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Ice Pack Test
The ice pack test is performed by holding an ice cube, wrapped in a towel or a surgical glove, over the levator palpebrae superioris muscle of a ptotic eye for 2-10 minutes. Improvement of ptosis is said to be specific for myas- thenia gravis: cold improves transmission at the neuromuscular junction (myasthenic patients often improve in cold as opposed to hot weather).
This phenomenon is not observed in other causes of ptosis. A pooled analysis of several studies gave a test sensitivity of 89% and specificity of 100% with correspondingly high positive and negative likelihood ratios.
The test is easy to perform and without side effects (cf. Tensilon test).
Whether the ice pack test is also applicable to myasthenic diplopia has yet to be determined. False positives have been documented.
References
Larner AJ. The place of the ice pack test in the diagnosis of myasthe- nia gravis. International Journal of Clinical Practice 2004; 58: 887-888 Larner AJ, Thomas DJ. Can myasthenia gravis be diagnosed with the
“ice pack test”? A cautionary note. Postgraduate Medical Journal 2000; 76: 162-163
Cross References Diplopia; Fatigue; Ptosis Ideational Apraxia
- see APRAXIA Ideomotor Apraxia (IMA)
- see APRAXIA Illusion
An illusion is a misinterpretation of a perception (cf. delusion, hallu- cination). Illusions occur in normal people when they are tired, inat- tentive, in conditions of poor illumination, or if there is sensory impairment. They also occur in disease states, such as delirium, and psychiatric disorders (affective disorders, schizophrenia).
Examples of phenomena which may be labeled illusory include:
Visual: metamorphopsia, palinopsia, polyopia, telopsia, Pulfrich phenomenon, visual alloesthesia
Auditory: palinacusis Vestibular: vertigo References
Tekin S, Cummings JL. Hallucinations and related conditions. In:
Heilman KM, Valenstein E (eds.). Clinical neuropsychology (4th edi- tion). Oxford: OUP, 2003: 479-494
Impersistence I Cross References
Delirium; Delusion; Hallucination Imitation Behavior
Imitation behavior is the reproduction by the patient of gestures (echopraxia) and/or utterances (echolalia) made by the examiner in front of the patient; these “echophenomena” are made by the patient without preliminary instructions to do so. They are consistent and have a compulsive quality to them, perhaps triggered by the equivo- cal nature of the situation. There may be accompanying primitive reflexes, particularly the grasp reflex, and sometimes utilization behavior.
Imitation behavior occurs with frontal lobe damage; originally mediobasal disease was thought the anatomical correlate, but more recent studies suggest upper medial and lateral frontal cortex.
Certainly imitation behavior never occurs with retrorolandic cortical lesions.
A distinction has been drawn between “naïve” imitation behavior, which ceases after a direct instruction from the examiner not to imi- tate his/her gestures, which may be seen in some normal individuals;
and “obstinate” imitation behavior which continues despite an instruction to stop; the latter is said to be exclusive to frontotemporal dementia.
References
De Renzi E, Cavalleri F, Facchini S. Imitation and utilisation behavior.
Journal of Neurology, Neurosurgery and Psychiatry1996; 61: 396-400 Lhermitte F, Pillon B, Serdaru M. Human autonomy and the frontal lobes. Part I: imitation and utilization behavior: a neuropsychological study of 75 patients. Annals of Neurology 1986; 19: 326-334
Shimomura T, Mori E. Obstinate imitation behavior in differentiation of frontotemporal dementia from Alzheimer’s disease. Lancet 1998;
352: 623-624 Cross References
Echolalia; Echopraxia; Grasp reflex; Utilization behavior Imitation Synkinesis
- see MIRROR MOVEMENTS Impersistence
Impersistence is an inability to sustain simple motor acts, such as con- jugate gaze, eye closure, protrusion of the tongue, or keeping the mouth open. It is most commonly seen with lesions affecting the right hemisphere, especially central and frontal mesial regions, and may occur in association with left hemiplegia, neglect, anosognosia, hemi- anopia, and sensory loss. These patients may also manifest persevera- tion, echolalia and echopraxia.
Impersistence is most often observed following vascular events but may also be seen in Alzheimer’s disease and frontal lobe dementias, and metabolic encephalopathies. Impersistence of tongue protrusion
and hand grip may be seen in Huntington’s disease. Neuro- psychologically, impersistence may be related to mechanisms of directed attention which are needed to sustain motor activity.
