ARGANTE BOZZI – Curriculum scientifico ed elenco pubblicazioni:
Prof. ARGANTE BOZZI (Breve Curriculum Vitae)
Argante Bozzi, nato a Monterado (An) il 26.01.1946, si è laureato in Scienze Biologiche nel novembre 1969 presso l’Università di Roma “La Sapienza” discutendo una tesi sperimentale dal titolo “Effetti degli antibiotici polienici su cellule tumorali”. Dal Dicembre 1973 è stato Assistente di ruolo presso la prima Cattedra di Chimica Biologica della Facoltà di Medicina e Chirurgia , e , dal 1982 al 1990 , Professore Associato di Biochimica Cellulare presso la Facoltà di Medicina e Chirurgia dell'Università di Roma "La Sapienza". Dal 1 novembre 1990 è Professore Ordinario di Biochimica (BIO-10) presso la Facoltà di Medicina e Chirurgia dell'Università dell'Aquila. Dal 1992 al 2000, è stato Coordinatore del Dottorato di Ricerca in Enzimologia Applicata alle Scienze Mediche con sede amministrativa presso il Dipartimento di Scienze e Tecnologie Biomediche dell'Università dell'Aquila. Dal 2000 al 2004, è stato Coordinatore del Dottorato di Ricerca in Scienze Biochimiche e Psicobiologia dei Processi Cognitivi. A partire dal 2004, è Coordinatore del Dottorato di Ricerca in Scienze Biochimiche e Neuroscienze. Negli anni accademici 1972-73 e 1973-74 è stato Professore Incaricato di Chimica Biologica presso la Facoltà di Medicina e Chirurgia dell'Università Nazionale Somala a Mogadiscio. Nell'Ottobre 1972 ha vinto una borsa di studio della European Molecular Biology Organization (E.M.B.O.), presso l'Istituto di Radioterapia e Cancerologia dell'Università di Ghent (Belgio), per una ricerca sugli aspetti biochimici della invasività delle cellule neoplastiche e l'interazione tra cellule embrionali e tumorali, utilizzando come modello sperimentale blastodermi di embrioni di pollo. Dal Gennaio 1983 al Marzo 1984 e, nell’Agosto- Settembre dello stesso anno, ha soggiornato in qualità di “visiting scientist” presso il Laboratory of General and Comparative Biochemistry, National Institutes of Health, (N.I.H.), Bethesda, MD (U.S.A.), nell'ambito di un programma di ricerca in collaborazione tra C.N.R. e N.I.H. su "metilazioni biologiche e differenziamento cellulare" occupandosi in particolare dello studio dei meccanismi di regolazione della S-adenosilomocisteina idrolasi, enzima responsabile del controllo delle reazioni di metilazione dipendenti dalla S-adenosilmetionina. Dal 1984 al 1990 è stato responsabile, in qualità di Dirigente Biologo, dei laboratori di Enzimologia Clinica (Servizio Aggregato al Laboratorio di Biochimica Clinica del Policlinico Umberto I dell’Università di Roma “La Sapienza”, diretto dal Prof. Roberto Strom), occupandosi principalmente di determinazioni di attività enzimatiche in eritrociti di soggetti portatori (o sospetti) di carenze di enzimi correlati con patologie emolitiche. Dal 1 ottobre 1990 è professore ordinario (P.O.) di Biochimica (BIO/10) presso la Facoltà di Medicina e Chirurgia dell'Università dell'Aquila.
Gli incarichi didattici del Prof Bozzi, per il corrente anno accademico (2012-2013) sono:
● Titolare del Corso di Propedeutica Biochimica, nel Corso di Laurea Magistrale in Medicina e Chirurgia.
● Titolare del Corso di Neurochimica nella Scuola di Specializzazione in Neurologia della Facoltà di Medicina e Chirurgia.
Il Prof. Bozzi è stato (fino ad oggi), Coordinatore del dottorato di ricerca in Scienze Biochimiche e Neuroscienze.
Gli interessi scientifici del prof. Bozzi sono attualmente rivolti alle seguenti tematiche:
- Lo studio delle interazioni tra modelli di membrana (liposomi, monolayers), e membrane
biologiche con peptidi naturali o sintetici dotati di attività antimicrobica e di potenziale interesse terapeutico.
- Studio dei meccanismi della morte cellulare programmata (apoptosi) indotta, in cellule umane normali e neoplastiche coltivate in vitro, sia da composti di origine naturale (flavonoidi e polifenoli), che da farmaci antitumorali e/o antivirali.
- Studi strutturali e funzionali di isoenzimi dell’alcool deidrogenasi da lievito Kluyveromyces
lactis (KlADHs) nativi e ingegnerizzati mediante mutagenesi sito-specifica.
