Index
Acute myeloid leukemia 3 l 3 , 3 14,325, 326,327,330,331,336,350
Adhesion 24 AMD3 100 29,40
AML See Acute Myeloid Leukemia.
Angiogenesis 21,34,35,36,42, 102, 175, 185, 187, 188, 199,203,262, 309,310
Angiostasis 2 1 Angiostatin 175
BCR-ABL 55,64,66
Bevacizumab 254,262,280,303,304 Bladder cancer 221,236,237,370
Caspase 57,59,60,68,75,96, 107, 109, 112, 114, 116, 120, 121, 123, 124, 125, 165, 167,168,190,202,251,260 Cbl 26,50,63,64
CCL2 16, 18,22,30,32,33,34,41 CCL5 17
CD30L 70,72,73,86,88,89 CD40L 70
Cetuximab 25 1,252
Chemokines 15, 16, 18, l9,2O, 21,22, 23,24,28,30,31,32,33,39,40,42, 43,44,71, 189,230,324,371
COX-1 297,300
COX-2 290,297,299,300,301,305, 308,309
CrkII 50,51,52,64 CrkL 50,63,64,211,232 CXCL8 19,20,22,24,28,3 1,34 CXCR 40,209
CXCRl 20,24,25,27,33,34 CXCR2 19,20,22,24,27,3 1,33,34,
39,40,42
CXCR4 19,20,22,25,26,27,28,29, 34,39,40,41,94
CXLlO 209
Cyclin Dl 113, 124, 136, 150 Cyclooxygenase 117,237,290,296,
308,309
EGF 1,2,4, 10,64, 150, 157, 163, 167, 171,249,252,256,259,260,261 EGFR 1. See epidermal growth factor
receptor.
EGFRIErbB-1 2
Epidermal growth factor receptor 1,63, 130, 143,244,248,258,259,260, 26 1,262,290,305
ER See estrogen receptors Erlotinib 252,261
Estrogen receptors 243,250,259 G-CSF 313,3l5,316,317,318,319,
321,322,324,325,328,329,333,
CYTOIUNES AND CANCER
334,335,336,337,338,339,340, 341,342,343,344,345,346, 347, 348,349,350
Gefitinib 253
GM-CSF 64,209,278,294,295,296, 313,315,316,317,318,319,322, 325,327,33 1,333,334,336,342, 343,344,345,349,350,358 Grb2 50,52,63,64, 141, 147 GW572016 7,12,252,253,262
Hematopoietic stem cell transplantation 333,343,346,349,350,351 Hepatocellular carcinoma 220,235 HER1 2,244,248,249,259 HER2 2,7,244,245,246,247,248,
249,250,253,254,255,257,258, 259,260,290
HER3 2,3,244 HER4 2,244
Herceptin 7,245,255,257,258,262 HSCT See hematopoietic stem cell
transplantation
IFNa 45 IFNS 45,208 IFNs See Interferons IFNz 45
IFNy 45,47,48,49,50,51,52,55,57, 59,60
IL-2 233,263,281,282,284,285,286, 322,329
IL-6 80,100 IL-10 82,101,286 IL-11 42,324 IL-12 83 IL-13 85, 102 IL-18 353,368,369
IL-21 353,354,359,360,361,362, 363,367,370,371
IL-24 353,354,364,365,366,367,372, 37 3
Interferons 45,61,65,68,228,230, 235,240,290,291,292,305,306 Invasion 23,24,136,3 10
IRESSA 8
IKB 104, 110, 111,112, 113, 114, 116, 117, 355
JAK kinases 46,63, 81,210,211,265, 355,360,364
JAKl 48,49,59,62,83,210 JAK2 84
Kaposi's sarcoma 19,218
Leukocytes 15, 16, 18,45, 140, 166, 228,360,365
Lewis lung carcinoma 176 LLC See Lewis lung carcinoma Lung cancer 8, 16,23,25,30,39,40,
41, 110, 118, 179, 194,223,224,238, 239,240,25 1,260,261,262,289, 290,291,292,293,295,296,299, 300,302,304,305,306,307,308, 309,310
MapKapK-2 55,57 MapKapK-3 55 MEKK 108,117
Melanoma 17, 19,20,21,24,25,26, 27,29,31,32,40,41,42,43,44,57, 59,66,67,83,96, 102, 114, 118, 125, 135, 140, 141, 148, 154, 179, 183, 189, 198,204,208,211,212,214, 215,218,219,226,227,230,231, 232,233,234,240,263,264,265, 266,267,268,269,270,273,275, 277,278,279,281,282,283,284, 285,286,294,307,357,363,366,372 Migration 24
Msk-1 55
p27Kipl 150,162,235
p38 49,54,55,56,57,63,65,66,71, 79,96, 112, 123, 125, 130, 137, 142,
145,170,355,369,372 Pak 8,66
PAW 107
PEG- rHuMGDF 323
PgR 243. See progesterone receptors PI-3 kinase 25
PKC-F 48,108
PKR 60,68,115, 117, 119,126
Index
Plasminogen 5, 11, 130, 150, 176, 177, 180, 181, 182, 184, 188, 189, 194, 195,197, 198, 199,200,201,202,203 Progesterone receptors 243,256 PSA 157,158,167,173
RANKL 70,74,77,78,86,88,90,97 RANTES 17,35,7 1. See CCL5 Renal cell carcinoma 216
Smads 131,135,160,161,162,167, 170
STATs 61,63,65,68,81,83,84,85, 101, 144,210,211,220,231,265, 355,360,364,370,372
Stem cells 335 SU5416 304,311 SU6668 304
TNF 41,57,58,69,70,74,76,78,80, 83,85,86, 87,88,89,91,92,93,94, 95,96,97,98,99, 100, 108, 109, 110, 111, 112, 113, 114, 116, 117, 118, 121, 122, 125, 126, 127, 130, 141, 209,270,280,334,354
TRAIL 57,60,66,67,68,70,74,75, 76,77, 86, 87, 88,89,90,94,95,96, 108,112,117,118,123,127,209,236 Trastuzumab 7,245,248,256,257,258 TYK2 81,84,210
Vascular endothelial growth factor 18, 41,178, 197,202,219,220,235,254, 262,280,290,302,3 10,3 1 1 Vav 54,66
VEGF See vascular endothelial growth factor
VEGF-R1 254 VEGF-R2 254 VEGF-R3 254
