RIMeL / IJLaM 2005; 1
302
Corrispondenza a: Dott. Romolo M. Dorizzi, Laboratorio di Analisi Chimico Cliniche ed Ematologia, Azienda Ospedaliera di Verona, Piazzale Stefani 1, 37126 Verona. Tel. 045-8073045, fax 045-74431187, e-mail: romolo.dorizzi@azosp.vr.it
TDM e farmaci anticomiziali vecchi e nuovi
Sesto Convegno di Studio Lab Automation and Medical Decision Making
Romolo M Dorizzi
Villalta-Gazzo Padovano (PD) 7 ottobre 2005
The danger arises of treating the blood level rather than the patient, so that the dose is
adjusted not to the patient’s clinical need, but in order to
achieve the
“therapeutic level”
Lancet 1975; ii: 265-7
• 27% (24% to 30%) of levels had an appropriate indication
• No significant difference in the
appropriateness rate among the four drugs
• Only 4 out 624 (0.6%) levels considered inappropriate were more than 20% higher than the upper limit of normal,
• None of the four patients had clinical signs of drug toxicity
1995; 274: 1622-6
Generalized: seizures begin simultaneously in both hemispheres, strong genetic component,neurologic function is normal in
most.
Partial: seizures originate in one or more localized foci, can spread to
involve the entire brain, may result from CNS insults
First 50%
Second 20%
Refractory 30%
303
RIMeL / IJLaM 2005; 1