I risultati di tali studi, e più in generale, di quelli condotti nel corso della sua carriera, sono in parte riportati nell’elenco allegato. I lavori pubblicati su riviste internazionali sono consultabili sul sito:
http://www.ncbi.nlm.nih.gov/ PubMed
L’Aquila, 23 Aprile 2013 Prof. Argante Bozzi Dipartimento di Scienze Cliniche Applicate e
Biotecnologiche Via Vetoio, Coppito 2 , 67100 L’Aquila
Tel. 0862-433472 Fax 0862-433433
E-mail: bozzi@cc.univaq.it
LAVORI A STAMPA DEL PROF. ARGANTE BOZZI
1. B.Mondovì, R.Strom, A.Finazzi Agrò, P.Caiafa, P.De Sole, A.Bozzi, G.Rotilio and A.Rossi Fanelli. Effect of polyenic antibiotics on Ehrlich ascites and Novikoff hepatoma cells. Cancer Res. 31; 505-509, 1971.
2. R.Strom, A.Scioscia Santoro, A.Bozzi, C.Crifò, B.Mondovì and A.Rossi Fanelli. Effect of polyenic antibiotics on nucleic acids biosynthesis of mammalian cells. In: 1th Europ. Biophys.
Congr. ed. by E.Broda, A.Locker, H.Springer; pp. 447-453, 1971.
3. R.Strom, A.Bozzi, A.Scioscia Santoro, C.Crifò, B.Mondovì and A.Rossi Fanelli. Studies on the mechanism of inhibition by polyenic antibiotics of nucleic acids biosynthesis in ascites tumor cells. Cancer Res. 32; 868-876, 1972.
4. R.Strom, C.Crifò, R.Faiola, A.Bozzi, A.Scioscia Santoro. Il legame tra antibiotici polienici e membrane: stechiometria, siti di legame ed effetti sulla permeabilità cellulare. Boll. Soc Ital.
Biol. Sper. 48; 412-413, 1972.
5. R.Strom, A.Scioscia Santoro, C.Crifò, A.Bozzi, B.Mondovì and A.Rossi Fanelli. The biochemical mechanism of selective heat sensitivity of cancer cells: IV. Inhibition of RNA syn- thesis. Eur. J. Cancer 9; 103-112, 1973.
6. R.Strom, C.Crifò and A.Bozzi. The interaction of the polyene antibiotic lucensomycin with cholesterol in erythrocyte membranes and in model systems: I. A fluorometric and spectrophotometric study. Biophys. J. 13; 568-580, 1973.
7. C.Crifò, A.Bozzi, B.Mondovì and R.Strom. Inhibition of uridine incorporation into RNA in mammalian cells by agents affecting the properties of the cell membrane: chloropromazine,
dipyridamole and phenylethanol. Biochem. Pharmacol. 22; 2511-2519, 1973.
8. M.Mareel, L.Vakaet, L.De Ridder, M.Debrabander, A.Bozzi and J.Deman. Possibility of distinction between malignant and non malignant cells by transplantation into chick bla- stoderms: further evidence from animal and human biopsy specimens. J. Natl. Cancer Inst. 53;
1351-1358, 1974.
9. R.Strom, C.Crifò, A.Bozzi and A.Rossi Fanelli. Inhibition by elevated temperatures of ribosomal RNA maturation in Ehrlich ascites cells. Cancer Biochem. Biophys. 1; 57-62, 1975 10. A.Bozzi, I.Mavelli, A.Finazzi Agrò, R.Strom, A.M.Wolf, B.Mondovì and G.Rotilio.
Enzyme defense against reactive oxygen derivatives.II. Erythrocytes and tumor cells. Mol. Cell.
Biochem. 10; 11-16, 1976.
11. A.Bozzi, I.Mavelli, B.Mondovì, G.Rotilio and R.Strom. Faulty enzymatic scavenging of oxygen radicals and sensitivity of tumor cells to photo-oxidation. In: 14th Int. Meet. C. T. O. C.
pp. 42-46, 1976.
12. C.Crifò, A.Bozzi, S.Quadri, P.Cardelli and R.Strom. The interaction of short chain aralkyl alchools and amines with the erythrocyte membrane. Biochem. Exper. Biol. 14; 137-141, 1978.
13. C.Cangiano, F.Rossi Fanelli, A.Bozzi, V.Calcaterra, A.Cascino and L.Capocaccia. Plasma phenylethanolamine in hepatic encephalopathy. Eur. J. Clin. Invest. 8; 183-184, 1978.
14. F.Rossi Fanelli, C.Cangiano, A.R.Smith, A.Bozzi, J.H.James, L.A.Kay, B.A.Perelle, L.Capocaccia and J.E.Fisher. A selective radioenzymatic assay for the determination of octopamine and phenylethanolamine in plasma and cerebrospinal fluid: preliminary results in human and experimental hepatic encephalopathy. It. J. Biochem. 27; 450-465, 1978.
