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7. RIFERIMENTI BIBLIOGRAFICI

Abramson J.S., Wheeler J.G., editors. (1993). The neutrophil. Oxford: IRL Press at Oxford University Press.

Acampora D., Annino A., Puelles E., Alfano I., Tuorto F., Simeone A., (2003).Otx1 compensates for Otx2 requirement in regionalisation of anterior neuroectoderm. Gene Exp. Patterns 3: 497–501.

Acampora D., Annino A., Tuorto F., Puelles E., Lucchesi W., Papalia A., Simeone A., (2005 ). Otx genes in the evolution of the vertebrate brain. Brain Res Bull. 66(4-6):410-20.

Acampora D., Avantaggiato V., Tuorto F., Barone P., Perera M., Choo D., Wu D., Corte G., Simeone A., (1999). Differential transcriptional control as the major molecular event in generating Otx1−/− and Otx2−/− divergent phenotypes. Development 126 :1417–1426.

Acampora D., Avantaggiato V., Tuorto F., Briata P., Corte G., Simeone A., (1998a). Visceral endoderm-restricted translation of Otx1 mediates recovering of Otx2 requirements for specification of anterior neural plate and proper gastrulation. Development 125: 5091– 5104.

Acampora D., D'Esposito M., Faiella A., Pannese M., Migliaccio E., Morelli F., Stornaiuolo A., Nigro V., Simeone A, Boncinelli E., (1989).The human Hox gene family. Nucleic Acids Res.17(24):10385-402.

Acampora D., Mazan S., Avantaggiato V., Barone P., Tuorto F., Lallemand Y., Brulet P., Simeone A.,(1996). Epilepsy and brain abnormalities in mice lacking the Otx1 gene. Nat. Genet. 14 : 218–222.

Acampora D., Mazan S., Lallemand Y., Avantaggiato V., Maury M., Simeone A., Brulet P., (1995). Forebrain and midbrain regions are deleted in Otx2−/− mutants due to a defective anterior neuroectoderm specification during gastrulation. Development 121: 3279–3290.

Acampora D., Mazan S., Tuorto F., Avantaggiato V., TremblayJ.J., Lazzaro D., di Carlo A., Mariano A., Macchia P.E.,Corte G., Macchia V., Drouin J., Brulet P., Simeone A.,(1998b). Transient dwarfism and hypogonadism in mice lacking Otx1 reveal prepubescent stage-specific control of pituitary levels of GH, FSH and LH. Development 125: 1061–1072.

Adams B., Dorfler P., Aguzzi A., Korzmik Z., Urbanek P., Mauer-Fogy I. and Busslinger M., (1992). Pax-5 encode the transcription factor BSAP and is expressed in B lymphocytes, the developing CNS and adult testis. Genes Dev.6: 1589-1607.

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of Flt3 expression within the bone marrow Lin−Sca1+c-kit+ stem cell compartment is accompanied by loss of self-renewal capacity. Immunity 15: 659–669.

Adolfsson J., Mansson R., Buza-Vidas N., et al., (2005). Identification of Flt3 lympho-myeloid stem cells lacking erythro-megakaryocytic potential a revised road map for adult blood lineage commitment. Cell 121:295–306.

Akashi K., He X., Chen J., Iwasaki H., Niu C., Steenhard B., Zhang J., Haung J. and Li L. (2003). Transcriptional accessibility for genes of multiple tissues and hematopoietic lineages is hierarchically controlled during early hematopoiesis. Blood 101: 383-390.

Akbarzadeh S., Layton J.E., (2001). Granulocyte colony-stimulating factor receptor: structure and function. Vitam Horm 63: 159–94.

Alvarez-Dolado M., Pardal R., Garcia-Verdugo J.M., Fike J.R., Lee H.O., Pfeffer K, Lois C., Morrison S.J., Alvarez- Buylla A., (2003). Fusion of bone-marrow-derived cells with purkinje neurons, cardiomyocytes and hepatocytes.

Nature 425: 968.

Andre C., d'Auriol L., Lacombe C., Gisselbrecht S., Galibert F., (1989). C-kit mRNA expression in human and murine hematopoietic cell lines. Oncogene 4: 1047-1049.

Ang S.L., Conlon R.A., Jin O., Rossant J., (1994). Positive and negative signals from mesoderm regulate the expression of mouse Otx2 in ectoderm explants. Development 120: 2979–2989.

Ang S.L., Jin O., Rhinn M., Daigle N., Stevenson L., Rossant J., (1996). A targeted mouse Otx2 mutation leads to severe defects in gastrulation and formation of axial mesoderm and to deletion of rostral brain. Development 122: 243–252.

Apiou F., Flagiello D., Cillo C., Malfoy B., Poupon M.F., Dutrillaux B. (1996) Fine mapping of human Hox gene clusters. Cytogenet Cell Genet 73: 114–115. Aplan P.D., Begley C.G., Bertness V., Nussmeier MA., Ezquerra A., Coligan J., Kirsch I.R., (1990). The Scl gene is formed from a transcriptional complex locus. Mol. Cell. Biol. 10(12): 6426-6435.

Aplan P.D., Raimondi S.C., Kirsch I.R., (1992). Disruption of the Scl gene by a t(1;3) translocation in a patient with T cell acute lymphoblastic leukemia. J Exp Med 176:1303.

Aplan P.D., Jones C.A., Chervinsky D.S., Zhao X., Ellsworth M., Wu C., McGuire E.A., Gross K.W., (1997). An scl gene product lacking the transactivation domain induces bony abnormalities and cooperates with LMO1 to generate T-cell malignancies in transgenic mice. EMBO J. 16(9): 2408-2419.

(3)

Arai F., Hirao A., Ohmura M., et al., (2004). Tie2/angiopoietin-1 signaling regulates hematopoietic stem cell quiescence in the bone marrow niche. Cell.118:149–161.

Asakura A. and Rudnicki M.A., (2002). Side population cells from diverse adult tissuer are capable of in vitro hematopoietic differentiation. Exp.Hematol. 30: 1339-45.

Asnagli H., Afkarian M., Murphy K.M., (2002). Identification of an alternative GATA-3 promoter directing tissue-specific gene expression in mouse and human. J Immunol 168:4268–71.

Avecilla S.T., Hattori K., Heissig B., Tejada R., Liao F., Shido K., Jin D.K., Dias S., Zhang F., Hartman T.E., Hackett N.R., Crystal R.G., Witte L., Hicklin D.J., Bohlen P., Eaton D., Lyden D, de Sauvage F., Rafii S., (2004). Chemokine-mediated interaction of hematopoietic progenitors with the bone marrow vascular niche is required for thrombopoiesis. Nature Med. 10: 64–71. Balazs A.B., Fabian A.J., Esmon C.T., Mulligan R. (2006). Endothelial protein C receptor (CD201) explicitly identifies hematopoietic cells in murine bone marrow. Blood 107 (6): 2317-2321.

Barreda D.R, Belosevic M. (2001). Transcriptional regulation of hemopoiesis. Dev Comp Immunol. 25(8-9):763-89.

Barreda D.R., Hanington P.C., Belosevic M., (2004). Regulation of myeloid development and function by colony stimulating factors. Developmental and Comparative Immunology 28: 509–554.

Bazan J.F. (1990) Structural design and molecular evolution of a cytokine receptor superfamily. Proc Natl Acad Sci U S A. 87(18):6934-8.

Beau C., Rauch M., Joulin V., Jegou B., Guerrier D., (2000). GATA-1 is a potential repressor of anti-Mullerian hormone expression during the establishment of puberty in the mouse. Mol Reprod Dev. 56(2):124-38.

Begley C.G., Aplan P.D., Davey M.P., Nakahara K., Tchorz K., Kurtzberg J., Hershfeld M.S., Haynes B.F., Cohen D.I., Waldman T.A., Kirsh I.R., (1989). Chromosomal translocation in a human leukemic stem cell line disrupts the T-cell antigen receptor-chain diversity region and results in a previously unreported fusion transcript. Proc. Natl. Acad. Sci. U.S.A. 86(6): 2031-2035.

Begley C.G., Green A.R., (1999). The Scl gene: from case report to critical hematopoietic regulator. Blood 93:2760–2770.

Begley C.G., Robb L., Rockman S., Visvader J., Bockamp E.O., Chan Y.S., Green A.R., (1994). Structure of the gene encoding the murine Scl protein. Gene 138(1-2): 93-99.

(4)

Bellon T., Perrotti D., Calabretta B., (1997).Granulocytic differentiation of normal hematopoietic precursor cells induced by transcription factor PU.1 correlates with negative regulation of the c-myb promoter. Blood.90(5):1828-39. Bernard O., Guglielmi P., Jonveaux P., Cherif D., Gisselbrecht S., Mauchauffe M., Berger R., Larsen C.J., Mathieu-Mahul D., (1990). Two distinct mechanisms for the Scl gene activation in the t(1;14) translocation of T-cell leukemias. Genes Chromosomes Cancer 1: 194-208.

Bernstein I.D., Andrews R.G., Zsebo KM., (1991). Recombinant human stem cell factor enhances the formation of colonies by CD34+ and CD34+lin- cells, and the generation of colony-forming cell progeny from CD34+lin- cells cultured with interleukin-3, granulocyte colony-stimulating factor, or granulocyte-macrophage colony-stimulating factor. Blood.77(11):2316-21.

Bernstein A., Rottalpel R., Giddens E., Brady C. and Forrester L., (1990). W mutant mice with mild or severe development defects contain distinct point mutations in the kinase domain of the c-kit receptor. Genes Dev. 4: 390-400. Bertrand JY, Giroux S, Golub R, et al., (2005). Characterization of purified intraembryonic hematopoietic stem cells as a tool to define their site of origin. Proc Natl Acad Sci U S A.;102:134–139.

