Is HPV-DNA testing a useful tool in predicting low-grade squamous intraepithelial lesion outcome? A retrospective longitudinal study.
10
0
0
Testo completo
(2)
(3) 16 5267651 54
(4) 5676. T©ª¤ª¤¬Uª©¸®©°¤°¥. 0S TU1523S2015 S3 7266701 43020176VU453SW 5
(5) 6 S 012453 023705773S0616 26
(6) 3X543246S 320T376102 0157 S2 / / / ,1 * + * +L L + Z1 +33 C M* CO3 +O* + J1YCLLC +D3C/N1 CJC .O* -1 +O3*/D1CONJ.+YY*/-1L.3J? *278D1J+D*O* [\]^_`a\b`cdecfbgdhdijc^bkcl\m_dngo\bg\npcq\g`odbcdeccrj`d]^`sdhdijpctuvckwxbbmbyodzc{bo|\_no`jc decrso\`o}~\ng^_^crj`d]^`sdhdijc{bo`pc\by\``ocdn]o`^hpc^bgo^bdpcrso\`oc[\]^_`a\b`cdec \kogob\c^bkcxiobipcq\g`odbcdecfn`\`_ognc^bkcujb^\gdhdijpctqqcxbbmbyo^`^zcdn]o`^hpcrso\`oc xio bic\n\^_gscr\b`\_cr\vqvvpctuvckwxbbmbyodzc{bo|\_no`jcdmbk^`odbpcrso\`o}~\ng^_^pc`^hj \g\o|\kcxmimn`cpcccxgg\]`\kc[\g\a\_cpc TU152 ¡¢£ ¤¥¦§ TU15¨X©¥V¡¡§Xª¥0 TU15 ¢«¡X2¦ ¡«¡¨ 2¡«¢¡¨«©¬©¦¢£§¨ «7¦US ¡¡07®7S07¥¯§ TU15§¨¨§ ¡©®©¥
(7) °±²¤¤¡ 4¯«¦U¡¡¢ªU¨¯¨ «¡«¦U¡ ¨¦«« § TU15¦¢¨ TU15¡« ¡15³ª´µ«®¶·°¸¸¥¹ TU15¡¦ º¨¡®·°°¸¥V TU15¢¡¦«¡ ¢«§¦7S07®·°³±¥º¨Uº TU15¢¦««¦¨º®·°°¤¥0¡ TU 15¢«§¡§¢¡«¢§2º ¡«¢»¼»«¢¨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Ã\jcÄd_kn½c~Å}[lxc`\n`obipc]_dibdn`ogca^_Æ\_npchdÄ}i_^k\cg\_|og^hch\nodbn. ^ohobic^kk_\nn½cJ (:"&2Y2 26 0&2ZN/L%N !& 2&% 5 $!?7#&/ +0:825: 5#7#6#@@2& ¾DD1C7747@#2&2¿/ M#28:#M:0#/ %#:&#/*&25! 3:5ÀQQÁB FB9-2RÀQQÁB FB :=2#5À@2 26 0&2Â% &=2#516 =. . B. !"#$%&'(!)*+,*-./012101 3%#04(5#62&# 72789 "2"A:#0; "#78#<#842540: 75!278=2!7 &(:;4"&%:" ":" 846:8>#&% 4&>"#&&:7:"=#00# 7;" =&%:6 !"#$%&% 58:"1 ?724&% "#@:8":" 846&# 7=2!":045A7276#25278 &%:":725&#:0.
(8) 012. HIJKLMMLNOPQLJRQJLSI. 3456783
(9) 5 3 35
(10) 3 663 3
(11) 7
(12) 3 3 6 3 8 3 8 3
(13)
(14) 733
(15) 3
(16) 5
(17) 5 3 348
(18) 38 8 58 3 538 3
(19) 8
(20)
(21) 36
(22) 3 38
(23) . 35 3
(24) 3 83 58 3
(25) 348
(26) 38 !3 3 37 3858 675 63 . 3
(27) 53 3 65 3 58 75 83
(28) 53 3835
(29) 3 55 6 3 5
(30) 85 5 8 675 5
(31) 3 "5665
(32) 58
(33) 5 5 3 3 #$
(34) %# 3 3
(35) 3 $388& 53 6
(36)
(37) ' 3 385 5 5788 65
(38) 3 3 3
(39) 7
(40) 3
(41) 7 63 3
(42) 3 3 ( )535
(43) $388 3473
(44)
(45) $$*+ %0& $$*+
(46) 5
(47) 73! 65 753 "5665 7 3 0, %-.0,/$$)01& 337 5(83 5 5
(48) 5 7 3 5 3 663 3
(49) 7
(50) 3 *538 3 3
(51) (3 3 663 35
(52) 635
(53) 6 58 5 3
(54) 3 73
(55)
(56) 33 3
(57) 3 388' 3 73
(58)
(59) 33 3 3 3 ( *
(60) 2 5788 65
(61) %* & 785
(62) 5 23 83 3 5 358 5 33
(63)
(64) 5 5
(65) 3 7
(66) 58
(67) 5 3 35 58 3 63 3 3 63 3
(68) 388 5 3 3473
(69)
(70) 3+/34 7 3
(71) %0& 55
(72) 3 3
(73) 3 (
(74) 35
(75) 3 33 53 8. (
(76) 35 6 358 83
(77)
(78) 5
(79) 3633 5 3
(80) 563 63 5 3655363 5. 3 35 63
(81) 3 3
(82) 3
(83) 7 53
(84) 3
(85) 8 .