15. R.Strom, P.Cardelli, A.Bozzi. Metabolismo epatico degli aminoacidi. In: Aminoacidi ed Encefalopatia Epatica; (Pacini Ed.); pp. 5-18, 1979.
16. R.Strom, C.Crifò and A.Bozzi. A comparative study of the hemolytic effect of polyenic antibiotics and of other cholesterol binding agents. Biochem. Pharmacol. 28; 2427-2432, 1979.
17. A.Bozzi, I.Mavelli, B.Mondovì, R.Strom and G.Rotilio. Differential sensitivity of tumor cells to externally generated hydrogen peroxide. Role of glutathione and related enzymes.
Cancer Biochem. Biophys. 3; 135-141, 1979.
18. G.Rotilio, A.Bozzi, I.Mavelli, B.Mondovì and R.Strom. Tumor cells as models for oxygen dependent cytotoxycity. In: Biological and Clinical aspects of superoxide and superoxide dismutase; (J.V.Bannister and W.H.Bannister) ,Elsevier; IIB pp.118-126, 1980.
19. O.Riggio, C.Cangiano, A.Bozzi and F.Rossi Fanelli. Simultaneous determination of octopamine and phenylethanolamine in a large series of patients. It. J. Gastroenterol. 12; 237, 1980.
20. A.Bozzi, I.Mavelli, B.Mondovì, R.Strom and G.Rotilio. Differential cytotoxycity of daunomycin in tumor cells is related to glutathione dependent hydrogen peroxide metabolism.
Biochem. J. 194; 369-372, 1981.
21. A.Bozzi, I.Mavelli, B.Mondovì, R.Strom and G.Rotilio. Oxygen cytotoxycity in tumor cells. Bull. Europ. Physipath. Resp. 17; 267-271, 1981.
22. L.Capocaccia, F.Rossi Fanelli, A.Cascino, C.Cangiano, O.Riggio, S.Gentile, M.Merli, A.Bozzi, P.Cardelli, A.De Conciliis and R.Strom. Aspetti patogenetici e terapeutici dell'encefalopatia epatica. In: Update on acute and chronic hepatitis; (P.Gentilini, C.Surrenti, N.Tygstrup eds.); pp. 375-393, 1981.
23. A.Bozzi, P.Cardelli, R.Strom, F.Rossi Fanelli, C.Cangiano, O.Riggio, S.Gentile and L.Capocaccia. Simultaneous radioenzymatic determination of phenylethylamine, phe- nylethanolamine, tyramine and octopamine in plasma of patients with hepatic encephalopathy.
Clin. Biochem. 14; 187-190, 1981.
24. S.Scarpa, A.Bozzi and R.Strom. Analysis by two-dimensional gel electrophoresis of developmentally regulated membrane proteins in L5/4C4 myoblast cell line. In: Membranes in tumor growth; (T.Galeotti, A.Cittadini, G.Neri and S.Papa eds.), Elsevier; pp. 233-240, 1982.
25. G.Rotilio, A.Bozzi, I.Mavelli, B.Mondovì and R.Strom. Correlation between sensitivity to quinone drugs and the ratio of glutathione peroxidase over superoxide dismutase activity in Ehrlich and Yoshida tumor cells. Acta Medica Romana 20; 185-190, 1982.
26. G.Mariutti, M.Vischetti, B.Mondovì, A.Bozzi. Effetto combinato dell'ipertermia e della radiazione ultravioletta su fibroblasti di criceto V-79. In: Convegno Nazionale Ass. Ital. Prot.
Rad. (AIRP); pp. 83-89, 1983.
27. S.Scarpa, A.Bozzi, R.Strom and G.L.Cantoni. Effect of 3-deazaadenosine on L5 myoblast differentiation in colture. It. J. Biochem. 32; 63, 1983.
28. A.Bozzi, G.Mariutti, B.Mondovì and R.Strom. Effect of hyperthermia on DNA repair synthesis in chinese hamster fibroblasts V79 exposed to ultraviolet light. It. J. Biochem. 32;
61-62, 1983.
29. S.Scarpa, R.Strom, A.Bozzi, R.R.Aksamit, P.S.Backlund, J.Chen and G.L,Cantoni.
Differentiation of myoblast cell lines and biological methylation: 3-deazaadenosine stimulates formation of multinucleated myofibers. Proc. Natl. Acad. Sci. USA 81; 3064-3068, 1984.
30. G.Delle Fave, B.Annibale, R.Strom, L.De Magistris, M.Puoti, A.Bozzi and A.Torsoli.
Mechanism of action of somatostatin-14 on dispersed rat pancreatic acini. Israel J. Clin.
Biochem. Lab. Sci. 4; 104, 1985.
