VII - Comportamenti Disadattivi 1.66±1.87

7. BIBLIOGRAFIA

1. Abenhaim L, Dab W, Salmi LR. Study of civilian victims of terrorist attacks (France 1982-1987). J Clin Epidemiol 1992;45(2):103-109.

2. Adamec RE. Partial kindling of the ventral hippocampus: identification of changes in limbic physiology which accompany changes in feline aggression and defense. Physiol Behav 1991;49:443-453.

3. Altar CA Neurotrophins and depression. Trends Pharmacol Sci 1999;20:59-61. 4. American Psychiatric Association. Diagnostic and Statistical Manual of Mental

Disorders (DSM). APA Press. Washington DC, 1952.

5. American Psychiatric Association. Diagnostic and Statistical Manual of Mental Disorders (DSM-II). APA Press. Washington DC, 1968.

6. American Psychiatric Association. Diagnostic and Statistical Manual of Mental Disorders (DSM-III). APA Press. Washington DC, 1980.

7. American Psychiatric Association. Diagnostic and Statistical Manual of Mental Disorders (DSM-IV). APA Press. Washington DC, 1994.

8. American Psychiatric Association. Diagnostic and Statistical Manual of Mental Disorders (DSM-IV-TR). APA Press. Washington DC, 2000.

9. Armenian HK, Morikawa M, Melkonian AK, Hovanesian AP, Haroutunian N, Saigh PA, Akiskal K, Akiskal HS. Loss as a determinant of PTSD in a cohort of adult survivors of the 1988 earthquake in Armenia: implications for policy. Acta Psychiatr Scand 2000;102(1):58-64.

10. Bamji SX, Rico B, Kimes N, Reichardt LF. BDNF mobilizes synaptic vesicles and enhances synapse formation by disrupting cadherin-beta-catenin interactions. J Cell Biol 2006;174(2):289-299.

11. Bazak N, Kozlovsky N, Kaplan Z, Matar M, Golan H, Zohar J, Richter-Levin G, Cohen H. Pre-pubertal stress exposure affects adult behavioral response in association with changes in circulating corticosterone and brain-derived neurotrophic factor. Psychoneuroendocrinology 2009, in stampa.

12. Beecher HK. Pain in men wounded in battle. Ann Surg 1946;123:96-105.

Genazzani AD, Luisi S, Genazzani AR. Influence of endogenous and exogenous sex hormones on plasma brain-derived neurotrophic factor. Hum Reprod 2007;22(4):995-1002.

14. Bekinschtein P, Cammarota M, Igaz LM, Bevilaqua LR, Izquierdo I, Medina JH. Persistence of long-term memory storage requires a late protein synthesis- and BDNF- dependent phase in the hippocampus. Neuron 2007;53(2):261-277.

15. Blanchard EB, Kiolb LC, Pallmeyer TP, Gerardi RJ. A psychophysiological study of posttraumatic stress disorder in Vietnam combat veterans. Psychiatr Q 1982;54:220–229.

16. Blanchard EB, Hickling EJ, Forneris CA, Taylor AE, Buckley TC, Loos WR, Jaccard J. Prediction of remission of acute posttraumatic stress disorder in motor vehicle accident victims. J Trauma Stress 1997;10:215-234.

17. Blanchard EB, Buckley TC, Hickling EJ, Taylor AE. Posttraumatic stress disorder and comorbid major depression: is the correlation an illusion? J Anxiety Disord 1998;12:21-37.

18. Blank Jr. The longitudinal course of posttraumatic stress disorder. In: Davidson JRT, Foa EB eds. “Posttraumatic Stress Disorder: DSM-IV and Beyond”. American Psychiatric Press. Washington DC, 1993.

19. Blatt SJ. Levels of object representation in anaclitic and introjective depression. Psychoanalytic Study Child 1974;29:107-157.

20. Blatt SJ, Quinlan DM, D’Afflitti. The Depressive Experiences Questionnaire, 1976. 21. Bleich A, Koslowsky M, Dolev A, Lerer B. Post-traumatic stress disorder and

depression. An analysis of comorbidity. Br J Psychiatry 1997;170:479-482.