References
Fisher M. Left hemiplegia and motor impersistence. Journal of Nervous and Mental Disease1956; 123: 201-218
Kertesz A, Nicholson I, Cancelliere A, Kassa K, Black SE. Motor imper- sistence: a right-hemisphere syndrome. Neurology 1985; 35: 662-666 Cross References
Anosognosia, Echolalia; Echopraxia; Hemianopia; Milkmaid’s grip;
Neglect; Perseveration; Trombone tongue Inattention
- see NEGLECT Incontinence
Urinary incontinence may result from neurological disease.
Neurological pathways subserving the appropriate control of micturi- tion encompass the medial frontal lobes, a micturition centre in the dorsal tegmentum of the pons, spinal cord pathways, Onuf’s nucleus in the spinal cord segments S2-S4, the cauda equina, and the pudendal nerves. Thus the anatomical differential diagnosis of incontinence is broad. Moreover incontinence may be due to inappropriate bladder emptying or a consequence of loss of awareness of bladder fullness with secondary overflow. Other features of the history and/or exami- nation may give useful pointers as to localization. Incontinence of neu- rological origin is often accompanied by other neurological signs, especially if associated with spinal cord pathology (see Myelopathy).
The pontine micturition centre lies close to the medial longitudinal fasciculus and local disease may cause an internuclear ophthalmople- gia. However, other signs may be absent in disease of the frontal lobe or cauda equina.
Causes of urinary incontinence include:
● Idiopathic generalized epilepsy with tonic-clonic seizures; how- ever, the differential diagnosis of “loss of consciousness with incontinence” also encompasses syncopal attacks with or with- out secondary anoxic convulsions, nonepileptic attacks, and hyperekplexia
● Frontal lobe lesions: frontal lobe dementia; normal pressure hydrocephalus
● Spinal cord pathways: urge incontinence of multiple sclerosis; loss of awareness of bladder fullness with retention of urine and overflow in tabes dorsalis
● Sacral spinal cord injury; degeneration of the sacral anterior horn cells in Onuf’s nucleus (multiple system atrophy)
● Cauda equina syndrome; tethered cord syndrome (associated with spinal dysraphism)
● Pelvic floor injury.
I Inattention
Neurogenic incontinence may be associated with urgency, which results from associated abrupt increases in detrusor pressure (detrusor hyperreflexia); this may be helped by anticholinergic medication (e.g., oxybutynin). In addition there may be incomplete bladder emptying, which is usually asymptomatic, due to detrusor sphincter dyssynergia;
for post-micturition residual volumes of greater than 100 ml (assessed by in-out catheterization or ultrasonography), this is best treated by clean intermittent self-catheterization.
References
Fowler CJ. Investigation of the neurogenic bladder. In: Hughes RAC (ed.). Neurological Investigations. London: BMJ Publishing, 1997:
397-414
Garg BP. Approach to the patient with bladder, bowel, or sexual dys- function and other autonomic disorders. In: Biller J (ed.). Practical neurology(2nd edition). Philadelphia: Lippincott Williams & Wilkins, 2002: 366-376
Cross References
Cauda equina syndrome; Dementia; Frontal lobe syndromes;
Hyperekplexia; Internuclear ophthalmoplegia; Myelopathy; Seizures;
Urinary retention Intention Myoclonus
- see MYOCLONUS Intermanual Conflict
Intermanual conflict is a behavior exhibited by an alien hand (le main étranger) in which it reaches across involuntarily to interfere with the voluntary activities of the contralateral (normal) hand. Diagonistic dyspraxia probably refers to the same phenomenon. The hand acts at cross purposes to the other following voluntary activity. A “compul- sive grasping hand” syndrome has been described which may be related to intermanual conflict, the difference being grasping of the contralateral hand in response to voluntary movement. Intermanual conflict is more characteristic of the callosal, rather than the frontal, subtype of anterior or motor alien hand. It is most often seen in patients with corticobasal degeneration, but may also occur in associ- ation with callosal infarcts or tumors or following callosotomy.
Cross References
Alien hand, alien limb; “Compulsive grasping hand”; Diagonistic dyspraxia
Intermetamorphosis
A form of delusional misidentification in which people known to the patient are believed to exchange identities with each other (cf. Fregoli syndrome, in which one person can assume different physical appearance).
