Siciliano Gabriele
Department of Clinical and Experimental Medicine, Neurological Clinics, University of Pisa
TRS-2018-00001625 1 - Rare Diseases Deflazacort TREATment in LMNA-
related congenital muscular dystrophy: study of clinical effectiveness and search for reliabl e biomarkers.
5,00
Cannavò Salvatore University of Messina TRS-2018-00001591 1 - Rare Diseases
IDENTIFICATION AND VALIDATION OF NEW CIRCULATING BIOMARKERS FOR PREDICTION OF GH-SECRETING PITUITARY TUMORS SENSITIVITY TO FIRST GENERATION SOMATOSTATIN
ANALOGS TREATMENT AND IMPROVEMENT OF ACROMEGALY MANAGEMENT 6,50
Scaroni Carla
Endocrine Unit, Department of Medicine DIMED, University- Hospital of Padova
TRS-2018-00001632 1 - Rare Diseases Medical combination therapy with retinoic acid and cabergoline in ACTH-secreting pituitary
adenoma: a prospective and randomized study 7,50
Crotti Lia IRCCS Istituto Auxologico Italiano TRS-2018-00001470 1 - Rare Diseases Novel therapy for the Long QT Syndrome type 2 based on the mechanism of action of the
disease-causing mutations 7,50
Chiarion Sileni Vanna Istituto Oncologico Veneto TRS-2018-00001567 3 - Gender Medicine Circulating markers as gender-specific predictors of response to Immune Checkpoint
Inhibitors in melanoma and non-small-cell lung cancer patients 7,50 Perno Carlo Federico Università degli studi di Milano TRS-2018-00001336 5 - AMR Strategies to Contain HIV Drug-Resistance Emergence in Virologically Suppressed Patients
Requiring Antiretroviral Therapy Optimization: Unraveling the Role of Mutational Burden in PBMCs
7,50
Saccà Francesco University Federico II TRS-2018-00001358 1 - Rare Diseases A double-blind, randomized, placebo-controlled trial to test the efficacy, safety and
tolerability of Dimethylfumarate in Friedreich Ataxia (DMF-FA-201). 7,50 Villa Erica University of Modena and Reggio
Emilia TRS-2018-00001238 3 - Gender Medicine Gender-related response to Tyrosine Kinase-Inhibitor drugs in hepatocellular carcinoma 7,50 Voso Maria Teresa Universita' di Roma Tor Vergata TRS-2018-00001687 1 - Rare Diseases
Prospective randomized study on the feasibility of allogeneic stem cell transplantation in higher-risk-myelodysplastic syndromes, performed upfront or preceded by azacitidine or
conventional chemotherapy, according to the BM-blast proportion (ACROBAT trial) 9,00 Bassi Claudio AOUI Verona TRS-2018-00001695 5 - AMR Antibiotic stewardship program in pancreatic surgery: a multicenter time series analysis. 9,00 Milani Paolo Foundation IRCCS Policlinico San
Matteo TRS-2018-00001624 1 - Rare Diseases A multi-center open label phase II study of daratumumab and pomalidomide in previously
treated patients with AL amyloidosis. 9,00
Disma Nicola Massimo Istituto Giannina Gaslini TRS-2018-00001250 2 - Pediatric Diseases
Neurodevelopmental outcome after standard dose sevoflurane versus low-dose sevoflurane/dexmedetomidine/remifentanil anaesthesia in young children. The TREX Study.
9,00
Piperno Alberto ASST- Monza Ospedale San
Gerardo TRS-2018-00001468 1 - Rare Diseases
Replacement of ceruloplasmin through transfusion of plasma from selected high ceruloplasmin expressing donors as a novel therapeutic approach to revert systemic and
neurological derangements in aceruloplasminemia 9,25
Finocchiaro Gaetano Fondazione IRCCS Istituto
Neurologico Besta TRS-2018-00001312 1 - Rare Diseases Dendritic cell IMmunotherapy with or without concomitant local chemotherapy in patients
with PROgressiVE glioblastomas. 9,50
Bonovas Stefanos IRCCS Istituto Clinico Humanitas TRS-2018-00001654 4- Safety Elderly Biologic therapies in inflammatory bowel disease: systematic review and meta-analysis of
harmful effects in elderly patients 9,50
Garufi Carlo Ospedale Spirito Santo, ASL
Pescara TRS-2018-00001568 3 - Gender Medicine A prospective multicentric trial investigating clock-gene signature and sex-effect in Italian
advanced colorectal cancer patients treated according to RAS/BRAF status 9,50 Marchetti Paolo
Sapienza Università di Roma- Azienda Ospedaliero-universitaria Sant'Andrea
TRS-2018-00001524 4- Safety Elderly
Clinical Management of Polypharmacy in Elderly: Personalized medical approach in geriatric poly-treated Patients to increase drugs safety, drug efficacy and adherence to treatments
9,50 Buonocore Giuseppe Università degli studi di Siena TRS-2018-00001534 2 - Pediatric Diseases PREterm infants treated with MELatonin: an innovative medical CARE 9,50 Lemoli Roberto M. Clinic of Hematology, Department
of Internal Medicine (DiMI), University of Genoa
TRS-2018-00001792 1 - Rare Diseases A reduced intensity induction chemotherapy with increased anti-metabolic activity for
elderly Philadelphia-negative acute lymphoblastic leukemia patients 10,00 Corsini Alberto
Dep. Pharmacological and Biomolecular Sciences, University of Milan
TRS-2018-00001561 4- Safety Elderly Manage polypharmacy in elderly: development of tools for medication review and
deprescribing built on real-world data and intervention study on general practitioners 10,00 Bossi Paolo Fondazione IRCCS Istituto
Nazionale dei Tumori TRS-2018-00001248 1 - Rare Diseases
TO PROVE THE CONCEPT OF AN IMMUNOMEDIATED EFFECT OF DENOSUMAB BY REPURPOSING IT IN NON-ENDEMIC, EBV-RELATED NASOPHARYNGEAL CANCER AND BIOMARKER VALIDATION.
