• Non ci sono risultati.

IL-36 receptor antagonist with special emphasis on IL-38.

N/A
N/A
Protected

Academic year: 2021

Condividi "IL-36 receptor antagonist with special emphasis on IL-38."

Copied!
10
0
0

Testo completo

(1)

!"#$!%" &!%'()&*$!%'(&+( ,,*!&-%".&'&/0(%!1(-.%$,%2&'&/0( !"#$%!& '(& )!* +,-./0123'4'5.'67897:;<'=>?>=> @20='-A5B0C?30,D'?DEF,/'?/30CBG'0='H,/'0DE0I0EA?B'A=G',DB.'?DE'J?.'D,3'5G'HA/32G/ /G-/,EACGE'K032,A3'K/033GD'-G/J0==0,D'H/,J'32G'C,-./0123'2,BEG/> LD?A32,/0MGE'/G-/,EAC30,D'J?.'/G=AB3'0D'ND?DC0?B'?DE',32G/'-GD?B30G= 1 32'&3*$#4(%''(%*".&$3($#-&$"(!&(2&!+' 2"3(&+( !"#$#3"($#'#5%!"("&(". 3(%$" 2'#6

&O

!"#$%"&'

5786(9:;(<76(=;(9>?@:(A9B=@C ()*+,-./01+"'2345+"'2365+7*8-9:;)05+:;<=>>=8:-;5+:>>?;:8* @=:A:;B+=//.)001+P/>'Q>'R2?0S< PG-?/3JGD3',H'TGE0C0DG<' 6,=3,D'AD0IG/=03.'RC2,,B',H'TGE0C0DG<' %U 'VB5?D.'R3< 6,=3,D<'TV' &))W<'LRV @GB>X'Y)'%)O'#)#'U&O ':?ZX'Y)'%)O'#)#'U&W G$J?0BX'5?=2?=.[5A>GEA

'?@:( DE( F<7GHIJ( KFLD8M( LILNIJ( 7K( '?=( F<O( D<OPQIE( GHI( RJ7OPQGD7<( 7K( RJ7D<SFLLFG7JM( QMG7TD<IE(

F<O(FQGDUFGIE(,%-V(F<O(!+WX(RFGHYFME6( '?@:(DE(F(Q7LL7<(LIODFG7J(7K(D<<FGI(F<O(FOFRGDUI(DLLP<I(

JIER7<EI(F<O(DE(D<HDNDGIO(NM( '?@:(JIQIRG7J(F<GFZ7<DEG(A$%C6( '?@:$%'FQGE(7<( '?@:(JIQIRG7J(8DZF<O(YHDQH(

I[IJGE(RJ7D<SFLLFG7JM(IKKIQG( !"# #$(F<O( !"# %&$6(( '?@\(ND<OE(G7( '?@:(JIQIRG7J(FE(O7IE( '?@:$%(F<O(

HFE(EDLD8FJ(ND787ZDQF8(IKKIQGE(7<(DLLP<I(QI88E6( '?@\(DE(F8E7(F(LILNIJ(7K( '?=(QMG7TD<I(F<O(EHFJIE(E7LI(

QHFJFQGIJDEGDQE(7K( '?=$%;(ND<OD<Z(GHI(EFLI( '?=(JIQIRG7J(GMRI( 6( '?@\(R8FME(F(J78I(D<(GHI(RFGH7ZI<IEDE(7K(

D<SFLLFG7JM(ODEIFEIE;(I[IJGD<Z(RJ7GIQGDUI(IKKIQG(D<(E7LI(FPG7DLLP<I(ODEIFEIE6(X7GH( '?@\(F<O( '?@:$%(

HFUI(F<(F<GD?D<SFLLFG7JM(ND787ZDQF8(IKKIQG;(H7YIUIJ(D<(E7LI(QFEIE(HFUI(Q7<GJFJM(IKKIQGE6

'?@:($#2#-"&$(%!"%/&! 3"(] ".(3-#2 %'(#,-.%3 3(&!( '?@\

Q>'R\V7]

)

<(^>'RV6V@7_8

&

<'^>'TV++VL`8

!

<'^>'aV`aV`V

#

<'^>'TL`TL`V

#

<

'V>'RV^^7_7

U

<'T>'`8RV@7

%

<':>'+8_@7

%

<';>'+7V_+\;@@7

O

<'V>'+V`V::V

W

<'

b>'V_@7_89:7

W

<':>'bV_P89:7

"

<'^>'b8@V97a8

W

<'`>'^V9c78

)

<'

b>'+8_@7

))

'?DE'@>+>'@\;8\V`7P;R

)&' C

!)D=.8>);8+-E+@)/:7:;)5+F-08-;+G;:H).0:8*+I7J--A+-E+@)/:7:;)5+F-08-;5+@&5+GI&K+

L

M)-;=8-A-B*+

!:H:0:-;5+G;:H).0:8*+-E+NJ:)8:5+"8=A*K+

3

!)D=.8>);8+-E+$.8J-D)/:705+N=8J-A:7+G;:H).0:8*+-E+%->)5+

"8=A*K+

O

!);8=A+I7J--A5+G;:H).0:8*+-E+NJ:)8:2P)07=.=5+"8=A*K+

Q

!)D=.8>);8+-E+!).>=8-A-B*5+G;:H).0:8*+

-E+%->)+#-.+R).B=8=5+%->)5+"8=A*K+

4

S*;)7-A-B*+!:H:0:-;5+P)07=.=+T-0D:8=A5+P)07=.=5+"8=A*K+

U

$.8-;=+

T-0D:8=A5+G;:H).0:8*+-E+NJ:)8:2P)07=.=5+"8=A*K+

6

$.8J-D)=/:70+!:H:0:-;5+G;:H).0:8*+-E+P).?B:=5+

P).?B:=+"8=A*K+

V

!)D=.8>);8+-E+";8).;=A+@)/:7:;)5+N=8J-A:7+G;:H).0:8*+-E+8J)+I=7.)/+T)=.85+%->)5+

"8=A*K+

CW

!)D=.8>);8+-E+T)=A8J+I7:);7)05+G;:H).0:8*+-E+'X&Y?:A=5+"8=A*K+

CC

">>?;-A-B*+!:H:0:-;5+

!)D=.8>);8+-E+ ZD).:>);8=A+=;/+NA:;:7=A+I7:);7)05+G;:H).0:8*+-E+NJ:)8:5+"8=A*K+

CL

!)D=.8>);8+

-E+PJ=.>=7-A-B*+=;/+ ZD).:>);8=A+#J).=D)?8:705+F:-7J)>:08.*+=;/

+

";8).;=A+@)/:7:;)+#?E80+

G;:H).0:8*+I7J--A+-E+@)/:7:;)5+#?E802M),+ ;BA=;/+@)/:7=A+N);8).5+F-08-;5+@&5+GI&[

%)7):H)/+M-H)>\).+CQ5+LWCL+2+&77)D8)/+])\.?=.*+65+LWC3

d60,B,10C?B' /G=-,D=G' J,E0NG/=e' ?/G' =,BA5BG'

H?C3,/=' (C.3,S0DG=*<' ?' B?/1G' ?DE' 2G3G/,1GDG,A='

1/,A-'32?3'50DE'3,'CGBB'=A/H?CG'/GCG-3,/='?DE'K20C2'

2?IG' E0IG/=G' HADC30,D=>' +.3,S0DG=' ?/G' =GC/G3GE'

H/,J' CGBB=' 3,' GB0C03' 32G0/' GHHGC3=' 0D' ?D' d?A3,C/0DGe'

?DE'd-?/?C/0DGe'J?DDG/<'5A3'?B=,'32G.'C?D'?C3'0D'?D'

d0D3/?C/0DG<e'D,D$=GC/G3GE'J?DDG/'?='DACBG?/'H?C3,/=>'

+.3,S0DG='/G1AB?3G'0D3G/CGBBAB?/'C,JJAD0C?30,D'?DE'

-B?.'?D'0J-,/3?D3'?DE'G==GD30?B'/,BG'0D'32G'0DD?3G'?DE'

?E?-30IG'0JJADG'/G=-,D=G='()$%*>'

79$)f'?DE'79$)g'?/G'-/,$0Dh?JJ?3,/.'C.3,S0DG='

K20C2'?C3'32/,A12'32G'50DE0D1',H'3.-G'7'79$)'/GCG-3,/'

(79$)`7*>'@2G'79$)'H?J0B.',H'C.3,S0DG='0='C,J-,=GE'

,H'))'E0HHG/GD3'B01?DE=<'D?JGB.<'79$)f'(?B=,'3G/JGE'

79$):)*<' 79$)g' (79$):&*<' 79$)' /GCG-3,/' ?D3?1,D0=3'

(79$)`V',/'79$):!*<'79$)W'(79$):#*<'79$):U'3,'79$

):) <'?DE'79$):))'(,/'79$!!*>'79$)`V'GZG/3='?D'?D30$

0Dh?JJ?3,/.'?C30I03.'5.'50DE0D1'79$)`7'(O$))*>

(2)

&W

06(3.% V(#"(%'6

79$!%'0='?'H?J0B.'JGJ5G/',H'0D3G/BGAS0D$)'(79$)*<'

0='-/,EACGE'5.'J?D.'E0HHG/GD3'CGBB=<'?C30I?3G='TVb]'

?DE'_:$S6'-?32K?.=<'?DE'0='?'C,JJ,D'JGE0?3,/',H'

5,32'0DD?3G'?DE'?E?-30IG'0JJADG'/G=-,D=G='()&$)%*'

(@?5BG'7*>'PA/0D1'32G'-?=3'=GIG/?B'.G?/='J?D.'-?-G/='

2?IG' EG=C/05GE' ?' SG.' /,BG' H,/' 79$!%' 0D' -=,/0?=0='

K20C2'0=',IG/GZ-/G==GE'0D'32G'=S0D',H'2AJ?D'-B?iAG'

-=,/0?=0=' ()O$)"*>'@2G' 0D205030,D' ,H' 79$!%' K032' 79$

!%`V' 0D' 2AJ?D' -=,/0?30C' =S0D' 2?=' 5GGD' H,ADE' 3,'

?JGB0,/?3G'32G'0Dh?JJ?3,/.'/G?C30,D='(& $&!*>'73'2?='

5GGD'=2,KD'32?3'79$&&<'79$)OV<'?DE'@_:$f'0DEACG'

32G')Z+H:H-'-/,EAC30,D',H'?BB'32/GG'79$!%'5.'2AJ?D'

SG/?30D,C.3G=<'K2G/G?='7:_$j'=GBGC30IGB.'0DEACG='79$

!%g'(&#$&%*>'7D'?EE030,D<'79$!%f'?DE'79$!%g<'5A3'D,3'

79$!%j<' E0/GC3B.' 0DEACG' @_:$f' J`_V' ?DE' -/,3G0D'

=.D32G=0='0D'SG/?30D,C.3G='EGJ,D=3/?30D1'32?3'79$!%f'

?DE' 79$!%g' C,ABE' /G1AB?3G'@_:$f' E0/GC3B.' (&O$&"*>'

79$!%' 0DEACG=' 32G' -/,EAC30,D' ,H' -/,$0Dh?JJ?3,/.'