31. C.Salerno, A.Bozzi, C.Crifò and R.Strom. Kinetic properties of human erythrocytes adenosylhomocysteinase. In: Purine and Pyrimidine Metabolism in Man. (V). 195A;
(W.L.Nyhan, L.F.Thompson and R.W.E.Watts eds.); pp. 271-274, 1986.
32. A.Bozzi, C.Crifò, R.Strom and C.Salerno. Kinetic properties of Sadenosylhomocysteine hydrolase purified from human erythrocytes. It. J. Biochem. 35; 173-175, 1986.
33. G.De La Haba, S.Agostini, A.Bozzi, A.Merta, C.Unson and G.L.Cantoni. S- -adenosylhomocysteinase: mechanism of reversible and irreversible inactivation by ATP, cAMP and 2'-deoxyadenosine. Biochemistry 25; 8337-8342, 1986.
34. A.Bozzi, G.Mariutti, B.Mondovì and R.Strom. Effect of temperature on DNA repair synthesis in V79 mammalian cells exposed to ultraviolet light. Bull. Mol. Biol. Med. 12;
59-75, 1987.
35. A.Bozzi, A.Ferretti, C.Salerno and C.Crifò. Inactivation of human erythrocyte S-adenosylhomocysteinase by adenosine and thiol containing molecules. It. J. Biochem. 36;
105-107, 1987.
36. A.Bozzi, N.Laudonio, G.Zupi, E.Poggi, C.Greco, L.Marcocci, I.Mavelli, G.Rotilio and B.Mondovì. Interaction of superoxide dismutase-containing liposomes with a human melanoma cell line in hyperthermic conditions. Int. J. Hyperthermia 3; 553, 1987.
37. A.Bozzi, A.Ferretti, C.Crifò and C.Salerno. Mechanisms involved in the inactivation of S-adenosylhomocysteinase. Klin. Wochenschr. 65; 32, 1987.
38. A.Bozzi, E.De Fazi, R.Strom and A.Giacomello. Enhancement of light emission from isoluminol-xanthine oxidase-oxygen-hypoxanthine by 4-iodophenol and D-luciferin. Clin.
Chem. Enzym. Comms. 1; 97-101, 1988.
39. A.Bozzi, M.Ferrazzi, F.Sorice and R.Strom. Adenosine deaminase / pyruvate kinase ratio in erythrocytes as a useful marker of HIV infection. Clin. Chem. Enzym. Comms. 1; 361-366, 1989.
40. F.Podo, M.Di Vito, A.Ferretti, A.Bozzi, R.Strom. NMR studies of glucose metabolism in human pathological red blood cells. In: Magnetic Resonance Spectroscopy of Biofluids, Ch.
XIV; ed. by J.D. de Certaines, World Scientific; pp. 217-231, 1989.
41. C.Quaratino, F.Leonardi, F.Martini, R.Strom and A.Bozzi. Variations of adenine nucleotide levels in normal and pathologic human erythrocytes exposed to oxidative stress. It. J. Biochem.
38, 406A, 1989.
42. A.Bozzi, M.Ferrazzi, L.De Rinaldis, R.Strom, A.Ferretti, M.Di Vito and F.Podo. Enzymatic and 31P-NMR studies on metabolic alterations in red blood cells isolated from HIV-infected subjects. Int. J. Immunopath. Pharmacol. 3; 75-78, 1990.
43. A.Bozzi, B.Furciniti, R.Strom and C.Crifò. S-adenosylhomocysteine hydrolase and adenosine deaminase activities in human red cell ageing. Clin. Chim. Acta 189; 81-86, 1990 44. N.Laudonio, L.Marcocci, G.Arancia, A.Calcabrini, D.Del Bufalo, C.Greco, G.Zupi, I.Mavelli, J.Z.Pedersen, A.Bozzi and B.Mondovì. Enhancement of hyperthermic damage on M14 melanoma cells by liposome pretreatment. Cancer Res. 50; 5119-5126, 1990.
45. A.Bozzi, A.Ferretti, M.Di Vito, F.Podo, R.Strom. NMR studies of glucose metabolism in normal and G6PD-deficient human erythrocytes exposed to oxidative stress. It. J. Biochem. 40;
276-278, 1991.
46. P.Caprari, A.Bozzi, L.Ferroni, A.Giuliani, B.Furciniti La Chiusa, R.Strom and A.M.Salvati.
Membrane alterations in G6PD- and PK-deficient erythrocytes exposed to oxidizing agents.
Biochem. Med. Metab. Biol. 45; 16-27, 1991.
47. A.Bozzi, F.Leonardi, M.L.De Rinaldis, M.Ferrazzi,
R.Strom. S-adenosylhomocysteine hydrolase activity in erythrocytes from HIV-infected patients. In: Advances in Experimental Medicine and Biology, 309B; (R.A.Harkness, G.B.Elion and N.Zollner eds.), Plenum Press; pp. 213-217, 1991.