10,00 Di Cosimo Serena Fondazione IRCCS Istituto
Nazionale dei Tumori TRS-2018-00001592 1 - Rare Diseases A tRanslational research prOject to amenD clinIcal practice for metapLastic carcInoma of
the breAst (MPBC): the RODILIA Study 10,00
Maghnie Mohamad Istituto Giannina Gaslini TRS-2018-00001422 1 - Rare Diseases Efficacy of FSH+testosterone and FSH+hCG after pre-treatment with FSH compared to standard testosterone therapy on testicular volume and quality of life during pubertal induction: a randomized trial in hypogonadotropic hypogonadism patients (FaTHEr study)
10,00
Aguglia Umberto Magna Graecia University of
Catanzaro TRS-2018-00001576 3 - Gender Medicine Influence of hormonal contraceptives on seizure frequency and depression in women with
epilepsy: multicentre, longitudinal, prospective, cohort study. 10,00 Sansone Valeria A Neurorehab Unit, University of
Milan, The NEMO Clinical Center TRS-2018-00001732 1 - Rare Diseases RILUZOLE FOR SYMPTOMS AND SIGNS OF MYOTONIA AND PAIN IN MYOTONIC
DYSTROPHIES: A CROSS-OVER RANDOMIZED CONTROLLED TRIAL 10,00
Auriti Cinzia Ospedale Pediatrico Bambino
Gesù TRS-2018-00001360 5 - AMR
Fluconazole prophylaxis against fungal colonization and invasive infections in newborns and infants with majorsurgical pathologies: a multicenter prospective double blind
randomized clinical trial. 10,00
Cappuzzo Federico Ospedale S. Maria delle Croci TRS-2018-00001787 4- Safety Elderly
An open-label, randomized phase III study of immunotherapy versus chemotherapy or best supportive care as second-line treatment of elderly patients with advanced non-small cell
lung cancer 10,00
Pozzilli Carlo Sapienza University of Rome TRS-2018-00001615 3 - Gender Medicine Gender differences in the effectiveness and safety of preventive treatment of Relapsing-
Remitting Multiple Sclerosis: a multicenter, longitudinal real-world cohort study 10,00 Onder Graziano Universitá Cattolica del Sacro
Cuore TRS-2018-00001476 4- Safety Elderly Frailty, drug use and health-related outcomes in three clinical settings: generating evidence
to guide drug prescription in frail older adults 10,00
Cattoretti Giorgio Universita degli Studi Milano-
Bicocca TRS-2018-00001486 1 - Rare Diseases Biomarker-driven single-cell lung pathology prediction of disease progression and
therapeutic response in idiopathic pulmonary fibrosis. 10,00
Iorio Raffaele University Federico II Naples TRS-2018-00001478 1 - Rare Diseases A multicenter, randomized, cross-over trial to assess the benefits of domperidone in
Wilson Disease 10,00
Ruscitti Piero University of L'Aquila TRS-2018-00001458 1 - Rare Diseases
Searching for the best therapeutic strategy in rare paediatric monogenic autoinflammatory diseases: the effectiveness of anti-interleukin 1 biologic drugs. A systematic review and
meta-analysis 10,00
Ceccherini Silberstein Franc University of Rome Tor Vergata TRS-2018-00001311 5 - AMR HCV resistance surveillance in HCV mono and HIV/HCV co-infected patients failing a DAA
containing IFN-free regimen across all genotypes circulating in Italy 10,00 Di Raimondo Francesco AOU Policlinico Universitario di
Catania TRS-2018-00001636 1 - Rare Diseases Development of a Myeloma Immune Dysregulation Score to personalize treatment in
elderly patients: the MIDS observational study 10,50
Invernizzi Pietro ASST Monza TRS-2018-00001259 1 - Rare Diseases Phase II one-arm, open-label, multicenter clinical trial to assess the efficacy and safety of oral NOX1/NOX4 inhibitor (GKT137831) in patients with primary sclerosing cholangitis. The NOX-PSC study
10,50 Renieri Alessadra Azienda Ospedaliera Universitaria
Senese TRS-2018-00001557 1 - Rare Diseases Amiloride repurposing and CRISPR/Cas9 Gene Therapy for a Combined Personalized
Therapeutic Strategy in Alport Syndrome. 10,50
Vignoli Aglaia
Childhood and Adolescence Neurology and Psychiatry -
Department of Health Sciences TRS-2018-00001392 1 - Rare Diseases Repurposing Mirtazapine to target the Rett syndrome: a randomized placebo-controlled
Phase II multicenter study to evaluate safety and efficacy. 10,50 Scarpa Maurizio Department For the Woman and
Child Health University of Padova, Padova, Italy
TRS-2018-00001637 1 - Rare Diseases Information Technology approach to explore the impact of therapies and the cost of rare
inherited metabolic disorders. 10,50
Prodam Flavia Department of Health Sciences,
University of Piemonte Orientale TRS-2018-00001460 3 - Gender Medicine Gender and age-related responses to the treatment with long-acting GLP-1 receptor
agonists in type 2 diabetes and obesity: a systematic review and meta-analysis 10,50 Landoni Giovanni Fondazione Centro San Raffaele TRS-2018-00001438 4- Safety Elderly
Management of Angiotensin-conveRting enzyme inhibitoGs/angiotensin Receptor blockers and statIns before cArdiac and non-cardiac surGery in the Elderly. A multicenter, randomized trial.