C.3,S0DG=<' 0DCBAE0D1' 79$)&<' 79$)g<' 79$%<' @_:$f<'

?DE' 79$&!' 5.' EGDE/030C' CGBB=' K032' ?' J,/G' -,3GD3'

=30JAB?3,/.'GHHGC3'32?D'32?3',H',32G/'79$)'C.3,S0DG=>'

79$!%'?B=,'0DEACGE'32G'-/,EAC30,D',H'7:_$j<'79$#<'?DE'

79$)O'5.'+P#(Y*'@'CGBB='?DE'CAB3A/GE'=-BGD,C.3G=<'

32G=G' =30JAB?3,/.' GHHGC3=' KG/G' ?D3?1,D0MGE' 5.' 79$

'''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''

!

"#$%&'$() $*( +",- './ 01!2'33'4 3'$*5'6)

!

". %7389$'.$ 3:'6(9 %. %..'$( './ '/'3$%&( %77;.( 9()38.)(

!

,'$*83*6)%8:8<6 8= )(&(9': /%)(')()

!

>.%$%'$%8. 89 9(<;:'$%8. 8= %77;.( 9()38.)() './ %.=:'77'$%8.

!

>?!@1A B9(.'7(/ >?!CDE"F (G(9$) 9(#(3$89 '.$'<8.%)$ '#$%&%$%()

!

>?!@1A %.*%H%$) 01! 4 %. #(9$'%. #(:: $63()

!

+(/%'$() :()%8.': 3)89%')%) )2%.

!

+(/%'$() (3%/(97%) './ /(97%) %.=:'77'$%8.

!

+(/%'$() $*( 398:%=(9'$%8. 8= 2(9'$%.8#6$() './ %. '#$%&'$( (3%$*(:%': $%));()

!

I$98.<:6 %.#9(')(/ %. 3)89%'$%#!:%2( 78;)( )2%. 3:'J;()

!

>?!CD! './ >?!CD"K H;$ .8$ >?!CD#K /%9(#$:6 %./;#(/ L01!!

!

>?!CD #'. H( %./;#(/ H6 L*@M #6$82%.()

!

N%9(#$:6 9(<;:'$() >?!O './ >?!D

!

E(<;:'$() $*( (G39())%8. './ (.*'.#( $*( =;.#$%8. 8= L*@M

!

>.$(99(:'$%8. 5%$* >?!PP %. )2%. %.=:'77'$%8.

!

+(/%'$( #*98.%# 2%/.(6 /%)(')(K './ *;7'. 9*(;7'$8%/ )6.8&%': $%));()

QQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQ

QQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQ

>.*%H%$) $*( 398/;#$%8. 8= >10!#K >?!RK './ >?!@M H6 SNRBTF L #(::) './ )3:(.8#6$()

>.*%H%$)

%.=:'77'$896 )2%. :()%8.)

>.*%H%$) 3)89%')%)

>$ %) ' .'$;9': '.$'<8.%)$ 8= >?!CDE

>$) '.$'<8.%)$ '#$%&%$6 %) /(3(./(.$ ;38. 9(78&': 8= %$) 0!$(97%.': 7($*%8.%.(

L*( 7(#*'.%)7 8= >?!CDE" '.$'<8.%)7 %) '.':8<8;) $8 $*'$ 8= >?!@E"

E(/;#() >?!O 398/;#$%8. %./;#(/ H6 >?!CD#

S';)( /8)(!9()38.)( );339())%8. 8= S'./%/'!%./;#(/ >?!PP './ >?!@M

>$ *') H%8:8<%#': (==(#$) 8. %77;.( #(::) H6 (.<'<%.< $*( >?!CDE

>.*%H%$) >?!CD 9(#(3$89 9(/;#%.< ")3(9<%::;)!%./;#(/ >?!@M './ >10!#

^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^

"FN8I( 6(F:-A-B:7=A+)EE)780+-E+"'234[ "FN8I( 6("'234%&+=78:H:8*[

(3)

&"

<G6()6( LLP<7RFGH786(-HFJLFQ786

!%'0='GZ-/G==GE'0D'EGDE/030C'CGBB='?DE'+P#

Y

'@'CGBB='

?DE' 0=' ?5BG' 3,' =30JAB?3G' 32G' -/,EAC30,D' ,H' =GIG/?B'

C.3,S0DG='0D'J?D.'E0HHG/GD3'3?/1G3'CGBB=<'K2G/G?='79$

!%`V'GZG/3='?D'0D20503,/.'GHHGC3>

`G=AB3='H/,J'E0HHG/GD3'=3AE0G='=A11G=3'32?3'79$!%'0='

?'-/,$0Dh?JJ?3,/.'C.3,S0DG'?DE'J?.'5G'?'JGE0?3,/'

,H'5,32'0DD?3G'?DE'?E?-30IG'0JJADG'/G=-,D=G='(!U$

!W*>' 79$!%' /GCG-3,/' ?D3?1,D0=3' 3,C0B0MAJ?5' 2?=' ?D'

0D20503,/.'GHHGC3',D'79$!%<'?DE'0='GHHGC30IG'0D'=,JG'

-?30GD3=' K032' 0Dh?JJ?3,/.' E0=G?=G=' (!"$#&*>' 7D'

GZ-G/0JGD3?B' ?D0J?B<' ,IG/GZ-/G==0,D' ,H' 79$!%f' 0D'

SG/?30D,C.3G='GZ20503'0Dh?JJ?3,/.'=S0D'BG=0,D=<'?DE'

320='GHHGC3'K?='BG=='=GIG/G'?H3G/'79$!%`Vk3/G?3JGD3'

:;+ H:H-' (#!$#%*>' @?SGD' 3,1G32G/<' 32G=G' ,5=G/I?30,D='

0DE0C?3G'32?3'79$!%`'B01?DE=<'0DCBAE0D1'79$!%f<'79$

!%g<' ?DE' 79$!%j<' GZG/3' -/,0Dh?JJ?3,/.' GHHGC3=' :;+

H:8.-'?DE':;+H:H-+?DE'32?3'79$!%`V'?C3='?='?'D?3A/?B'

?D3?1,D0=3>' @2G=G' -?32K?.=' 0D3G/?C3' D,3' ,DB.' 3,'

!%`V'(! *>'

79$!%`<' 0=' 3G/JGE' 79$)`/-&' ?DE' 03=' B01?DE=' ?/G'

D?JGE' 79$!%f' (79$):%*<' 79$!%g' (79$):W*<' ?DE' 79$

!%j'(79$):"*l'K20BG'79$):U<'K20C2'2?='5GGD'=2,KD'

3,' GZG/3' /GCG-3,/' ?D3?1,D0=3' ?C30I030G=<' 2?=' 5GGD'

/GD?JGE'79$!%`V>'@2G/GH,/G<'32G=G'C.3,S0DG='50DE'3,'

79$!%`'(79$)`/-&*'?DE'79$)`VCb<'?C30I?30D1'=0J0B?/'

0D3/?CGBBAB?/'=01D?B='?='79$)<'K2G/G?='79$!%`V'(79$

):U*' ?C3=' ?=' ?D' 79$!%`' ?D3?1,D0=3' (79$!%`V*>' 79$

!%($f$g$j*' 0=' 2012B.' GZ-/G==GE' 0D' G-032GB0?B' 30==AG='

?DE'=S0D'K20C2'?/G'GZ-,=GE'3,'-?32,1GD='?DE'?/G'?B=,'

GZ-/G==GE'?5ADE?D3B.'0D'-=,/0?=0='(!)$!#*>'

@2G=G'NDE0D1='/GIG?B'32?3'79$!%`'B01?DE='(79$!%f<'

79$!%g<'?DE'79$!%j*<'GZG/3'-/,$0Dh?JJ?3,/.'GHHGC3='

?DE'32?3'79$!%`V'?C3='?='03='?D3?1,D0=3'(@?5BG'77*>'79$

!%`' ?1,D0=3' B01?DE=' ?/G' -,3GD3' /G1AB?3,/=' ,H' @$CGBB'

/G=-,D=G=':;+H:8.-'?DE':;+H:H-'?DE'-B?.'?D'0J-,/3?D3'

/,BG' 0D' 0DD?3G' ?DE' ?E?-30IG' 0JJADG' /G=-,D=G=>' 79$

!"#$"% &' ()" *+,- '.#/01 &' 0/2.345

, 6"3" 0&7.("4 &3 )8#.3 7)%&#&5&#" 9:-;,-<=- 3".% ()" *+,->? 2"3"

, @37&4"5 -A9,.#/3& .7/4 B%&("/3

, C).%"5 $"(D""3 <-E .34 <;E .#/3& .7/4 /4"3(/(1 D/() )8#.3 *+,->?

, C).%"5 7).%.7("%/5(/75 &' ()" *+,->? '.#/01

, *( /5 "FB%"55"4 /3 )".%(G B0.7"3(.G '"(.0 0/H"%G 5B0""3G ()1#85G .34 )8#.3 (&35/0

, >&0" /3 /3'0.##.(&%1 %"5B&35" .34 )&5( 4"'"35"

, ?7(5 .5 .3 *+,->?G .34 $/345 ()" 5.#" *+,- %"7"B(&% (1B" *

, I/345 (& ()" *+,;J>G .5 4&"5 *+,;J>?

, I/34/32 .''/3/(1 &' *+,;K /5 0&D"% ().3 ().( &' *+,->? .34 *+,-

, *( /5 /3H&0H"4 /3 ()" %"280.(/&3 &' /##83" %"5B&35"5

, *( B0.15 . %&0" /3 B5&%/.(/7 .%()%/(/5 .34 .3L10&5/32 5B&3410/(/5

, *( /5 B%&("7(/H" /3 B5&%/.5/5

, *3H&0H"4 /3 /37%".5"4 38#$"% &' 01#B)&71("5 M)-N

, *3H&0H"4 /3 ()" )/2) B%&487(/&3 &' *+,-N?G *+,9-G .34 *+,99

, O0.15 . %&0" /3 !?OP .7(/H.(/&3

, >"487"5 ()" B%&487(/&3 &' N=;/:/=,/3487"4 *+,-N .34 *+,99

, Q&"5 3&( .''"7( ()" B%&487(/&3 &' M)- 71(&L/3" *RS,!

, C/#/0.% $/&0&2/7.0 "''"7(5 D/() *+,;J>?

, C).%"5 B%/#.%1 .#/3& .7/4 )&#&0&21 D/() *+,->? .34 *+,;J>?

, Q&"5 3&( $/34 *+,-K>

, Q"7%".5"5 B%&,/3'0.##.(&%1 71(&L/3"5 /3 OI!T5

, *37%".5"5 B%&,/3'0.##.(&%1 71(&L/3"5 /3 4"34%/(/7 7"005

, U.5 .3 /3)/$/(&%1 "''"7( &3 M)-N 71(&L/3"5

(4)

!

