63
Bibliografia
(1) Nikolic D., Li Y., Chadwick L. R.; “Metabolism of xanthohumol and isoxanthohumol, prenilated flavonoids from hops, by human lever microsomes”; Journal Mass Spectrom: 40, 289-299.
(2) Barbara Vanhoecke, Lara Derycke, Veerle Van Marck; “Antiinvasive effect of xanthohumol, a prenylated chelcone present in hops (Humulus lupulus L.) and beer”; Int. J. Cancer: 117, 889-895 (2005)
(3) Christoph Dorn, Thomas S. Weiss, Jorg Heilmann; “Xanthohumol, a prenylated chalcone derived from hops, inhibits proliferation, migration and interleukin-8 expression of hepatocellular carcinoma cells”; International Journal of Oncology: 36, 435-441 (2010).
(4) Rajeshwar P. Verma and Corwin Hansch; “Matrix metalloproteinases (MMPs): Chemical- biological functions and (Q)SAR”; Bioorganic and Medicinal Chemistry: 15, 2223-2268 (2007).
(5) M. Whittaker, C.D. Floyd, P. Brown; “Design and therapeutic of matrix metalloproteinase inhibitors”; Chem. Rev: 99, 2735-2776 (1999).
(6) E.Nuti, T. Tuccinardi, A. Rossello; “Matrix metalloproteinase inhibitors: new challenges in the era of post broad-spectrum inhibitors”; Current Pharmaceutical Design: 13, 2087-2100 (2007).
(7) E. Morgunova, A. Tuuttila, U. Bergmann; “Structure of human pro-matrix metalloproteinase-2: activation mechanism revealed”; Science: 284, 1667-1670 (1999).
(8) Jung-Ae Kim, Youra Kang, Dinesh Thapa; “Anti-invasive and anti-angiogenic effects of Xanthohumol and its synthetic derivatives”; Biomolecules & Terapeutics: 17, 422-429 (2009).
(9) Adriana Albini, Raffaella Dell‟Eva, Nicoletta Ferrari; “Mechanisms of the antiangiogenic activity by the hop flavonoid xanthohumol: NF-kB and Akt as targets”; The FASEB Journal: 10.1096/fj.05-5128fje, 30 Dicembre 2005.
64 (10) Rita Negrao, Raquel Costa, Delfim Duarte; “Angiogenesis and Inflammation Signaling Are Targets of Beer Polyphenols on Vascular Cells”; Journal of Cellular Biochemistry: 111, 1270-1279 (2010).
(11) Pepper MS.,Hazel SJ.,Schini-Kerth VB.; “8-Prenylnaringenin, a novel phytoestrogen, inhibits angiogenesis in vitro and in vivo”; Journal Cell Physiol: 199, 98-107 (2004).
(12) Brunelli E., Minassi A., Appendino G.; “8-Prenylnaringenin, inhibits estrogen receprot-alpha mediated cell growth and induces apoptosis in MCF-7 breast cancer cells”; Journal Steroid Biochem Mol Biol: 107, 140-148 (2007).
(13) Kuzhuvelil B. Harikumar, Ajaikumar B. Kunnumakkara, Kwang S. Ahn; “Modification of the cysteine residues in IkBα kinase and NF-kB (p65) by xanthohumol leads to suppression of NF-kB-regulated gene productis and potentiation of apoptosis in leukemia cells”; Blood: 113(9), 2003-2013 (2009). (14) D. Deeb, X. Gao, H.Jiang; “Growth inhibitory and apoptosis-inducing effects of
xanthohumol, a prenylated chalcone present in hops, in human prostate cancer cells”; Internation Journal of Cancer Research and Treatment: 30 (9), 3333-3339 (2010).
(15) Clarissa Gerhäuser; “Broad spectrum antiinfective potential of xanthohumol from hop (Humulus lupulus L.) in comparison with activities of other hopconstituents and xanthohumol metabolites”; Mol. Nutr. Food Res: 49, 827-831 (2005).
(16) Teuber M., Schmalreck A.F.,” Membrane leakage in Bacillus subtilis 168 induced by the hop constituents lupulone, humulone, isohumulone and humulinic acid” ; Arch. Mikrobiol: 94, 159-171 (1973).
(17) Mizobuchi S., Sato Y; “A new Flavone with antifungal activity isolated from hops”; Agricultural and Biological Chemistry: 48, 2771-2775 (1984).
(18) Bhattacharya S.,Virani S. Zavro M., Haas G. J.; “Inhibition of streptococcus mutans and other oral streptococci by hop (Humulus Lupulus L.) constituents”; Economic Botany: 57, 118-125 (2003).
65 (19) Buckwold V. E., Wilson R. J., Nalca A., Beer B. B. et Al.; “Antiviral activity of hop constituents against a series of DNA and RNA viruses”; Antiviral Research: 61, 57-62 (2004).