10,50 Silani Vincenzo IRCCS Istituto Auxologico Italiano TRS-2018-00001613 1 - Rare Diseases Activity and lomg term safety of Fingolimod in Amyotrophic Lateral Sclerosis (ALS): a Phase
IIb study 10,50
Dionisi Vici Carlo Ospedale Pediatrico Bambino
Gesù TRS-2018-00001743 1 - Rare Diseases
An observational multicenter longitudinal study to evaluate the impact on developmental aspects and cost-effectiveness of Liver Transplantation in Intoxication type Metabolic
Diseases in a rapidly evolving therapeutic era. 10,50
Tartaglia Marco Ospedale Pediatrico Bambino
Gesù TRS-2018-00001752 1 - Rare Diseases Natural history, patient stratification and personalized medicine in RASopathies: from
registry to care 10,50
Simoni Manuela
Unit of Endocrinology, Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia
TRS-2018-00001386 3 - Gender Medicine
Toward reduction of the burden of assisted reproduction technologies in women suffering from couple infertility due to male factor: assessing the pharmacodynamics of human
recombinant luteinising hormone in hypogonadal men 10,50
Clementi Emilio Giuseppe Università di Milano TRS-2018-00001477 2 - Pediatric Diseases Cardiometabolic risk in children naïve to second generation antipsychotics treatment, an
observational Italian cohort study with genetic biomarkers. 10,50 Marengoni Alessandra University of Brescia TRS-2018-00001507 4- Safety Elderly SARCopenia and Adverse Drug Reactions in older persons prescribed with polypharmacy:
gender differences- SARC-ADR 10,50
Cox Maria Christina azienda ospedaliera universitaria
sant'andrea TRS-2018-00001508 1 - Rare Diseases Phase II study of Immunotherapy based on intra-nodal IFN-DC and/or Rituximab in
Follicular Lymphoma 11,00
Cingolani Antonella Università Cattolica del Sacro
Cuore TRS-2018-00001376 3 - Gender Medicine
Role of menopausal status on hepatic and extra hepatic events in HIV-HCV co-infected women: interplay with anti HCV Direct Antiviral Agents (DAA) and with Hormone
Replacement Therapy (HRT) 11,00
Lunetta Christian Centro Clinico NEMO -
Fondazione Serena Onlus TRS-2018-00001780 1 - Rare Diseases Edaravone for Amyotrophic Lateral Sclerosis: an open label multicenter clinical trial 11,00 Lauro Davide
Department of Systems Medicine, University of Rome Tor Vergata, Italy
TRS-2018-00001667 4- Safety Elderly New Therapeutic Strategies for Type 2 Diabetes Mellitus in Elderly: Prevention of Cognitive
Decline and Frailty 11,00
Selmi Carlo Humanitas Research Hospital TRS-2018-00001702 3 - Gender Medicine
SAFETY AND EFFICACY OF BIOLOGIC AGENTS AND TARGETED SYNTHETIC DMARDS IN WOMEN AND ELDERLY PATIENTS WITH INFLAMMATORY ARTHRITIS: A STUDY PROTOCOL
FOR A SYSTEMATIC LITERATURE REVIEW AND META-ANALYSIS 11,00
Zecca Marco Oncoematologia pediatrica, Fondazione IRCCS Policlinico San Matteo
TRS-2018-00001503 1 - Rare Diseases Phase I/II clinical trial of somatic cell therapy with donor-derived anti-leukemia cytotoxic T lymphocytes for prevention of relapse in children given haploidentical hematopoietic stem cell transplantation.
11,00
Savonitto Stefano Ospedale Alessandro Manzoni TRS-2018-00001488 4- Safety Elderly Two-month dual antiplatelet treatment in elderly patients with Acute Coronary Syndromes.
A randomised comparison with standard 12-month treatment. 11,00
Camerota Filippo Policlinico Universitario Umberto I TRS-2018-00001552 1 - Rare Diseases Assessing and predicting duloxetine efficacy and safety for treating pain in patients with
joint hypermobility syndrome/Ehlers-Danlos syndrome 11,00
Manunta Paolo San Raffaele Scientific Institute TRS-2018-00001720 4- Safety Elderly COST-EFFECTIVENESS OF PERSONALIZED DIURETIC THERAPY IN AN ELDERLY POPULATION:
BODY SODIUM HOMEOSTASIS AND INFLAMMATION 11,00
Falsini Benedetto Universita Cattolica del S. Cuore TRS-2018-00001314 1 - Rare Diseases
Treatment of Non-cell Autonomous Cone Photoreceptor Degeneration in Retinitis Pigmentosa. A ¿Rescue and Restore¿ Strategy Targeting Oxidative Defense and Energy
Metabolism 11,00
Di Leo Alfredo Università degli Studi di Bari TRS-2018-00001582 5 - AMR Comparison of antibiotic susceptibility-guided therapy versus empiric concomitant non- bismuth quadruple regimen as first-line treatment for Helicobater pylori infection in people receiving hemodialysis: a randomized controlled trial.