J?0D3?0D'CGBBAB?/'2,JG,=3?=0='?DE'0D3G1/03.'5A3'?B=,'

3,'/G1AB?3G'0Dh?JJ?3,/.'?DE'?A3,0JJADG'E0=G?=G=>

"'236+^"'2C]CW_

79$!W'K?='CB,DGE'?DE'C2?/?C3G/0MGE'?='?'JGJ5G/'

,H' 32G' 79$)' H?J0B.' ,H' B01?DE=' 0D' & )' (#O$U)*>'@2G'

J,=3'/GCGD3'?EE030,D'3,'32G'GIG/$1/,K0D1'H?J0B.',H'

C.3,S0DG=' 0DCBAEG' 0D3G/BGAS0D$!W' K20C2' K?=' N/=3'

0EGD30NGE'5.'\?0=2?D'90D('?DE'6GD=GD'm@<'G3'?B>'(U&$

U%*>'@2G=G'?A32,/='=2,K'32?3'79$!W'0='?'JGJ5G/',H'

32G'79$)'H?J0B.<'0D'H?C3<'32G'D,IGB'79$)$B0SG'1GDG<'79$

):) <'0='B,C?3GE',D'2AJ?D'C2/,J,=,JG'&i)!$)#>)'

DG?/'32G'79$)'/GCG-3,/'?D3?1,D0=3'1GDG'(UO$% *>'79$

):) ' CP_V' GDC,EG=' )U&$?J0D,' ?C0E' -/,3G0D' 32?3'

=2?/G=' 5G3KGGD' #)n' ?DE' #!n' ?J0D,' ?C0E' 0EGD303.'

K032'2AJ?D'79$)'/GCG-3,/'?D3?1,D0=3'(79$)`V*>'79$

):) ' =2?/G=' C2?/?C3G/0=30C=' ,H' 32G' 79$)`V' H?J0B.<'

0DCBAE0D1'SG.'?J0D,'?C0E'C,D=GD=A='=GiAGDCG='?DE'

?'=0J0B?/'1GD,J0C'=3/AC3A/G'(%)$%U*>'79$):) 'J`_V'

0='GZ-/G==GE'0D'=GIG/?B'30==AG'=AC2'?='2G?/3<'-B?CGD3?<'

HG3?B'B0IG/<'=-BGGD<'32.JA=<'?DE'?C30I?3GE'6'CGBB=',H'

32G'2AJ?D'3,D=0B'(%%$O *>'@2G'GZ-/G==0,D'0D'?'I?/0G3.'

,H'0JJADG'30==AG='?DE'=0J0B?/03.'3,'79$)`?'=A11G=3'

?'/,BG',H'79$):) '0D'32G'0Dh?JJ?3,/.'/G=-,D=G'?DE'

2,=3'EGHGD=G'(U&<'O)$O!*>'

6?=GE' ,D' 03=' ?J0D,' ?C0E' 2,J,B,1.' 3,' 79$)`?<'

03' 2?=' 5GGD' /G-,/3GE' 32?3' 79$!W' ?C3=' ?=' ?D' 79$)`V<'

?DE' 50DE=' 32G' =?JG' ' 79$)' /GCG-3,/' 3.-G' 7' (O#$OO*>'

\,KGIG/<' 32G' 50DE0D1' ?HND03.' ,H' /GC,J50D?D3' 79$

!W' 0=' =01D0NC?D3B.' B,KG/' 32?D' 32?3' ,H' 79$)`V' ?DE'

79$)g' (OW$W)*>' @20=' DGKB.' E0=C,IG/GE' C.3,S0DG'

=GGJ=' 3,' ?C3' J,/G' ?=' ?D' 0JJADG' /G1AB?3,/' 32?D' ?'

-/,$0Dh?JJ?3,/.' C.3,S0DG' B0SG' ,32G/' 79$)' H?J0B.'

JGJ5G/=>'@2G/GH,/G<'03'0='0DI,BIGE'0D'32G'/G1AB?30,D'

,H'D,/J?B'0JJADG'/G=-,D=G=>'\,KGIG/<'79$!W'-B?.='

?' /,BG' 0D' 32G' -?32,1GDG=0=' ,H' 32G=G' 0Dh?JJ?3,/.'

E0=G?=G=' =AC2' ?=' -=,/0?30C' ?/32/030=' ?DE' ?DS.B,=0D1'

=-,DE.B030=' (W&$W#*<' GZG/30D1' ?' -/,3GC30IG' /,BG' 0D'

-=,/0?=0=' (@?5BG' 777*>' ' 7D' 32G=G' 0Dh?JJ?3,/.' ?DE'

,32G/'?A3,0JJADG'E0=G?=G='32G'DAJ5G/',H'C0/CAB?30D1'

B.J-2,C.3G=' @$2GB-G/' )O' (@2)O*' 0=' 0DC/G?=GE' K032'

2012' -/,EAC30,D' ,H' 79$)OV<' 79$&)<' ?DE' 79$&&' (WU$

WW*>'7D'H?C3<'79$!W'-B?.='?'/,BG'0D'TVb]'?C30I?30,D'

K20C2'0='HA/32G/'GD2?DCGE'5.'32G'=30JAB?30,D'32/,A12'

3,BB$B0SG' /GCG-3,/<' /G=AB30D1' 0D' 32G' GD2?DCGE' -/,$

0Dh?JJ?3,/.'C.3,S0DG'-/,EAC30,D'(W"$"&*>

`GCGD3B.<' P0D?/GBB,' G3' ?B>' EGJ,D=3/?3GE' 32?3'

5,32' 79$!W' ?DE' 79$!%`V' /GEACG' 32G' -/,EAC30,D' ,H'

N=;/:/=$0DEACGE'79$)O'?DE'79$&&'("!*<'C,DN/J0D1'

32G'?D30$0Dh?JJ?3,/.'GHHGC3',H'320='DGK'-/,3G0D>'@20='

GHHGC3'K?='?5=GD3',D'@2)'C.3,S0DG'7:_$j>'\,KGIG/<'

2,K'79$!W'J,EAB?3G='@2)O'/G=-,D=G=<'0='=30BB'ADCBG?/>'

73' ?--G?/=' 32?3' 79$!%`?' ?DE' 79$!W' 2?E' =0J0B?/'

50,B,10C?B' GHHGC3=' ,D' 9bR$0DEACGE' 79$%' 0D' 2AJ?D'

P+=<'2,KGIG/<'DG032G/'79$!%`?'D,/'79$!W'-G/H,/J='

?=' ?' 3.-0C?B' /GCG-3,/' ?D3?1,D0=3<' B0SG' 79$)`V' ("#$

"O*>' 6B,CS0D1' 32G' 79$!%`?' ,/' 32G' 79$)`' -?32K?.'

J0J0CSGE'32G'GHHGC3=',H'79$!W',D'32G'-/,EAC30,D',H'

@2)O'C.3,S0DG='("W$) &*>'73'2?='5GGD',5=G/IGE'32?3'

79$!W'=2?/G='-/0J?/.'?J0D,'?C0E'2,J,B,1.'K032'79$

)`?' ?DE' 79$!%`?' 5A3' 0=' 0DC,D=0=3GD3' K032' 50DE0D1'

3,'32G'79$)W`'() !$) %*>'R,JG'GHHGC3=',H'79$!W'?DE'

79$!%`V' /GJ?0D' ADCBG?/<' H,/' 0D=3?DCG<' K2.' 32G.'

EGC/G?=G' -/,$0Dh?JJ?3,/.' C.3,S0DG=' 0D' -G/0-2G/?B'

5B,,E' J,D,DACBG?/' CGBB=' K2G/G?=' 0DC/G?=GE' -/,$

0Dh?JJ?3,/.'C.3,S0DG='0D'EGDE/030C'CGBB=>

@2G' GHHGC3=' ,H' 79$!W' ?/G' =0J0B?/' 3,' 32,=G' ,H' 79$

!%`V' 5A3' 32G=G' 3K,' /GCG-3,/' ?D3?1,D0=3' E,' D,3'

5G2?IG'?='CB?==0C'/GCG-3,/'?D3?1,D0=3='B0SG'79$)`V>'

@2G/GH,/G<'32G.'?/G'-?/30?B'/GCG-3,/'?D3?1,D0=3='?DE'

J0123' ?C3' ?=' ?1,D0=3=' ?3' 2012G/' C,DCGD3/?30,D=>' 7D'

?EE030,D<'79$!W'-/,I0EG='GI0EGDCG'H,/'50DE0D1'3,'32G'

79$!%'B01?DE$50DE0D1'C2?0D<'?DE'79$)`V<'79$!%`V<'

?DE'79$!W',IG/B?-'0D'32G0/'?50B03.'3,'/GEACG'79$&&'?DE'

79$)O'BGIGB='() O$)) *>'R0DCG'79$!W'2?='?D'0D20503,/.'

GHHGC3' ,D' @2)O' C.3,S0DG=' 32G=G' NDE0D1=' J?.' 2?IG'

0J-,/3?D3' CB0D0C?B' ?DE' 32G/?-GA30C' 0J-B0C?30,D='

?DE' J?.' /G-/G=GD3' D,IGB' 3?/1G3=' H,/' 3/G?3JGD3>' 7D'

C,DCBA=0,D<'03'0='GI0EGD3'32?3'79$!W'50DE='3,'32G'79$

!%`<'?='E,G='79$!%`V<'?DE'32?3'79$!W'?DE'79$!%`V'

2?IG' =0J0B?/' 50,B,10C?B' GHHGC3=' ,D' 0JJADG' CGBB='

32/,A12'32G'79$!%'/GCG-3,/>

`;:;`;_+;R

)>'' T0M1G/E' mb>' T,BGCAB?/' JGC2?D0=J=' ,H' DGA3/,-20B' /GC/A03JGD3'GB0C03GE'5.'5?C3G/0?'0D'32G'BAD1=>'RGJ0D' 7JJAD,B'& &l')#X)&!$!&> &>'' 60D0C0' P_<' ^oDGp' _<' ]?.?3?p' ]<' b0pS0D-?p?' _>' @2G' GHHGC3=' ,H' 0D3G/HG/,D$f&5' ,D' 0D3G=30D?B' h,/?' 0D' -G/03,DG?B'N5/,=0=>';A/'m'7Dh?JJ'& ))l'"X)!U$)!"> !>'' +?3?DM?/,'`<'T?/,33?':<'m?0D'R<'`?=3J?DG=2'`<'VB$ BG1/0':<'+GBG-'^<'9,/GDMG330'V<'b,B0JGD0'V<'Q?E?I'\>' 6GDGNC0?B'GHHGC3',H'?'=3A/1G,D$5?=GE'50,?C30IG'C,J$ -,ADE',D'1GDG'GZ-/G==0,D',H'3AJ,/'DGC/,=0='H?C3,/$f<' 06(3.% V(#"(%'6

(5)

!)