(86) 34 3 53 358 53 3 3
(87) 8 (3 358 5( 658 3
(88) 5 7 3 58 73
(89)
(90) 33 5 5
(91) 2 3 8 3 #6$76/)6.) 53 6 5 68 3 3 5 683 7
(92) 73 3 58 3
(93) 5 3 3 7 658 655363 63 5 8 58 5
(94)
(95) . #6$76/)6.) ( 33 33 577 53
(96) 9 3735 3 8 :;# 53 /5 6635 3 87
(97) 7 :3 7. 37 (8 . 8 58 5 87
(98) 7 34565 :;# 53 3633 5
(99) 3 (3
(100)
(101) 5 3 %<& $
(102)
(103) 3 333 6 3 5( 363 3
(104) 383 5 3 57785 5 :;# 3
(105) 63 #6$76 8
(106) !5 8 33
(107) 3 6(3 87
(108) 73
(109) 8
(110)
(111)
(112) 3
(113) 6753 3735 3 8 5 3 3 358 87
(114) 7 = )6.) 83
(115)
(116) 3
(117) 5
(118) 6 3 67834 # 66 67 5 3523
(119)
(120) :;# 53 )6.) 83
(121)
(122)
(123) 3 8
(124) 73! 5 3 8 7
(125) 3. 73 3 583 3 3 $.;0> 83
(126)
(127) 3 . 3 735833 5
(128) 3 3
(129) %?& . 3 #) 6
(130) %33 3 58 8 5
(131)
(132) 3 5 33 3 635 53 63 )6.) 5
(133) 0<@ 35
(134) & 7
(135) 5
(136) (33 20A. 8 53 5( 658 3
(137) '
(138)
(139) 3
(140) 3 86 3 8 :;# 3
(141) 56 3
(142) 3 75 3
(143) %<& $
(144) 3 3 8 3 7
(145) 67 3 3
(146) 3 73 653
(147) B . 3 36
(148)
(149) 3 63 8 53 358 5( 658 3
(150) 53 83
(151)
(152) 8238 . 338 7 $.;0> 83
(153)
(154)
(155) 67 5 5
(156) 3 5 3 3 3 57785 :;# 3
(157) . 83 63 373
(158) 3
(159) 3 (3
(160)
(161) 5 3 . ( 5 5 (3 3 5
(162) 55 655 )6.) 75 3
(163) 3 #*
(164)
(165) 3 5 835 53 3733 9 56 63 68
(166) 25
(167)
(168) 24A
(169) 3 53 010?
(170) 33 :;# 7
(171) 3 3
(172)
(173) +?2A.
(174) 3 53 <1+1
(175) ' 3 733 53 335
(176) 3. ?@A 63 53 5( 3 +1
(177) %+& C3 3 55(8 37 3 !
(178) 5D 3
(179) 3
(180) 53 333
(181) 3 5 7
(182)
(183) (83 83 :;# 3
(184) 3 655363 63 )6.) 57 3
(185) 3
(186) 8
(187) .
(188) 34
(189) 3
(190) 5
(191) 73! 3
(192) 53 67 5
(193)
(194) 3
(195) 33 53 73 3
(196)
(197) 5( 3 6
(198) 577 75 3 :;# 3 3 63 %42& (3
(199) 3 3 3
(200) 63 3 73
(201) 6
(202) 36
(203) 5 3
(204) 3
(205) 5
(206) 73! * 3 ( 6
(207) 58
(208) 3 333 (
(209) 3
(210)
(211) = 36 3
(212) 3 3
(213) !
(214) 53 5
(215) !5 "33. 858 655363 3 3
(216) E
(217) 73 3 583 6
(218) 58
(219) 53 (33 8588 585 3 36
(220)
(221) 35
(222) 3 63 3
(223) 3 :;# 3
(224) 5D . 8
(225) 3 8 (5
(226) 3 :;# (
(227) 5 3 3
(228) %3 ( $57 3 ..
(229)
(230) 36& 5
(231) 3
(232)
(233) 763
(234) $* ( $57 3 5
(235)
(236) 5 %$0 :33 $ 7&
(237) 3 8 3
(238) 3 8 =:#577 3 3 3585
(239) 558 58 73 653
(240) !6
(241) 3 385(8 5 37 (8
(242) 3 3 3
(243) 735
(244) 3 %2& $* 63
(245)
(246) 33 F 3 (3
(247) G 36
(248)
(249) 3
(250) 3 3 :;# $
(251) 3 3
(252) 67 53 3
(253) 5 3 365 6 3 5 3 3
(254) 533 58 6 8385 ( 8 3
(255) 8
(256)
(257) 33
(258)
(259) 5 5
(260)
(261) 3
(262)
(263) 5 6753 3 73 653 3
(264) 3 63 8 3
(265) 5 .