11,00
Padovani Alessandro University of Brescia TRS-2018-00001699 1 - Rare Diseases Safety and biological effect of trazodone in Progressive Supranuclear Palsy: a 24-weeks
placebo-controlled double blind pilot trial 11,00
Parazzini Fabio University of Milan TRS-2018-00001502 3 - Gender Medicine Effect of supplmentation with Vitamin D and high doses of folic acid in improving in vitro
fertilization outcome: a factorial double blind randomized clinical trial. 11,00
Benemei Silvia Careggi Hospital -University of
Florence TRS-2018-00001481 1 - Rare Diseases
The RegistRare Network Prospective Initiative: a cohort prospective study and a registry to collect gender-based data on drug utilization and burden of rare primary headaches in
patients referring to Italian tertiary Headache Centres. 11,50
Tedeschi Gioacchino
Department of Medical, Surgical, Neurological, Metabolic and Aging Sciences, University of Campania
"Luigi Vanvitelli"
TRS-2018-00001516 1 - Rare Diseases Detection of Plasma and neuroimaging biomarkers of oxidative stress for monitoring the
antioxidant effect of Edaravone in Amyotrophic Lateral Sclerosis (ALS) 11,50
Cittadini Antonio Federico II University of Naples TRS-2018-00001635 4- Safety Elderly METformin in Old fragile patients affected by Heart Failure with Preserved Ejection fraction
with insulin-resistance. 11,50
Palla Roberta Fondazione Luigi Villa TRS-2018-00001298 1 - Rare Diseases mAPP the drug: a pharmacovigilance system of extended half-life treatment products for
hemophilia 11,50
Chimenti Cristina La Sapienza University TRS-2018-00001406 1 - Rare Diseases
Immune-Mediated Myocarditis in Fabry Disease Cardiomyopathy. Immunosuppression May Contrast DiseaseProgression and Resistance To Enzyme Replacement Therapy: Proof
of Concept. 11,50
Pinnetti Carmela National Institute for Infectious
Disease "L. Spallanzani" TRS-2018-00001485 4- Safety Elderly A randomized controlled trial to assess the protective effect of atorvastatin on the HIV-
associated neurocognitive disorders (HAND) in older HIV-infected individuals 11,50 Ferrari Giulio Ospedale San Raffaele TRS-2018-00001678 1 - Rare Diseases Safety and efficacy of topical Fosaprepitant in the treatment of ocular cicatritial
pemphigoid: monocentric, randomized, double blind cross-over clinical trial 11,50 Fantini Maria Pia University of Bologna TRS-2018-00001464 5 - AMR Improvement of antibiotic use in hospitals through pragmatic, multifaceted, computerized
interventions: two sequential randomised controlled trials 11,50
Staszewsky Lidia IRCCS-Istituto di Ricerche
Farmacologiche Mario Negri TRS-2018-00001383 4- Safety Elderly Insulin treatment in Older people with Heart Failure and Diabetes, INSIDE-HF: a prospective
randomized trial. 11,75
Ungar Andrea AOU Careggi TRS-2018-00001292 4- Safety Elderly Monitoring Older subjects with DEmentia to Reduce Antihypertensive ThErapy
(MODERATE). A randomizedcontrolled trial of treatment de-intensification 12,00 Bellelli Giuseppe ASST San Gerardo Monza TRS-2018-00001414 4- Safety Elderly MELATONIN FOR THE PREVENTION OF INCIDENT DELIRIUM IN HOSPITALIZED OLDER
PATIENTS: A RANDOMIZED CONTROLLED TRIAL 12,00
Olivotto Iacopo Careggi University Hospital -
Cardiomyopathy Unit_ TRS-2018-00001726 1 - Rare Diseases A pilot study to assess the effects of ranolazine on LVOT gradients and exertional
symptoms during exercise in HCM patients with dynamic obstruction. 12,00
Cirillo Massimo Dept. "Scuola Medica
Salernitana", University of SalernoTRS-2018-00001558 3 - Gender Medicine Population-based study about sex-associated differences in 1,25(OH)2-vitamin D and
objective indices of vitamin D deficiency. 12,00
Pallini Roberto Fondazione Policlinico Gemelli - Università Cattolica del Sacro Cuore
TRS-2018-00001511 1 - Rare Diseases mesenchymal STem cells for Advanced Therapy Of Glioblastoma (STATOG) 12,00 Pupillo Elisabetta IRCCS Istituto Mario Negri TRS-2018-00001777 1 - Rare Diseases The outcome of amyotrophic lateral sclerosis and the treatment of the disease and its
comorbidities 12,00
Simonini Gabriele NEUROFARBA Dpt University of
Florence AOU A Meyer TRS-2018-00001560 2 - Pediatric Diseases
Randomized controlled trial to evaluate the eFficacy and safety of Adalimumab in combination with methotrexate as firST line therapy in children with Juvenile Idiopathic Arthritis associated uveitis
12,00
Cancrini Caterina Ospedale Pediatrico Bambino
Gesù TRS-2018-00001538 1 - Rare Diseases
An open-label exploratory study of theophylline in subjects with activated phosphoinositide 3 kinase (PI3K) delta syndrome (APDS) and autoimmune lymphoproliferative syndrome (ALPS).
12,00
Cianfarani Stefano Ospedale Pediatrico 'Bambino
Gesù' TRS-2018-00001626 2 - Pediatric Diseases Impact of continuous glucose monitoring technology and different basal insulin regimens
on cognitive function and glycemic control in children with Type 1 Diabetes. 12,00 Specchio Nicola Ospedale Pediatrico Bambino
Gesù, IRCCS TRS-2018-00001510 2 - Pediatric Diseases Assessment of value, safety and efficacy of personalized therapy in undiagnosed non-
syndromic epilepsy (E) and intellectual disabilities (ID). 12,00
Martelli Maria Paola Università degli studi di Perugia,
Dipartimento di Medicina TRS-2018-00001234 1 - Rare Diseases
A novel chemo-free approach by drug repurposing in acute myeloid leukemia: "A Phase IIa Study of The Clinical Activity and Safety of Combined Omacetaxine Mepesuccinate (Synribo) and Venetoclax (Venclyxto) in Patients with Relapsed/Refractory Acute Myeloid Leukemia with Nucleophosmin (NPM1) Gene Mutation"
12,00
Strippoli Giovanni University of Bari - Department of
Emergency and Organ Transplant TRS-2018-00001540 4- Safety Elderly Value-based versus intensified pharmaceutical care for hemodialysis patients: A pragmatic,
open-label, blinded endpoint, non-inferiority, randomized controlled trial (VALUE-HD) 12,00 Ferlini Alessandra University of Ferrara TRS-2018-00001417 1 - Rare Diseases IDENTIFICATION OF NOVEL DISEASE GENES IN RARE NEUROMUSCULAR DISORDERS BY NEW
INTEGRATED GENOME AND TRANSCRIPTOME DATA ANALYSIS AND GENE EDITING 12,00 Brandi Maria Luisa University of Florence TRS-2018-00001519 1 - Rare Diseases Italian network and registry for chronic hypoparathyroidism. 12,00 Corrao Giovanni University of Milano-Bicocca TRS-2018-00001387 4- Safety Elderly Risks and benefits of reducing polypharmacy in elderly outpatients 12,00 Gemmati Donato Azienda Ospedaliera -
Universitaria di Ferrara TRS-2018-00001290 3 - Gender Medicine Gender-specific prognostic biomarker(s) to early predict Left Ventricular Remodeling after Acute Myocardial Infarction and to evaluate gender-specific different effectiveness of anti- remodeling drugs: a three years observational longitudinal study.