Bittner R.E., Schöfer C., Weipoltshammer K., Ivanova S., Streubel B., Hauser E., Freilinger M., Höger H., Elbe-Bürger A., Wachtler F., (1999). Recruitment of bone-marrow-derived cells by skeletal and cardiac muscle in adult dystrophic mdx mice. Anat Embryol 199:391-396.

Bockamp E.O., Fordham J.L., Gottgens B., Murrell A.M, Green AR., (1998). Transcriptional regulation of the stem cell leukemia gene by PU.1 and ELF-1. J. Biol. Chem. 273: 29032-29042.

Bockamp E.O., McLaughlin F., Gottgens B., Murrell A.M., Elefanty AG., Green A.R., (1997). Distinct mechanisms direct Scl/tal-1 expression in erythroid cells and CD34 positive primitive myeloid cells. J. Biol. Chem. 272(13): 8781-8790.

Bockamp E.O., McLaughlin F., Murrell A.M., Gottgens B., Robb L., Begley C.G., Green A.R., (1995). Lineage-restricted regulation of the murine Scl/Tal-1 promoter. Blood 86(4): 1502-1514.

Boncinelli E., Acampora D., Pannese M., D’Esposito M., Somma R., Gaudino G., Stornaiuolo A., Cafiero M., Faiella A., Simeone A., (1989). Organization of human class I homeobox genes. Genome 31: 745–756.

Bradley C.K., Takano E.A., Hall M.A., Gothert J.R., Harvey A.R., Begley C.G, van Eekelen J.A., (2006). The essential haematopoietic transcription factor Scl is also critical for neuronal development

.

Eur J Neurosci. 23(7):1677-89.

(5)

Brendolan A., Ferretti E., Salsi V., Moses K., Quaggin S., Blasi F., Cleary M.L., Selleri L., (2005). A Pbx1-dependent genetic and transcriptional network regulates spleen ontogeny. Development. 132(13):3113-26.

Brown L., Cheng J.T., Chen Q., Siciliano M.J., Crist W., Buchanan G., Baer R., (1990). Site specific recombination of the tal1 gene is a common occurrence in human T cell leukemia. EMBO J. 9(10): 3343-3351.

Brun A.C., Bjornsson J.M., Magnusson M., Larsson N., Leveen P., Ehinger M., Nilsson E., Karlsson S., (2004). Hoxb4-deficient mice undergo normal hematopoietic development but exhibit a mild proliferation defect in hematopoietic stem cells. Blood 103(11):4126-33.

Busslinger M., Klix N., Pfeffer P., Graninger P.G. and Kozmik Z., (1996). Deregulation of Pax5 by translocation of the Em enhancer of the IgH locus adjacent to two alternative Pax5 promoters in a diffuse large-cell lymphoma. Proc. Natl. Acad. Sci. USA 93: 6129-6134.

Bjornsson J.M., Larsson N., Brun A.C., Magnusson M., Andersson E., Lundstrom P., Larsson J., Repetowska E., Ehinger M., Humphries R.K. and Karlsson S. (2003). Reduced proliferative capacity of hematopoietic stem cells deficient in Hoxb3 and Hoxb4. Mol.Cell.Biol. 23: 3872-83.

Bjornson C.R.R., Rietze RL., Reynolds B.A., Magli M.C., Vescovi A.L., (1999). Turning brain into blood: a hematopoietic fate adopted by adult neural stem cells in vivo. Science 283: 534.

Byrne P.V., Guilbert L.J., Stanley E.R., (1981). Distribution of cells bearing receptors for a colony-stimulating factor (CSF-1) in murine tissues. J Cell Biol 91(3 Part 1):848–53.

Calvi L.M., Adams G.B., Weibrecht K.W., Weber J.M., Olson D.P., Knight M.C., Martin R.P., Schipani E., Divieti P., Bringhurst F.R., Milner L.A., Kronenberg H.M., Scadden D.T., (2003). Osteoblastic cells regulate the haematopoietic stem cell niche. Nature.425(6960):778-9.

Camargo F.D., Chambers S.M., Drew E., McNagny K.M., Goodell M.A., (2006). Hematopoietic stem cells do not engraft with absolute efficiencies. Blood. 107(2):501-7.

Camargo F.D., Chambers S.M. and Goodell M.A. (2004). Stem cell plasticity: from transdifferentiation to macrophage fusion. Cell Prolif. 37: 55-65.

Camargo F.D., Green R., Capetenaki Y., Jackson K.A., Goodell M.A., (2003). Single hematopoietic stem cells generate skeletal muscle through myeloid intermediates. Nat. Med. 9: 1520.

Carlos T.M., Harlan J.M., (1994). Leukocyte-endothelial adhesion molecules. Blood.84:2068–2101.

(6)

Carrasco A.E., McGinnis W., Gehring W.J. and De Robertis E.M., (1984). Cloning of an X. leavis gene expressed during early embryogenesis coding for a peptide region homologous to Drosophila homeotic genes. Cell 37: 409-414. Castro R.F., Jackson K.A., Goodell M.A., Robertson C.S., Liu H. and Shine H.D., (2002). Failure of bone marrow cells to transdifferentiate into neural cells in vivo. Science 297: 1299.

Chen Q., Cheng J.T., Tsai L.H., Schneider N., Buchanan G., Carroll A., Crist W., Ozanne B., Siciliano M.J., Baer R., (1990). The tal gene undergoes chromosome translocation in T-cell leukemia and potentially encodes a helix-loop-helix protein. EMBO J. 9(2): 415-424.

Chen C.Z., Li M., de Graaf D., Monti S., Gottgens B., Sanchez M.J., Lander E.S., Golub T.R., Green A.R., and Lodish H.F., (2002). Identification of endoglin as a functional marker that defines long-term repopulating hematopoietic stem cells. Proc.Natl.Acad.Sci.USA 99: 15468-73.

Choi K., Kennedy M., Kazarov A., Papadimitriou J.C., Keller G., (1998). A common precursor for hematopoietic and endothelial cells. Development. 125:725–732.

Christensen, J.L., and Weissman, I.L., (2001). Flk-2 is a marker in hematopoietic stem cell differentiation: a simple method to isolate long-term stem cells. Proc. Natl. Acad. Sci. USA 98: 14541–14546.

Cillo C., Barba P., Freschi G., Bucciarelli G., Magli M.C., Boncinelli E., (1992). Hox gene expression in normal and neoplastic human kidney. Int J Cancer 51: 892–897.

Civin C.I., Almeida -Porada G., Lee M.J., Olweus J., Terstappen L.W. and Zanjani E.D., (1996). Sustained, retransplantable, multilineage engrafment of highly purified adult human bone marrow stem cells in vivo. Blood 88(11): 4102-4109.

Clarke D., Frisén J., (2001). Differentiation potential of adult stem cellsCurrent Opinion in Genetics & Development 11:575–580.

Clarke D.L., Johansson C.B., Wilbertz J., Veress B., Nilsson E., Karlstrom H., Lendahl U., Frisen J., (2000). Generalized potential of adult neural stem cells.

Science 288, 1660.

Cohen S.M., Jurgens G., (1990). Mediation of Drosophila head development by gap-like segmentation genes. Nature 346(6283):482-5.

Cook W.D., McCaw B.J., Herring C., John D.L., Foote S.J., Nutt S.L., Adams J.M., (2004). PU.1 is a suppressor of myeloid leukemia, inactivated in mice by gene deletion and mutation of its DNA binding domain. Blood. 104(12):3437-44.

(7)

Cotta C.V., Zhang Z., Kim H.G. And Klug C.A., (2003). Pax5 determines B-versus T-cell fate and does not block early myeloid-lineage development. Blood 101: 4342-4346.

Crawley J.T., Gu J.M., Ferrel G., Esmon C.T.,(2002).Distribution of endothelial cell protein C/activated protein C receptor (EPCR) during mouse embryo development. Thromb. Haemos.88: 259-266.

Crispino J.D. Lodish M.B. MacKay J.P., Orkin S.H., (1999). Use of altered specificity mutants to probe a specific protein-protein interaction in differentiation: the GATA-1:FOG complex. Molec. Cell 3: 219-228.

Cumano A.,Dieterlen-Lièvre F., Godin I., (1996). Lymphoid potential, probed before circulation in mouse, is restricted to caudal intraembryonic splanchnopleura. Cell. 86(6):907-16.

Dagher R.N., Hiatt K., Traycoff C., Srour E.F, Yoder M.C., (1998). c-Kit and CD38 are expressed by long-term reconstituting hematopoietic cells present in the murine yolk sac. Biol Blood Marrow Transplant. 4(2):69-74.

Dahl R., Walsh J.C., Lancki D., Laslo P., Iyer S.R., Singh H., Simon M.C., (2003). Regulation of macrophage and neutrophil cell fates by the PU.1:C/EBPalpha ratio and granulocyte colony-stimulating factor. Nat Immunol. 4(10):1029-36.

Dame C., Fahnenstich H., Freitag P., Hofmann D., Abdul-Nour T., Bartmann P. and Fandrey J., (1998). Erythropoietin mRNA expression in human fetal and neonatal tissue. Blood 92: 3218-3225.

Dancey J.T., Deubelbeiss K.A., Harker L.A., Finch C.A., (1976). Neutrophil kinetics in man. J. Clin. Invest. 58: 705-711.

De Bruijn M., Speck N., Peeters M., Dzierzak E.,(2000). Definitive hematopoietic stem cells develop within the major arterial regions of the mouse embryo. EMBO J.;19:2465-2474.

De la Chapelle A., Fantoni A., Marks P., (1969). Differentiation of mammalian somatic cells: DNA and hemoglobin synthesis in fetal mouse yolk sac erythroid cells. Proc Natl Acad Sci U S A. 63:812–819.

Delgado M.D., Hallier M., Meneceur P., Tavitian A., Moreau-Gachelin F.,(1994). Inhibition of friend cells proliferation by spi-1 antisense oligodeoxynucleotides. Oncogene 9:1723.