(266) 345686399 4
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`GCEHIGGCHABIDaEFGBbCE`cC`@c@ABIDE@DbEHdAIGIeBH@GE Cf@_BD@ABID g )%"( + S, )& &! %!" %( + 1+(!, !- % , 1 % +S- 4 ! "% J &"! 5, -! % ! % KT , / ! +JMJJ )$ S& "( ):4R V"% (, %",%! % J ( 2 , !#; / (MJJ ) $ S& "( ):4R-!"! % (!% !) - - S! %- / " %" #. 012. 4! !- +" %, ( !&- % % "& &% % (!!#J ((%( +%! ! -! , % %( Z$ !%7! ,KTT1]# J ( !"! ( %&!!* !! , % %KTT1)- + % $ !% 7! ,KTT1 , ( !!"%# h?ijklmEbCACHABIDE 4 &! , ( +" ) !%" (!, !- ! % .=1./01234 % 5KLK ! % ./01234 % , %&.JK !5& .JK%/J= !- +& !"&! M1NUR - , )- .JK !-! % "& /J=#./0234 ( !- , % !, ( !, ! % , (#; , + ! , !, ! (!% !- ; / %" !& % , ! !"&! V" ./01234 !!M2R# / %" ! (%( "./01 234 !(- , %"!( ( 1!' & ! M1Q)1P)01)00)0U)02)NU)U1)UK)UQ)UP) U2)QPR% %( ,"" \! ! % !& % ! - M1TR#; .JK !-! , % ," %( ,"" \!!" !# ; !"! ! , - S !! %!=6X!) - , " ( ./01 234 ! ! , #; ,, % %"1 +" !+ !"!1#T=6X) V"+ 1#T (./01234n, !, (&" M ! %( o1TT)TTT./011Q( , !n, U)TTT./0 ! )! ,"" \! R#= +" p1#T -! !% %! "1 ./01234 !+ !"M11R# g -( .JK !)+ ", 1, , 1NU !%" +!, !-! , + % ,/J= %" &"!(:qT2n11 ! !"! , !#:qT2n11 % ( , !% !( % , NUT&! (, % 61 ( ./0( , #4 "( + ! 0UTT , KT, , , " ) -! 1!"! % %QTTr /$7#234 S -! , %"!(s84, 234,'Ms( 8#) 0 )J4R) %( ,"" \! %" # 234 -! !, %! , MtuKQT,R%!, !- %" %* 1T(nr- .>#; , " % ./0-! + %&"!K ( ! %1/J=- ./061 ! !"! , !:qT2n11M4, , % 7 2( ![ " )4!!( )8R) %( ,"" \! #$ v)/J=, * -! , %1TT1,+ ", (UT,:wJ).
(268) 012. nohpqrrqstuvqhwvhqxo. 3256789
(269)
(270) 03566 112256 ! 9 "89 "2#$9 "% &2'7(121)*+,-.$/ 58 15 !"8895825 9 88958 0 5.$//591"9( 885 8 ""& 7 18 "3 9 " 3 59"2&3 359"&3 359"413 7 9"58"!8( !5 6!" (8 "03 9"902 (8885 (9" " " 8 85"8 ! 7 5989"88"9 " % 7 8 !" (8  $!899:;6 <9%8 !" 7= 69 "8 8 " (8 "9 (9" " 9 9!55859 325>5 .$/( 99 !9? 5 @!8 ! 8)A 9 ";93% 9"99.$/85
(271) %A 3B8
(272) %A 3 59 "99"8 (89! 98! 8"89"8 !8 (8( "99 9"99 8"9 !""59"9 7 8958 9% 75 "859 5 9 "59 998.$/85" 530
(273) 7
(274) %A" 9! 9"
(275) 1. "899 6!9""99985"95!"8 >5
(276) %A 9" 5 C DEFG+FG-HIJKHLG7"8 "99 " " "9" ( 889 !" 9 89" M8NM!"5< "9 9 9 . . 9 9 ""! "8"95 9"895&23BO2215" " 141(5(8 . 9 "" 8 98"%8 "9 . % P % 3P8 "95859" (9" !" 9"89"9: % 1P8 9 "( 8 899 9 : % 0P88. 9M8NM" 9 8 9 "9 1
(277) 8NM
(278) 9 8 86!5! N"89" 9M 9 9 "9 185 N$1Q % 3 0(8" 88" (9"
(279) %A .$/ ""! " 5 9(9" ! 90 8 !" 31 RJ+JEFJEK+S-+T+SUFGF N" !5 "3&"9" 9( 9 5"
(280) 1 % 7(85 (! V W9! 8"8 (9" 2#1 9"89 5 !8 " 85"5"(" "(" " /8 9"" ""9 "99"8"!8W-9! 2&2 9 9"885"9! 852&2"24 99 98" 85" 9! X24 9" "85";8 " "! 9 " 8 5" (" 9!" 9"999" 919" 9"99 "998 9"999! %%A $%A8 "99 (9" 2# N98 9"988. 9" N$1Q899 6$58" "( ! "9!" 98 . 9885 7"9 95"(
(281) %A .$/8 !""5 9 M81NM!"558! (89!" 5 " Y" "(9" "9!9" 88"98;9 8V " " "( 889") 9989" 9 5"(
(282) %A .$/"5 9 899 !"5( 5 " Z 6985" 5 ! 9" 8=" "" "859 ""9 "9 98 8""9 "9 (8885 5 ! 98%88. "(88%888[9 ( N 9NM98 9 327 991"9( ""\28. ""9 "9 . 7]8)M78 ^HL_+`EFHT-Ha-b^c-+Td-e^f-`GFISJF [5(8. 91 99 9"998 "99
(283) %A .$/8 !"g9830B2# (5" "
(284) %A 9"99 30B2#" " "99N" !5 "3&"9" 9( 9 5"
(285) 1 % 7" " (8889 !"(. (
(286) 1 9"999" 9 9 " "(&1#
(287) 1"999" 99 " " 841# 95 % 7 9"999" 9 9 " 5 &3&# % 7 "999" 99 " 19 B#/"( ( 589 8 !" 5"9 5 " 9"9 5"
(288) %A .$/" 96! h9 ( 975N [! 988"85"0&# 2# NP4402B:6$58" "i234i22& V =9!2BB:1& 5 34# 9 9 8 "8 !" P30(8
(289) 1 9"995!" % 7 "9933(8
(290) 1 "995!"% 7 9"99 7 !8 5"
(291) %A .$/. 8 8 9"98 9 "">88. 99899 9 8 !5589? 9h75NN6$58" "i0: i22 bejkDlm-`GFISJ-+Td-dEFG+FG-HIJKHLG "988" . . 9899 9 . ""! "" "958"9"9 ( 8 5859"9 9124&#(55 0&0O2&8 9 "M8NM9130# "9" 50&1O2 88. 992 00#(55024O1g" "9" ( 859. 9" 98 "95859"9 5 98@
(292) %A" " ( 9"99922&0# "99932B 34# :5"9" (9" 8 9 ""M8NM.
