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From the Editor-in-Chief

n the more than a century since Sir James Paget brilliantly delineated the clinical and patho-logical aspects of Paget’s disease of bone, an enormous amount of new information has been generated at the clinical as well as the laboratory level. Accumulating evidence sug-gests that Paget’s disease is a common disorder in the Caucasian population.

But despite our extensive knowledge about the management of the patient per se, it is still larly a mystery the pathogenetic basis of this disorder. Over the past few years molecular and ge-netic studies have modified our understanding of the etiology of Paget’s disease. By so doing this progress is affecting our understanding of the disease and other related syndromes, with the potential to offer the opportunity to stop or reverse its downhill course.

In this number of Clinical Cases in Mineral and Bone Metabolism a m é l a n g eof special features on Paget’s disease are gathered and presented by experts in the field. You will find articles written by authorities on epidemiology, mechanisms and molecules, diagnostic approaches and therapeutic in-terventions in Paget’s disease. Recent ad-vances, spearheaded by genetic informa-tion, are the focus of an article by Alberto Falchetti and Maria Luisa Brandi. The wealth of information generated is opening new possibili-ties for the knowledge about the natural history and cause of Paget’s disease. The scientific con-sensus on the role of the sequestosome gene could form the basis for meaningful clinical appli-cations. Particularly useful to the clinician is the excellent summary of the variety of drugs now being used to treat patients with Paget’s disease by Silvano Adami.

The Journal also features original case reports on Paget’s disease.

We trust that you will find this issue of Clinical Cases in Mineral and Bone Metabolism to be of particular interest.

Maria Luisa Brandi, M.D., Ph.D.

I

Clinical Cases in Mineral and Bone Metabolism 2004; 1(3): 181 181

FOR REVIEW ONLY

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