22. Bocchio-Chiavetto L, Zanardini R, Bortolomasi M, Abate M, Segala M, Giacopuzzi M, Riva MA, Marchina E, Pasqualetti P, Perez J, Gennarelli M. Electroconvulsive Therapy (ECT) increases serum Brain Derived Neurotrophic Factor (BDNF) in drug resistant depressed patients. Eur Neuropsychopharmacol 2006;16(8):620-624.

23. Bracha HS, Ralston TC, Matsukawa JM, Williams AE, Bracha AS. Does "fight or flight" need updating?. Psychosomatics 2004;45:448-449.

24. Brady KT, Killeen TK, Brewerton T, Lucerini S. Comorbidity of Psychiatric Disorders and Posttraumatic Stress Disorder. J Clin Psychiatry 2000;61:22-32.

25. Braun A, Lommatzsch M, Mannsfeldt A, Neuhaus-Steinmetz U, Fischer A, Schnoy N, Lewin GR, Renz H. Cellular sources of enhanced brain-derived neurotrophic factor production in a mouse model of allergic inflammation. Am J Respir Cell Mol Biol 1999;21:537-546.

26. Braun A, Lommatzsch M, Neuhaus-Steinmetz U, Quarcoo D, Glaab T, McGregor GP, Fischer A, Renz H. Brain-derived neurotrophic factor (BDNF) contributes to neuronal dysfunction in a model of allergic airway inflammation. Br J Pharmacol 2004;141(3):431-440.

27. Bremner JD, Randall P, Scott TM, Bronen RA, Seibyl JP, Southwick SM, Delaney RC, McCarthy G, Charney DS, Innis RB. MRI-based measurement of hippocampal volume in patients with combat-related posttraumatic stress disorder. Am J Psychiatry 1995;152:973-981.

28. Bremner JD, Southwick SM, Darnell A, Charney DS. Chronic PTSD in Vietnam combat veterans: course of illness and substance abuse. Am J Psychiatry 1996;153:369-375.

29. Bremner JD, Innis RB, Ng CK, Staib LH, Salomon RM, Bronen RA, Duncan J, Southwick SM, Krystal JH, Rich D, Zubal G, Dey H, Soufer R, Charney DS. Positron emission tomography measurement of cerebral metabolic correlates of yohimbine administration in combat-related posttraumatic stress disorder. Arch Gen Psychiatry 1997a;54(3):246-254.

30. Bremner JD, Licinio J, Darness A, et al. Elevated CSF corticotropin-releasing factor concentrations in post-traumatic stress disorder. Am J Psychiatry 1997b; 154: 624-629.

31. Bremner JD, Randall P, Vermetten E, Staib L, Bronen RA, Mazure C, Capelli S, McCarthy G, Innis RB, Charney DS. Magnetic resonance imaging-based measurement of hippocampal volume in posttraumatic stress disorder related to childhood physical and sexual abuse--a preliminary report. Biol Psychiatry 1997c;41:23-32.

32. Bremner JD, Narayan M, Staib LH, Southwick SM, McGlashan T, Charney DS. Neural correlates of memories of childhood sexual abuse in women with and without posttraumatic stress disorder. Am J Psychiatry 1999a;156(11):1787-1795. 33. Bremner JD, Staib LH, Kaloupek D, Southwick SM, Soufer R, Charney DS. Neural

with and without posttraumatic stress disorder: a positron emission tomography study. Biol Psychiatry 1999b;45:806-816.

34. Bremner JD. Functional neuroanatomical correlates of traumatic stress revisited 7 years later, this time with data. Psychopharmacol Bull 2003a;37:6-25.

35. Bremner JD, Vythilingam M, Vermetten E, Southwick SM, McGlashan T, Nazeer A, Khan S, Vaccarino LV, Soufer R, Garg PK, Ng CK, Staib LH, Duncan JS, Charney DS. MRI and PET study of deficits in hippocampal structure and function in women with childhood sexual abuse and posttraumatic stress disorder. Am J Psychiatry 2003b;160:924-932.