<G6()6( LLP<7RFGH786(-HFJLFQ786

79$!%g<'?DE'79$!%j*',/'?D3?1,D0=3'(79$!%`?*'?C30I03.>' m'60,B'+2GJ'& ))l'&W%X#&U"#$% &>'

)!>'' +?/BG=0J,' T<' _?/C0=0' V<' 8/=0D0' P<' +,/3G=0' ^<' V5/AMMG=G'+<'^0,I?1D,B0'R<'^0A5G330D0'T<'+?J-B,DG' ^>' V' /?/G' C?=G' ,H' =?/C,0E,=0=' ?DE' J,/-2G?>' ;A/' m' 7Dh?JJ'& ))l'"X&"O$""> )#>'' T?/30D,330' ^<' P0' 7,/0,' ^<' T?/0D0' R<' `0CC0' a<' PG' 6G/?/E0='P<'P0'^0?DD?D3,D0,'T>'_G/IG'1/,K32'H?C3,/' ?DE'5/?0D$EG/0IGE'DGA/,3/,-20C'H?C3,/'C,DCGD3/?30,D=' 0D' =C20M,-2/GD0?X' ?' /GI0GK>' m' 60,B' `G1AB' \,JG,=3' V1GD3='& )&l'&%X!#O$U%> )U>'' +?/BG=0J,' T<' _?/C0=0' V<' 8/=0D0' P<' V5/AMMG=G' +<' P0' `A==,' bb<' 9?' aG/EG' ^<' +,Z' T+>' ;,=0D,-20B0C' EG/J?3,=0=' ?==,C0?3GE' K032' 2?GJ?3,B,10C?B' J?B01D?DC0G=X'?'/G-,/3',H'3K,'C?=G=>';A/'m'7Dh?JJ' & )&l') X&#O$U >

)%>'' 90D'qQ<'qA' 6@<' 9GG' ++<' R2GA' mm<' 90A' R\<'q?D1' q:<'@=?0'+\<'90A'\b<'@=?0':m>'V==,C0?30,D'?D?B.=0=' ,H' E,-?J0DG/10C' 1GDG' I?/0?D3=' (+,J3<' P/E#' VDE' P?3)*' K032' VBM2G0JG/r=' E0=G?=G>' m' 60,B' `G1AB' \,$ JG,=3'V1GD3='& )&l'&%X# )$) > )O>'' ^05=,D' TR<' R?BJ,D' _<' 60/E' R<' ]?0=G/' b<' :0HG' T>' 7EGD30NC?30,D<'CB,D0D1'?DE'C2?/?C3G/0=?30,D',H'0D3G/$ BGAS0D$):U' (79$!%`_*' 0D' 32G' C20CSGD>' PGI' +,J-' 7JJAD,B'& )&l'!WX)!%$#O> )W>'' PGB' ^0?CC,' R`<' :0/0DA' P<' b0BAEA' ^<' RG33GJ5/0D0' VT<'@ABB0'T<'b0/?/0'b<'_?BB0';<'TA/?'T_<'T?DC,D0' b;<' PGB' ^0?CC,' ^R>' `?.D?AEr=' -2GD,JGD,D' ?DE' =CBG/,EG/J?' ?==,C0?3GE' K032' =0B0C,DG' 1GB' 5/G?=3' 0J-B?D3=X' ?D' GZ?J-BG' ,H' V=0?' =.DE/,JG>' ;A/' m' 7Dh?JJ'& )&l') X&!!$&!W>

)">'' V5E?BB?2' \?ss' \A==G0D' 7<' P?B0' 6?B3?' _<' mA/sA=' `V<' q?3H?' q<' ^G/1G=' V<' V30.G2' 6<' bABB?/' +<' 9G,DG' V<' mA/sA=' V`>' `?3' J,EGB' ,H' 5A/D' K,ADE' 2G?B0D1X' GHHGC3',H'6,3,Z>'m'60,B'`G1AB'\,JG,=3'V1GD3='& )&l' &%X!W"$# >

& >'' I?D' EG' aGG/E,DS' :9<' R3,GCSJ?D' V]<' qA' ^<' 6,GCSG/J?DD'V_<'VM?J'@<'_G3G?'T^<'m,,=3GD'9V<' I?D' EG/' TGG/' mq<' \?,' `<' ]?B?5,S0=' a<' P0D?/GBB,' +V>' 79$!W' 50DE=' 3,' 32G' 79$!%' /GCG-3,/' ?DE' 2?=' 50,B,10C?B'GHHGC3=',D'0JJADG'CGBB='=0J0B?/'3,'79$!%' /GCG-3,/'?D3?1,D0=3>'b/,C'_?3B'VC?E'RC0'LRV'& )&l' ) "(W*X! )$U>' &)>'' aGD?'^V<'T?=3/?DE/G?'a<'6?33?1B0D0'R<'9,C,D=,BG':<' 6AiA0CC20,'`<'+?==?D,'_>'+,J50D?30,D',H'G3?DG/CG-3' ?DE' 3K0CG$KGGSB.' ?EJ0D0=3/?30,D' ,H' C.CB,=-,/0D' 0D' J?3/0Z' JG3?BB,-/,3G0D?=G=' ?DE' 3.-G$) ' C,BB?1GD' 0D' 2AJ?D'C2,DE/,C.3G=>'m'60,B'`G1AB'\,JG,=3'V1GD3=' & )&l'&%X!!O$#U> #>'' 6?//G/?'+<'^?30C?'V<'T,/1?D'+>'85G=G'I0=CG/?B'?E0$ -,=G' 30==AG' 1/?H3GE' 0D' BG?D' J0CG' C?D' ?B3G/' 1BAC,=G' 2,JG,=3?=0='?DE'GDG/1.'GHNC0GDC.(m'60,B'`G1AB'\,$ JG,=3'V1GD3='& )&l'&%X#))$)O> U>'' T0/M?G0' ]<' \,==G0D$_GM2?E' V<' T,S23?/0' :<' _?sJ?H=2?/' V<' ]2,=2D0?3' _0S,,' T>' a7R:V@7_F _VTb@Fb6+;:' ?DE' C.3,S0DG' C,DCGD3/?30,D' 0D' JAB30-BG' =CBG/,=0=' -?30GD3=' C,J-?/GE' 3,' 2G?B32.' =A5sGC3=>';A/'m'7Dh?JJ'& ))l'"X!)$!O> %>'' P/?1,'9<'a?==GD?'+<'P,M0,';<'+,/=0'TT<'PG'aGCC20' ;<' T?330D?' `<' `,J?Dt' +>' b/,C?BC03,D0D<' +$/G?C30IG' -/,3G0D<' 0D3G/BGAS0D$%<' ?DE' =,BA5BG' 0D3G/CGBBAB?/' ?E$ 2G=0,D' J,BGCABG$)' ?=' J?/SG/=' ,H' -,=3,-G/?30IG' ,/$ 32,-?GE0C's,0D3'-/,=32G=0='0DHGC30,D=>'7D3'm'7JJAD,$ -?32,B'b2?/J?C,B'& ))l'&#X#!!$# >

O>'' TA/?S?J0' T<' @?SG3,J0' Q<' ^0/?/E' +<' Q?J?J,3,' ]<' 9?J5G?A' ^>' ;JG/10D1' /,BG=' ,H' =GC/G3GE' -2,=-2,B0-?=G'V&'GDM.JG=X'9G==,D='H/,J'3/?D=1GD0C' ?DE'SD,CS,A3'J0CG>'60,C20J0G'& ) l'"&XU%)$W&> W>'' P,M0,';<'T?B?I?M,='V;<'P,1B0,330'^<'^,110'R<'^?BB0G/?' ;<'R,BI0JGDG'L<'T?1D0'b<'+,=3?';<'T,//0C,DG'9<'+,/=0' TT>' V=.JJG3/0C' E0JG32.B?/10D0DGX' /GB?30,D=20-' K032' C0/CAB?30D1' 50,J?/SG/=' ,H' 0Dh?JJ?30,D' ?DE' C?/E0,I?=CAB?/' E0=G?=G' /0=S' 0D' ADC,J-B0C?3GE' ,5G=G' K,JGD>';A/'m'7Dh?JJ'& ))l'"X&#"$UU>

">'' `01?D3G' P<' c?J-G330' V<' 6G/=?D0' ^<' +?DEGBB0' T<' b0/?='V<' `GDEGB0' +<'VD3AMM0' P<' :GB0C0?D0' +<' R3?50BG' V>( RG/AJ' 0D3G/BGAS0D$)W' 0D' C20BE/GD' K032' \GD,C2$ RC2uDBG0D' -A/-A/?X' ?' -/,J0=0D1' J?/SG/' ,H' E0=G?=G' ?C30I03.>';A/'m'7Dh?JJ'& ))l'"X)UO$%W> ) >'' ^2?H,A/0?D'R<'T,2G50'`<'RGS?K0'c<'`?H3?/0'T<'_GGB?' a<'^2?H,A/0?D';<'V5,A?B01?BG2E?/0';<'`?25?/'T<'R?$ EG120H?/E'_>';HHGC3',H'3?DD0D'GZ3/?C3'?1?0D=3'P0)?/-2 >-;=0+=).?B:;-0=+-/,EAC0D1'JG3?BB,'5G3?$B?C3?J?=G>' m'60,B'`G1AB'\,JG,=3'V1GD3='& )&l'&%X&!)$&!%> ))>'' R20' v<' ^?,' cQ<' w0G' :<'q?D1' 9:<' ^A'Qb<'Q?D1'@m<'

\A?D1' 9<' v0?D' v\<' v0A' Q\>'V' D,IGB' J,D,CB,D?B' ?D305,E.'?1?0D=3'2AJ?D'+PW '?DE'03='0JJADG'-/,$ 3GC30,D'0D'?'J,A=G'BA-A=$B0SG'E0=G?=G>'7D3'm'7JJAD,$ -?32,B'b2?/J?C,B'& ))l'&#XUW!$"!>

)&>'' @,KDG'm;<'`GD=2?K'6`<'P,A?D1-?D.?'m<'90-=S.'6b<' R2GD'T<'^?5GB'+V<'R0J='m;>'7D3G/BGAS0D$!%'(79$!%*' B01?DE=' /GiA0/G' -/,CG==0D1' H,/' HABB' ?1,D0=3' (79$!%f<'

(6)

!&

! >'' a01DG' R<' b?BJG/' ^<' 9?J?CC20?' +<' G3' ?B>' 79$!%`' B01?DE='?/G'-,3GD3'/G1AB?3,/=',H'EGDE/030C'?DE'@'CGBB=6' 6B,,E'& ))l'))WXUW)!$&!>' !)>'' 6BAJ5G/1'\<'P0D2'\<'@/AG5B,,E';R<'G3'?B>'8--,=0D1' ?C30I030G=',H'3K,'D,IGB'JGJ5G/=',H'32G'79$)'B01?DE' H?J0B.'/G1AB?3G'=S0D'0Dh?JJ?30,D>'m';Z-'TGE'& Ol' & #())*X&% !$&%)#>

!&>'' 6,.?C0'\<'b?B?'V<'V/1AD'6?/0p'R<'6?p.0103'7<'Q0BE0M' :<' 7B1?MB0' V>' @2G' GHHGC3=' ,H' 0D2?BGE' =3G/,0E' ?DE' 32G,-2.BB0DG' ,D' =.=3GJ0C' 0Dh?JJ?30,D' 0D' +8bP>' ;A/'m'7Dh?JJ'& ))l'"X&#)$&#W>