DeKoter R.P., Singh H., (2000). Regulation of B lymphocyte and macrophage development by graded expression of PU.1. Science 288(5470):1439-41.

De Maria R., Zeuner A., Eramo A., Domenichelli C., Bonci D., Grignani F., Srinivasula S.M., Alnemri E.S., Testa U., Peschle C.,(1999). Negative regulation of erythropoiesis by caspase-mediated cleavage of GATA-1. Nature.401(6752):489-93.

(8)

De Vita G., Barba P., Odartchenko N., Givel J.C., Freschi G., Bucciarelli G., Magli M.C., Boncinelli E., Cillo C., (1993). Expression of homeobox- containing genes in primary and metastatic colorectal cancer. Eur J Cancer; 29A: 887–893.

Dick J.E., (1996). Normal and leukemic human stem cells assayed in SCID mice. Semin Immunol 196 ; 8: 197–206.

Dieterlen-Lievre F., Godin I., Pardanaud L., (1997). Where do hematopoietic stem cells come from? Int. Arch. Allergy Immunol. 112(1): 3-8.

Dietrelen-Lièvre F., Martin C., (1981). Diffuse intraembrionic hemopoiesis in normal and chimeric avian development. Developmental Biology 88: 180-8. DiMartino J.F., Selleri L., Traver D., Firpo M.T., Rhee J., Warnke R., O'Gorman S., Weissman I.L., Cleary M.L., (2001). The Hox cofactor and proto-oncogene Pbx1 is required for maintenance of definitive hematopoiesis in the fetal liver. Blood. 98(3):618-26.

Drake C.J., Brandt S.J., Trusk T.C., Little C.D., (1997). Tal1/Scl is expressed in endothelial progenitor cells/angioblasts and defines a dorsal-to ventral gradient of vasculogenesis. Dev Biol. 192:17–30.

Dusanter-Fourt I., Muller O., Ziemiecke A., Mayeux O., Drucker B., Djiane J., Wilks A., Harpur A.G , Fischer S. and Gisselbrecht S., (1994). Identification of JAK protein tyrosine kinases as signaling molecules for prolactin. Functional analysis of prolactin receptor and prolactin-erythropoietin receptor chimeras expressedin lymphoid cells. EMBO J. 13: 2583-2583.

Dzierzak E., Medvinsky A., De Bruijn M., (1998). Qualitative and quantitative aspects of haematopoietic cell development in the mammalian embryo. Immunology Today 19:228-236.

Elefanty A.G., Begley C.G., Hartley L., Papaevangeliou B., Robb L., (1999).

Scl expression in the mouse embryo detected with a targeted lacZ reporter gene

demonstrates its localization to hematopoietic, vascular, and neural tissues.

Blood. 94:3754–3763.

Elefanty A.G, Begley C.G., Metcalf D., Barnett L., Kontgen F., Robb L., (1998). Characterization of hematopoietic progenitor cells that express the transcription factor Scl, using a lacZ “knock-in” strategy. Proc Natl Acad Sci U S A. 95:11897–11902.

Elwood N.J., Zogos H., Pereira D.S., Dick J.E., Begley C.G., (1998). Enhanced megakaryocyte and erythroid development from normal human CD34_ cells: consequence of enforced expression of Scl. Blood. 91:3756–3765.

Ernst P., Fisher J.K., Avery W., Wade S., Foy D., Korsmeyer S.J., (2004). Definitive hematopoiesis requires the mixed-lineage leukemia gene. Dev Cell. 6(3):437-43.

(9)

Esmon C.T., (2000). The endothelial cell protein C receptor. Thromb. Haemost. 83: 639-643.

Ferrari G., Cusella-De Angelis G., Coletta M., Paolucci E., Stornaiuolo A., Cossu G., Mavilio F., (1998). Muscle regeneration by bone marrow-derived myogenic progenitors. Science 279:1528-1530.

Fischbach N.A., Rozenfeld S., Shen W., Fong S., Chrobak D., Ginzinger D., Kogan S.C., Radhakrishnan A., Le Beau M.M., Largman C., Lawrence H.J. (2005). Hoxb6 overexpression in murine bone marrow immortalizes a myelomonocytic precursor in vitro and causes hematopoietic stem cell expansion and acute myeloid leukemia in vivo. Blood 105(4):1456-66.

Fisher R.C., Scott E.W.,(1998). Role of PU1 in hematopoiesis. Stem Cells 16:25-37.

Fixe P., Praloran V., (1997). Macrophage colony-stimulating-factor (M-CSF or CSF-1) and its receptor: structure–function relationships. Eur Cytokine Netw 8(2):125–36.

Flodby P., Barlow C., Kylefjord H., Ahrlund-Richter L., Xan thopoulos K.G., (1996). Increased hepatic cell proliferation and lung abnormalities in mice deficient in CCAAT/enhancer binding protein α. J Biol Chem 271:24753.

Ford C.E., Hamerton J.L., Barnes D.W. and Loutit J.F., (1956). Cytological identification of radiation-chimaeras. Nature 177, 452.

Frantz G.D., Weimann J.M., Levin M.E., McConnell S.K., (1994). Otx1 and Otx2 define layers and regions in developing cerebral cortex and cerebellum. J Neurosci. 14(10):5725-40.

Frenette P.S., Subbarao S., Mazo I.B., von Andrian U.H., Wagner D.D., (1998). Endothelial selectins and vascular cell adhesion molecule-1 promote hematopoietic progenitor homing to bone marrow. Proc Natl Acad Sci U S A. 95:14423–14428.

Freytag S.O., (1988). Enforced expression of the c-myc oncogene inhibits cell differentiation by precluding entry into a distinct predifferentiation state in G0/G1. Mol Cell Biol. (4):1614-24.

Frisén J., (2002). Stem Cell Plasticity? Neuron 35, 415–418.

Fukudome K., Esmon C.T.,(1994). Identification, cloning, and regulation of a novel endothelial cell protein C/activated protein C receptor. J. Biol. Chem. 269: 26486-26491.

Fuller J.F., McAdara J., Yaron Y., Sakaguchi M., Fraser J.K. and Gasson J., (1999). Characterization of Hox gene expression during myelopoiesis: role of Hoxa5 in lineage commitment and maturation. Blood 93, 3391-3400.

(10)

Garcia-Porrero J.A., Godin I.E., Dieterlen-Lièvre F.,(1995). Potential intraembryonic hemogenic sites at pre-liver stages in the mouse. Anat. Embryol. 192:425-435.

Garland J.M., Quesenberry P.J., Hilton D.J., editors, (1997). Colony stimulating factors: molecular and cellular biology, 2nd ed. New York: Marcell Dekker. Garrell J., Campuzano S., (1991). The helix-loop-helix domain: a common motif for bristles, muscle and sex. Bioessays 13: 493-498.

Gehring W.J., Hiromi Y., (1986). Homeotic genes and the homeobox. Annu. Rev. Genet.20: 147-173

Gehring W., Qian Y.Q., Billeter M., Furukubo-Tokunaga K., Schier A.F., Resendez-Perez D., Affolder M., Otting G. and Wuthrich K. (1994). Homeodomain-DNA recognition. Cell 78: 211-223.

Gekas C., Dieterlen-Lievre F., Orkin S.H., Mikkola H.K.A., (2005). The placenta is a niche for hematopoietic stem cells. Dev Cell.;8:365–375.

Giampaolo A., Felli N., Diverio D., Morsilli O., Samoggia P., Breccia M., Lo Coco F., Peschle C., Testa U., (2002). Expression pattern of Hoxb6 homeobox gene in myelomonocytic differentiation and acute myeloid leukemia. Leukemia 16(7):1293-301.

Ginsburg H., Sachs L., (1963). Formation of pure suspensions of mast cells in tissue culture by differentiation of lymphoid cells from the mouse thymus. J Natl Cancer Inst. 31:1-39.

Godin I., Dieterlen-Lièvre F.,Cumano A., (1995)..Emergence of multipotent

hemopoietic cells in the yolk sac and paraaortic splanchnopleura in mouse embryos, beginning at 8.5 days postcoitus. Proc Natl Acad Sci U S A. 92(3):773-7.

Godin I.E., Garcia-Porrero J.A., Coutinho A., Dieterlen-Lièvre F., Marcos M.A., (1993). Para-aortic splanchnopleura from early mouse embryos contains B1a cell progenitors. Nature.364(6432):67-70.

Goodell M.A., Brose K., Paradis G., et al., (1996). Isolation and functional properties of murine hematopoietic stem cells that are replicating in vivo. J.Exp.Med. 183: 1797-1806.

Gory-Faure S., Prandini M.H., Pointu H., et al., (1999). Role of vascular

endothelial-cadherin in vascular morphogenesis. Development.; 126:2093– 2102.

Green A.R., Salvaris E., Begley C.G., (1991). Erythroid expression of the ‘helix-loop-helix’ gene, Scl. Oncogene. 6:475–479.

(11)

Green A.R., Visvader J., LInts T., Harvey R., Begley C.G., (1992). Scl is coexpressed with GATA-1 in haemopoietic cells but is also expressed in developing brain. Oncogene 7: 653-660.

Guilbert L.J., Stanley E.R., (1980). Specific interaction of murine colony-stimulating factor with mononuclear phagocytic cells. J Cell Biol 85(1):153–9. Gupta S., Verfaillie C., Chmielewski D., et al., (2002). A role for extrarenal cells in the regeneration following acute renal failure. Kidney Int. 62: 1285-1290.

Gussoni E., Soneka Y., Strickland C.D., Buzney E.A., Khan M.K., Flint A.F., Kunkel L.M., Mulligan R.C., (1999). Dystrophin expression in the mdx mouse restored by stem cell transplantation. Nature 401: 390-394.

Hagemeier C., Bannister A.J., Cook A., Kouzarides T., (1993). The activation domain of transcription factor PU.1 binds the retinoblastoma (RB) protein and the transcription factor TFIID in vitro: RB shows sequence similarity to TFIID and TFIIB. Proc Natl Acad Sci USA 90:1580.