36. Bremner JD, Vermetten E. Neuroanatomical changes associated with pharmacotherapy in posttraumatic stress disorder. Ann N Y Acad Sci 2004;1032:154-157.

37. Breslau N, Davis G. Post traumatic stress disorder. The stressor criterion. J Nerv Ment Dis 1987;175:255-264.

38. Breslau N, Davis GC, Andreski P, Peterson E. Traumatic events and posttraumatic stress disorder in an urban population of young adults. Arch Gen Psychiatry 1991; 48:216–222.

39. Breslau N, Davis GC, Andreski P. Risk factor for PTSD-related traumatic events: a prospective analysis. Am J Psychiatry 1995;152:529-535.

40. Breslau N, Davis GC, Andreski P, Peterson EL, Schultz LR. Sex differences in post-traumatic stress disorder. Arcg Gen Psychiatry 1997;54:1044-1048.

41. Breslau N, Kessler RC, Chilcoat HD. Trauma and posttraumatic stress disorder in the community: the 1996 Detroit Area Survey of Trauma. Arch Gen Psychiatry 1998;55:626-632.

42. Breslau N, Chilcoat HD, Kessler RC, Peterson EL, Lucia VC. Vulnerability to assaultive violence: further specification of the sex difference in post-traumatic stress disorder. Psychol Med 1999;29:813-821.

43. Breslau N, Davis GC, Peterson EL, Schultz LR. A second look at comorbidity in victims of trauma: the posttraumatic stress disorder-major depression connection. Biol Psychiatry 2000;48:902-909.

44. Breuer J, Freud S. Studies on Hysteria. In: Strachey J,ed-trans. The standard edition of the complete psychological works of Sigmund Freud. London, UK: Hogarth

Press 1955;2:1-305. (Original work published 1893-1895).

45. Brewin CR, Andrews B, Rose S, Kirk M. Acute stress disorder and posttraumatic stress disorder in victims of violent crime. Am J Psychiatry 1999;156:360-366. 46. Brewin CR, Andrews B, Valentine JD. Meta-analysis of risck factors for

posttraumatic stress disorder in trauma-exposed adults. J Consult Clin Psychol 2000;68:748-766.

47. Bryant RA, Harvey AG, Guthrie RM, Moulds ML. A prospective study of psychophysiological arousal, acute stress disorder, and posttraumatic stress disorder. J Abnorm Psychol 2000;109:341-344.

48. Carlier IV, Gersons BP. Partial Posttraumatic Stress Disorder (PTSD): the issue of psychological scars and the occurrence of PTSD symptoms. J Nerv Ment Dis 1995;183:107-109.

49. Carlson EB, Rosser-Hogan R Trauma experiences, post-traumatic stress, dissociation, and depression in Cambodian refugees. Am J Psychiatry 1991;148(11):1548-1551.

50. Carter AR, Chen C, Schwartz PM, Segal RA. Brain-derived neurotrophic factor modulates cerebellar plasticity and synaptic ultrastructure. J Neurosci 2002;22:1316-1327.

51. Cassano GB, Michelini S, Shear Mk, Coli E, Maser JD, Frank E: The panic- agoraphobic spectrum: a descriptive approach to the assessment and treatment of subtle symptoms. Am J Psychiatry 1997;154;27-38.

52. Castrogiovanni P, Goracci A, Bossini L. Le diverse espressioni dell’ansia e della paura. Firenze:SEE, 2003.

53. Charcot JM. Leçon sur le maladies du mystème nerveux faites à la Salpệtrière. In: Progrès Medical. 3rd vol. Paris, France: Delahaye A, Lecrosnie E, 1887.

54. Chen B, Dowlatshahi D, MacQueen GM, Wang JF, Young LT. Increased hippocampal BDNF immunoreactivity in subject treated with antidepressant medication. Biol Psychiatry 2001;50(4):260-265.