48 F.Leonardi, C.Quaratino, R.Strom and A.Bozzi. Variations of adenine nucleotide and glutathione levels in normal and pathologic human erythrocytes exposed to oxidative stress.
Ital. J. Biochem. 40; 248A, 1991.
49.M.Sette, M.R.Ciriolo, M.Paci, A.Bozzi, A.De Martino, and G.Rotilio. Mechanisms of GSH as an antioxidant drug from NMR stdies of intact red blood cells. In: Biological free radical oxidations and antioxidants; (F.Ursini and E.Cadenas eds.); Cleup University Publ., pp.
99-103, Padova 1992.
50. R.M.Corbo, R.Ingianna, R.Scacchi and A.Bozzi. Kinetic properties of the common electrophoretic variants of human S- adenosylhomocysteine hydrolase (AHCY): effect of four nucleoside analogue inhibitors. Ann. Hum. Genet. 56; 35-43, 1992.
51. A.Ferretti, L.L.Chen, M.Di Vito, A.Bozzi, S.Barca, M.Cianfriglia, R.Strom and F.Podo.
Detection by 31P MRS of metabolic alterations associated with multi-drug resistant phenotype expression in human leukemic T cells. Acta Medica Romana 30; 330-333, 1992.
52. P.Caprari, A.Bozzi, L.Ferroni, R.Strom and A.M.Salvati. Oxidative erythrocyte membrane damage in hereditary spherocytosis. Biochemistry Int. 26; 265-274, 1992.
53. A.Ferretti, A.Bozzi, M.Di Vito, F.Podo and R.Strom. 13C and 31P NMR studies of glucose
and 2-deoxyglucose metabolism in normal and enzyme deficient human erythrocytes. Clin.
Chim. Acta 208; 39-61, 1992.
54. A.Ferretti, L.L.Chen, M.Di Vito, S.Barca, M.Tombesi, M.Cianfriglia, A.Bozzi, R.Strom and F.Podo. Pentose phosphate pathway alterations in multi-drug resistant Leukemic T-cells: 31P NMR and enzymatic studies. Anticancer Res. 13; 867-872, 1993.
55. A.Bozzi, M.Parisi and F.Martini. Adenosine analogues as inhibitors or inactivators of S-adenosylhomocysteine hydrolase from bovine pancreas. J. Enz. Inhibit. 7; 159-167, 1993.
56. N.Franceschini, A.Impagnatiello, A.Oratore, R.Strom and A.Bozzi. S-a- denosylhomocysteine hydrolase from Acinetobacter calcoaceticus: purification and partial characterization. Biochem. Mol. Biol. Int. 32; 95-103, 1993.
57. M.R.Ciriolo, M.Paci, M.Sette, A.De Martino, A.Bozzi and G.Rotilio. Transduction of reducing power across the plasma membrane by reduced glutathione: a 1H-NMR spin-echo study of intact human erythrocytes. Eur. J. Biochem. 215; 711-718, 1993.
58. A.Bozzi, F.Martini, F.Leonardi and R.Strom. Variations of adenine nucleotides levels in normal and pathologic human erytrocytes exposed to oxidative stress. Biochem. Mol. Biol. Int.
32; 95-103, 1994.
59. A.Di Giulio, M.A.Saletti, G.Maurizi, G.Amicosante, A.Bozzi and A.Oratore. Derivative spectroscopy studies on drug-loaded liposomes. It. J. Biochem. 43; 87-88, 1994.
60. A.M.Salvati, P.Caprari, A.Bozzi, W.Malorni, A.Bottini and F.Iosi. Oxidative denaturation of spectrin in human erythrocytes treated with tert-butylhydroperoxide. It. J. Biochem. 43;
88-89, 1994.
61. C.Severi, L.Pizzuti, A.DiGiulio, A.Bozzi, A.Oratore, R.Strom and G.Delle Fave. Studio metodologico in vitro dell'azione dei neuropeptidi enterici sulla contrattilità delle fibrocellule muscolari lisce gastrointestinali: desensitizzazione omologa ed eterologa. Giorn. Ital. Chim.
Clin. 19; 17-25, 1994.
62. P.Caprari, A.Bozzi, W.Malorni, A.Bottini, F.Iosi, M.T.Santini and A.M.Salvati. Junctional sites of erythrocyte skeletal proteins are specific targets of t-BHP oxidative damage. Chem.
Biol. Interact. 94; 243-258, 1995.
63. A.Di Giulio, M.A.Saletti, A.Oratore and A.Bozzi. Monitoring by cis-parinaric fluorescence of free radical induced lipid peroxidation in aqueous liposome suspensions. J.
Microencapsulation 13; 435-445, 1996.
64. A.Impagnatiello, N.Franceschini, A.Oratore and A.Bozzi. Inhibition studies of S-a denosylhomocysteine hydrolase purified from Acinetobacter calcoaceticus ULA-501.