Hall M.A., Curtis D.J., Metcalf D., Elefanty A.G., Sourris K., Robb L., Gotherd J.R., Jane S.M. and Begley C.G., (2003). The critical regulator of embryonic hematopoiesis, Scl, is vital in the adult for megakaryopoiesis, erythropoiesis, and lineage choice in CFU-S12. Proc. Natl. Acad. Sci. USA 100: 992-997. Hamilton J.A., (1997a). CSF-1 signal transduction. J Leukoc Biol 62(2):145–55. Hamilton J.A., (1997b). CSF-I signal transduction: what is of functional significance? Immunol Today 18(7):313–7.

Hammond W.P., Csiba E., CaninA., et al., (1991). Chronic neutropenia. A new canine model induced by human granulocyte colonystimulating factor. J Clin Invest 87(2):704–10.

Harrison D., (1980). Competitive repopulation: a new assay for long-term stem cell functional capacity. Blood 55: 77-81.

Henkel G., McKercher S., Yamamoto H., Anderson K.L., Oshima R.G., Maki R.A., (1996). PU.1 but not Ets-2 is essential for macrophage development from embryonic stem cells. Blood 88:2917-2926.

Hetzer-Egger C., Schorpp M., Boehm T., (2000). Evolutionary conservation of gene structures of the Pax1/9 gene family. Biochim Biophys Acta. 1492 (2-3):517-21.

Hirayama F., Katayama N., Neben S., Donaldson D., Nickbarg E.B., Clark S.C. and Ogawa M., (1993). Synergistic interaction between interleukin-12 (natural killer cell stimulatory factor, cytotoxic lymphocyte maturation factor) and steel factor in support of proliferation of murine lymphohemopoietic progenitors in culture. J.Cell.Biochem.(suppl) 17B:225.

(12)

Hirth F., Reichert H., (1999). Conserved genetic programs in insect and mammalian brain development.Bioessays. 21(8):677-84.

Hoang T., Paradis E., Brady G., et al., (1996). Opposing effects of the basic helix-loop-helix transcription factor Scl on erythroid and monocytic differentiation. Blood.87:102–111.

Hofmann C., Drossopoulou G., McMahon A., Balling R. and Tickle C., (1998). Inhibitory action of BMPs on Pax1 expression and on shoulder girdle formation during limb development. Dev.Dyn. 213(2): 199-206

Hofstetter W., Wetterwald A., Cecchini M.C., et al., (1992). Detection of transcripts for the receptor for macrophage colonystimulating factor, c-fms, in murine osteoclasts. Proc Natl Acad Sci USA 89(20):9637–41.

Holland P.W.H., Garcia-Fernandez J., Williams N.A., Sidow A., (1994). Gene duplications of the origins of vertebrate development. Development Suppl 125– 133.

Holmes M.L., Carotta S., Corcoran L.M., Nutt S.L.,(2006). Repression of Flt3 by Pax5 is crucial for B-cell lineage commitment. Genes Dev. 20(8):933-8. Houssaint E., (1981). Differentiation of the mouse hepatic primordium, II:estrinsic origin of the haemopoietic cell line. Cell. Diff. 10: 243-247.

Hromas R., Orazi A., Neiman R.S. et al., (1993). Hematopoietic lineage- and stage-restricted expression of the ETS oncogene family member PU.1. Blood 82:2998-3004.

Hsu H.C., Ema H., Osawa M., Nakamura Y., Suda T., Nakauchi H., (2000). Hematopoietic stem cells express Tie-2 receptor in the murine fetal liver. Blood.96(12):3757-62.

Huang S., Chen Z., Yu J.F., et al., (1999). Correlation between IL-3 receptor expression and growth potential of human CD34 hematopoietic cells from different tissues. Stem Cells 17(5):265–72.

Huber K., Kouskoff V., Fehling H.J., Palis J., Keller G., (2004). Haemangioblast commitment is initiated in the primitive streak of the mouse embryo. Nature. 432:625–630.

Hume D.A., Yue X., Ross I.L., et al., (1997). Regulation of CSF-1 receptor expression. Mol Reprod Dev 46(1):46–52.

Ianus A., Holz G.G., Theise N.D. and Hussain M.A.,(2003). In vivo derivation of glucose-competent pancreatic endocrine cells from bone marrow without evidence of cell fusion. J.Clin.Invest. 111: 843-850.

Ihle J.N., Witthuhn B.A., Quelle F.W., Yamamoto K. and Silvennoinen O., (1995). Signaling through the hematopoietic cytokine receptors. Annu. Rev. Immunol. 13, 369-398.

(13)

Ikebuchi K., Clark S.C., Ihle J.N., Souza L.M. and Ogawa M.,(1988). Granulocyte colony-stimulating factor enhances interleukin 3-dependent proliferation of multipotential hematopoietic progenitors. Proc.Natl.Acad.Sci.USA 85: 3445.

Ikebuchi K., Wong G.G., Clark S.C., Ihle J.N. and Ogawa M.,(1987). Interleukin-6 enhancement of interleukin 3-dependent proliferation of multipotential hematopoitic progenitors. Proc.Natl.Acad.Sci.USA 84:9035.

Ikuta K., and Weissman I.L., (1992). Evidence that hematopoietic stem cells express mouse c-kit but do not depend on steel factor for their generation. Proc.

Natl. Acad. Sci. USA 89: 1502–1506.

Inaba T., Gotoda T., Ishibashi S., et al., (1996). Transcription factor PU.1 mediates induction of c-fms in vascular smooth muscle cells: a mechanism for phenotypic change to phagocytic cells. Mol Cell Biol 16(5):2264–73.

Iscove N.N.,(1978). Erythropoietin independent simulation of early erythropoiesis in adult bone marrow culture by conditioned medium from lecitin-stimulated mouse spleen cells in hematopoietic cell differentiation. Golde D.W., Cline M.J., Metcalf D., Fox C.F. Ed.:New York Academic Press. 37-52.

Iscove N.N. and Sieber F., (1974). Macroscopic erytroid colony formation in colture of mouse bone marrow cells. Exp. Hemat. 2: 278.

Iscove N.N. and Sieber F. (1975). Erytroid progenitors in mouse bone marrow detected by macroscopic colony formation colture. Exp. Hemat. 3: 32-43.

Ito E., Toki T., Ishihara H., Ohtani H., Gu L., Yokoyama M., et al., (1993). Erythroid transcription factor GATA-1 is abundantly transcribed in mouse testis. Nature 362:466–8.

Ivanova N.B., Dimos J.T., Schaniel C., Hackney J.A., Moore K.A. and Lemischka I.R., (2002). A stem cell molecular signature. Science 298: 601-604. Izon D.J., Rozenfeld S., Fong S.T. et al., (1998). Loss of function of the homeobox gene Hoxa-9 perturbs early T-cell development and induces apoptosis in primitive thymocytes. Blood 92: 383-393.

Jackson K.A., Majka S.M., Wang H., Pocius J., Hartley C.J., Majesky M.W., Entmann M.L., Michael L.H., Hirschi K.K. and Goodell M.A., (2001). Generation of ischemic cardiac muscle and vascular endothelium by adult stem cells. J.Clin.Invest. 107: 1395-1402.

Jackson K.A., Mi T., Goodell M.A., (1999). Hematopoietic potential of stem cells isolated from murine skeletal muscle. Proc. Natl Acad. Sci. USA 96, 14482.

(14)

Jaffredo T., Gautier R., Eichmann A., Dieterlen-Lièvre F., (1998). Intraaortic hemopoietic cells are derived from endothelial cells during ontogeny. Development.125:4575–4583.

Jaffredo T., Nottingham W., Liddiard K., Bollerot K., Pouget C. De Bruijn M.,(2005). From hemangioblast to hematopoietic stem cell: An endothelial connection? Experimental Hematology ;33: 1029-1040.

Jiang Y., Jahagirdar B.N., Reinhardt R.L. et al., (2002). Pluripotency of mesenchymal stem cells derived from adult marrow. Nature 418: 41-49.

Jo D.Y., Rafii S., Hamada T., Moore M.A., (2000). Chemotaxis of primitive hematopoietic cells in response to stromal cell-derived factor-1. J Clin Invest.105:101–111.

Johnson G.R. and Barker D.C., (1980). Colony formation in agar by adult bone marrow multipotential hematopoietic cells. Cell. Physiol. 103(3): 371-83.

Johnson P.F., Landschulz W.H., Graves B.J., McKnight S.L., (1987). Identification of a rat liver nuclear protein that binds to the enhancer core element of three animal viruses. Genes Dev 1:133.

Johnson G. and Moore M. (1975). Role of stem cell migration in initiation of mouse fetal liver hematopoiesis. Nature 258: 726-728.

Jordan C.T., McKearn J.P., Lemischka I.R., (1990). Cellular and developmental properties of fetal hematopoietic stem cells.Cell. 61(6):953-63.

Jubinsky P.T. and Stanley E.R., (1985). Purification of hemopoietin 1: a multilineage hematopoietic growth factor. Proc.Natl.Acad.Sci.USA 82: 2764. Kallianpur A.R., Jordan J.E., Brandt S.J., (1994). The Scl/Tal-1 gene is expressed in progenitors of both the hematopoietic and vascular systems during embryogenesis. Blood 83: 1200-1208.

Kappen C.,

(

2000). Disruption of the homeobox gene Hoxb-6 in mice results in increased numbers of early erythrocyte progenitors. Am J Hematol. 65(2):111-8. Kappen C., Schughart K., Ruddle F.H., (1993). Early evolutionary origin of major homeodomain sequence classes. Genomics 18: 54–70.

Katayama Y., Hidalgo A., Furie B..C, Vestweber D., Furie B., Frenette P.S. (2003). PSGL-1 participates in E-selectin-mediated progenitor homing to bone marrow: evidence for cooperation between E-selectin ligands and alpha4 integrin. Blood 102:2060–2067.