(293) 345686399 4
(294) 5 6 9 6. 012. f gh36iY]jTkWXYUSYlSkRXZm[XSYn[TWURVSnoS[pRSTjjmW\T[WYUS &- !"#$,/)'(/-&.% ), & C2!0*;)/ YlSqrstuvPS[R\pUYmYQWRXw <)/&-;^0;)- &-_0;)- 9)*+0`, H., - ! '6;%)', 8087-)/ ., -0 ;- 4&37H&210 H&7 %& ''(';0`, {x|hz 5z xyhz 5z H., - !7+(%)', K2017-)/ 0;- #/)'( & ''( $++ &-&(-4KA0K&37H&2 !"#$%& ''(0 #/)'( G1 20 8 $2&,/7&2,)/ 28!0K;)- 4G80821AD2A <+)- H+ '&,428021D2AH) %- ' , & ''( 22 K A EF1E), 002D2A H&7 %-&/- '&,& $++ 80 A1 }~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`# 9HJ,&7+ /H) a! ',3<'&,' )%-! -b.' '3&-H%)H&/, ' &3<-('<)+<),<-20 H) + &H (+&%2,&32&+<.+)-<H,'b. )*+&'2%-&(Hb.)+';), H)<<.-)<;&3H <;&+&/'<)+6)2',)'&,&3<-('<)+ %<'2, 0 c),; . ' H)(3&<. H'-),'&,&, ! "#$ ',/22!210d' -),/ &32H& )- <.--,+;)()'+)*+3&- !"#$ <'&,', <;&+&/'<)+ %<'2, BH , ''(';&3"#$ ',/ %, .%&,H;%&3 . 01,H' <&,64 ) ); ), )- 'e)'&,*<&2 ),&*+'/)'&,2K0. f gh336rRklYk]TU\RSWUVW\T[YkXSYlSqi?STUVSriSWUSVR[R\[WUQSjRkXWX[RU[jkYQkRXXWRS\RkW\TmSmRXWYUw.
(295) 011. LJ EJEJL. 7
(296) 8 438 78 37 7 4 87 3
(297) 4 !"#$%
(298)
(299) 7 73 343
(300) 4334
(301) 7
(302)
(303) . 378
(304) &
(305) 4 ' (7 93(7 3&&
(306) )34
(307) 3 )49
(308) 5 4
(309) 43 !"#$% EFGHIJKKKLJMNOPQRSTUVNQWNNTUXYZ[\]^U_QPQ`_UPTaUaR_NP_NU 4 3
(310) 73 (3
(311)
(312) (17 7 S`QbScNde 345 873%*+,
(313) 584 734 4 -./012334
(314)
(315)
(316) 353
(317) (4356.4
(318) phqhgp fghijkl 4
(319) 4>6mnoe 8 7 437 43
(320)
(321) (7
(322)
(323) 7 ) 8 4
(324)
(325)
(326) $7 4>6 %88 395
(327) 3 4*3 7./01233-./01233 (8737 114=<0>6 309453?>6 105 - 583 298, 2353
(328) %58:7 4 ) 74.