55. Chilcoat HD, Breslau N. Investigation of casual pathway between PTSD and drug use disorders. Addict Behav 1998;23:827-840.

controlled trial of debriefing. J Psychosom Res 1999;46:37-44.

57. Corneil W, Beaton R, Murphy S, et al. Exposure to traumatic incidents and prevalence of posttraumatic stress symptomatology in urban firefighters in two countries. J Occup Health Psychol 1999;4:131-141.

58. Cotman CW, Berchtold NC. Exercise: a behavioral intervention to enhance brain health and plasticity. Trends Neurosci. 2002;25(6):295-301.

59. Cox BJ, MacPherson PSR, Enns MW, McWilliams LA. Neuroticism and self- criticism associated with posttraumatic stress disorder in a nationally representative sample. Behavior Research and Therapy 2004;42:105-114.

60. Craddock N, O'Donovan MC, Owen MJ. The genetics of schizophrenia and bipolar disorder: dissecting psychosis. J Med Genet 2005;42(3):193-204.

61. Curran PS, Gregg W. Psychiatric aspects of terrorist violence in Northern Ireland (1969 to 1989). Med Leg J 1990a;58( Pt 2):83-96.

62. Curran PS, Bell P, Murray A, Loughrey G, Roddy R, Rocke LG.. Psychological consequences of the Enniskillen bombing. Br J Psychiatry 1990b;156:479-482. 63. Czéh B, Michaelis T, Watanabe T, Frahm J, de Biurrun G, van Kampen M,

Bartolomucci A, Fuchs E.Stress-induced changes in cerebral metabolites, hippocampal volume, and cell proliferation are prevented by antidepressant treatment with tianeptine. Proc Natl Acad Sci U S A 2001;98(22):12796-12801. 64. Dalgleish T, Joseph S, Thrasher S, Tranah T, Yule W. Crisis support following the

Herald of Free-Enterprise disaster: a longitudinal perspective. Journal of Trauma Stress 1996;9(4):833-845.

65. Daly RJ. Samuel Pepys and Post Traumatic Stress Disorder. Br J Psychiatry 1983;143:64-68.

66. Damasio H, Grabowski T, Frank R, Galaburda AM, Damasio AR. The return of Phineas Gage: clues about the brain from the skull of a famous patient. Science 1994;264(5162):1102-1105.

67. Davidson J, Swartz M, Storck M, Krishnan RR, Hammett E. A diagnostic and family study of posttraumatic stress disorder. Am J Psychiatry 1985;142:90-93. 68. Davidson JR, Hughes D, Blazer DG, George LK. Post-traumatic stress disorder in

69. Davis M. Animal models of anxiety based on classical conditioning: the conditioned emotional response (CER) and the fear-potentiated startle effect. Pharmacol Ther 1990;47(2):147-65.

70. Davis M. Pharmacological analysis of fear-potentiated startle. Braz J Med Biol Res 1993;26:235-260.

71. Davis LL, Frazier EC, Williford RB, Newell JM. Long-term pharmacotherapy for post-traumatic stress disorder. CNS Drugs 2006;20(6):465-76.

72. De Bellis MD, Lefter L, Trickett PK, Putnam FW Jr. Urinary catecholamine excretion in sexually abused girls. J Am Acad Adolesc Psychiatry 1994;33:320-327. 73. Dell’Osso L, Shear MK, Carmassi C, Rucci P, Maser JD, Frank E, Endicott J,

Lorettu L, Altamura CA, Carpiniello B, Perris F, Conversano C, Chiapparelli A, Carlini M, Sarno N, Cassano GB. Validità and reliability of the Structured Clinical Interview for the Trauma and Loss Spectrum (SCI-TALS). Clin Pract Epidemiol Ment Health 2008;4:2.

74. Dell’Osso L, Carmassi C, Rucci P, Shear MK, Calugia S, Maser JD, Endicott J, Fagiolini A. Cassano GB. A multidimensional spectrum approach to Post-Traumatic Stress Disorder: comparison between the Structured Clinical Interview for Trauma and Loss Spectrum (SCI-TALS) and the Self-Report Instrument (TALS-SR). Compr Psychiatry 2008 in stampa.