Kehrl J.H., (1994). Homeobox genes in hematopoiesis. Crit Rev Oncol Hematol 16: 145–156.

Keller G., Lacaud G., Robertson S., (1999). Development of the hematopoietic system in the mouse. Exp Hematol.;27:777–787.

(15)

Kessel M., Gruss P., (1991). Homeotic transformation of murine vertebrae and concomitant alteration of Hox code induced by retinoic acid. Cell 67: 89–104. Kiel, M. J., Yilmaz, O. H., Iwashita, T., Terhorst, C., Morrison, S.J., (2005). SLAM family receptors distinguish hematopoietic stem and progenitor cells and reveal endothelial niches for stem cells. Cell 121: 1109–1121.

Kinder S.J., Tsang T.E., Quinlan G.A., Hadjantonakis A.K., Nagy A., Tam P.P., (1999). The orderly allocation of mesodermal cells to the extraembryonic structures and the anteroposterior axis during gastrulation of the mouse embryo. Development. 126(21):4691-701.

Kingsley P.D., Malik J., Fantauzzo K.A., Palis J., (2004). Yolk sac-derived primitive erythroblasts enucleate during mammalian embryogenesis.

Blood.104:19–25.

Kingston R.E.,(1989). Transcription control and differentiation: the HLH family, c-myc, and C/EBP. Curr. Opin. Cell. Biol. 1(6): 1081-1087.

Kishimoto T., Akira S., Narazaki M., Taga T., (1995). Interleukin-6 family of cytokines and gp130. Blood 86:1243–54

Kishimoto T., Taga T., Akira S., (1994). Cytokine signal transduction. Cell 76:253–62

Klein W.H., Li X., (1999). Function and evolution of Otx proteins. Biochem Biophys Res Commun. 258(2):229-33. Erratum in: Biochem Biophys Res Commun 260(2):575.

Kodandapani R., Pio F., Ni C.Z., Piccialli G., Klemsz M., McKercher S., Maki R.A., Ely K.R., (1996). A new pattern for helix-turn-helix recognition revealed by the PU.1 ETS-domain-DNA complex. Nature 380(6573):456-60.

Kopp H.G., Avecilla S.T., Hooper A.T., Rafii S., (2005).The bone marrow vascular niche: home of HSC differentiation and mobilization. Physiology (Bethesda Md.) 20: 349–356.

Krause D.S., Theise N.D., Collector M.I. et al., (2001). Multi-organ, multi-lineage engraftment by a single bone marrow-derived stem cell. Cell 105: 369. Kroon E., Krosl J., Thorsteinsdottir U., at al.,(1998). Hoxa9 transforms primary bone marrow cells through specific collaboration with Meis1a but not Pbx1b. EMBO J. 17: 3714-3725.

Krosl G., He G., Lefrancois M., Charron F., Romeo PH., Jolicoeur P., Kirsch I.R., Nemer M., Hoang T., (1998). Transcription factor Scl is required for c-kit expression and c-Kit function in hematopoietic cells. J. Exp. Med. 188: 439-450.

(16)

Ku, H., Y. Yonemura, K. Kaushansky, and M. Ogawa.,(1996). Thrombopoietin, the ligand for the Mpl receptor, synergizes with steel factor and other early cytokines in supporting proliferation of primitive hematopoietic progenitors of mice. Blood 87:4544-4551.

Kulessa H., Frampton J. And Graf T., (1995). GATA-1 reprograms avian myelomonocytic cell lines into eosinophilis, thromboblasts and erythroblasts. Genes Dev. 9(10): 1250-62.

Kumaravelu P., Hook L., Morrison A.M., et al., (2002). Quantitative developmental anatomy of definitive haematopoietic stem cells/long-term repopulating units (HSC/RUs): role of the aorta-gonad-mesonephros (AGM) region and the yolk sac in colonisation of the mouse embryonic liver. Development.;129:4891–4899.

Labastie M.C., Cortes F., Romeo P.H., Dulac C., Peault B., (1998). Molecular identity of hematopoietic precursor cells emerging in the human embryo. Blood 92: 3624-3635.

Lagasse E., Connors H., Al-Dhalimy M., Reitsma M., Dohse M., Osborne L., Wang X., Finegold M., Weissman I.L., Grompe M., (2000). Purified hematopoietic stem cells can differentiate into hepatocytes in vivo. Nat Med 6:1229-1234.

Lawrence H.J., Helgason C.D., Sauvageau G., (1995). Mice homozygous for a targeted disruption of the homeobox gene Hoxa9 have defects in lymphoid and myeloid hematopoiesis. Blood 86: 254a.

Lawson K.A., Meneses J.J., Pedersen R.A., (1991). Clonal analysis of epiblast fate during germ layer formation in the mouse embryo. Development.113(3):891 911.

Leary A.G., Yang Y.C., Clark S.C., et al., (1987). Recombinant gibbon interleukin 3 supports formation of human multilineage colonies and blast cell colonies in culture: comparison with recombinant human granulocyte-macrophage colony-stimulating factor. Blood 70(5):1343–8.

Lécuyer E., Hoang T., (2004). Scl: From the origin of hematopoiesis to stem cells and leukaemia. Exp. Hemat. 32:11-24.

Levantini E., Giorgetti A., Cerisoli F., Traggiai E., Guidi A., Martin R, Acampora D., Aplan P.D., Keller G., Simeone A., Iscove N.N., Hoang T., Magli MC.,(2003).Unsuspected role of the brain morphogenetic gene Otx1 in hematopoiesis. Proc Natl Acad Sci U S A. 100(18):10299-303.

Levine M., Hoey T.,(1988). Homeobox proteins as sequence specific transcription factors. Cell 55:537-540.

Levine M., Rubin G.M., and Tjian R., (1984). Human DNA sequences homologous to a protein coding region conserved between homeotic genes of Drosophila. Cell 38: 667-673.

(17)

Lewis E.B., (1978). A gene complex controlling segmentation in Drosophila. Nature 276(5688): 565-570.

Li C.L., and Johnson G.R., (1995). Murine hematopoietic stem and progenitor cells: I. Enrichment and biologic characterization. Blood 85: 1472–1479.

Li W., Johnson S.A, Shelley W.C., Ferkowicz M., Morrison P, Li Y., Yoder M.C., (2003). Primary endothelial cells isolated from the yolk sac and para-aortic splanchnopleura support the expansion of adult marrow stem cells in vitro.Blood 102 4345–4353.

Li, W., Johnson, S. A., Shelley, W. C., Yoder, M. C., (2004). Hematopoietic stem cell repopulating ability can be maintained in vitro by some primary endothelial cells. Exp. Hematol. 32: 1226–1237.

Lill M.C., Fuller J.F., Herzig R., Crooks G.M. and Gasson J., (1995). The role of the homeobox gene, Hoxb7, in human myelomonocytic differentiation. Blood 85: 692-697.

Link H., Arseniev L., Bahre O., Kadar J., Diedrich H. and Poliwoda H., (1996). Transplantation of allogenic CD34+ blood cell. Blood 87: 4903.

Lloberas J., Soler C., Celada A., (1999). The key role of PU.1/Spi-1 in B cells, myeloid cells and macrophages. Immunol Today. 20(4):184-9.

Lord B.I., (1990). The architecture of bone marrow cell populations. Int J Cell Cloning.8:317–331.

Lotem J, Sachs L.,(1999). Cytokines as suppressors of apoptosis. Apoptosis. 4(3):187-96

Magli M.C., (1998).The role of homeobox genes in hematopoiesis. Biotherapy 10(4):279-94.

Magli M.C., Barba P., Celetti A., De Vita G., Cillo C. and Boncinelli E., (1991). Coordinate regulation of Hox genes in human hematopoietic cells. Proc.Natl.Acad.Sci.USA 88(14): 6348-6352.

Magli M.C., Iscove N.N., Odartchenko N., (1982). Transient nature of early hematopoietic spleen colonies. Nature 295: 527-558.

Magli M.C., Largman C., Lawrence H.J., (1997).Effects of Hox homeobox genes in blood cell differentiation. J Cell Physiol. 173(2):168-77.

Mallamaci A., Di Blas E., Briata P., Boncinelli E., Corte G., (1996). Otx2 homeoprotein in the developing central nervous system and migratory cells of the olfactory area. Mech Dev. 58(1-2):165-78.

Manak J.R. and Scott M.P., (1994). A class act: conservation of homeodomain protein function. Dev.Suppl. 61-71.

(18)

Marshall C.J., Thrasher A.J., (2001). The embryonic origins of human haematopoiesis. Br J Haematol. 112(4):838-50.

Mason T.M., Lord B.I., Hendry J.H., (1989). The development of spatial distributions of CFU-S and in-vitro CFC in femora of mice of different ages. Br J Haematol.;73:455–461.

Massari M.E., Murre C., (2000). Helix-loop-helix proteins: regulators of transcription in eucaryotic organisms. Mol Cell Biol. 20:429–440.

Matsuo I., Kuratani S., Kimura C., Takeda N., Aizawa S., (1995). Mouse Otx2 functions in the formation and patterning of rostral head, Genes Dev. 9 2646– 2658.

Matsuoka S., Ebihara Y., Xu M., Ishii T., Sugiyama D., Yoshino H., Ueda T., Manabe A., Tanaka R., Ikeda Y., Nakahata T., Tsuji K.,(2001).CD34 expression on long term repopulating hematopoietic stem cells changes during developmental stages. Blood.97(2):419-25.

Matsuzaki Y., Kinjo K., Mulligan R.C., Okano H., (2004).Unexpectedly efficient homing capacity of purified murine hematopoietic stem cells. Immunity.20(1):87-93.

Mazo I.B., Gutierrez-Ramos J.C., Frenette P.S., Hynes R.O., Wagner D.D., von Andrian U.H., (1998). Hematopoietic progenitor cell rolling in bone marrow microvessels: parallel contributions by endothelial selectins and vascular cell adhesion molecule 1. J Exp Med.188: 465–474. Erratum in: J Exp Med. 1998;188:1001.