(329) 353
(330) 34
(331) 3
(332) 758:7 4 3
(333)
(334) 11450>6 11450>6 5< 34
(335) 3
(336) 8 73
(337)
(338) 43 !" 343
(339)
(340) 4 <4<<1>6 34333>6 1 #$% 4 4396+443; 4)8
(341)
(342) rsr :3
(343)
(344) 4573 3
(345) 8
(346) 345
(347) 4 %88 309 309 37 4 4 (17 ./012334
(348)
(349)
(350) 353
(351) EFGHIJKtLJMNOPQRSTUVPNQWNNTUXYZ[\]^U_QPQ`_UPTaUaR_NP_NU ( +4 437 78)4 4<0=>6
(352) S`QbScNuU`_RTvUMwxUyPQRSUzU{d|d 735 ) 4 33
(353)
(354) 97
(355) 4 (1 phqhgp 7 4 3
(356) ' ./012334
(357)
(358)
(359) 758:7 4 fghijkl 4
(360) 4>6mnoe $7 4>6 %88 484
(361) 43?6& 7
(362)
(363) 457 43
(364) 7
(365)
(366)
(367)
(368) 87;4
(369)
(370) )
(371)
(372) 4"788 (8737 004393>6 3?14<01>6 105 7 37 353
(373) 4./012336 3
(374)
(375) 4) 3
(376)
(377) <430<>6 504<91>6 5< 9. 334357
(378) 4
(379) 353
(380)
(381) 788 4 458 8 4
(382) %4
(383)
(384) 98 343
(385)
(386) 4 34333>6 <4<<1>6 1 7
(387) 4 43
(388) 4 37 43 3
(389) 8
(390) 5 9 rsr 3 %88 =1 100. 4 78 4
(391) 758
(392) @ 7843'758 8 737: 59
(393)
(394)
(395) 43<6A4
(396) PMwx} UMNOPQR~NUwRvQUxTRQ 57 378
(397) 97
(398) 4 7577 375 E F G H I J t L J MN O P Q R S T U V N Q WN N T U XYZ [ \]^ U _ Q P Q ` _ u U P v N U P T a U #$%
(399) 4
(400)
(401) 98 7 ./01233(487 d ¡¢£¤¥¦¥§¨©ª«¬ª¦®¯ wwUS`QbS cN 784)3758:7 4 37 7 4 34
(402)
(403)
(404) 353
(405)
(406) 34
(407) 84 3(34
(408) 4=50 °±²³´µ¶·¸¹³· 96& 7
(409) 9 78
(410) 4343
(411) 73: 4 º»¼½¾¿À½ Á½»¼½¾¿À½ ./01233353
(412) " ! 4
(413) 393<030501=553517 9<4316A
(414) ÃÄÅƱ²³ ÇÈÉÊËÌÍÎÏ ÇÈÉÊËÌÍÏÊÏÇÈÉÊËÌÍÏÎÏ ÇÈÉÊËÌÍ ÍÓÓ !.
(415) 734)388 9 (1+ 4 437 78)49 7 4573 ÐÑÒÏ ÐÑÒÏ ÐÑÒÏ ÊÏÐÑÒÏ (17 ./01233( 4 4 :35 87
(416)
(417) 4
(418) ./01233353
(419) 85 4)3 43 Ö×ÏÏÏÏÏÏÏÏÏÏ ÖÖ ØÝÏÏÏÏÏÏÏÏÏ Ü×ÏÏÏÏÏÏÏ ß×Û '3 ÈÔÕ (34 448)7
(420) 54387943
(421) ÐØÙÚÛÑÒ ÐÜÕÚØÑÒ ÐØÜÚÞÑÒ ÐØÛÚÙÑÒ 4334 787 4 7 (1 484 ) )7
(422) 78
(423) 48
(424)
(425) 5"4
(426) 5 ÕÝÏÏÏÏÏÏÏÏÏÏ Õ×ÏÏÏÏÏÏÏÏ Õ×ÏÏÏÏÏÏÏÏÏ ÕÝÏÏÏÏÏÏÏÏ ÈÔß ÛÞ & 3
(427)
(428) )7 (17 ( ÐÕÕÚÝÑÒ ÐÖÚßÑÒÏ ÐÞÚÝÑÒÏ ÐÕÙÑÒ 737 7 43
(429) 7 3345 4
(430) 49
(431) 3 9 4 3
(432)
(433) 4106B
(434)
(435) 788
(436)
(437) 5873 ÛÏÏÏÏÏÏÏÏÏÏÏ ×ÏÏÏÏÏÏÏÏÏÏ ØÏÏÏÏÏÏÏÏÏÏ ÕÏÏÏÏÏÏÏÏ ÈÔØ Ý 3
(438) 8
(439) )3773387 4 3 73 ÐØÚÕÑÒÏ Ð×ÑÒÏ ÐßÚÙÑÒÏ Ð×ÚÝÑÒÏ )
(440) 7
(441) C48
(442) 7 73D% 78 78737 7
(443) 538 33
(444) 4 798 4 4 4 ÍÓÓÏÐÑÒÏ ÕÖ×ÏÐÛÞÚÞÑÒÏ ÕÕßÏÐÜÕÚßÑÒÏ àáà 4 7 4 & 4 37
(445) ))7 47
(446)
(447)
(448)
(449) 23457879437 43
(450) 7 4
(451) 798 4733 4 3 548873
(452)
(453) 345
(454) 75
(455) 758
(456) 537 7 5 34778 448 4
(457) 7843 543 73437 57 75 4.