12,50
Clementi Maurizio Dept SDB University of Padua TRS-2018-00001735 3 - Gender Medicine Maternal and fetal risks associated with the pharmacologic treatment of rheumatic
autoimmune diseases during pregnancy. 12,50
Vullo Vincenzo Dipartimento di Sanità Pubblica e Malattie Infettive Università Sapienza
TRS-2018-00001585 4- Safety Elderly Study of the effects of probiotic supplementation on neurocognitive function in elderly HIV
infected subjects 12,50
Esposito Susanna Fondazione IRCCS Ca' Granda
Ospedale Maggiore Policlinico TRS-2018-00001297 2 - Pediatric Diseases TRYPTOphan metabolism as potential biomarker for personalized immunotherapy in autoimmune diabetes: a proof-of-concept study with tocilizumab in children and adolescents with type 1 DIAbetes
12,50
Raimondi Ferdinando Humanitas Research Hospital TRS-2018-00001730 5 - AMR REal time mass SPEctrometry analysis of volatile organic Compounds for Targeted
antibiotic therapy in Ventilator Associated Pneumonia: The RESPECT-VAP study 12,50 Eleopra Roberto IRCCS Fondazione Istituto
Neurologico Carlo Besta TRS-2018-00001512 1 - Rare Diseases BOTULINUM TOXIN A INJECTIONS IN CERVICAL AND TRUNCAL MUSCLES TO TREAT
ISOLATED AXIAL DYSTONIA: A DOUBLE-BLIND RANDOMIZED PHASE-III TRIAL 12,50 Guidoboni Massimo IRCCS IRST TRS-2018-00001462 1 - Rare Diseases Pembrolizumab associated with autologous dendritic cell vaccine in patients with PD-L1
negative advanced mesothelioma who have failed prior therapies: a phase Ib study 12,50 Anghileri Elena IRCCS Istituto Neurologico Carlo
Besta TRS-2018-00001330 1 - Rare Diseases Metformin as repurposed drug in newly diagnosed glioblastoma 12,50
Fossati Roldano IRCCS Mario Negri Institute TRS-2018-00001675 1 - Rare Diseases
Phase III, multicenter, randomized trial comparing metformin plus standard platinum- based therapy with standard platinum-based therapy alone in women with relapsed
platinum sensitive epithelial ovarian cancer. 12,50
Baviera Marta IRCCS-Istituto di Ricerche
Farmacologiche "Mario Negri" TRS-2018-00001442 4- Safety Elderly Effectiveness and safety of the new antihyperglycemic drugs (GLP-1 receptor agonists and
SGLT2 inhibitors) in the real world: a large-scale evaluation in the elderly population. 12,50
Ascierto Paolo Antonio Istituto Nazionale Tumori
Fondazione "G. Pascale" TRS-2018-00001701 4- Safety Elderly
DURANIVOL study: defining treatment DURAtion of NIVOlumab in eLderly patients with unresectable or metastatic melanoma treated for two years and with a clinical benefit from
treatment (complete or partial responder or stable disease) 12,50 Rosati Anna Meyer Children's Hospital TRS-2018-00001308 2 - Pediatric Diseases Personal and health system implications of pseudo-intractability in pediatric epilepsy: a
multicentre, national, real world, retro-prospective, observational cohort study. 12,50 Pontrelli Giuseppe Ospedale Pediatrico Bambino
Gesù TRS-2018-00001790 5 - AMR PROcalcitonin Guidance for antibiotic REduction in Suspected paediatric Sepsis (PROGRESS
2.0): a multicenter randomised controlled trial. 12,50
Ardizzoni Andrea Policlinico S.Orsola-Malpighi TRS-2018-00001305 4- Safety Elderly
A MULTICENTER RETROSPECTIVE-PROSPECTIVE COHORT STUDY TO INVESTIGATE OUTCOMES OF VERY ELDERLY ( >=80 YEARS-OLD) PATIENTS WITH LOCALLY ADVANCED OR METASTATIC NON-SMALL CELL LUNG CANCER TREATED WITH IMMUNE-CHECKPOINT INHIBITORS
12,50
Giannella Maddalena Sant'Orsola-Malpighi Hospital,
University of Bologna TRS-2018-00001551 5 - AMR A multi-arm multi-stage randomized clinical trial comparing three different ceftazidime-
avibactam based regimens for carbapenemase producing Enterobacteriaceae bacteremia 12,50 Taliani Gloria Sapienza University of Rome,
Policlinico Umberto I TRS-2018-00001622 3 - Gender Medicine Cardiovascular and cerebrovascular events in HCV: gender differences and impact of
clinical monitoring and treatment 12,50
Quattrocchi Carlo Cosimo Università Campus Bio-Medico di
Roma TRS-2018-00001650 4- Safety Elderly SAfety of GAdolinium-Based Contrast agents and Efficacy toward optimizing the use of
biological therapy: a focused survey on elderly and ultraelderly population 12,50
Lambiase Alessandro Università di Roma "Sapienza" -
Dipartimento Organi di Senso TRS-2018-00001517 1 - Rare Diseases Multicenter, randomized, double-blind, vehicle-controlled clinical trial to evaluate safety and efficacy of Cenegermin eye drops treatment in patients with mucous membrane pemphigoid (MMP).