!!>'' ;A=G50,' T<' ]/?=MAB?' 9<' ]A-CM.S' T<' ]AD?' b<' b0G3/ACMAS' T>' 9,K' H/GiAGDC.' ,H' +PWY+P&UY:8wb!6`7^\@' @' CGBB=' ?DE' :8wb!' J`_V'GZ-/G==0,D'0D'32G'-G/0-2G/?B'5B,,E',H'?BBG/10C' ?=32J?'-?30GD3=>(m'60,B'`G1AB'\,JG,=3'V1GD3='& )&l' &%X&))$&& > !#>'' PG' VJ0C0' T<' a0BB?D0' TV<' T0B?DG=0' ;<' `,==0D0' 6<' 6?/C,'R<'^G/BG330'T<'+0-/?DE0'^>'VEIG/=G'/G?C30,D=' 3,' ?D?G=32G30C=' -/GIGD3GE' 5.' 32G' A=G' ,H' =-GC0NC' B?5,/?3,/.'3G=3=';A/'m'7Dh?JJ'& ))l'"XO"$W) !U>'' @/0-,E0' P<' +,D30' :<' `,=?30' T<' G3' ?B>' 79$!%' ?' DGK' JGJ5G/',H'32G'79$)'H?J0B.'C.3,S0DG=>'m'60,B'`G1AB' \,JG,=3'V1GD3='& )&l'&%XO$)#> !%>'' V=B?D0'R<'\,==G0D$_GM2?E'V<'T0/M?G0']<'T?125,,B0' c<'V=1?/?5?E'R_<']?/0J0':>'@?DEGJ'/G-G?3=',H'32G' +V@@' GBGJGD3' ,H' J?C/,-2?1G' J01/?30,D' 0D20503,/.' H?C3,/'1GDG'J?.'-/GE0C3'1G=3?30,D?B'E0?5G3G='JGBB03A=' =GIG/03.>';A/'m'7Dh?JJ'& ))l'"X)"!$)"O> !O>'' b?DE,BN' :<' +0?DC0' `<' +?=C0?D,' :<' b?1B0?/0' P<' PG' b?=iA?BG' @<' 9?DE,BN' `<' P0' R?D3G' ^<' ]A/D0CS' m@<' `0?' :>( RSGKGE' @$CGBB' /GCG-3,/' /G-G/3,0/GX' J,/G' 32?D' ?' J?/SG/' ,H' J?B01D?DC.<' ?' 3,,B' 3,' E0==GC3' 32G' 0JJAD,-?32,B,1.' ,H' 0Dh?JJ?3,/.' E0=G?=G=>' m' 60,B' `G1AB'\,JG,=3'V1GD3='& ))l'&UX)U!$%)> !W>'' q?D1'm+<'R,DD.B?B'R<'V/DG33':+<'PG'+/,J5/A112G' 6<'c2,A'w>'V33GDA?30,D',H'GZ-/G==0,D',H'GZ3/?CGBBA$ B?/'J?3/0Z'1GDG='K032'=0`_V='3,'R-?/C'?DE'+31H'0D' =S0D'N5/,5B?=3=',H'+@^:'3/?D=1GD0C'J0CG>'7D3'm'7J$ JAD,-?32,B'b2?/J?C,B'& ))l'&#XU"U$% )> !">'' m,2D=3,D'V<'w0D1'w<'^AMJ?D'VT<'G3'?B[+79$):U<'$:%<' $:W<'?DE'$:"X'?'D,IGB'79$)'H?J0B.'=01D?B0D1'=.=3GJ' 32?3'0='?C30IG'0D'-=,/0?=0='?DE'-/,J,3G='SG/?30D,C.3G' ?D30J0C/,50?B' -G-30EG' GZ-/G==0,D>' m' 7JJAD,B' & ))l' )W%(#*X&%)!$&&>

# >'' R?I?=3?D,' R<' 6?B?3,' _<' ^?AE0GBB,' :<' P0' R,JJ?' +<' -=,/0?=0=' AD=?30=H?C3,/0B.' C,D3/,BBGE' 5.' G3?DG/CG-3'

J,D,32G/?-.X'?'/G3/,=-GC30IG'?D?B.=0=>';A/'m'7Dh?JJ' & )&l') X&!"$&#&>

&&>'' RC?/?JAMM,' 9<' T?D0C,DG' b:<' ^/?C0' +<' TA/?3,/0' :<' R-0DGBB0' TR<' P?J0=' ^<' `?HH?GBB0' 9<' T?CC?A/,' ^>' T,/-2,B,10C?B' J,E0NC?30,D=' 0D' ,=3G,?/32/030=X' ?' =C?DD0D1' GBGC3/,D' J0C/,=C,-.' =3AE.' ;A/' m' 7Dh?JJ' & ))l'"XO!$OW>

&!>'' _G1/GI' _<' @?=2GI' `<' `?EGI' `<' _D,1G0?D?S0' V<' 7I?D,I?' T>( \,/J,DG=' ,H' 2.-,32?B?J0C$-03A03?/.$ 32./,0E' ?Z0=' ?/G' =01D0NC?D3' /G1AB?3,/=' ,H' =.D32G=0=' ?DE'=GC/G30,D',H'I03?J0D']$EG-GDEGD3'-B?=J?'C,?1A$ B?30,D' H?C3,/=>' m' 60,B' `G1AB' \,JG,=3'V1GD3=' & ))l' &UX&)$&%>

&#>'' @2G,2?/0EG=' @+<' c2?D1' 6<' ]GJ-A/?s' P<' @?1GD' T<' a?=0?E0' T<' VD1GB0E,A' V<' VB.=?DE/?3,=' ]P<' ]?B,1G/,J03/,='P<'V=?E0'R<'R3?I/0?DG?='_<'bG3G/=,D' ;<' 9GGJ?D' R<' +,D30' b>' 79$!!' ?A1JGD3=' =A5=3?DCG' b$0DEACGE' a;^:' =GC/G30,D' H/,J' 2AJ?D' J?=3' CGBB=' ?DE'0='0DC/G?=GE'0D'-=,/0?30C'=S0D>'b/,C'_?3B'VC?E'RC0' LRV'& ) l') O("*X###W$U!> &U>'' P0'b0G3/,'T<'@/?J,D30'V<'PG'R?D30=':<'PG'60?=G'P<' RC20?I,D0'^<':0B?/E,'R<'c?1?1B0?'+<'RG==?'`>'VD?B.$ =0=',H'1GDG'GZ-/G==0,D'0D'-GD0C0BB0D'^'0DEACGE'-G/=0=$ 3GDCG' ,H' NJA=>*/:=+ D;)?>-;:=)>' m' 60,B' `G1AB' \,$ JG,=3'V1GD3='& )&l'&%X&OO$W#>

&%>'' R.JG,D0E,A' 7<' \?3M0=30B0?D,A' T<' b?-?E,-,AB,=' ;<' P,I?=' +7<' ]?/?1,AD0' ;<' b?--?' R<' b?D3M?/3M0' +_<' ],A/GB0='V<':/.E?='R>'RA=CG-3050B03.'?DE'/G=0=3?DCG'3,' C?D0DG'BG0=2J?D0,=0='0='?==,C0?3GE'3,'-,B.J,/-20=J=' ,H'32G'C?D0DG'@_:$f'1GDG>';A/'m'7Dh?JJ'& ))l'"X&!$ &"> &O>'' 6G/GD3$T?,M' 6<' R?BGJ0' R<' T?DSA3?' P<' R0J,D' \L<' 9GI0$RC2?HHG/' :>' \AJ?D' J?=3' CGBB=' GZ-/G==' 0D3/?CGBBAB?/'@`V79>'+GBB'7JJAD,B'& ) l'&%&(&*XW $ !> &W>'' 6A,D=GD=,'P<'b0//,D30'@<'^GD,IG=G'8<'^?/10ABB,'9<' `?DD,' 8<' a?BGD30D0' b>' R0EG' GHHGC3=' ,H' 32G' 0JJADG' =.=3GJX' BG==,D=' H/,J' 3A5G/CAB,=0=$/GB?3GE' 0JJADG' /GC,D=303A30,D' 0Dh?JJ?3,/.' =.DE/,JG>' ;A/' m' 7Dh?JJ'& )&l') X)$) >

&">'' \,D1'Q<'c2?,'wT<'\A?D1'99<'90'9<'+2GD'w9<'Q?D1' Pc>' RG/AJ' I0=H?30D' 0=' GBGI?3GE' 0D' +20DG=G' K,JGD' K032'-,B.C.=30C',I?/.'=.DE/,JG<'5A3'J0123'D,3'5G'?' /GB0?5BG'-/GE0C3,/',H'32G0/'1BAC,=G'0D3,BG/?DCG>'m'60,B' `G1AB'\,JG,=3'V1GD3='& )&l'&%X&&)$&&">

(7)

!!

<G6()6( LLP<7RFGH786(-HFJLFQ786

GD3' h?I,A/=X' ?' =A5sGC30IG' GI?BA?30,D>' m' 60,B' `G1AB' \,JG,=3'V1GD3='& )&l'&%X&!O$#!> U >'' c?DD?'b<'T?0E?'7<'@A/-0D'RGI0BB?'T+<'G3'?B>(T,BGCAB?/' C2?/?C3G/0M?30,D',H'D,IGB'JGB?D,J?'CGBB'B0DG=>'m'60,B' `G1AB'\,JG,=3'V1GD3='& ))l'&UX&!"$#O> U)>'' 6GBB,B0' 9<' +?/B,$R3GBB?' _<' L120' _<' T?/?=0D0' 6>( +?DCG/' 0D' 73?B0?D' -?30GD3=' K032' =.=3GJ0C' =CBG/,=0=>' ;A/'m'7Dh?JJ'& ))l'"X)U)$U%> U&>'' 6GD=GD' m@<' P?K=,D' bV<' T.C2?BGCS.s' m+<' 6,KEGD' Pq>'7EGD30NC?30,D',H'?'D,IGB'2AJ?D'C.3,S0DG'1GDG' 0D'32G'0D3G/BGAS0D'1GDG'CBA=3G/',D'C2/,J,=,JG'&i)&$ )#>'m'7D3G/HG/,D'+.3,S0DG'`G='& )l'&)())*XW""$" #> U!>'' T?CC?A/,' ^<' @/0-,E0' P<' R?110D0'V<' G3' ?B>' +?BC0AJ'

0,D,-2,/G' V&!)WO' ?DE' C,J-,ADE' #WFW ' 0DEACG' b^P&' ?DE' 3/.-3?=G' 0D' 2AJ?D' C,/E' 5B,,E$EG/0IGE' J?=3' CGBB=X' B?CS' ,H' GHHGC3' ,H' 79$)W>' ;A/' m' 7Dh?JJ' & )&l') X!!$#!>

U#>'' T?MM,CC,B0' ^<' ^0AB0?D0' :<' R,32G/D' `6>( V' JG32,E' 3,' GI?BA?3G' E.D?J0C=' ?DE' -G/0,E0C03.' ,H' 2,/J,DG' =GC/G30,D>' m' 60,B' `G1AB' \,JG,=3' V1GD3=' & ))l' &UX&!)$!W>

UU>'' ]?=-G/=S?$c?s?C' V<' +MGC0,/' ;<' ^/M?DS?' V<' T?C2A/?' ;<' T0=0,BGS' T>' @2G' 5B,,E' A/,S0D?=G' =.=3GJ'0D'-?30GD3='K032'=G?=,D?B'?BBG/10C'/20D030='?DE' C,DC,J03?D3' =G?=,D?B' ?=32J?' EA/0D1' -,BBGD' =G?=,D>' ;A/'m'7Dh?JJ'& ))l'"X&WU$WW>

U%>'' QG2' m9<' \=A' m\<' \,D1'QR<' qA' m`<' 90?D1' m+<' qA' 6_<'+2GD'7m<'90,A'R:>';A1GD,B,B'?DE'1B.CG/.B$0=,GA$ 1GD,B' =A--/G==' 9bR$0DEACGE' 0_8R' GZ-/G==0,D' 5.' E,KD$/G1AB?30D1'_:$S?--?6'V_P'Vb$)'32/,A12'0D$ 205030,D',H'TVb]R'?DE'V]@F7S?--?6?B-2?'=01D?B$ 0D1' -?32K?.=' 0D' J?C/,-2?1G=>' 7D3' m' 7JJAD,-?32,B' b2?/J?C,B'& ))l'&#X!#U$U%> UO>'' 9G?'q7<'9GG'Q\>'@2G'?==,C0?30,D='5G3KGGD'0D3G/BGA$ S0D$)'-,B.J,/-20=J='?DE'=A=CG-3050B03.'3,'?DS.B,=$ 0D1' =-,DE.B030=X' ?' JG3?$?D?B.=0=>' m,0D3' 6,DG' R-0DG' & )&l'O"(#*X!O $#>

