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duration of stimulation, cumulative dosage of gonadotropins number of oocyte retrieved

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Academic year: 2021

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SUMMARY

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The study is retrospective analyses about 21 cancer patients occur to our centre, Infertility And Assisted Reproduction of University of Pisa, in order to preserve their fertility before cancer treatment. We investigate the use of different stimulation protocol, according to different phases of menstrual cycle and according to cancer disease.

Patients are divided into two groups depending on the phase of menstrual cycle, follicular or late follicular/luteal phase, at the moment of first examination. Standard stimulation protocol with gonadotropins is administered in the follicular group, whereas in the second group we use GnRH (gonadotropin releasing hormone) antagonist before gonadotropins administration in order to have a rapid luteolysis. Among the 21 cancer patients, three are affected by breast cancer and two of them receive a controlled ovarian stimulation with a combined letrozole-gonadotropins protocol after GnRH-antagonist induced luteolysis.

The outcome measures are number of days needed before starting procedure,

duration of stimulation, cumulative dosage of gonadotropins number of oocyte retrieved

(2)

SUMMARY

2 and percentage of mature oocytes and vitrified ones. We focus our attention also on estradiol levels during ovarian stimulation.

The results don’t show any differences between two groups if we consider days of stimulation, total amount of gonadotropins administered and the number of good mature quality oocytes retrieved. Moreover estradiol levels in letrozole group are lower than those in other patients.

This study suggests that oocytes can be obtained before cancer treatment irrespective of menstrual cycle phase without compromising the efficacy of procedure.

Moreover starting ovarian stimulation anytime during menstrual cycle allows patients to not postpone the beginning of cancer treatment.

Different stimulation protocols, according to different kind of disease, are available in order to obtain the maximum results without any complication for patients.

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