McGinnis W., Levine M.S., Hafen E., Kuroiwa A. and Gehring W.J. (1984a). A conserved DNA sequence in homeotic genes of the Drosophila Antennapedia and Bhitorax complexes. Nature 308: 428-433.

McGinnis W., Hart C.P., Gehring W.J. and Ruddle F.H., (1984b). Molecular cloning and chromosome mapping of a mouse DNA sequence homologous to homeotic genes of Drosophila. Cell 38: 675-680.

McGrath K.E., Palis J., (2005). Hematopoiesis in the yolk sac: more than meets the eye. Experimental Hematology 33, 1021–1028.

McIvor Z., HeinS., Fiegler H., Schroeder T., Stocking C., Just U., Cross M., (2003 ). Transient expression of PU.1 commits multipotent progenitors to a myeloid fate whereas continued expression favors macrophage over granulocyte differentiation. Exp Hematol. 31(1):39-47.

McKercher S.R., Torbett B.E., Anderson K.L., Henkel G.W., Vestal D.J., Baribault H., Klemsz M., Feeney A.J., Wu G.E., Paige C.J., Maki R.A., (1996). Targeted disruption of the PU.1 gene results in multiple hematopoietic abnormalities. EMBO J 15:5647.

(19)

McKinney-Freeman S.L., Jackson K.A., Camargo F.D., Ferrari G., Mavilio F., Goodell M.A. (2002). Muscle-derived hematopoietic stem cells are hematopoietic in origin. Proc Natl Acad Sci U S A. 99(3):1341-6.

Medvinsky A.L., Gan O.I. Semenova M.L., Samolyna N.L.,(1996) Development of day-8 colony-forming unit-spleen hematopoietic progenitors during early murine embryogenesis: spatial and temporal mapping. Blood.87:557-66.

Medvinsky A.,Dzierzak E., (1996). Definitive hematopoiesis is autonomously initiated by the AGM region. Cell. 86(6):897-906.

Metcalf D., (1993). Hematopoietic regulators: redundancy or subtlety? Blood 82:3515–23

Metcalf D., Johnson J.R., Burgess A.W.,(1975). Growth of mouse megakaryocyte colonies in vitro. Proc. Natl. Acad. Sci. USA 72: 1744-1748. Mikkola H.K., Klintman J., Yang H., Hock H., Schlaeger T.M., Fujiwara Y. and Orkin S.H.,(2003). Haematopoietic stem cells retain long-term repopulating activity and multipotency in the absence of stem-cell leukaemia SCL/tal-1 gene. Nature 421: 547-551.

Miller B.A., Floros J., Cheung J.Y., Wojchowski D.M., Bell L., Begley C.G., Elwood N.J., Kreider J., Christian C., (1994). Stell factor affects Scl expression during normal erythroid-differentiation. Blood 84: 2971-2976.

Minegishi N., Ohta J., Suwabe N., Nakauchi H., Ishihara H., Hayashi N., et al., (1998). Alternative promoters regulate transcription of the mouse GATA-2 gene. J Biol Chem 273:3625–34.

Miyajima A., Hara T., Kitamura T., (1992). Common subunits of cytokine receptors and the functional redundancy of cytokines. Trends Biochem. Sci. 17:378–82

Miyajima A., Mui A.L.F., Ogorochi T., Sakamaki K., (1993). Receptors for granulocyte-macrophage colony-stimulating factor, interleukin- 3, and interleukin-5. Blood 82:1960–74

Mochizuki D.Y., Eisenman J.A., Conlon P.J., Larsen A.D. and Tushinski R.J., (1987). Interleukin 1 regulates hematopoietic activity, a role previously ascribed to hemopoietin 1. Proc.Natl.Acad.Sci.USA 84: 5267.

Molkentin J.D.,(2000 ).The zinc finger-containing transcription factors GATA-4, -5, and -6. Ubiquitously expressed regulators of tissue-specific gene expression. J Biol Chem.275(50):38949-52.

Moore M., Metcalf D., (1970).Ontogeny of the haematopoietic system: yolk salc origin of in vivo and in vitro colony forming cells in the developing mouse embryo. Br. J. Haematol. 18: 279-296.

(20)

Moreau-Gachelin F., Ray D., Mattei M., et al., (1989). The putative oncogene Spi-1: murine chromosomal localization and transcriptional activation in murine acute erythroleukemias. Oncogene 4:1449-1456.

Moreau-Gachelin F., Tavitian A., Tambourin P. (1988) Spi-1 is a putative oncogene in virally induced murine erythroleukemias. Nature 331:277-280. Moreau-Gachelin F., Wendling F., Molina T., Denis N., Titeux M., Grimber G., Briand P., Vainchenker W., Tavitian A., (1996). Spi-1/PU.1 transgenic mice develop multistep erythroleukemias. Mol Cell Biol 16:2453.

Moretti P., Simmons P., Thomas P., Haylock D., Rathjen P., Vadas M., D’Andrea R., (1994). Identification of homeobox genes expressed in human haemopoietic progenitor cells. Gene 144: 213–219.

Morsli H., Tuorto F., Choo D., Posiglione M.P., Simeone A., Wu D.K., (1999). Otx1 and Otx2 activities are required for the normal development of the mouse inner ear. Development 126: 2335–2343.

Morrison SJ, Hemmati HD, Wandycz AM, Weissman IL.(1995). The purification and characterization of fetal liver hematopoietic stem cells.Proc Natl Acad Sci U S A. 92(22):10302-6.

Motoyoshi K., (1998). Biological activities and clinical application of M-CSF. Int J Hematol 67(2):109–22.

Muller A., Medvinsky A., Strouboulis J., Grosveld F., Dzierzac E., (1994). Development of hematopoietic stem cell activity in the mouse embryo. Immun. 1: 291-301.

Musashi M., Yang Y.C., Paul S.R., Clark S.C., Sudo T. and Ogawa M.,(1991). Direct and synergistic effects of interleukin-11 on murine hematopoiesis in culture. Proc.Natl.Acad.Sci.USA 88: 765.

Nagulapalli S., Pongubala J.M., Atchison M.L.,(1995). Multiple proteins physically interact with PU.1. J Immunol 155:4330.

Nera K.P., Kohonen P., Narvi E., Peippo A., Mustonen L., Terho P., Koskela K., Buerstedde J.M., Lassila O., (2006). Loss of Pax5 promotes plasma cell differentiation. Immunity. 24(3):239-40.

Nerlov C., Graf T., (1998 ). PU.1 induces myeloid lineage commitment in multipotent hematopoietic progenitors. Genes Dev.12(15):2403-12.

Nguyen H.Q., Selvakumaran M., Liebermann DA., Hoffman B.,(1995). Blocking c-Myc and Max expression inhibits proliferation and induces differentiation of normal and leukemic myeloid cells. Oncogene.11(11):2439-44. Erratum in: Oncogene 1996 12(11):2481.

(21)

Nicola N.A. and Metcalf D.,(1985). Bilding of 125I-labered granulocyte colony-stimulating factor to normal murine hematopoietic cells. Cell.Physiol. 124, 313-321.

Niemeyer C.M., Sieff C.A., Mathey-Prevot B., et al., (1989). Expression of human interleukin-3 (multi-CSF) is restricted to human lymphocytes and T-cell tumor lines. Blood 73(4): 945–51.

Nilsson S.K., Johnston H.M., Whitty G.A., Williams B., Webb RJ., Denhardt D.T., Bertoncello I., Bendall L.J., Simmons P.J., Haylock D.N., (2005). Osteopontin, a key component of the hematopoietic stem cell niche and regulator of primitive hematopoietic progenitor cells. Blood. 106(4):1232-9. Nilsson S.K., Simmons P.J., Bertoncello I., (2006). Hemopoietic stem cell engraftment. Exp Hematol. 34(2):123-9.

Novelli E.M., Ramirez M., Civin C.I., (1998). Biology of CD34+CD38- cells in lymphohematopoiesis. Leuk Lymphoma. 31(3-4):285-93.

Nutt S.L., Heavey B., Rolink A.G., Busslinger M., (1999). Commitment to the B-lymphoid lineage depends on the transcription factor Pax5. Nature 401(6753): 556-562.

Ogawa M., (1993). Differentiation and Proliferation of Hematopoietic Stem Cells. Blood 81(11): 2844-2853.

Ohneda O., Fennie C., Zheng Z., Donahue C., La H, Villacorta R, Cairns B., Lasky L.A., (1998). Hematopoietic stem cell maintenance and differentiation are supported by embryonic aorta-gonad-mesonephros region-derived endothelium. Blood. 92(3):908-19.

Okada S., Nakauchi H., Nagayoshi K., Nishikawa S., Miura Y. and Suda T. (1991). Enrichment and characterization of murine hematopoietic stem cells that express c-kit molecule. Blood 78: 1706.

Okamoto R., Yajima T., Yamazaki M., Kanai T., Mukai M. Okamoto S., Ikeda Y., Hibi T., Inazawa J. and Watanabe M., (2002). Damage epithelia regenerated by bone marrow-derived cells in the human gastrointestinal tract. Nat.Med. 8: 1011.

Okuda T., van Deursen J., Hiebert S.W. Grosveld G.,Drowning J.R., (1996). AML1, the target of multiple chromosomal translocations in human leukaemia, is essential for normal fetal liver hematopoiesis. Cell.;84:321-330

Olson M.C., Scott E.W., Hack A.A., Su G.H., Tenen D.G., Singh H., Simon M.C., (1995). PU.1 is not essential for early myeloid gene expression but is required for terminal myeloid differentiation. Immunity 3:703-714.

Orkin S.H., (1996). Development of the hematopoietic system. Curr. Opin. Genet. Dev. 6(5): 597-602.