UW>'' ],A/GB0=' @a<' T,A=3?S?S0=' T_<' R0BS' `<' b2?/J' P<' 6,/AC2,I' V<' 60B1/?J0' R:>' PGC03?50DG' H,/' ?CA3G' J.GB,0E' BGASGJ0?' 0D' ?' -?30GD3' ADEG/1,0D1' 2GJ,E0?B.=0=>';A/'m'7Dh?JJ'& ))l'"X&W"$&"&> U">'' b,J-G0' V<' @,D0?3,' ;<' 7DD,CGD30' b<' G3' ?B>' +.?D0E0D'

/GEACG=' -/G?E0-,C.3G' E0HHG/GD30?30,D' ?DE' /GB?30IG' +\`;6b'GZ-/G==0,D>'m'60,B'`G1AB'\,JG,=3'V1GD3=' & )&l'&%X&U!$%!> % >'' TGD120D0'9<'9G-,/0D0'9<'RC?DA'_<'b0D3,/G'^<'9?'`,$ 6/?DC?3,'a<'+,B?,'V<'V.?B?':<'@?/?D30D,'^>'7D=AB0D$ B0SG' 1/,K32' H?C3,/$)<' -=,/0?=0=<' ?DE' 0Dh?JJ?30,DX' ?' JxD?1G'y'3/,0=z';A/'m'7Dh?JJ'& ))l'"X&OO$W!> #)>'' R,M0,'b<'`?-0D,'T<'P0'a?BG/0,'a<'9?=G//?'R<'b?CGBB?'R<' P0'R3GH?D,'V<'+?3?BE0'V>'-b]+?B-2?$JGE0?3GE'GHHGC3' ,D':;+H:8.-+V5G3?'-/,EAC30,D'0D'/G=-,D=G'3,'1?JJ?' =GC/G3?=G' 0D20503,/' 9Q#))UOU' 0D' /?3' +@w@_V&' ?=$ 3/,C.3G=>'m'60,B'`G1AB'\,JG,=3'V1GD3='& )&l'&%X&#U$ U)>

#&>'' R20J0MA' Q<' P,5?=20' ]<' :AGS0' _<' :AGS0' T<' 8S?E?' @<' @,J0,S?' R<' T?S0D,' R<' T,/0' T>( +2?D1G=' ,H' 0JJAD,J,EAB?3,/.' C.3,S0DG=' ?==,C0?3GE' K032' ,J?B0MAJ?5' 32G/?-.' H,/' =GIG/G' -G/=0=3GD3' ?=32J?>' m' 60,B'`G1AB'\,JG,=3'V1GD3='& ))l'&UX)OO$W%>' #!>'' 6GB0M{/0,' m;>' b?32,1GD=' ?DE' EG?E' CGBB=' C,,-G/?3G' K032'C.3,S0DG='0D'?C30I?30D1'32G'0DD?3G'?DE'?E?-30IG' /G=-,D=G>';A/'m'7Dh?JJ'& ))l'"X)$))> ##>'' ^?BB0G/?' ;<' PG' ^0/,B?J,' 9<' `?DEGBB0' b<' G3' ?B>( \012' ?/30CAB?/'BGIGB=',H'32G'?D10,1GDG30C'H?C3,/='a;^:'?DE' a;^:$/GCG-3,/'&'?='30==AG'2G?B0D1'50,J?/SG/='?H3G/' =0D1BG'5ADEBG'?D3G/0,/'C/AC0?3G'B01?JGD3'/GC,D=3/AC$ 30,D>'m'60,B'`G1AB'\,JG,=3'V1GD3='& ))l'&UXWU$")> #U>'' _?/A0=20' ]<' 8J,/0' ]<' T?GE?' \<' G3' ?B>' 7JJADG'

/G=-,D=G=' 3,' P-.DJ*.->-;=0+ B:;B:H=A:0+ 0DHGC30,D' =A--/G==' =.=3GJ0C' 0Dh?JJ?3,/.' /G=-,D=G' 0D' GZ-G/0JGD3?B' JA/0DG' J,EGB>' m' 60,B' `G1AB' \,JG,=3' V1GD3='& ))l'&UX)"U$& &>

#%>'' T?125,,B0' c<' \,==G0D$_GM2?E' V<' R20/M?E' T<'' 6G2M?E0'\>'@2G'/,BG',H',=3G,-/,3G1/0DF'DACBG?/'H?C3,/' |5'B01?DE'0D'C,/,D?/.'C,BB?3G/?B'EGIGB,-JGD3'';A/'m' 7Dh?JJ'& ))l'"XUO$%#> #O>'' 90A'\<'9G,'+<'+2GD'w<'q,D1'6`<'q0BB0?J='9@<'90D' \<'\G'w>'@2G'JGC2?D0=J',H'=2?/GE'5A3'E0=30DC3'+R:$ )`'=01D?B0D1'5.'32G'D,D$2,J,B,1,A='C.3,S0DG='79$!#' ?DE'+R:$)>'60,C20J'60,-2.='VC3?'& )&l')W&#X"!W$ #U> #W>'' T?=AGBB0' 9<' b,J-?' ^<' :?5/0M0' T<' G3' ?B>' b?30GD3=' K032' -G/00J-B?D3030=<' ADB0SG' 32,=G' K032' ?' 2G?B32.' -G/0$0J-B?D3' J0C/,GDI0/,DJGD3<' E0=-B?.' ?D305,E0G=' 3,'J,/G'32?D',DG'2G?3'=2,CS'-/,3G0D'(\Rb'&O<'\Rb' %U'?DE'\Rb'" *'B0DG?/'G-03,-G>';A/'m'7Dh?JJ'& ))l' "X&UO$%O> #">'' ^?/M?/,'T<'`?0J,DE,'9<'bGC,/?/0'^<'`0I?'^<'RGD=0$ D0'T<'_?iG'_<'^0,/E?D,'+>'b?B?3?50B03.<'E01G=3050B03.' ?DE'GJ,30,D?B'-?33G/D'0D'% '2G?B32.'I,BAD3GG/='?H3G/' 0D1G=30,D',H'?D'0CGE'EG==G/3'-/G=GD3GE'0D'H,A/'E0HHG/$

(8)

!#

DA3/?CGA30C?B' 0D3G/IGD30,D>' m' 60,B' `G1AB' \,JG,=3' V1GD3='& ))l'&UX&&)$&"> O)>'' @?/?S?D,I'7<'@0S2,J0/,I?'9<'@?/?=,I?'_<'R?H,D,I'a<' 60?BS,K=S?'T<'b,S,/=S0'T>(^V6V'/G-/G=GD3?30,D'0D' 2.-,Z0?'=GD=0D1X'?'IGD30B?3,/.'=3AE.'0D'32G'/?3>'m'60,B' `G1AB'\,JG,=3'V1GD3='& ))l'&UX)%"$OU> O&>'' R0B?J5?/?=?D' ^<' `?J?D?32?D' @<' _?5GGB' TV<' ]?B?0C2GBI?D' a]<' ]?320/G=?D' ]<' 6?B?=A5/?J?D0?D' @>' VD30$0Dh?JJ?3,/.' ?C30I03.' ,H' 32G' J?/0DG' C.?D,5?C3G/0AJ' 8.:7J-/)0>:?>+ ).*8J.=)?>+ ?1?0D=3' C?//?1GGD?D$0DEACGE' -?K' ,GEGJ?' 0D' K0=3?/' ?B50D,' /?3=>';A/'m'7Dh?JJ'& ))l'"XU!$U%> O!>'' T?/,33?' :<' _?03,'Q<' m?0D' R<' 9,/GDMG330'V<' R,/G=0'a<' ]AJ?/0'V<' +?//G/?' 6?=3,=' b<' @,JGBB?' +<'Q?E?I' \>' 7=' 32G/G' ?' -,3GD30?B' ?--B0C?30,D' ,H' ?' HG/JGD3GE' DA$ 3/?CGA30C?B'0D'?CA3G'/G=-0/?3,/.'0BBDG==G=z'VD':;2H:H-+ -B?CG5,$C,D3/,BBGE<'C/,==$,IG/'CB0D0C?B'=3AE.'0D'E0H$ HG/GD3'?1G'1/,A-=',H'2G?B32.'=A5sGC3=>'m'60,B'`G1AB' \,JG,=3'V1GD3='& )&l'&%X&WU$"#> O#>'' 90D'\<'9GG';<'\G=30/']<'G3'?B>'P0=C,IG/.',H'?'C.3,S0DG' ?DE'03='/GCG-3,/'5.'HADC30,D?B'=C/GGD0D1',H'32G'GZ3/?$ CGBBAB?/'-/,3G,JG>'RC0GDCG'& Wl'!& (UWOO*XW O$))> OU>'' T?/,33?':<'+2A0'P\<'Q?E?I'\<'9,/GDMG330'V<'+GBG-' ^<'m?0D'R<'6,J5?'V<'b,B0JGD0'V<'c2,D1']<'VBBG1/0' :>';HHGC30IG'-/,-G/30G=',H'?'=3A/1G,D$5?=GE'50,?C30IG' C,J-,ADE',D'=3/G==$0DEACGE'20--,C?J-?B'EG1GDG/?$ 30,D'?DE',D':;+H:8.-+DGA/,1GDG=0=>'m'60,B'`G1AB'\,$ JG,=3'V1GD3='& )&l'&%X!&O$!U> O%>'' @?/?D30D,'^<'+,B?,'V<'+?-,DG'P<'G3'?B>(+0/CAB?30D1' BGIGB=' ,H' C.3,C2/,JG' C<' 1?JJ?$1BA3?J.B' 3/?D=HG/$ ?=G<'3/01B.CG/0EG='?DE'ADC,DsA1?3GE'50B0/A50D'0D',IG/$ KG0123F,5G=G'-?30GD3='K032'D,D$?BC,2,B0C'H?33.'B0IG/' E0=G?=G>'m'60,B'`G1AB'\,JG,=3'V1GD3='& ))l'&UX#O$ U%> OO>'' c2?D1'm<'c2A'm$R<'c2,A'c<'+2GD'q$w<'+2GD'_$q>' @2G/?-GA30C' GHHGC3=' ,H' G32.B' -./AI?3G' ,D' 3AJ,/' 1/,K32' ?DE' JG3?=3?=0=' 0D' ?' =GIG/G' C,J50DGE' 0JJAD,EGNC0GDC.' J,A=G' ,/32,3,-0C' 0J-B?D3?30,D' J,EGB>';A/'m'7Dh?JJ'& )&l') X&U$!&>

OW>' 90D' \<' G3' ?B>+ +B,D0D1' ?DE' C2?/?C3G/0M?30,D' ,H' 79$ )\Q&<'?'D,IGB'0D3G/BGAS0D$)'H?J0B.'JGJ5G/>''m'60,B' +2GJ'& )l'&O%X& U"O$% &>