75. Diamond DM, Fleshner M, Ingersoll N, Rose GM. Psychological stress impairs spatial working memory: relevance to electrophysiological studies of hippocampal function. Behav Neurosci 1996;110:661-72.

76. Dohrenwend BP, Turner JB, Turse NA, Lewis-Fernandez R, Yager TJ. War-related posttraumatic stress disorder in Black, Hispanic, and majority White Vietnam veterans: the roles of exposure and vulnerability. J Trauma Stress 2008;21(2):133- 141.

77. Donovan MJ, Miranda RC, Kraemer R, McCaffrey TA, Tessarollo L, Mahadeo D, Sharif S, Kaplan DR, Tsoulfas P, Parada L, et al. Neurotrophin and neurotrophin receptors in vascular smooth muscle cells. Regulation of expression in response to injury. Am J Pathol 1995;147:309-324.

78. Dowlatshahi D, MacQueen GM, Wang JF, Young LT. Increased temporal cortex CREB concentrations and antidepressant treatment in major depression. Lancet 1998;352(9142):1754-1755.

79. D'Sa C, Duman RS. Antidepressants and neuroplasticity. Bipolar Disord 2002;4(3):183-194.

80. Duman RS, Heninger GR, and Nestler EJ. A molecular and cellular hypothesis of depression. Arch Gen Psychiatry 1997;54:597-606.

81. Duman RS, Malberg J, Thome J. Neural plasticity to stress and antidepressant treatment. Biol Psychiatry 1999;46(9):1181-1191.

82. Duman RS. The neurochemistry of mood disorders: preclinical studies. In: Charney DS, Nestler EJ, Bunney BS (eds) The neurobiology of mental illness. Oxford University Press, New York, 1999;333–347.

83. Duman RS, Malberg J, Nakagawa S. Regulation of adult neurogenesis by psychotropic drugs and stress J Pharmacol Exp Ther 2001;299:401-407.

84. Duman RS. Synaptic plasticity and mood disorders. Mol Psychiatry 2002;7:S29- S34.

85. Dwivedi Y, Rizavi HS, Conley RR, Roberts RC, Tamminga CA, Pandey GN. Altered gene expression of brain-derived neurotrophic factor and receptor tyrosine kinase B in postmortem brain of suicide subjects. Arch Gen Psychiatry 2003;60(8):804-815.

86. Eberly RE, Engdahl BE. Prevalence of somatic and psychiatric disorders among former prisoners of war. Hosp Community Psychiatry 1991;42:807–813.

87. Edwards RH, Selby MJ, Mobley WC, Weinrich SL, Hruby DE, Rutter WJ. Processing and secretion of nerve growth factor: expression in mammalian cells with a vaccinia virus vector. Mol Cell Biol 1988;8(6):2456-2464.

88. Egan MF, Kojima M, Callicott JH, Goldberg TE, Kolachana BS, Bertolino A, et al. The BDNF val66met polymorphism affects activity-dependent secretion of BDNF and human memory and hippocampal function. Cell 2003;112:257-69.

89. Ellis PS. The origins of the war neuroses. Part I. J R Nav Med Serv 1984;70:168- 177.

90. Ergin C. Turkish health personnel norms for Maslach Burnout Inventory. J Psychiatry Psychol Psychopharmacology 1996;4:28-33.

91. Erichsen, John Eric. On Concussion of the Spine, Nervous Shock and Other Obscure Injuries to the Nervous System in Their Clinical and Medico-Legal Aspects. William Wood and Company New York, 1886.

92. Ernfors P, Lee KF, Jaenisch R. Mice lacking brain-derived neurotrophic factor develop with sensory deficits. Nature 1994;368:147-150.

93. Evenden J. Impulsivity: a discussion of clinical and experimental findings. J Psychopharmacol 1999;13:180-192.

94. Everly GS, Horton AM Jr. Neuropsychology of posttraumatic stress disorder: a pilot study. Percept Mot Skills 1989;68:807-810.

