• Non ci sono risultati.

VISUAL EVOKED POTENTIALS IN INFANTS AFTER DIETARY SUPPLY OF DOCOSAHEXAENOIC ACID AND 5- METHYLTETRAHYDROFOLATE DURING PREGNANCY

N/A
N/A
Protected

Academic year: 2021

Condividi "VISUAL EVOKED POTENTIALS IN INFANTS AFTER DIETARY SUPPLY OF DOCOSAHEXAENOIC ACID AND 5- METHYLTETRAHYDROFOLATE DURING PREGNANCY"

Copied!
2
0
0

Testo completo

(1)

VISUAL EVOKED POTENTIALS IN INFANTS AFTER DIETARY SUPPLY OF

DOCOSAHEXAENOIC ACID AND 5-

METHYLTETRAHYDROFOLATE DURING PREGNANCY

I. Broekaert

1

, C. Campoy

2

, C. Iznaola

3

, B. Hoffmann

1

, W. Müller- Felber

4

, B. Koletzko

1

1

Division Metabolic Diseases and Nutrition, Dr. von Hauner Children’s Hospital, Ludwig Maximilian University, Munich, Germany;

22

Department of Paediatrics, University of Granada, Spain;

3

Neurophysiology Service, Un N N iversity Hospital, Granada, Spain;

44

Friedrich-Baur-Institute, Ludwig Maximilian University, Munich, Germany

Introduction: Docosahexaenoic acid (DHA) plays an important role in the visual development of infants and is preferentially transferred across the placenta. Supplementation with folic acid in pregnancy might enhance placental DHA transfer.

Methods: Women recruited in Spain (S) and Germany (G) were randomized to 4 supplementation groups: 0,5 g DHA and 0,4 mg 5-methyl-tetrahydrofolate (5- MTHF)/d, 0,5 g DHA/d, 0,4 mg 5-MTHF/d or placebo from week 20 of gestation until birth. Infants not fully breastfed were supplied with formulae +DHA according to the nutritional code assigned. Cortical visual evoked potentials (VEPs) were obtained at the age of 8 weeks. 249 pregnant women (152 S, 97 G) were recruited and in 109 children (77 S, 32 G) cortical VEPs suitable for evaluation were obtained.

Results: No significant differences in latencies, amplitudes and calculated minimal angle of resolution were detected between the 4 supplementation groups (S and G both separately and combined). The analysis of combined groups with DHA and without DHA showed a significant difference in the minimal angle of resolution between the DHA vs. non-DHA groups (1.4’+7.7’

vs. 3.0’+4.9’, p<0.05).

Conclusions: The maternal supply of 500 mg DHA per day from week 20 of gestation significantly enhanced infant visual resolution of 8 weeks after births.

201

(2)

202 I. Broekaert et al.

Key words: cortical visual evoked potentials, visual development, docosahexaenoic acid, 5-methyltetrahydrofolate

Disclosure: The project has been supported by the Commission of the European

Union within the 5

th

framework program (research grant nutrition an healthy

lifestyle (NUHEAL), grant no. CLK1-CT-1999-00888).

Riferimenti

Documenti correlati

Aims of the study are to improve feed formulation and optimize feed additives such taurine, as well as butyrate, salt of a short chain fatty acid (SCFA), to protect fish intestine

Department of Clinical Radiology University Hospitals – Grosshadern Ludwig Maximilian University of Munich Marchioninistrasse 15.. 81377

Key factors of fast-track surgery involve thorough patient education, a multidisci- plinary team approach to surgical management, epidural anesthetic administra- tion, and

The features used for the attack and the defense model is only obtained by RSS channel model that use A+S, because the defense models that used RSS channel model with A+S+F are

• Dijkstra’s algorithm for the global navigation, that is used for compute the path from the current position and the local goal.. The local goal is selected using a greedy

• Length of segment between 15 and 60 seconds, normally used 30-second intervals As last point, we observe the power spectrum of the neural signals in these segments and we

It is recent news that the “New Guidelines for internal architectures in schools” (Italian Ministerial Decree April 11 th 2013) have been approved, whose inspiration is drawn from

Indeed, in order to evaluate if iPA could be a useful agent able to inhibit tumor angiogenesis, we tested in vitro the ability of iPA to arrest the proliferation and