(22)

Orlic D., Kajstura J., Chimenti S., Jakoniuk I., Anderson S.M., Li B., Pickel J., McKay R., Nadal-Ginard B., Bodine D.M. et al.,(2001). Bone marrow cells regenerate infarcted myocardium. Nature 10:701-705.

Osawa M., Hanada K., Hamada H., and Nakauchi H., (1996). Long-term lymphohematopoietic reconstitution by a single CD34- low/negative hematopoietic stem cell. Science 273: 242–245.

Ottersbach K., Dzierzak E., (2005). The murine placenta contains hematopoietic stem cells within the vascular labyrinth region. Dev Cell.;8: 377–387.

Palacios R. and Nishikawa S.Y., (1992). Developmentally regulated cell surface expression and function of c-kit receptor during lymphocyte ontogeny in the embryo and adult mouse. Development 115: 1133.

Palis J., Robertson S., Kennedy M., Wall C., Keller G., (1999). Development of erythroid and myeloid progenitors in the yolk sac and embryo proper of the mouse. Development.;126:5073–5084.

Pan X., Minegishi N., Harigae H., Yamagiwa H., Minegishi M., Akine Y., et al., (2000). Identification of human GATA-2 gene distal IS exon and its expression in hematopoietic stem cell fractions. J Biochem127:105–12.

Perea-Gomez A., Lawson K.A., Rhinn M., Zakin L., Brulet P., Mazan S.,. Ang S.L., (2001). Otx2 is required for visceral endoderm movement and for the restriction of posterior signals in the epiblast of the mouse embryo, Development 128: 753–765.

Petersen B.E., Bowen W.C., Patrene K.D., Mars W.M., Sullivan A.K., Murase N., Boggs S.S., Greenberger J.S., Goff J.P., (1999). Bone marrow as a potential source of hepatic oval cells. Science 284:1168-1170.

Pluznik D.H. and Sachs L., (1965). The cloning of normal “mast” cells in tissue culture. J. Cell. Physiol. 66: 319-325.

Pluznik D.H., Sachs L., (1966). The induction of clones of normal mast cells by a substance from conditioned medium. Exp Cell Res.43(3):553-63.

Pollard J.W., Bartocci A., Arceci R., et al., (1987). Apparent role of the macrophage growth factor, CSF-1, in placental development. Nature 330(6147):484–6.

Porcher C., Swat W., Rockwell K., Fujiwara Y., Alt F.W., Orkin S.H., (1996). The T cell leukemia oncoprotein Scl/tal-1 is essential for development of all hematopoietic lineages. Cell.86:47–57.

Qui F., Ray P., Brown K., Barker P.E., Jhanwar S., Ruddle F.H. and Besmer P. (1988). Primary structure of c-kit: relationship with the CSF-1/PDGF receptor kinase family-oncogenic activation of v-kit involves delection of extracellular domain and C terminus. EMBO J. 7:1003.

(23)

Ray D., Bosselut R., Ghysdael J., Mattei M.G., Tavitian A., Moreau-Gachelin F., (1992). Characterization of Spi-B, a transcription factor related to the putative oncoprotein Spi-1/PU.1. Mol Cell Biol 12:4297.

Rampon C., Huber P., (2003). Multilineage hematopoietic progenitor activity generated autonomously in the mouse yolk sac: analysis using angiogenesis-defective embryos. Int J Dev Biol. 47:273–280.

Reddy V.A., Iwama A., Iotzova G., Schulz M., Elsasser A., Vangala R.K., Tenen D.G, Hiddemann W., Behre G., (2002).Granulocyte inducer C/EBPalpha inactivates the myeloid master regulator PU.1: possible role in lineage commitment decisions. Blood 100(2):483-90.

Reddy E.P., Korapati A., Chaturvedi P., et al., (2000). IL-3 signaling and the role of Src kinases, JAKs and STATs: a covert liaison unveiled. Oncogene 19(21):2532–47.

Reddy M.A., Yang B.S., Yue X., et al., (1994). Opposing actions of c-ets/ PU.1 and c-myb protooncogene products in regulating the macrophage-specific promoters of the human and mouse colony-stimulating factor-1 receptor (c-fms) genes. J Exp Med 180(6):2309–19.

Regulski M., Harding K., Kostriken R., Karch F., Levine M., McGinnis W., (1985). Homeobox genes of the Antennapedia and bithorax complexes of Drosophila. Cell. 43(1):71-80.

Rekhtman N., Radparvar F., Evans T. and Skoultchi A.I., (1999). Direct interaction of hematopoietic transcription factors PU.1 and GATA-1: functional antagonism in erythroid cells. Genes Dev. 13: 1398-1411.

Reya, T., Morrison, S.J., Clarke, M.F., and Weissman, I.L., (2001). Stem cells, cancer, and cancer stem cells. Nature 414: 105–111.

Robb L., Elwood N.J., Elefanty A.G., et al., (1996). The Scl gene product is required for the generation of all hematopoietic lineages in the adult mouse.

EMBO J.15:4123–4129.

Robb L., Lyons I., Li R., et al., (1995). Absence of yolk sac hematopoiesis from mice with a targeted disruption of the Scl gene. Proc Natl Acad Sci U S A.92:7075–7079.

Roberts W.M., Shapiro L.H., Ashmun R.A., et al., (1992). Transcription of the human colony-stimulating factor-1 receptor gene is regulated by separate tissue-specific promoters. Blood 79(3):586–93.

Rolink A.G., Nutt S.L., Merchers F. and Busslinger M., (1999). Long-term in vivo reconstitution of T-cell development by Pax5-deficient B-cell progenitors. Nature 401: 603-606.

Rosenbauer F., Wagner K., Kutok J.L., Iwasaki H., Le Beau M.M., Okuno Y., Akashi K., Fiering S., Tenen D.G., (2004). Acute myeloid leukemia induced by

(24)

graded reduction of a lineage-specific transcription factor, PU.1. Nat Genet.36(6):624-30.

Russel E.S., (1979). Hereditary anemias of the mouse: a review for geneticist. Adv.Genet. 20, 357-459.

Sanchez M.J., Bockamp E.O., Miller J., Gambardella ., Green A.R., (2001). Selective rescue of early haematopoietic progenitors in Scl-/- mice by expressing

Scl under the control of a stem cell enhancer. Development. 128:4815–4827.

Sanchez M., Gottgens B., Sinclair A.M., et al., (1999). An Scl 3′ enhancer targets developing endothelium together with embryonic and adult haematopoietic progenitors. Development.126:3891–3904.

Sanchez M.J.,Holmes A., Miles C., Dzierzak E., (1996). Characterization of the first definitive hematopoietic stem cells in the AGM and liver of the mouse embryo.Immunity. 5(6):513-525.

Sanderson C.J., (1992). Interleukin-5, eosinophils, and desease. Blood 79: 3101. Sapi E., Flick M.B., Rodov S., et al., (1998). Expression of CSF-I and CSF-I receptor by normal lactating mammary epithelial cells. J Soc Gynecol Investig 5(2):94–101.

Sasaki K., Kendall M.D., (1985). The morphology of the haemopoietic cells of the yolk sac in mice with particular reference to nucleolar changes. J.Anat.;140:279–295.

Sato T., Laver J.H. and Ogawa M., (1999). Reversible expression of CD34 by murine hematopoieic stem cells. Blood 94: 2548.

Sauvageau G., Lansdorp P.M., Eaves C.J., Hogge D.E., Dragowska W.H., Reid D.S., Largman C., Lawrence H.J., Humphries R.K., (1994). Differential expression of homeobox genes in functionally distint CD34+ subpopulations of human bone marrow cells. Proc.Natl.Acad. Sci. USA 91: 12223-7.

Sauvageau G., Thorsteinsdottir U., Eaves C.J.,et al., (1995). Overexpression of Hoxb4 in hematopoietic cells causes the selective expansion of more primitive populations in vitro and in vivo. Genes Dev 9:1753-1765.

Sauvageau G., Thorsteinsdottir U., Hough M.R. et al., (1997). Overexpression of Hoxb3 in hematopoietic cells causes defective lymphoid development and progressive myeloproliferation. Immunity 6: 13-22.

Schaniel C., Bruno L., Melchers F. and Rolink A.G., (2002). Multiple hematopoietic cell lineages develop in vivo from transplanted Pax5-deficient pre-BI-cell clones. Blood 99: 472-78.

Schooley J.K. and Garcia J.F., (1962). Immunologic studies on the mechanism of action of erythropoietin. proc. Soc. Exp. Biol. Med. 110, 636-640.

(25)

Schuetze S., Stenberg P.E., Kabat D.,(1993). The Ets-related transcription factor PU.1 immortalizes erythroblasts. Mol Cell Biol 13:5670.

Schweitzer K.M., Drager A.M., Van der Valk P., et al., (1996).Constitutive expression of E-selectin and vascular cell adhesion molecule-1 on endothelial cells of hematopoietic tissues. Am J Pathol. 148:165–175.

Scott L.M., Civin C.I., Rorth P., Friedman A.D., (1992). A novel temporal expression pattern of three C/EBP family members in differentiating myelomonocytic cells. Blood 80:1725.

Scott E., Fisher R., Olson M. et al., (1997). PU.1 functions in a cell autonomous manner to control the differentiation of multipotential lymphoid-myeloid progenitors. Immunity 6:437-447.

Scott E.W., Simon M.C., Anastasi J. et al., (1994). Requirement of transcription factor PU.1 in the development of multiple hematopoietic lineages. Science 265:1573-1577.

Scott M.P. and Weiner A.J., (1984). Structural relationship among genes that control development: sequence homology between the Antennapedia, Ultrabithorax and fushi tarazu loci of Drosophila. Proc. Natl. Acad. Sci. USA 81: 4115-4119.