(20) Ni Zhang, Zhengwen Liu, Qunying Han; “Xanthohumol enances antiviral effect of interferon α-2b against bovine viral diarrhea virus, a surrogate of hepatitis C virus”; Phytomedicine: 17, 310-316 (2010).
(21) Frölich S., Schubert C., Bienzle U.; “In vitro antiplasmodial activity of prenylated chalcone derivates of hops (humulus Lupulus) and their interaction with haemin”; Journal of Antimicrobial Chemotherapy: 55, 883-887 (2005). (22) Ik-Soo Lee, Juhee Lim, Jiyeong Gal; “Anti-inflammatory activity of
xanthohumol involves heme oxygenase-1 induction via NRF2-ARE signaling in microglial BV2 cells”; Neurochemistry International: 58, 153-160 (2011).
(23) Branislav Radovic, Ragna Hussong, Clarissa Gerhauser; “Xanthohumol, a prenylated chalcone from hops, modulates hepatic axpression of genes involved in Thyroid hormone distribution and metabolism”; Mol. Nutr. Food Res: 54, S225-S235 (2010).
(24) Franziska Felk, Wolfgang W. Huber, Metka Filipic; “Xanthohumol, a prenylated flavonoid contained in beer, prevents the induction of preneoplastic lesions and DNA damage in liver and colon induced by the heterocyclic aromatic amine amino-3-methyl-imidazo[4,5-ƒ]quinoline (IQ)”; Mutation Research: 691, 17-22 (2010).
(25) Hajime Nozawa; “Xathohumol, the chalcone from beer hops (Humulus lupulus L.), is the ligand for farnesoid X receptor and ameliorates lipid and glucose metabolism in KK-Ay mice”; Biochemical and Biofysical Research Communications: 336, 754-761 (2005).
(26) Xiaohua Gao, Dorrah Deeb, Yongbo Liu; “Immunomodulatory activity of xanthohumol: inhibition of T cell proliferation, cell-mediated cytotoxicity and Th1 cytokine production through suppression of NF-kB”; Immunopharmacol Immunotoxicol: 31, 477-484 (2009).
66 (27) M. Samuel, R. Arena, J. Conte; “Direct inhibition of elastase and matrixmetalloproteinases and stimulation of biosynthesis of fibrillar collagens, elastin, and fibrillins by Xanthohumol”; International Journal of Cosmetic Science: 61, 125-132 (2010).
(28) American Cancer Society, Atlanta; “Cancer facts and figures.” (2008).
(29) Spiridon K. “Terrestrial plant-derived anticancer agents and plant species
used in anticancer research”; Critical Reviews in Plant Sciences: 25, 79–113
(2006).
(30) Gordaliza M.; “Natural products as leads to anticancer drugs”; Clin Translat Oncol: 9, 767–776 (2007).
(31) Caitlin E. Cassidy, William N. Setzer; “Cancer-relevant biochemical targets of
cytotoxic Lonchocarpus flavonoids: A molecular docking analysis”; Journal
Molecular Model: 16, 311-326 (2010).
(32) Vogel S, Heilmann J; “Synthesis, Cytotoxicity, and Antioxidative Activity of Minor Prenylated Chalcones from Humulus Lupulus”; Journal Nat. Prod: 71, 1237–41 (2008).
(33) Emily Ho, Frederik Stevens, Cristobal L. Miranda, et Al; “Prostate cancer and binign prostatic hyperplasia treatments”; United States Patent Application 2008 0233221.
(34) Dell„Eva R, Ambrosini C, Vannini N, et Al.; “AKT/NF-KB inhibitor xanthohumol targets cell growth and angiogenesis in hematologic malignancies”; Cancer: 110, 2007–11 (2007).
(35) Delmulle L, Bellahcene A, Dhooge W, et Al.; “Anti-proliferative properties of prenylated flavonoids from hops (Humulus lupulus L.) in human prostate cancer cell lines”; Phytomedicine: 13, 732–4 (2006).
(36) Ho YC, Liu CH, Chen CN, et Al.; “Inhibitory effects of xanthohumol from hops (Humulus lupulus L.) on human hepatocellular carcinoma cell lines”; Phytother Res: 22, 1465–8 (2008).
67 (37) Koo JH, Kim HT, Yoon HY, et Al.; “Effect of xanthohumol on melanogenesis
in B16 melanoma cells”; Exp Mol Med: 40, 313–9 (2008).
(38) R. S. Khupse, P. W. Erhardt; “Total Synthesis of Xanthohumol”; J. Nat. Prod: 70, 1507–1509 (2007).
(39) Aouregan M.; Jacob and Christopher J. Mooby; “Microwave-assisted combined Mitsunobu reaction-Claisen rearrangement and microwave-assisted phenol oxidation: rapid synthesis of 2,6-disustituted-1,4-benzoquinone natural products”; Science direct; Tetrahedron letters: 46, 8823-8825 (2005).