Biochimie 78; 267-272, 1996.
65. M.Petrone, R.Strom and A.Bozzi. Alterations of hexokinase activity and of glutathione level in human erythrocytes exposed to oxidizing agents. Clin. Chem. Enzym. Comms. 7; 143- 153, 1996.
66. A.Bozzi, M.Parisi and R.Strom. Erythrocyte glutathione determination in the diagnosis of glucose-6-phosphate dehydrogenase deficiency. Biochem. Mol. Biol. Int. 40; 561-569, 1996.
67. M.Lucarelli, F.Palitti, D.Carotti, M.Cianfriglia, C.Signoretti, A.Bozzi and R.Strom. AZT- induced hypermethylation of human thymidine kinase gene in the absence of total DNA hypermethylation. FEBS Letters 396; 323-326, 1996.
68. A.Bozzi, M.Saliola, C.Falcone, F.Bossa and Filippo Martini. Biochemical properties of yeast alcohol dehydrogenases from Kluyveromyces lactis: evidence for NAD(P) dependence of
the mitochondrial isozymes. Biochim. Biophys. Acta 1339; 133-142, 1997.
69. M.Di Vito, A.Bozzi, A.Ferretti, M.Cianfriglia, S.Barca, C.Signoretti, L.Lenti, F.d'Agostino, R.Strom and F.Podo. Intracellular metabolism of AZT: A Nuclear Magnetic Resonance study on human T-lymphoblastoid cell lines with different resistance to AZT. Biochem. Pharmacol.
54; 979-990, 1997.
70. C.Severi, V.Carnicelli, A.Di Giulio, G.Romano, A.Bozzi , A.Oratore, R.Strom and G. Delle Fave. Progression from homologous to heterologous desensitization of contraction in gastric smooth muscle cells. J. Pharmacol. Exp. Ther. 288; 389-398, 1999.
71. A.M.D’Alessandro, G.D’Andrea, L.Di Ciccio, F.Brisdelli, A.C.Rinaldi, A.Bozzi and A.Oratore. 3’-Azido-3’-deoxythymidine reduces the rate of transferrin receptor endocytosis in K562 cells. Biochim. Biophys. Acta 1450; 232-241, 1999.
72. M.L.Mangoni, A.C.Rinaldi, A.Di Giulio, G.Mignogna, A.Bozzi, D.Barra and M.Simmaco.
Structure-function relationships of temporins, small antimicrobial peptides from amphibian skin. Eur. J. Biochem. 267; 1447-1454, 2000.
73. A.M.D’Alessandro, A.C.Rinaldi, G.D’Andrea, F.Brisdelli, L.Di Ciccio, A.Di Giulio, A.Oratore and A.Bozzi. Evidences that zidovudine (AZT) could not be responsible for iron overload in AZT-treated patients: an in vitro study. Clin. Chim. Acta 300; 119-130, 2000.
74. V.Carnicelli, A.Di Giulio, G.Romano, A.Bozzi, A.Oratore, G.Delle Fave, R.Strom and C.Severi. Regional differences in signalling transduction pathways among smooth muscle cells from rabbit colon. Cell. Signalling 12; 683-689, 2000.
75. P.Sacchetta, R.Di Rado, M.Saliola, A.Bozzi, C.Falcone, C.Di Ilio and F.Martini. Multiple unfolded states of alcohol dehydrogenase I from Kluyveromices lactis by guanidinium chloride.
Biochim. Biophys. Acta 1545; 238-244, 2001.
76. M.Di Vito, L.Lenti, A.Knijn, E.Iorio, F.D’Agostino, A.Molinari, A.Calcabrini, A.Stringaro, S.Meschini, G.Arancia, A.Bozzi, R.Strom and F.Podo. 1H NMR-visible mobile lipid domains correlate with cytoplasmic lipid bodies in apoptotic T-lymphoblastoid cells. Biochim. Biophys.
Acta 1530; 47-66, 2001.
77. A.C.Rinaldi, A.Di Giulio, M.Liberi, G.Gualtieri, A.Oratore, M.E.Schininà, M.Simmaco and A.Bozzi. Effects of temporins on molecular dynamics and membrane permeabilization in lipid vesicles. J. Peptides Res. 58; 213-220, 2001.
78. G.D’Andrea, L.Di Ciccio, F.Brisdelli, A.M.D’Alessandro, A.Bozzi and A.Oratore.
Purification and partial characterization of an α-2,8-sialyltransferase from human erythroleukemia K562 cells. Prep. Biochem. & Biotechnol. 31(4); 355-368, 2001.
79. P.Cardelli, S.Scarpa, F.Ceci, M.Lucarelli, F.Tabacco, G.Ferraguti, F.Brisdelli, R.Strom and A.Bozzi. Effects of different oxidizing agents on neutral amino acid transport systems in isolated bovine brain microvessels. Neurorochem. Int. 41; 29-36, 2002.