Shalaby F., Ho J., Stanford W.L., et al., (1997) A requirement for flk-1 in primitive and definitive hematopoiesis and vasculogenesis. Cell.;89:981–990. Shalaby F., Rossant J., Yamaguchi T.P., Gertsenstein M., Wu X.F., Breitman M.L., Schuh A.C., (1995). Failure of blood-island formation and vasculogenesis in Flk-1-deficient mice. Nature. 376(6535):62-6.

Shen W.F., Detmer K., Mathews C.H., Hack F.M., Morgan D.A., Largman C. and Lawrence H.J., (1992). Modulation of homeobox gene expression alters the phenotype of human hematopoietic cell lines. EMBO J. 11(3): 983-989

Sherr C.J., (1990). Colony-stimulating factor-1 receptor. Blood 75, 1-12.

Shivdasani R.A., Mayer E.L., Orkin S.H., (1995). Absence of blood formation in mice lacking the T-cell leukaemia oncoprotein tal-1/Scl. Nature.373:432– 434.

Shivdasani R.A. and Orkin S.H., (1996). The transcriptional control of hematopoiesis. Blood 87: 4025-4039.

Shughart K., Kappen C., Ruddle F.H., (1989). Duplication of large genomic regions during the evolution of vertebrate homeobox genes. Proc Natl Acad Sci USA 86: 7067–7071.

Simeone A., Acampora D., Mallamaci A., Stornaiuolo A., D'Apice M.R., Nigro V., Boncinelli E., (1993). A vertebrate gene related to orthodenticle contains a

(26)

homeodomain of the bicoid class and demarcates anterior neuroectoderm in the gastrulating mouse embryo. EMBO J. 12(7):2735-47.

Simeone A. and Boncinelli E., (1993). Omeogeni espressi nello sviluppo del sistema nervoso centrale. Morfogenesi del cervello in “Prospettive e pediatria” Pagg.13-19.

Simeone A., Gulisano M., Acampora D., Stornaiuolo A., Rambaldi M., Boncinelli E., (1992). Two vertebrate homeobox genes related to the Drosophila empty spiracles gene are expressed in the embryonic cerebral cortex. EMBO J. 11(7):2541-50.

Siminovitch L., McCulloch E., and Till J. (1963). The distribution of colony-forming cells among spleen colonies. J. Cell. Comp. Physiol. 62, 327–336. Singh H. (1996). Gene targeting reveals a hierarchy of transcription factors regulating specification of lymphoid cell fates. Curr Opin Immunol. 8:160–165. Sitnicka, E., N. Lin, G. V. Priestley, N. Fox, V. C. Broudy, N. S. Wolf, and K. Kaushansky., (1996). The effect of thrombopoietin on the proliferation of murine hematopoietic stem cells. Blood 87:4998-5005.

Smith L.T., Hohaus S., Gonzalez D.A., et al., (1996). PU.1 (Spi-1) and C/ EBP alpha regulate the granulocyte colony-stimulating factor receptor promoter in myeloid cells. Blood;88(4): 1234–47.

Socolovsky M., Fallon A.E.J. and Lodish H.F., (1998). The prolactin receptor rescues EpoR-/- erythroid progenitors and replaces Epo-R in a synergistic

interaction with c-kit. Blood 92: 1491-1496.

Solanilla A., Grosset C., Duchez P., et al., (2003). Flt3-ligand induces adhesion of haematopoietic progenitor cells via a very late antigen (VLA)- 4- and VLA-5-dependent mechanism. Br J Haematol.120: 782–786.

Spangrude G.J., Heimfeld S., Weissman I.L., (1988). Purification and characterization of mouse hematopoietic stem cells

.

Science 241(4861):58-62. Stanley E.R., (1994). Colony stimulating factor-1 (macrophage colony stimulating factor). In: Thompson A, editor. The cytokine handbook, 2nd ed. New York: Academic Press; p. 387–418.

Stanley E.R., Berg K.L., Einstein D.B., et al., (1997). Biology and action of colony-stimulating factor-1. Mol Reprod Dev 46(1): 4–10.

Stanley E.R., Heard P.M., (1977). Factors regulating macrophage production and growth: purification and some properties of the colony stimulating factor from medium conditioned by mouse L cells. Journal of Biological Chemistry 252: 4305–12.

(27)

Stephenson J.R., Axelrad A.A., Mcleod D.L. and Shreeve M.M., (1971). Induction of colonies of haemoglobin-synthetising cells by erythropoietin in vitro. Proc. Natl. Acad. Sci. USA 68: 1542-1548.

Stier S., Ko Y., Forkert R., Lutz C., Neuhaus T, Grunewald E., Cheng T., Dombkowski D., Calvi L.M., Rittling S.R., Scadden DT., (2005). Osteopontin is a hematopoietic stem cell niche component that negatively regulates stem cell pool size. J Exp Med. 201(11):1781-91.

Suda T, Suda J, Ogawa M, Ihle JN. (1985) Permissive role of interleukin 3 (IL-3) in proliferation and differentiation of multipotential hemopoietic progenitors in culture. J Cell Physiol. 124(2):182-90.

Sugiyama D., Ogawa M., Hirose I., Jaffredo T., Arai K., Tsuji K., (2003). Erythropoiesis from acetyl LDL incorporating endothelial cells at the preliver stage. Blood.;101:4733–4738.

Szilvassy S.J., Humphries R.K., Lansdorp P.M., Eaves A.C., Eaves C.J., (1990). Quantitative assay for totipotent reconstituting hematopoietic stem cells by a competitive repopulation strategy. Proc Natl Acad Sci U S A. 87(22):8736-40. Tajima F., Deguchi T., Laver J.H., Zeng H., Ogawa M., (2001). Reciprocal expression of CD38 and CD34 by adult murine hematopoietic stem cells. Blood. 97(9):2618-24.

Takahashi S., Komeno T., Suwabe N., Yoh K., Nakajima O., Nishimura S., Kuroha T., Nagasawa T. and Yamamoto M., (1998). Role of GATA-1 in proliferation and differentiation of definitive erythroid and megakaryocytic cells in vivo. Blood 92: 434-442.

Takano H., Ema H., Sudo K., Nakauchi H., (2004). Asymmetric division and lineage commitment at the level of hematopoietic stem cells: inference from differentiation in daughter cell and granddaughter cell pairs. J Exp Med. 199:295–302.

Tenen D.G., Hromas R., Licht J.D., Zhang D.E., (1997).Transcription factors, normal myeloid development, and leukemia. Blood 90(2):489-519.

Terskikh A.V., Miyamoto T., Chang C., Diatchenko L., and Weissman I.L., (2003). Gene expression analysis of purified hematopoietic stem cells and committed progenitors. Blood 102:94-101.

Thorsteinsdottir U., Mamo A., Kroon E., Jerome L., Bijl J., Lawrence H.J., Humphries K., Sauvageau G., (2002). Overexpression of the myeloid leukemia-associated Hoxa9 gene in bone marrow cells induces stem cell expansion. Blood. 99(1):121-9.

Thorsteinsdottir U., Sauvageau G., Hough M.R., Dragowska W., Lansdorp P.M, Lawrence H.J., Largman C., Humphries R.K. (1997). Overexpression of hoxa10 in murine hematopoietic cells perturbs both myeloid and lymphoid differentiation and leads to acute myeloid leukemia. Mol Cell Biol 17: 495–505.

(28)

Thorsteinsdottir U., Sauvageau G. and Humphries K.R., (1999). Enhanced in vivo regenerative potential of Hoxb4-transduced hematopoietic stem cells with regulation of their pool size. Blood 94: 2605-12.

Till J.E. and McCulloch E.A., (1961). A direct measure of the radiation sensivity of normal mouse marrow cells. Radiat.Res. 14: 213-216.

Treisman J, Gonczy P, Vashishtha M, Harris E, Desplan C., (1989). A single amino acid can determine the DNA binding specificity of homeodomain proteins. Cell 59(3): 553-562.

Treisman J., Harris E. and Desplan C., (1991). The Paired Box encodes a second DNA-binding domain in the Paired homeodomain protein. Genes Dev. 5: 594-604.

Tsuchiya M., Asano S., Kaziro Y., et al., (1986). Isolation and characterization of the cDNA for murine granulocyte colony-stimulating factor. Proc Natl Acad Sci USA 83(20):7633–7.

Tsuji K., Lyman S.D., Sudo T., Clark S.C., Ogawa M., (1992). Enhancement of murine hematopoiesis by synergistic interactions between steel factor (ligand for c-kit), interleukin-11, and other early acting factors in culture. Blood. 79(11):2855-60.

Tsuji K., Zsebo K.M., Ogawa M., (1991). Enhancement of murine blast cell colony formation in culture by recombinant rat stem cell factor, ligand for c-kit. Blood. 78(5):1223-9.

Valtieri M., Tocci A., Gabbianelli M., et al., (1998). Enforced Tal-1 expression stimulates primitive, erythroid and megakaryocytic progenitors but blocks the granulopoietic differentiation program. Cancer Res.58:562–569.

Vangala R.K., Heiss-Neumann M.S., Rangatia J.S., Singh S.M, Schoch C, Tenen D.G., Hiddemann W., Behre G., (2003). The myeloid master regulator transcription factor PU.1 is inactivated by AML1-ETO in t(8;21) myeloid leukemia. Blood.101(1):270-7.

Van Oostveen J., Bijl J., Raaphorst F., Walboomers J., Meijer C., (1999). The role of homeobox genes in normal hematopoiesis and hematological malignancies. Leukemia 13(11): 1675-1690.

Vassilopoulos G., Wang P.R., Russell D.W., (2003). Transplanted bone marrow regenerates liver by cell fusion. Nature 422, 901.

Vignery A., (2000). Osteoclasts and giant cells: macrophage-macrophage fusion mechanism. Int. J. Exp Pathol. 81, 291.

Visnjic D., Kalajzic Z., Rowe D.W., Katavic V., Lorenzo J., Aguila H.L. (2004). Hematopoiesis is severely altered in mice with an induced osteoblast deficiency. Blood. 103(9):3258-64.

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