12,50
Pantaleo Maria Abbondanza
University of Bologna Azienda Opsedaliero Universiatria Po.
Sant'Orsola Malpighi
TRS-2018-00001310 1 - Rare Diseases Exploratory phase II Basket trial of precision treatments selected by NGS analysis in rare
tumors or rare sub-type tumors non oncogenic-addicted or resistant to approved drugs 12,50 De Giorgio Roberto University of Ferrara TRS-2018-00001335 1 - Rare Diseases PYridostigmine treatment for GAstrointestinal manifestations in Systemic Sclerosis
(PYGASS): A randomised, double-blind, placebo-controlled study 12,50 Scichilone Nicola University of Palermo TRS-2018-00001550 4- Safety Elderly Efficacy and safety of anti-IL5 treatment in asthma across ages: a metanalysis and
systematic review. 12,50
Previtali Stefano Fondazione Centro San Raffaele TRS-2018-00001367 1 - Rare Diseases A mini-invasive and multidisciplinary approach to monitor disease activity and response to
therapy in inflammatory idiopathic myopathies (IIM) 12,75
Viale Pierluigi Alma Mater Studiorum Università
di Bologna TRS-2018-00001407 5 - AMR
Is it possible to improve patient outcomes and reduce the duration of antibiotic therapy for Enterobacteriaceae bacteriemia? A cluster-randomized multicenter study with application of a bundle strategy
13,00
Grandaliano Giuseppe AOU "Ospedali Riuniti", Università
degli Studi di Foggia TRS-2018-00001237 4- Safety Elderly
Multicenter, controlled, randomized clinical trial to Valuate the efficacy of Etelcalcetide therapy in LOwering the incidence of Cardiovascular Events in elderly hemodialysis subjects with secondary hyperparathyroidism
13,00
Lapolla Annunziata Diabetology and Dietetics, ULSS 6
Euganea TRS-2018-00001793 4- Safety Elderly VIRGILIO(VIgilance Registry of GerIatric patients with diabetes newly treated with glucose
Lowering agents: a north-east Italy Observational prospective study) 13,00 Bugianesi Elisabetta Dipartimento di Scienze Mediche,
Università di Torino TRS-2018-00001401 3 - Gender Medicine Gender differences in the epidemiology and the severity of Non Alcoholic Fatty Liver
Disease in T2DM: the role of glucose-lowering therapy 13,00
Esposito Giovanni Federico II University TRS-2018-00001461 4- Safety Elderly
A Randomized Prospective Study to Assess the Efficacy of Tranexamic Acid on Reduction of Early Bleeding Events in Elderly Patients Undergoing Transcatheter Aortic Valve
Implantation. 13,00
Pasqualetti Patrizio Fondazione Fatebenefratelli per la Ricerca e la Formazione Sanitaria e Sociale
TRS-2018-00001571 3 - Gender Medicine Long-term Effects in school age children following exposure to Antidepressants During
pregnancy: a case-control study 13,00
Della Porta Matteo GiovannIRCCS Humanitas Research
Hospital TRS-2018-00001446 1 - Rare Diseases Multicenter observational study of patients with myelodysplastic syndrome (MDS) in Italy,
as a basis for theimplementation of precision medicine programs in a rare disease 13,00 Iatropoulos Paraskevas IRCCS-Istituto di Ricerche
Farmacologiche Mario Negri TRS-2018-00001683 1 - Rare Diseases Integrating Deep Phenotyping and 'Omics' approaches to unravel pathogenetic patterns in
Primary Nephrotic Syndrome and orient Therapies. 13,00
Taruscio Domenica Istituto Superiore di Sanità TRS-2018-00001436 1 - Rare Diseases Italian Network for solving undiagnosed rare diseases 13,00 Amore Mario Psychiatric Clinic, DINOGMI,
University of Genoa TRS-2018-00001545 4- Safety Elderly Deprescribing in Elderly Depressed Improving Cardiovascular health And sTability with
Exercise (DEDICATE study) 13,00
Ciccozzi Massimo università campus biomedico TRS-2018-00001527 5 - AMR A Multicentre longitudinal study on antimicrobial resistant: learn how to fight 13,00
Miraglia Del Giudice EmanuUniversità della Campania "Luigi
Vanvitelli" TRS-2018-00001403 2 - Pediatric Diseases Liraglutide in the management of weight loss in obese adolescents: a randomized
controlled trial 13,00
Durante Mangoni EmanueleUniversità della Campania 'L.
Vanvitelli' TRS-2018-00001271 5 - AMR
Efficacy of colistin plus minocycline compared to colistin alone for severe infections due to carbapenem-resistant Acinetobacter baumannii: an open label, randomised, multicentre clinical trial (EnCOMIA-Evaluation of COlistin plus MInocycline for Acinetobacter)
13,00
Perrotta Silverio University of Campania "L.
Vanvitelli" TRS-2018-00001712 1 - Rare Diseases A prospective clinical, genetic and metabolic evaluation of Italian Familial Erythrocytosis'
patients to improve therapies' appropriateness and find new areas of clinical intervention. 13,00 Gallieni Maurizio Alberto
University of Milano - Dipartimento di Scienze Biomediche e Cliniche 'L. Sacco' - DIBIC
TRS-2018-00001359 4- Safety Elderly
IntraVenous saline solution versus ORal hydration for preventing contrast induced nephropathy (CIN) in elderly patients with chronic kidney disease (CKD) stage 3b and 4. The IVOR-CKD contrast nephropathy study. A randomized, open label, multicenter, phase III, non-inferiority trial.