80. A.C.Rinaldi, M.L.Mangoni, A.Rufo, C.Luzi, D.Barra, H.Zhao, P.K.J.Kinnunen, A.Bozzi, A.Di Giulio and M.Simmaco. Temporin L: antimicrobial, haemolytic and cytotoxic activities, and effects on membrane permeabilization in lipid vesicles. Biochem. J. 368; 91-100, 2002.
81. H.X.Zhao, A.C.Rinaldi, A.Rufo, A.Bozzi, P.Kinnunen and A.Di Giulio. Structural and charge requirements for antimicrobial peptide insertion into biological and model membranes.
In: Pore forming peptides and protein toxins (Menestrina G., Dalla Serra M. and Lazarovici P.
Eds.) Taylor & Francis, London. Chapter 9; pp.151-177, 2003.
82. G.D’Andrea, A.R.Lizzi, F.Brisdelli, A.M.D’Alessandro, A.Bozzi and A.Oratore. Protein glycans alteration and a different distribution of some enzymatic activities involved in the
glycan processing are found in AZT-treated K562 cells. Mol. Cell. Biochem. 252; 45-51, 2003.
83. F.Brisdelli, E.Iorio, A.Knijn, A.Ferretti, D.Marcheggiani, L.Lenti, R.Strom, F.Podo and A.Bozzi. Two-step formation of 1H NMR visible mobile lipids during apoptosis of paclitaxel- treated K562 cells. Biochem. Pharmacol. 65; 1271-1280, 2003.
84. A.Bozzi, F.Brisdelli, A.M.D’Alessandro, G.D’Andrea, A.R.Lizzi, A.C.Rinaldi and
A.Oratore. Effects of AZT on cellular iron homeostasis (Mini-Review). BioMetals 17 (4); 443- 450, 2004.
85. M.L. Mangoni, N.Papo, D.Barra, M.Simmaco, A.Bozzi, A.Di Giulio and A.C.Rinaldi.
Effects of the antimicrobial peptide temporin L on cell morphology, membrane permeability and viability of Escherichia coli. Biochem J. 380; 859-865, 2004.
86. C.Luzi, F.Brisdelli, B.Cinque, G.Cifone and A.Bozzi. Differential sensitivity to resveratrol- induced apoptosis of human chronic myeloid (K562) and acute lymphoblastic (HSB-2)
leukemia cells. Biochem. Pharmacol. 68 (10); 2019-2030, 2004.
87. F.Brisdelli, M.Saliola, S.Pascarella, C.Luzi, N.Franceschini, C.Falcone, F.Martini and A.Bozzi. Kinetic properties of native and mutagenized isoforms of mitochondrial alcohol dehydrogenase III purified from Kluyveromyces lactis. Biochimie 86; 705-712, 2004.
88. A.R.Lizzi, A.M.D’Alessandro, N.Zeolla, F.Brisdelli, G.D’Andrea, G.Pitari, A.Oratore, A.Bozzi, R.Ippoliti. The effect of AZT and chloroquine on the activities of ricin and saporin- transferrin chimeric toxin. Biochem. Pharmacol. 70; 560-569, 2005.
89. A.Knijn, F.Brisdelli, A.Ferretti, E.Iorio, D.Marcheggiani, A.Bozzi. Metabolic alterations in K562 cells exposed to taxol and tyrphostin AG957: 1H NMR and biochemical studies. Cell. Biol. Int. 29; 890-897, 2005.
90. M.D’Abramo, A.C.Rinaldi, A.Bozzi, A.Amadei, G.Mignogna, A.Di Nola, M.Aschi.
Conformational behavior of Temporin L in aqueous solution: A computational/experimental study. Biopolymers, 81; 215-224, 2006.
91. A.C.Rinaldi, A.Bonamore, A.Macone, A.Boffi, A.Bozzi, A.Di Giulio. Interaction of Vitreoscilla Hemoglobin with membrane Lipids. Biochemistry 45; 4069-4076, 2006.
92. A.Giacometti, O.Cirioni, R.Ghiselli, F.Mocchegiani, F.Orlando, C.Silvestri, A.Bozzi, A.Di Giulio, C.Luzi, M.L.Mangoni, D.Barra, V.Saba, G.Scalise and A.C.Rinaldi. Interaction of antimicrobial peptide Temporin L with lipopolisaccaride in vitro and in experimental rat models of Gram-negative septic shock. Antimicrob. Agents Chemother. 50; 2478-2486, 2006.
93. G.D’Andrea, A.R.Lizzi, S.Venditti, L.Di Francesco, A.Giorgi, G.Mignogna, A.Oratore and A.Bozzi. Proteins pattern alteration in AZT-treated K562 cells detected by two-dimensional gel electrophoresis and peptide mass fingerprinting. Proteome Sci. 4; [PubMed - in process], 2006.