O">'' P?2?J=2G2'c<'6GBB,J,'`^<'R?110D0'`<'6?/?==0'^<' R?110D0'V>'@2G'-/GI?BGDCG',H'/2GAJ?3,0E'?/32/030='0D' 32G'=,A32',H'm,/E?D>';A/'m'7Dh?JJ'& ))l'"X&"!$"U> W >'' `A0M$bx/GM' Ta<' R{DC2GM$m0JxDGM' :<' vAG=?E?' V`<' IG/G'`<'P0':0B0--,';R<'b0G3/?D1GB,'@<':ABBG'R>(;HHGC3' ,H' -2.3,C2GJ0C?B' C,DCGD3/?30,D=' ,D' 50,B,10C?B' ?C$ 30I030G=',H'C/?D5G//.'GZ3/?C3=>'m'60,B'`G1AB'\,JG,=3' V1GD3='& ))l'&UX&O$!U>' %)>'' @,KDG'm;<'^?/S?'];<'`GD=2?K'6`<'a0/C?'^P<'R0J=' m;>' 7D3G/BGAS0D' (79*$):%<' 79$):W<' ?DE' 79$):"' =01$ D?B'32/,A12'79$)`/-&'?DE'79$)`VCb'3,'?C30I?3G'32G' -?32K?.'BG?E0D1'3,'_:$S?--?6'?DE'TVb]=>'m'60,B' +2GJ'& #l'&O"()#*X)!%OO$WW>

%&>'' c2A' m$R<' wA' c$b<' R,D1' T$v<' c2?D1' v>' ;HHGC3' ,H' ,Z.J?3/0DG' C,J50DGE' K032' B,K' E,=G' U$:L' ,D' B.J-2?30C' IG==GB' ?DE' J0C/,I?=CAB?/' GDE,32GB0?B' CGBB' 1/,K32' ,H' 1?=3/0C' C?DCG/' 0D' ?' =GIG/G' C,J50DGE' 0JJAD,EGNC0GD3' J,A=G' ,/32,3,-0C' 0J-B?D3?30,D' J,EGB>';A/'m'7Dh?JJ'& ))l'"X#U$U)> %!>'' vA0D3G/,'b<'^,DM{BGM$TAD0G=?'b<'T?/3}DGM'mV>(7DhA$ GDCG',H'E0HHG/GD3',Z.1GD'=A--B.',D'JG3?5,B0C'J?/S$ G/='?DE'1GDG'/G=-,D=G'0D'JA/0DG'?E0-,C.3G=>(m'60,B' `G1AB'\,JG,=3'V1GD3='& )&l'&%X!O"$WW> %#>'' c2?D1' +$Q<' R2?,' R$\<' +2GD' w<' R20' Q$9>' VD30$ H/,=3503G' GHHGC3=' ,H' D.?;?0+ 8->);8-0=+ 8J?;\+ 3,3?B' h?I,DG'';A/'m'7Dh?JJ'& ))l'"X%U$O)> %U>'' T?/M?D,'Va<'+A1D,'T<'@/GI0=?D'a<'9?MM?/0'`<':?D,$ D0'P<'6G/30';<'+/,=30'+>'7Dh?JJ?3,/.'CGBB=<'C.3,S0DG=' ?DE'J?3/0Z'JG3?BB,-/,3G0D?=G='0D'?J0C/,50?B'-A=3AB,$ =0=',H'32G'H,BE='?DE',32G/'DGA3/,-20B0C'EG/J?3,=G=>'7D3' m'7JJAD,-?32,B'b2?/J?C,B'& ))l'&#X#U)$% > %%>'' P0BGS':\<'R?20D'8<'@,S.,B'+<'T?MBAJ'T<'V.C0CGS' V>';Z-/G==0,D',H'C.CB,,Z.1GD?=G$)'?DE'&'0D'C2/,D0C' 3,D=0BB030=>'7DE0?D'm'b?32,B'T0C/,50,B'& ) l'U!(!*X#U)$ #>'

%O>'' ^A0BBxD' P<' T0BB{D' 8<' 6/ADG3' T>( ";+ H:8.-+ =3AE0G=' ,H' 32G' 0JJAD,J,EAB?3,/.' GHHGC3=' ,H' =3?30D=' ?B,DG' ?DE' 0D'C,J50D?30,D'K032'0JJAD,=A--/G==0IG'E/A1=>';A/' m'7Dh?JJ'& ))l'"X))O$&#>

%W>'' RC2AJ?DD'm<'ToBBG/'L<'6BG==0D1'T>'@^:$g'=01D?B0D1' 0D'@'CGBB='0='D,3'G==GD30?B'H,/'@2)O'CGBB'EGIGB,-JGD3' 0D' 32G' J,A=G>' m' 60,B' `G1AB' \,JG,=3'V1GD3=' & )&l' &%X!UO$%%>

%">'' P0' b?,B?' `<' T?MM,D' ;<' b?3G/D030' 7<' 7J-GBB0MMG/0' P<' 6/?J?D30'b<'+AMM,C/G?'R>(V-,C.D0D<'?'-B?D3$EG/0IGE' E/A1<'J0123'5G'A=GHAB'0D'32G'3/G?3JGD3',H'J.,C?/E0?B' 0=C2GJ0?' /G-G/HA=0,D' 0DsA/.' 0D' /?3' 2G?/3=>' ;A/' m' 7Dh?JJ'& ))l'"X)%"$O#>

O >'' T?/,33?':<'_?03,'Q<'b?E/0D0':<'G3'?B>(`GE,Z'5?B?DCG' =01D?BB0D1' 0D' ,CCA-?30,D?B' =3/G==X' J,E0NC?30,D' 5.'

(9)

!U

<G6()6( LLP<7RFGH786(-HFJLFQ786

EGDE/,C.3G' -/,1GD03,/' GZ-?D=0,D>' m' _GA/,=C0' & )!l' !!()*X)OU$W%> " >'' +2?3M,I,AB,=' b<' @=,A-/?=' V6<' R?J0,3?S0' T<' b?D?.,3,A' ^<' PGJ,-,AB,=' +V<' P,3=0S?' ;>' bV:' JG3?5,B0C' GDM.JG=' ?DE' bV:$B0SG' ?C30I03.' 0D' '[+ :;E=;8?>+?DE''[+>=`-.+-/,J?=301,3G=>';A/'m'7Dh?JJ' & ))l'"X&!)$!"> ")>'' T?MM,CC,B0'^<'+?0'Q<'90A'R<':/?DC?I0BB?'T<'^0AB0?D0' :<'b0G-,B0'V<'b?M0GDM?'a<'a0DC01AG//?'T<'Q?J?J,3,' @<'@?SAJ0'@>'% R2 %F=ADJ=+?DE'32G'CB,CS'1GDG'J?$ C20DG/.'0D'J,A=G'-G/0-2G/?B'30==AG=X'?'-,==05BG'/,BG' ?=' ?' =.DC2/,D0M0D1' 20D1G>( m' 60,B' `G1AB' \,JG,=3' V1GD3='& )&l'&%X&%U$O%> "&>'' ;=-,=03,'^<'`,==0':<'T?33G0D0'b<'bAC?'V<'VB5?DG=G'V<' R?5?30D,'^<'T?0/?'^<'b0D0'`>'b/G=GD3'=3?3A='?DE'DGK' -G/=-GC30IG=' 0D' B?=G/' KGBE0D1' ,H' I?=CAB?/' 30==AG=>' m' 60,B'`G1AB'\,JG,=3'V1GD3='& ))l'&UX)#U$U&> "!>'' I?D'EG'aGG/E,DS':9<'R3,GCSJ?D'V]<'qA'^<'6,GCS$ G/J?DD'V_<'VM?J'@<'_G3G?'T^<'m,,=3GD'9V<'I?D'EG/' TGG/'mq<'\?,'`<']?B?5,S0='a<'P0D?/GBB,'+V>'79$!W' 50DE='3,'32G'79$!%'/GCG-3,/'?DE'2?='50,B,10C?B'GHHGC3=' ,D'0JJADG'CGBB='=0J0B?/'3,'79$!%'/GCG-3,/'?D3?1,D0=3>' b/,C'_?3B'VC?E'RC0'L'R'V'& )&l') "(W*X! )$U> "#>'' a01DG'R<'b?BJG/'^<'9?J?CC20?'+<'T?/30D'b<'@?B?5,3$

V.G/' P<' `,E/01AGM' ;<' `,DC20' :<' R?BBA=3,' :<' P0D2' \<' R0J=' m;<' ^?5?.' +>' 79$!%`' B01?DE=' ?/G' -,3GD3' /G1AB?3,/=' ,H' EGDE/030C' ?DE' @' CGBB=>' 6B,,E' & ))l' ))W(&&*XUW)!$&!>'

"U>'' \,==G0D$_GM2?E' V<' T0/M?G0' ]<' V=B?D0' R<' @,,3GG' V<']?/0J0':>(T7:'GZ-/G==0,D'0D'0DEACGE'-G/0-2G/?B' 5B,,E' J,D,DACBG?/' CGBB=' 5.' I03?J0D' P!' ?DE' 03=' -,3GD30?B' C,//GB?30,D' K032' /G=30D1' JG3?5,B0C' /?3G' 0D' ,5G=03.>';A/'m'7Dh?JJ'& ))l'"X)&U$!#> "%>'' PrVB0J,D3G'7<'_?/10';<'T?=3/?D1GB,':<'G3'?B>'a?=CAB?/' GDE,32GB0?B'1/,K32'H?C3,/'GD2?DCG=':;+H:8.-+-/,B0HG/?$ 30,D'?DE',=3G,1GD0C'E0HHG/GD30?30,D',H'2AJ?D'EGD3?B' -AB-'=3GJ'CGBB=>'m'60,B'`G1AB'\,JG,=3'V1GD3='& ))l' &UXUO$%">

"O>'' 6,/E01D,D' a<' 6AB3/0D0' R<' b/01D?D,' ^<' G3' ?B>( \012' -/GI?BGDCG' ,H' B?3GD3' 3A5G/CAB,=0=' 0DHGC30,D' 0D' ?A3,0JJADG' E0=,/EG/=' =AC2' ?=' -=,/0?=0=' ?DE' 0D' C2/,D0C' /G=-0/?3,/.' E0=G?=G=<' 0DCBAE0D1' BAD1' C?DCG/>' m'60,B'`G1AB'\,JG,=3'V1GD3='& ))l'&UX&)!$&& > "W>'' :?/,,i'T<'_?S?0'\<':As0J,3,'V<':As0S?K?'\<'T?3$ =A.?J?'V<']?/0.?'_<'V0M?K?'V<':As0K?/?'\<'73,'T<' R20J,JA/?' Q>' TA3?30,D' ?D?B.=0=' ,H' 32G' 79!%`_' TGE0D?' TV>( V' /G$GI?BA?30,D' ,H' 32G' J03,1GD0C' GH$ HGC3',H'=G/,3,D0D',D'I?=CAB?/'GDE,32GB0?B'CGBB=>'m'60,B' `G1AB'\,JG,=3'V1GD3='& ))l'&UX)!$& >' W)>'' b/A=';<':05?C2';>'@2G'?D30,Z0E?D3'GHHGC3',H'HG/JGD3GE' -?-?.?' -/G-?/?30,D' 0DI,BIG=' 0/,D' C2GB?30,D>' m' 60,B' `G1AB'\,JG,=3'V1GD3='& )&l'&%X& !$) >