13,00
Martinelli Giovanni Azienda Ospedaliero-Universitaria di Bologna, Policlinico S. Orsola- Malpighi
TRS-2018-00001537 1 - Rare Diseases
Low intensity combination therapy with E. Coli asparaginase and cytarabine in
relapsed/refractory acute myeloid leukemia patients carrying monosomy 7, del(7q) or focal
deletion of 7q21. 13,50
Gambineri Alessandra Dept. of Medical and Surgical
Sciences, University of Bologna TRS-2018-00001754 1 - Rare Diseases
Comprehensive steroid profiling in serum and saliva for improving diagnosis and tailoring therapy of Non Classical Congenital Adrenal Hyperplasia due to 21-hydroxylase deficiency
in children and adults 13,50
Simonetti Giorgia Fondazione IRCCS Neurologico
Carlo Besta TRS-2018-00001295 1 - Rare Diseases The Role of Chemotherapy in adult Recurrent Atypical and Anaplastic Meningiomas: a
systematic review and a network meta-analysis. 13,50
Caltagirone Carlo Fondazione Santa Lucia IRCCS TRS-2018-00001254 1 - Rare Diseases Genistein for treatment of motor and cognitive symptoms of the early stage of Progressive
Supranuclear Palsy 13,50
De Cobelli Francesco IRCCS Ospedale San Raffaele TRS-2018-00001434 1 - Rare Diseases
Identification of hybrid imaging (PET/MRI) and molecular biomarkers to predict vascular progression in patients with large vessel vasculitis (LVV) to improve the appropriateness of biologic treatment
13,50
Appetecchia Marialuisa IRCCS-Istituto Nazionale Tumori
Regina Elena (IRE) TRS-2018-00001608 1 - Rare Diseases
Tailored versus standard doses of recombinant human TSH in patients affected by differentiated thyroid cancer: a randomized prospective clinical trial evaluating the feasibility of precision medicine.
13,50
Vinti Luciana Ospedale Pediatrico Bambino
Gesù TRS-2018-00001767 2 - Pediatric Diseases Off-label use of propranolol to reduce brown adipose tissue activation in pediatric
oncological patients undergoing 18F-FDG PET/CT 13,50
Mosca Marta Rheumatology Unit, University of
Pisa TRS-2018-00001719 1 - Rare Diseases
The role of Intravenous Immunoglobulin (IVIG) in the induction of remission in subjects with dermatomyositis (DM) and polymyositis (PM): multicenter randomized play the winner controlled single-blind parallel group trial to evaluate the 6-month effectiveness of IVIG versus standard corticosteroids (CS) therapy
13,50
Pivonello Rosario University Federico II TRS-2018-00001457 1 - Rare Diseases InnOvative therapies in rare disease: New replacement Treatment in adrenal Insufficiency
and identification of new bio-Markers of glucocorticoid Exposure. 13,50
Pedrotti Emilio Fondazione Banca degli Occhi del
Veneto onlus TRS-2018-00001518 1 - Rare Diseases
PROspective evaluation of efficacy and safety of autologous human corneal epithelial cells containing stem cells for the treatment of limbal stem cell DEficiency due to etiologies different from physical or chemical ocular burns.
14,00
Pisano Tiziana AOU Meyer TRS-2018-00001739 2 - Pediatric Diseases Children and Adolescent off-Label psychotropic Medicines in Emergency setting: a
retrospective study of efficacy and safety. 14,00
Tascini Carlo Azienda Ospedaliera dei Colli TRS-2018-00001620 5 - AMR
A double-blind, randomized, placebo-controlled, multicenter study assessing the impact of oral gentamycin on gut decolonization due to Klebsiella pneumoniae KPC: GENtamycin for
GUT decontamination study 14,00
Fiorica Francesco Azienda Ospedaliero Universitaria
di Ferrara TRS-2018-00001452 1 - Rare Diseases A translational approach for glioblastoma patients using NIMODIPINE 14,00 Murri Rita Catholic University of Rome TRS-2018-00001505 5 - AMR A prospective, multicenter, train-to-trainer Antimicrobial Stewardship Intervention study
for the reduction of inappropriate antimicrobial therapy in hospital and long-term Care facilities (CHAMPIONS)
14,00
Colao Annamaria Dipartimento Medicina Clinica e
Chirurgia, University Federico II TRS-2018-00001530 1 - Rare Diseases A multicenter, observational study on epidemiology, genetic and molecular diagnosis, and available treatments for patients with rare endocrine diseases from across reference centers in Southern Italy.