94. V. Carnicelli, A. Di Giulio, R. Strom, A. Bozzi and A. Oratore. Effect of 3’-azido-3’
deoxythymidine (AZT) of protein kinase activity in erythroleukemic cell line K562. Basic Clin.
Pharmacol. Toxicol. 99; 317-322, 2006.
95. F.Brisdelli, C.Coccia, B.Cinque, M.G.Cifone and A.Bozzi. Induction of apoptosis by quercetin: different response of human chronic myeloid (K562) and acute lymphoblastic (HSB-
2) leukemia cells. Mol. Cell. Biochem. 296; 137-149, 2007.
96. A.R.Lizzi, A.M.D’Alessandro, A.Bozzi, B.Cinque, A.Oratore and G.D’Andrea. Pattern expression of glycan residues in AZT-treated K562 cells analyzed by lectin cytochemistry. Mol.
Cell. Biochem. 300 (1-2); 29-37, 2007.
97. A.Bozzi, C.Coccia, A.Di Giulio, A.C.Rinaldi, A.Amadei, G.Mignogna, A.Bonamore, A.Fais, and M.Aschi. Folding propensity and biological activity of peptides: New insights from conformational properties of a novel peptide derived from Vitreoscilla haemoglobin.
Biopolymers 87 (1); 85-92, 2007.
98. G.D’Andrea, F.Brisdelli and A.Bozzi. AZT: An old drug with new perspectives (Review).
Current Clinical Pharmacology 3 (1); 20-37, 2008.
99. A.Bozzi, M.L.Mangoni, A.C.Rinaldi, G.Mignogna and M.Aschi. Folding propensity and biological activity of peptides: The effect of a single stereochemical isomerization on the conformational properties of bombinins in aqueous solution. Biopolymers 89 (9); 769-778, 2008.
100. A.Giuliani, G.Pirri, A.Bozzi, A.Di Giulio, M.Aschi and A.C.Rinaldi. Antimicrobial peptides: natural templates for synthetic membrane-active compounds. Cell Mol. Life Sci. 65 (16); 2450-2460, 2008.
101. T.Bucciarelli, M.Saliola, F.Brisdelli, A.Bozzi, C.Falcone, C.Di Ilio and F.Martini.
Oxidation of Cys278 of ADH I isozyme from Kluyveromyces lactis by naturally occurring disulfides causes its reversible inactivation. Biochim. Biophys. Acta, 1794 (3); 563-568, 2009.
102. F.Brisdelli, G.D’Andrea and A.Bozzi. Resveratrol: a natural polyphenol with multiple chemopreventive properties (Review). Current Drug Metab. 10; 530-546, 2009.
103. M.Aschi, A.Bozzi, R.Di Bartolomeo and F.Petruzzelli. The role of disulfide bonds and N- terminus in the structural stability of hepcidins: insights from Molecular Dynamics simulations.
Biopolymers 93(10); 917-26, 2010.
104. C.Coccia, A.C.Rinaldi, V.Luca, D.Barra, A.Bozzi, A.Di Giulio, E.C.Veerman and M.L.Mangoni. Membrane interaction and antibacterial properties of two mildly cationic peptide diastereomers, bombinins H2 and H4, isolated from bombina skin. Eur. Biophys. J. 40(4); 577- 588, 2011.
105. G. D'Andrea, S.Venditti, L.Di Francesco, V.Bernabei, ME Schininà, A.Bozzi . Differential Phosphoproteome Analysis of K562 Cells Exposed to 3’-Azido-3’- Deoxythymidine (AZT). Current Proteomics. vol. 9; 40-54, 2012.
106. F.Brisdelli, M.Perilli, D.Sellitri, M.Piovano, J.A.Garbarino, M.Nicoletti, A.Bozzi, G.Amicosante and G.Celenza. Cytotoxic activity and antioxidant capacity of purified lichen metabolites: an in vitro study. Phytother. Res. 27(3); 431-437, 2013.
107. I.Daidone, M.Aschi, M.Patamia, A.Bozzi and R.Petruzzelli. Structural and dynamical properties of KTS-disintegrins: A comparison between Obtustatin and Lebestatin. Biopolymers 99(1); 47-54, 2013.
108. G.Maisetta, A.Vitali, M.A.Scorciapino, A.C.Rinaldi, R.Petruzzelli, F.L.Brancatisano,
S.Esin, A.Stringaro, M.Colone, C.Luzi, A.Bozzi, M.Campa and G.Batoni (2013). pH-dependent disruption of Echerichia coli ATCC25922 and model membranes by the human antimicrobial peptides hepcidin 20 and 25. FEBS J. Apr 15. doi: 10.1111/febs.12288. [Epub ahead of print].
