Intracellualr transport of doxorubicin through block copolymer-coated multi-walled nanotubes

coFEM 2010

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di Chimica

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Roma,

2 - 4 Settembre

2010

Dipartimento _{di Roma - Università di Roma "sapienza"}

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rntracellular transport of doxorubicin through block copolymer-coated _{multi-walled carbon nanotubes}

A. Fontanau, A. Di crescerrzou, D. vellutob, J. A. Hubbellb

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Dipartimento di Scienze del Farmaco, (Jniversità "G. d'Annunzio',, Via dei Vestini, I-66013 Chieti, haly

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Insti|utlfor Bioengineering and Institute for Chemicàl Sciences and Engineering, Ecole Polytechnique Fédérale de Lausanne (EPFL), Station IS, CH:I7Is

Lausanne, Switzerland e -mail fontana@unic h. it

The biocompatible amphiphilic diblock copolymer poly(ethylene glycol-ó/-propylene sulfide) PEG++PPSzo _{has been usedl for the preparation of stable} dispersions _{of multi-walled carbon nanotubes (MWCNT5). The obtained} PEG++PPS2s-coated _{MWCNTs have been used as carriers of doxorubicin} (DOX) to cells. It has been demonstrated _{that the loading of DOX can be} tuned at will by varying the concentration _{of the block copolymer adsorbed} onto the nanotube _{surface. The obtained multi-walled òarbon} nanotube-based systems show enhanced cytotoxic activity with respect to non-vehicled doxorubicin.

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E. M. DiMeo, A. DiCrescenzo, D. Velluto, C. O'Neil, D. Demurtas, J. A. Hubbell and A. Fontana Macromo Ie ca le s, 20 10, 43, 3429.