(458) 23457528893
(459) 4 5
(460) 8
(461) 5. 010. EFG5p5qPKRPTPMUJUQ[PSJ_JRWTPSPUrQ\QZVNTUJQMP\SPLPYURWKrWRPTQTS_PLSWXSOsmtuaaSYWMTPMTZTSKRQVPRTS^`qnSvJMPSawS xyza{|SVWLPYZLJRSePQ_rUSVJR}PRnSvJMPTSafSdfS~SJM\StwSg^hNKWTQUQ[PS^`qSKRW\ZYUTnSvJMPScSJM\SLJMPTS|SUrRWZ_rS{wS g^hSMP_JUQ[PS^`qSKRW\ZYUTnSvQMPSamwSg^hNijkSKWTQUQ[PSYWMURWLnSvQMPSaawSMP_JUQ[PSYWMURWLS]ijkTQSJM\SqjkTQSXRPPS eJUPRbnS. EFG5H5IJKLJMNOPQPRSPTUQVJUQWMSWXSYZVZLJUQ[PSQMYQ\PMYPSWXSYLPJRP\S]^RW_MWTUQYS`LJTTSabSJM\SMWUNYLPJRP\S]^RW_MWTUQYS `LJTTPTScSJM\SdbSLWeN_RJ\PSYPR[QYJLSLPTQWMTfSJYYWR\QM_SUWSg^hNijkSRPTZLUTS]Klmnobn. ! " # " # "$ ! % & !! ! ' "# ( ! "$#! ! )*+,-. ! / 0 $" !/"#" ' (#-1" & # ( ( "$!0 '! 23456. ! 0$" # 7 ""$ !! #8" "0 !!09:19 ('" ! #! "( ;"# $ /! # ! ( ( ! 0 #9:19 " " " "'! 234<56.! !. "( -=" ! !"/ / ! # ! 0 # ( ( "$234<56. ! !"$#! ! " " "$"/<0# ( 0 !)1><1*,-1 !!!/ ! '! # 0< ( "#"!# ""$ ?" ! 0 (#'!0" "'! ( " 0 !!""$ !"!! "!/ ! )11,- ; " " ""$9:19 ! 056. "! ( / $"#/!@>A)B*-CA/" D0@!"$.
(462) 012. HIJKLMMLNOPQLJRQJLSI. 34560891
(463) 5 0 345
(464) 53 5 55 5 ! "11#109 $ ! 5%5 3 3$ 5 3 $ 4 $3. 5%53 53$3$ 5 3 $ 4
(465) 3!5 9&!5!$ '3 ()*% 5
(466) 5
(467) 55 5 +5 55 % ,-.1/3 ()* 543 5
(468) 5 "5 4%3 5 5! 5%3 5 3 !45 55 $5
(469) 5 3 5 53$3 $3 4 '$3 3!59 & 5 53 35 5()*#0. % 55! ! 5 5 - 545 3
(470) 53 - 5 5 %5 4 % 45 49- 5 43 4345#3 '5 $5 $35 !$ 5 5()*#0. % 5 4 !%
(471) 5 ! 3
(472) 5 345 0 5 5()*% 35
(473) 3
(474) 53 ! 45
(475) 5 3 35% 5 33!5 ()*0. 5 433 3 1! $ $ 4 4 !%
(476) 3 55! 4 '$3 3 ! 45
(477) 5 "129) 3553 33 4552%3 5
(478) 5
(479) 53 345
(480) 5 3 '5 4 !% 03 5
(481) 5
(482) % %
(483) 5 345 0#32"19 34 4345#3 '5 - !$ 5 ()*#0. 543 5%3 5
(484) 5$ ' 54 543 5%5 $ 53!5 0. 5 4 5%5$ 3 ! 45
(485) 5 "139 435 5()*#0. 543 5%3 5
(486) 5 ! 5
(487) 3 "0 345
(488) - % 455 4 $3$ '5 ,-.1/5 9 ' 4! 5 53!3 3% 5 +5 0. 5$ 5!59, 5 !% 56789:;; ),<3455!$!3 ;54 5 !6 54 555
(489) 5 ()*#0. 5435 . 5 $545 5"13#1=9(,15$ 4 ! 45 4 45#3 5 <. % 5"3 !8888 35%3
(490) $ $ %55 3 55 5 ()*#0. 55!5 $59()*45 5 543 $3!5 ;3 >145 5 55 6!55!5 5 <. % 5 ! 35 5$ 4 45 %5$ '$345 "189 5 ()*#0. 5 4 43 55$ 4 % 5 3 $ 45 $ 5$
(491) $()*#0. . 5435 5 45 5"119#089 - $ $! ! 33 3 5435 5$533 $ 3 5
(492) 55 ()* 5$ 3 5 %3 $$5 $35 6!5 5
(493) 5 35%3 +#5 5'3 3 9?5$ ! 5 3533 45% 5()*#0. 5 !'$ 5 53!35553$3 $5 +5 4. $3%35 4! 4
(494) #43 53 3 5. %3 5 545 5 5 5 %5 3 % 459()*#0. 55$ ! 5!5 3 %5 5 5 '$3 5'5% $5 $3 $3$ 45 5 ! 55 5 $ 55 % 4#43 5$5 $35 9 55!5 55 5. @
(495) $ 55354A 535%5 ()*#0. 5 4
(496) ! $ 5$$33$5 45 3 $5 $35 335 5 5 5 5 % 3 5 !3%5 5 6 5 53 3 45
(497) #!%%5 4$535%3 5 3 2 5 3 3% 35
(498) #!%9- ! %. 5 53 3455 354
(499) ! 55355 5B !3 + $3 $5C 5 53 %5 5 5 3 $535 + % 45
(500) 3 3 4 3 $
(501) !$ $5 45
(502) $
(503) ! 5 5' 5535 5$3!5 5 4% 3 545 9D35 55 $ 53 $ 43 ()*#0. 5 4 !45 55 !%%55 33+5%5 $ 5 535 !$ 53 35 4 53%5 $ 53!5 %5 5 $5% 45 545 $5 $3 5 "0;9 55 5 5 $5!445 43 55$ 3 $ 45 552%5 5$ 3 5$ 4$ !53 5%5$ '$ 3%% 3$ 5 53 4$. $3 4 '$3 . 5$ 9()* $ 45 552%5 3 5 554!3 $3 5 5 !4 5$ 55$ 3!#5 4>3:>=<. 3 $ % !4 55$ 5$5!3% 5 %;39E ()*<. 3 %;33%% 3$5$ 5$ 3 333555 !$5 3 !5 !! 5 3555 $ !$5
(504) 555 55 5 3 35 ! 5 34 $$ 52";8019 ,!5 5535% 4 33 $3 45 % 5 3 5 ()*#<. 5 4 %;3 $5 $3$3 $5$55 4$5 3 "00#09- ! %. 35 3%% $3 (<#()*0. % 5$35
(505) ! $53 % 55 34 $
(506) +#!%%55 !53
(507) ! 5 !$55 55 5%535 59 5' 33 3 345
(508) ! 55 $ 5$ 5 '$3
(509) 5
(510) 3!5 + 55 % 4$5 $3$3 $5"039 53! 5$353535 $ %5 4. 559 ,F.&? >0G>6>. 53! 35435! 093> $3, 3 . .