95. Fanselow MS, Sigmundi RA. Species-specific danger signals, endogenous opioid analgesia, and defensive behavior. J Exp Psychol Anim Behav Process 1986;12:301-309.

96. Favaro A, Rodella FC, Colombo G, Santonastaso P. Post-traumatic stress disorder and major depression among Italina Nazi concentration camp survivors: a controller study 50 years later. Psychol Med 1999;29(1):87-95.

97. Felitti VJ, Anda RF, Nordenberg D, Williamson DF, Spitz AM, Edwards V, Koss MP, Marks JS. Relationship of childhood abuse and household dysfunction to many of the leading causes of death in adults. The Adverse Childhood Experiences (ACE) Study. Am J Prev Med 1998;14:245-258.

98. Ferrada-Noli M, Asberg M, Ormstad K, Lundin T, Sundbom E. Suicidal behavior after severe trauma. Part 1: PTSD diagnoses, psychiatric comorbidity, and assessments of suicidal behavior. J Trauma Stress 1998;11:103-112.

99. Finkbeiner S. CREB couples neurotrophin signals to survival messages. Neuron 2000; 25:11–14.

100. First MB, Spitzer RL, Williams JBW, Gibbon M. Structured Clinical Interview for DSM-IV-Patient Edition (SCID-P). American Psychiatric Press. Washington DC, 1995.

101. Foy, D.W., Resnick, H.S., Sipprelle, R.C. & Carroll, E.M.. Preliminary, military and postmilitary factors in the development of combat related stress disorders. The Behaviour Therapist 1987;10:3-9.

102. Franklin CL, Zimmerman M. Posttraumatic stress disorder and major depressive disorder: investigating the role of overlapping symptoms in diagnostic comorbidity. J Nerv Ment Dis 2001;189:548-551.

103. Freedman SA, Brandes D, Peri T, Shalev A. Predictors of chronic post-traumatic stress disorder. A prospective study. Br J Psychiatry 1999;174:353-359.

104. Freeman TW, Cardwell D, Karson CN, Komoroski RA. In vivo proton magnetic resonance spectroscopy of the medial temporal lobes of subject with combat-related posttraumatic stress disorder. Magn Reson Med 1998;40:66-71.

105. Fukumoto T, Morinobu S, Okamoto Y, Kagaya A, Yamawaki S. Chronic lithium treatment increases the expression of brain-derived neurotrophic factor in the rat brain. Psychopharmachology(Berl) 2001;158(1):100-106.

106. Fujimura H, Altar CA, Chen R, Nakamura T, Nakahashi T, Kambayashi J, et al. Brain-derived neurotrophic factor is stored in human platelets and released by agonist stimulation. Thromb Haemost 2002;87:728-734.

107. Garrison CZ, Bryant ES, Addy CL, Spurrier PG, Freedy JR, Kilpatrick DG.. Posttraumatic stress disorder in adolescents after Hurricane Andrew. J Am Acad Child Adolesc Psychiatry 1995;34(9):1193-1201.

108. Geller B, Badner JA, Tillman R, Christina SL, Bolhofner K, Cool EH Jr. Linkage diseuilibrium of the brain-derived neurotrophic factor Val66Met polymorphism in children witj a prepubertal and early adolescent bipolar disorder phenotype. Am J Psychiatry 2004;161(9):1698-1700.

109. Giaconia RM, Reinherz HZ, Silverman AB, Pakiz B, Frost AK, Cohen E. Traumas and posttraumatic stress disorder in a community population of older adolescents. J Am Acad Child Adolesc Psychiatry 1995;34:1369–1379.

110. Gielen A, Khademi M, Muhallab S, Olsson T, Piehl F Increased brain-derived neurotrophic factor expression in white blood cells of relapsing-remitting multiple sclerosis patients.Scand J Immunol. 2003;57:493-497.

111. Glover H. Emotional numbing: A possible endorphin-mediated phenomenon associated with post-traumatic stress disorders and other allied psychopathologic states. Journal of Traumatic Stress 1992;5(4):643-676.

