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Carcinoma Renale

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Carcinoma renale

Dr. Aldo Chioni

ASL Toscana Sud Est U.O.C. Oncologia Medica

Grosseto

Supernovae in Oncologia

Pisa 19-20 settembre 2019

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Nel 2018

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Novità 2019

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Baseline Characteristics

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Overall Survival

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Overall Survival in Key Subgroups

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Progression-Free Survival

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Progression-Free Survival in Key Subgroups<br />

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Confirmed Objective Response Rate

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Treatment-Related Adverse Events: <br />Incidence ≥20%

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Pembrolizumab plus Axitinib as First-Line Therapy for mRCC: Outcomes in the Combined IMDC Intermediate/Poor Risk and Sarcomatoid Subgroups of KEYNOTE-426

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IMDC Favorable Risk: OS, PFS, and ORR

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Response: Presence of Sarcomatoid Featuresa

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PFS: Presence of Sarcomatoid Featuresa

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Biomarker analyses from JAVELIN Renal 101: avelumab + axitinib vs sunitinib <br />in advanced renal cell carcinoma

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Biomarker assessments and methodology

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PFS according to PD-L1 IHC

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Slide 9

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Slide 12

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Slide 13

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PFS according to expression of select genes

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Slide 17

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Slide 19

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Possibile algoritmo decisionale

Nature Clin Oncol Rev 2019

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Linee guida EAU 2019

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Conclusioni

Possibili criteri di scelta

• Valutazione multidisciplinare del paziente

• Importanza dei fattori prognostici

• Sedi di malattia/urgenza di risposta

• istologia

• Età e comorbidità

• Richiesta del paziente/distanza dal DH

• Valutazione dei costi/indicazioni AIFA

• Possibili sequenze terapeutiche

GRAZIE PER L’ATTENZIONE !

Riferimenti

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