(511) 345686399 4
(512) 5 6 9 6. 012. !" # $% && %% % #43 #4&#K3#2 %-&4-(36 # % % 199F@?0;?FIBA9 +9' ## .S % '.#8, 3H. '()('(* ( % #.7#&&.#H#&:H.( #<. + , -.* &/0.1#&23 . &456. - 7(./-'8 " 199+#: & : # #4 ;1990%#% !#%# #" && 4 !<: #%7"&4# = &2- : # 74:# ,#%,4#& -&4- <%"7"&>2/ 199?@+1A;+11?BC 1 = #&<4 %-!' %" % 03:7#&&:,#3 =;=<' /4" " ,&3#!%%#4 #%# D "3: E& C9=<' /4" 7 . >-.199F@00 0 '#&#/.=3 %# .)# #.7G <. &# H 4# ! 3%% !3&,%%##4# " % &&3&%%#:=6=::3"& 7":%&199C@11;1ICBFF ? <>5 4303:7#&&:,#3 #4!#4 ! J: J#"%-&4#% ,# % !&JB4 K3:3 # #" &#&& #;2 &# !::# #&6*& % = 1999@C1;0CFB?91 2 <D# L<.6 #:6. & /0. & %## ! # J#" K3:3 % &&%%#:# " -#%& K3:3 % && !3 :# #4#M%% N&JB4 K3:3 # #" &#& & ##4 3- % 199I@+9A;1+1B1+ I 3G#%"6. G J D#<. 32# 0. &/4 : !J: J" ##, !"#4"B# D- ! 03:7#&&:,#3 ;" 0<'5 3->% 1990@0I1;+AF+BI F GG#)/. &/# <. !##/. # . 73&##.5 ,# '' 3%#2#&#-!07E*< #42-0-2# 3 1# % #4 #4; #&2-# &2-K3&#-%&# , &2# #%##4#" : %&##%& #&<:6 "&1992@+1?;+BI A 3 %"# #L .H": ./ . 32# 0< 03:7#&&:,#3 #4!" :4 : !&JB4 % ,#%&2:&## #" OL =P3 % !4 #4 4-6 &#E#& 199F@0A;+?B+A C '%H. 3G#%"6. 4*. &;*5 JD#4 4307E#4 !&J4 Q> =>R%-&4- # # !J: , 02#: % ,#%&. 7#%%&:##/.7#%%&:##'/4 : #4 !J: #!&&JB3!&JB4 % ,#%& # ; %##!07EB*<'*<B2 : " =6=::3"&7":%&199F@19; 0?+BF ++H3-<.L#: .L-#/ .)$6(,&3#! T3%#, 07E #42-0-2# 3 ==U# J: J#":#%-&4#%&2:&## ! " #4 # ! =*1N0% %: # J#" %& %-8/ =! %#3 # 1990@0;10BC +1/3VG*. && 43 W. HG& G<8.H# : > " =;07E#" #&4-!"3:%% E%%# 199I@1?; +B F +0 T X .#G/. && 43XW. &#!! H.83#>./3VG*.8 %")W1&J# ,& % 4 - # #23#!% ,#%& "3:#&&:,#3 *<#J: J#":& %-&4-;: B&- # >% =! %# 199F@F; ?20BC +?<2-/. # #7./ #T 6. &, & .L& H.#&& 6 " C;%&##%&#: &#%# !07E #4; 3::-!:B&- E%%# 199I@ 1+; FAB AC +2 %"#!!:/.1" & . 43<. &:. & 7(.!" <>5 H3<%: # ! - 7 ' -0-2# 3 1! %# !%%#4 #%"3:#&&:,#3 *<#J: J#" K3#,%&:#&&-2:&7#%&3 : <:6 "&1992@+1?;+B++ +I7 .6 && -'.L& 8.Y3#1.8#D * %#! # "#4"# D"3: #&&:,#3 #! %#J#"0-2# 3 == %#M% 7)+9N>#7<6 &#E#&1992@01;1FABA2 +F #/5.& #7.8 ##(. & : # !" #4 0 1 -" '%" <: &#% 03:7#&&:,#3 Q07ER ! %# !"#4"B# D4 - #% ,#%& : & 6 &# /#%2#&199I@??;1+?+BI +AY31.6#4H. 3GZ. "4 6.0HZ.L& #' . 83D'7 ' %#!"3:#&&:,#3 ; %: # 2 J /Z9CN/Z++H72[NH7I[ #: - : 6 &#/#%2#&+CCF@02;+09?B+9.