112. Goenjian AK, Yehuda R, Pynoos RS, Steinberg AM, Tashjian M, Yang RK, Najarian LM, Fairbanks LA. Basal cortisol, dexamethasone suppression of cortisol, and MHPG in adolescents after the 1988 earthquake in Armenia. Am J Psychiatry 1996;153:929-934.

113. Gold SM, Schulz KH, Hartmann S, Mladek M, Lang UE, Hellweg R, Reer R, Braumann KM, Heesen C. Basal serum levels and reactivity of nerve growth factor and brain-derived neurotrophic factor to standardized acute exercise in multiple sclerosis and controls. J Neuroimmunol.2003;138:99-105.

114. Goldberg J, True WR, Eisen SA, Henderson WG.. A twin study of the effects of the Vietnam War on post-traumatic stress disorder. JAMA 1990;263(9):1227-1232. 115. Goldberg LR. The development of markers for the big-five factors structure.

Psychological Assessment 1992;4:26-42.

116. Goldstein G, van Kammen W, Shelly C, Miller DJ, van Kammen DP. Survivors of imprisonment in the Pacific theater during World War II. Am J Psychiatry 1987;144:1210–1213.

117. Goldstein DS, McEwen B. Allostasis, homeostats, and the nature of stress. Stress 2002;5(1):55-58.

118. Gonul AS, Akdeniz F, Taneli F, Donat O, Eker C, Vahip S. Effect of treatment on serum brain-derived neurotrophic factor levels in depressed patients. Eur Arch Psychiatry Clin Neurosci 2005;255(6):381-386.

119. Gorenstein C, Andreade L. Validation of Portuguese version of the Beck Depression Inventory and the State Trait Anxiety Inventory in Brazilian subjects. Braz J Med Biol Res 1996;29:453-457.

120. Gould E, Woolley CS, McEwen B. Adrenal steroids regulate postnatal developmente of the rat dentate gyrus: I.. Effects of glucocorticoids on cell death. J Comp Neurol 1991;313(3):479-485.

121. Gould E, McEwen BS, Tanapat P, Galea LA, Fuchs E. Neurogenesis in the dentate gyrus of the adult tree shrew is regulated by psychosocial stress and NMDA receptor activation. J Neurosci 1997;17:2492-2498.

122. Gould E, Tanapat P, McEwen BS, Flügge G, Fuchs E. Proliferation of granule cell precursors in the dentate gyrus of adult monkeys is diminished by stress. Proc Natl Acad Sci 1998; 95:3168–3171.

123. Gould E, Tanapat P, Hastings NB, Shors TJ. Neurogenesis in adulthood: a possible role in learning. Trends Cogn Sci 1999;3(5):186-192.

124. Grassi-Oliveira R, Stein LM, Pezzi JC. Translation and content validation of the Childhood Trauma Questionnaire into Poruguese language. Rev Saude Publica 2006;40:249-255.

125. Grassi-Oliveira R, Stein LM, Lopes RP, Teixeira AL, Bauer ME. Low plasma brain-derived neurotrophic factor and childhood physical neglect are associated with verbal memory impairment in major depression. A preliminary report. Biol

Psychiatry 2008;64(4):281-285.

126. Gray JA. The psychology of fear and stress. New York: Cambridge University Press 1998.

127. Gray JA. The neuropsychology of anxiety: an enquiry into the functions of the septo-hippocampal system. New York: Cambridge University Press 2003.

128. Gray MJ, Litz BT, Hsu JL, Lombardo TW. Psychometric properties of the life events checklist. Assessment 2004;11(4):330-341.

129. Green BL, Grace MC, Lindy JD, Titchener JL, Lindy JG.. Levels of functional impairment following a civilian disaster. The Beverly Hills Supper Club fire. J Consult Clin Psychol 1983;51(4):573-580.

130. Green BL, Lindy JD, Grace MC, Leonard AC. Chronic posttraumatic stress disorder and diagnostic comorbidity in a disaster sample. J Nerv Ment Dis

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