References
Ellis HD, Whitley J, Luaute JP. Delusional misidentification. History of Psychiatry1994; 5: 117-146
Intermetamorphosis I
Cross References Delusion
Internal Ophthalmoplegia
- see OPHTHALMOPARESIS, OPHTHALMOPLEGIA Internuclear Ophthalmoplegia (INO)
Internuclear ophthalmoplegia, or medial longitudinal fasciculus syn- drome, consists of ipsilateral weakness of eye adduction with con- tralateral nystagmus of the abducting eye (ataxic or dissociated nystagmus), but with preserved convergence. This may be obvious with pursuit eye movements, but is better seen when testing reflexive saccades or optokinetic responses when the adducting eye is seen to
“lag” behind the abducting eye. INO may be asymptomatic or, rarely, may cause diplopia, oscillopsia, or a skew deviation. INO may be uni- lateral or bilateral. The eyes are generally aligned in primary gaze, but if there is associated exotropia this may be labeled wall-eyed monoc- ular/bilateral internuclear ophthalmoplegia (WEMINO, WEBINO syndromes).
The most common cause of INO by far is demyelination, particu- larly in young patients, but other causes include cerebrovascular dis- ease (particularly older patients), Wernicke-Korsakoff syndrome, encephalitis, trauma, and paraneoplasia.
A similar clinical picture may be observed with pathology else- where, hence a “false-localizing “ sign and referred to as a pseudo- internuclear ophthalmoplegia (q.v.), especially in myasthenia gravis.
References
Zee DS. Internuclear ophthalmoplegia: pathophysiology and diagno- sis. In: Büttner U, Brandt Th. Ocular motor disorders of the brain stem.
London: Baillière Tindall, 1992: 455-470 Cross References
Diplopia; “False-localizing signs”; One-and-a-half syndrome;
Optokinetic nystagmus, Optokinetic response; Oscillopsia; Pseudo- internuclear ophthalmoplegia; Saccades; Skew deviation
Intrusion
An intrusion is an inappropriate recurrence of a response (verbal, motor) to a preceding test or procedure after intervening stimuli.
Intrusions are thought to reflect inattention, and may be seen in dementing disorders or delirium. These phenomena overlap to some extent with the recurrent type of perseveration.
The term intrusion is also used to describe inappropriate saccadic eye movements which interfere with macular fixation during pursuit eye movements.
References
Fuld PA, Katzman R, Davies P, Terry RD. Intrusions as a sign of Alzheimer dementia: chemical and pathological verification. Annals of Neurology1982; 11: 155-159
I Internal Ophthalmoplegia
Cross References
Delirium; Dementia; Perseveration; Saccadic intrusion, Saccadic pursuit Inverse Marcus Gunn Phenomenon
- see JAW WINKING; PTOSIS Inverse Uhthoff Sign
- see UHTHOFF’S PHENOMENON Inverted Reflexes
A phasic tendon stretch reflex is said to be inverted when the move- ment elicited is opposite to that normally seen, e.g., extension of the elbow rather than flexion when eliciting the supinator (brachioradialis) jerk; flexion of the forearm when tapping the triceps tendon (para- doxical triceps reflex); and flexion (hamstring contraction) rather than extension of the knee when tapping the patellar tendon.
The finding of inverted reflexes may reflect dual pathology, but more usually reflects a single lesion which simultaneously affects a root or roots, interrupting the local reflex arc, and the spinal cord, damag- ing corticospinal (pyramidal tract) pathways which supply segments below the reflex arc. Hence, an inverted supinator jerk is indicative of a lesion at C5/6, paradoxical triceps reflex occurs with C7 lesions; and an inverted knee jerk indicates interruption of the L2/3/4 reflex arcs, with concurrent damage to pathways descending to levels below these segments.
References
Boyle RS, Shakir RA, Weir AI, McInnes A. Inverted knee jerk: a neg- lected localizing sign in spinal cord disease. Journal of Neurology, Neurosurgery and Psychiatry1979; 42: 1005-1007
Cross References Reflexes Ipsipulsion
- see LATEROPULSION Iridoplegia
Paralysis of the iris, due to loss of pupillary reflexes. This may be partial, as in Argyll Robertson pupil or Holmes-Adie pupil, or com- plete as in the internal ophthalmoplegia of an oculomotor (III) nerve palsy.
Cross References
Argyll robertson pupil; Holmes-adie pupil, Holmes-adie syndrome;
Oculomotor (III) nerve palsy; Ophthalmoparesis, Ophthalmoplegia;
Pupillary reflexes
Iridoplegia I