(513) 012. KLMNOPPOQRSTOMUTMOVL. 345789
(514) 8
(515)
(516)
(517) 9
(518) 5
(519) 989
(520)
(521) 8
(522) !8""9 !9 #
(523) #98$%
(524) #9 8 9"&
(525) #'
(526)
(527) 88(#9 8 989
(528) 89#99#(5# 1))0*1)3%3+25 1)5, 9$
(529) -7 9!8.
(530)
(531) ,
(532) #5,"9
(533) 8
(534) !8""9 !9 8 9!"9 #9 8 989 8"
(535) 9#
(536) 8#98
(537) #9 85/# 8
(538) 08#1))1*3))%230+35 135#
(539) $
(540) 45/# 9# (8
(541) "9
(542) !9 $( .598
(543) #9 88
(544) 9 8
(545) 56(8
(546) 78 1))1*33)%78+35 1159 9$ # 7 9!85 98$#
(547) # !8 ""9 !9 :/#
(548) 9 + 8
(549)
(550)
(551) 898$5 /;1))0*081%814+4)5 1057 ! 8:7 9!8 8
(552) ,5 !" 9 8 #
(553)
(554) !8$
(555) !
(556) 8## #
(557) $9
(558) "#9
(559) 8# '9# #("9 <!
(560) 8
(561) #
(562) !98
(563) 9$89= 8
(564) %&
(565) 98
(566)
(567) # ! 8 !9-
(568) # 95/#8
(569) 08#1))3*40%140+45 185 9 (5 $ ##
(570) 89!"9 #9 8 .5" 9#99#( #
(571) ! 9#(
(572) !
(573) % 989 "
(574) "
(575) #9
(576) 5 (# "# $(1))1*30%120+25 125 > 5.5#
(577) #98$98"#9
(578) 8#?!8$
(579) !
(580) 8#%#("9 <!
(581) 8
(582) #
(583) !98
(584) 9$89= 8
(585) 8 '+ $
(586) <! 98#
(587) "9#
(588) 9
(589) 9 8508%;!
(590) $98$ 9
(591) 8.598
(592) #9 8% ! 9
(593) 8
(594) # " #9
(595) 53#
(596) 9#9 855 8 8
(597) $
(598) 5@ $
(599) 5 91))2*"531)5 125#
(600) ; >
(601) 89!
(602) #588(9 9$ + 9A !8""9 !9 :/+8
(603) $#9
(604)
(605) 9 "
(606) 8
(607) 98#
(608) 7B7+70 9$
(609) 7# (C 7D57&#
(610) #6(8
(611) 1))1*333%183+225 1357A !
(612) .@ 0790
(613) #5:9
(614) #
(615) #
(616) #
(617) 9 98 $
(618) 8
(619) 9# $ !,/508%;!
(620) $98$ 9
(621) 8.598
(622) #9 8% ! 9
(623) 8
(624) # " #9
(625) 53#
(626) 9#9 855 8 8
(627) $
(628) 5@ $
(629) 5 91))2*"5115 115
(630) #65. #
(631) $ !87 $
(632) 85 .!8""9 !9 98
(633) 9 8
(634)
(635)
(636) 898$% 9!" #8#
(637) &9 ! A
(638) 58
(639) ;"9
(640) !9 . 9 ! A
(641) 1))1*33%13)+335 145, 9$
(642) -,
(643) 75 8$9# 98 (# $9 '+" "#9
(644) 8#'9# "89 #
(645) # 98#
(646) "
(647) ##9 8 E#("9 <!
Documenti correlati
The new station for high speed rail at Napoli Afragola designed by Zaha Hadid is one of the most convincing examples of how today an important railway station should be conceived
Ben più complesso, almeno all’apparenza, risulta forse il conte- nuto polemico del dialogo che vede opposte le istanze luterane di Hans e Peter, e quelle cattoliche di Bruder
In this retrospective and multicenter study, we identified a small group of high-grade glioma patients, with immunohistochemical loss of mismatch repair protein expression:
Tecnica laparoscopica – L’esplorazione del cavo addominale ha evidenziato una regione substenotica del colon discendente, ma la reale invaginazione era a carico del trasverso
There are numerous points of interest to be noted: homogeneous data collection in a monoinstutional case-series; strict definition of postoperative seizure control as Engel Class
In the present paper an optical experiment has been devised to properly reproduce the statistical properties of gravity waves measured in a long wave tank with initial
The aim of this study is to develop an analytic framework to integrate and analyze data collected along all phases of a product lifecycle; this is done to give