W&>'' R0=J?D,-,AB,=' _<' PGB0I?D0=' PV<' VB.=?DE/?3,=' ]P<' VD1GB0E,A' V<' @2G/0?D,A' V<' ]?B,1G/,J03/,=' P<' @2G,2?/0EG=' @+>' T?=3' CGBB=' 0D' ?BBG/10C' ?DE' 0Dh?JJ?3,/.' E0=G?=G=>' +A//' b2?/J' PG=' & )&l' )W()%*X&&%)$OO> W!>'' T01B0,/G'V<' T?==?H/?' L<' 60MM0' ;<'a?CC?' :<' T?/30D$ T?/30D' 9R<' ^/?D?3?' T<' @,/JGD3?' R<' 9?1?Dy' 6>' ;HNC?C.' ?DE' =?HG3.' -/,NBG' ,H' 0D3/?$?/30CAB?/' ?EJ0D0=3/?30,D',H'm,0D3GZ~'0D'-?30GD3='=AHHG/0D1'H/,J' =.J-3,J?30C'20-',=3G,?/32/030=X'?D',-GD<'-/,=-GC30IG' =3AE.' K032' ?' )&$J,D32' H,BB,K$A->' ;A/' m' 7Dh?JJ' & ))l'"X&%"$O%> W#>'' VD1GB0D0' V<' +GD3A/0,DG' 9<' R?DC0B0,' RV<' +?=3GBB?D0' T9<'+,D30'b<'P0'7B0,'+<'b,//GC?';<'+ACCA/ABB,':<'P0' b0G3/,' `>( @2G' GHHGC3' ,H' 32G' -B?=30C0MG/' E0G32.B2GZ.B' -232?B?3G' ,D' 3/?D=-,/3' ?C30I03.' ?DE' GZ-/G==0,D' ,H' b$1B.C,-/,3G0D'0D'-?/GD3?B'?DE'E,Z,$/G=0=3?D3'2AJ?D' =?/C,J?' CGBB' B0DG=>' m' 60,B' `G1AB' \,JG,=3' V1GD3=' & ))l'&UX& !$))> WU>'' TG0'Q<'b?D':<'^?,'m<'G3'?B>'7DC/G?=GE'=G/AJ'79$)O'?DE' 79$&!'0D'32G'-?30GD3'K032'?DS.B,=0D1'=-,DE.B030=>'+B0D' `2GAJ?3,B'& ))l'! X&%"$O!> W%>'' 6G/?/E0' P<' PG' 6GDGE0330=' R<' RC,CC0?'V<' bG/HG330' ^>( ;I?BA?30,D' ,H' DG/0E/,D?3G' ,D' 32G' ,==G,0D3G1/?30,D' -/,CG==' ,H' GDEG,A=' 303?D0AJ' 0J-B?D3=' 0D' ?D0J?B' J,EGB=>';A/'m'7Dh?JJ'& ))l'"X)#)$#"> WO>'' T?/,33?' :<' +2A0' P\<' m?0D' R<' b,B0JGD0'V<' ],0SG' ]<' c2,A'9<'9,/GDMG330'V<'R20J0MA'\<'Q?D1'\>(;HHGC3',H' ?' HG/JGD3GE' DA3/?CGA30C?B' ,D' 320,/GE,Z0D' BGIGB' ?DE' @_:$f'=01D?BB0D1'0D'C0//2,30C'-?30GD3=>'m'60,B'`G1AB' \,JG,=3'V1GD3='& ))l'&UX!O$#U>' WW>'' RGE/0G-'R<'w0?'w<'T?/,33?':<'c2,A'9<'Q?E?I'\<'Q?D1' \<'R,/G=0'a<'+?3?DM?/,'`<'c2,D1']<'b,B0JGD0'V<'+2A0' P\>(6GDGNC0?B'DA3/?CGA30C?B'J,EAB?30,D',H'CG/G5/?B' G/.32/,-,0G30D' GZ-/G==0,D' ?DE' ,Z0E?30IG' =3/G==X' ?D' GZ-G/0JGD3?B' =3AE.>' m' 60,B' `G1AB' \,JG,=3' V1GD3=' & ))l'&UX)WO$"#>

W">'' 7=200'V<' :A/A=2,' T<' 6?D=?B' `>' RA=3?0DGE' ?C30I?30,D' ,H';`])F&'TVb]'0D',B01,EGDE/,C.3G='?DE'RC2K?DD' CGBB=' GD2?DCG=' J.GB0D' 1/,K32' ?DE' =30JAB?3G=' ,B01,$

(10)

!%

K032',/?B'JAC,=?B'1/?H3>';A/'m'7Dh?JJ'& ))l'"X)OU$W!> ) U>']?=?CS?' 7<' b0,3/,K=S?' <' +?/' \<' m?D0AS' 7<' €G5S,K=S0'q>'+,C?0DG$'?DE'?J-2G3?J0DG$/G1AB?3GE' 3/?D=C/0-3'X'0EGD30NC?30,D'?DE'E0=3/05A30,D'0D'2AJ?D' 1?=3/,0D3G=30D?B'3/?C3>'m'60,B'`G1AB'\,JG,=3'V1GD3=' & )&l'&%X#)"$&W> ) %>'b0MM0C?DDGBB?' m<' `?5,MM0' `<' @/A50?D0' 8<' P0' ^0?J$ J?/C,' ^>( \0=30E0DG$3/.-3,-2?D$SG3,1BA3?/?3G' =,BA$ 30,D'2GB-='3,'-/G=G/IG'GDE,32GB0?B'0D3G1/03.',H'=?-2G$ D,A='IG0DX'?D'0JJAD,20=3,C2GJ0C?B'?DE'AB3/?=3/AC$ 3A/?B' ?D?B.=0=>' m' 60,B' `G1AB' \,JG,=3'V1GD3=' & ))l' &UX"!$"">

) O>'6,=J?DD'T<'q?/E'bV>'@2G/?-GA30C'-,3GD30?B',H'3?/$ 1G30D1' 79$)O' ?DE' 79$&!' 0D' =G-=0=>' +B0D' @/?D=B' TGE' & )&l')()*X#$)&>

) W>'@=,AC?B?=' ^<' ]?/?J?D,A' ' T<' VDE/,A3=,=' ^>' @/?IGBB0D1' 32/,A12' 30JG' K032' ?=-0/0D<' ?' 2G?B0D1' C,J-?D0,D>(;A/'m'7Dh?JJ'& ))l'"X)!$)%>

) ">'aG//?330' a<' 6/ADG330' 9<' @GD?1B0?' `<' +20?I?/,B0' V<' :G//?D3G'+<'9G,DG'R<'8/B?DE,'^<'6G/?/E0DGBB0':<'P0' ^0AB0,'+<'a?CC?'T>(b2.=0,B,10C?B'?D?B.=0=',H'W$7=,$ b^:&' ?B-2?X' ?' 2,JG,=3?30C' ?1GD3' 0D' =A-G/NC0?B' 5B?EEG/'C?DCG/>'m'60,B'`G1AB'\,JG,=3'V1GD3='& ))l' &UXO)$O%> )) >'b,J-?' ^<' 601D,MM0' 7<' +/0=3?BB0' Tb<' vA?/?D3?' V<' P0' +?/B,' R<' VDD05?B0' R>' 60=-2,=-2,D?3G' ?DE' ,=3G,DGC/,=0=' ,H' 32G' s?KX' 32G' ,/?B' =A/1G,Dr=' -G/=-GC30IG>';A/'m'7Dh?JJ'& )&l') X))$&!>

^GDG'0D')#'m?-?DG=G'-?30GD3='K032'1GDG/?B0MGE'-A=3A$ B?/'-=,/0?=0=>'\AJ'TA3?3'& )!l'!#()*X)O%$W!> "">' @=,A-/?=' V6<' +20D0' T<' @=,1?=' _<' T?D1?H?=' _<' PGJ,-,AB,='+V<'9?M?D?='T+>(";+H:H-+GHHGC3=',H'?' S:;9B-+ \:A-\=+ GZ3/?C3' ,D' -B?3GBG3' ?C30I?30D1' H?C3,/' JG3?5,B0=J' 0D' 3K,' ?=.J-3,J?30C' \7a$0DHGC3GE' -?30GD3=>';A/'m'7Dh?JJ'& ))l'"X) O$)%> ) >'9ACC2G=G' V<' ^2G/B,DG' ;<' b,/3GBB0' T<' 6G/3,==0' P>' @,,32' ,/32,E,D30C' J,IGJGD3' ?H3G/' J?Z0BB,H?C0?B' =A/1G/.>';A/'m'7Dh?JJ'& )&l') X&&O$!&>

) )>'^?I/0B,I0'9<'T?DEA‚0'a<'R3,s0BsS,I0'a<']?=?-,I0' m<' R3,s0BsS,I0' R<' b?s,I0' R6<' P/,Ds?S' R>' ;HHGC3' ,H' C2/,D0C' H,/CGE' /ADD0D1' ,D' 1GDG' GZ-/G==0,D' ,H' C?3G$ C2,B?J0DG'50,=.D32G30C'GDM.JG='0D'=3GBB?3G'1?D1B0?',H' /?3=>(m'60,B'`G1AB'\,JG,=3'V1GD3='& )&l'&%X!%O$OO> ) &>'bG3/AMM0' T<' +?J-A=' ^<' b?-?/A==,' :<' 9ACC2G=G' V<'

9?A/03?D,'P<'PG'6GDGE0330='T<'RG/-0C,'`>'VD?B.=0=' ,H' -B?=J?' N5/,DGC30D' BGIGB=' 0D' -?30GD3=' ?HHGC3GE' 5.' ,/?B'B0C2GD'-B?DA=>';A/'m'7Dh?JJ'& )&l') X#U$U > ) !>'_,M?S0'Q<' ]0D,=203?' ]<'Q?D,' @<'V=?3,' ]<' R201?' @<'

\0D,' R<' _0S0' ]<' _?1?/G'Q<' ]0=20J,3,' ]<' R20J?MA' \<':AD?AC20'T<'T?3=AJA/?'7>'R01D?B0D1'32/,A12'32G' 0D3G/BGAS0D$)W' /GCG-3,/' f' ?33GDA?3G=' 0Dh?JJ?30,D' 0D'C0=-B?30D$0DEACGE'?CA3G'S0EDG.'0DsA/.>']0EDG.'7D3' & )&l'W&(W*XW"&$" &>'

) #>'`,J?D,'^<'6?/5?1B0'^<'9?MMG/0'T>(@2G'A=G',H'3,-0C?B' 2.?BA/,D0C'?C0E'?DE'=0BIG/'=ABH?E0?M0DG'(VB3G/1GD~*'0D' -?30GD3=' ADEG/1,0D1' 3K,$=3?1G' ?D3G/0,/' A/G32/,-B?=3.'

Riferimenti

Documenti correlati

CALCOLO DEL PREMIO CON APPLICAZIONE DELLA

mantenere i loro affetti I figli hanno il diritto di continuare ad essere figli e di vivere la loro età8. I figli hanno il diritto di essere

[r]

[r]

[r]

wû pýûyü

[r]

H eeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeee W8eeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeAf U8 6HI eeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeW... g7