14,00
Dilena Robertino Fondazione IRCCS Ca' Granda
Ospedale Maggiore Policlinico TRS-2017-00001208 2 - Pediatric Diseases RANDOMIZED CONTROLLED TRIAL OF LEVETIRACETAM VERSUS PHENOBARBITAL AS FIRST-
LINE ANTIEPILEPTIC TREATMENT OF NEONATAL SEIZURES IN ITALY 14,00
Canafoglia Laura Fondazione IRCCS Istituto
Neurologico Carlo Besta TRS-2018-00001697 1 - Rare Diseases
CREATION OF AN ITALIAN DATABASE FOR PROGRESSIVE MYOCLONUS EPILEPSIES AND NOVEL TREATMENT OF THE MOST COMMON FORM, UNVERRICHT-LUNDBORG DISEASE,
BASED ON THE HYPOTHESIS OF NEUROINFLAMMATION 14,00
Barbi Egidio Istituto per L'Infanzia Burlo
Garofolo TRS-2018-00001529 2 - Pediatric Diseases Pharmacogenetics and pharmacokinetics of ketamine in children presenting adverse
events during procedural analgesia and sedation outside of the operating room in children 14,00 Alunno Alessia Rheumatology Unit, Department
of Medicine, University of Perugia TRS-2018-00001769 4- Safety Elderly Safety and efficacy of biologic therapies for the treatment of rheumatic and
musculoskeletal diseases in elderly people. 14,00
Cucchiara Salvatore Sapienza University of Rome TRS-2018-00001662 1 - Rare Diseases
A RANDOMIZED DOUBLE-BLIND, MULTICENTER TRIAL TO EVALUATE THE EFFICACY AND SAFETY OF A NEW ORAL VISCOUS BUDESONIDE FORMULATION IN PEDIATRIC PATIENTS WITH EOSINOPHILIC ESOPHAGITIS
14,00 Piccolo Pasquale Telethon Institute of Genetics and
Medicine TRS-2018-00001420 1 - Rare Diseases Prognostic factors for liver disease due to Z mutant alpha1-antitrypsin 14,00 Novelli Giuseppe
Università degli Studi di Roma Tor Vergata - A.O.U Policlinico
Universitario Tor Vergata TRS-2018-00001513 1 - Rare Diseases Novel phenotypes in LAMINopathies: a multicentre study for molecular diagnosis
exploiting a high-throughput NGS strategy 14,00
Quaranta Luciano University of Brescia TRS-2018-00001509 4- Safety Elderly Selective laser trabeculoplasty (SLT) for deprescribing maximal tolerated medical therapy in elderly and ultra-elderly glaucoma patients: evaluation of the rate of progression of visual field damage and quality of life. (Selective Laser for Glaucoma Deprescribing: SLGD)
14,00
Mazzon Emanuela IRCCS Centro Neurolesi "Bonino
Pulejo" TRS-2018-00001425 5 - AMR Role of IDO in Multi-Drug Resistant Airway Infections 14,25
D'Avanzo Barbara IRCCS Istituto di Ricerche
Farmacologiche Mario Negri TRS-2018-00001439 4- Safety Elderly EFFECT OF BRIEF PSYCHOTHERAPY ON DISCONTINUATION OF LONG-TERM
ANTIDEPRESSANT MEDICATION IN THE ELDERLY 14,25
Eva Alessandra Istituto G. Gaslini TRS-2018-00001479 1 - Rare Diseases A prospective study of Glycogen Storage Disease type 1a to identify circulating exosomal
microRNA biomarkers. 14,25
Novelli Antonio Ospedale Pediatrico Bambino
Gesù TRS-2018-00001688 1 - Rare Diseases
A retrospective and prospective public database on a 20-year follow-up from two Italian academic hospital settings collecting information on the natural course, biomarkers, clinical workup, molecular markers and disease persistence in a cohort of 100 children with primary and secondary paediatric thyroid cancer diagnosed before 18 years. A real-life comparative effectiveness prospective study on recombinant human thyrotropin use in paediatric thyroid cancer
14,25
Pantoni Leonardo "L. Sacco" Department of Biomedical and Clinical Sciences, University of Milan
TRS-2018-00001261 1 - Rare Diseases Acetazolamide treatment to improve cognition in CADASIL patients 14,50
Cimaz Rolando Gilles Azienda Ospedaliero -
Universitaria Meyer TRS-2018-00001564 2 - Pediatric Diseases Analysis of the remission potential of canakinumab as a first-line treatment of systemic
juvenile idiopathic arthritis 14,50
Brunetti-Pierri Nicola Federico II University of Naples TRS-2018-00001326 1 - Rare Diseases Development of biomarkers and efficacy of Losartan in Myhre syndrome patients 14,50
Merli Pietro IRCCS Ospedale Pediatrico
Bambino Gesù TRS-2018-00001755 2 - Pediatric Diseases First-in-human, Italian academic Phase I-II Trial based on adoptive Chimeric Antigen receptor (CAR)-T cells specific for CD19 antigen in patients with relapsed/refractory B-cell Acute Lymphoblastic Leukemia (B-ALL) or B-cell Non-Hodgkin Lymphomas (B-NHL)
14,50
Lonardi Sara Istituto Oncologico Veneto IRCCS TRS-2018-00001779 1 - Rare Diseases Randomized phase 2 of avelumab or avelumab plus cetuximab in advanced squamous cell
carcinoma of the anal canal: a clinical and translational study 14,50 Ortona Elena Istituto Superiore di Sanità TRS-2018-00001394 3 - Gender Medicine
A Gender Approach in Rheumatoid Arthritis management: identification and validation of sex-specific predictive and prognostic biomarkers in patients treated with TNF-inhibiting
drugs 14,50
Luciani Matteo Ospedale Pediatrico Bambino
Gesù TRS-2018-00001773 2 - Pediatric Diseases Study to address the safety and efficacy of recombinant tissue Plasminogen Activator off
label use in a cohort of neonates and children with Acute Ischemic Stroke (AIS). 14,50 Vincenzi Bruno Università Campus Bio-Medico di
Roma TRS-2018-00001415 1 - Rare Diseases Identification of genetic PolymorphISms to predict drug Toxicity in soft tissue sarcoma
patients treated with Adjuvant CHemOtherapy 14,50
Di Maio Massimo Università degli Studi di Torino,
Dipartimento di Oncologia TRS-2018-00001500 4- Safety Elderly A systematic review and literature-based meta-analysis of the efficacy of immune checkpoint inhibitors in elderly patients with solid tumors: the IMAGE (IMmunotherapy and AGE) study
14,50 Di Marco Vito Università di Palermo TRS-2018-00001495 4- Safety Elderly UTILITY AND BENEFIT OF DIRECT-ACTING ANTIVIRALS (DAAs) IN ELDERLY PATIENTS WITH
HEPATITIS C VIRUS (HCV) LIVER DISEASE 14,50
Terzolo Massimo University of Turin TRS-2018-00001405 4- Safety Elderly
Treatment with the glucocorticoid receptor antagonist Mifepristone in Old patients with Subclinical Cushing syndrome and Arterial hypertension: a randomized, placebo-controlled crossover trial (trial MOSCA).
14,50
Snijders Deborah
Dipartimento Salute della Donna e del Bambino (SDB) Università
degli Studi di Padova TRS-2018-00001404 1 - Rare Diseases Can Ataluren restore ciliary activity in PCD patients by overcoming non-sense mutations? 15,00 Lanari Marcello AOSP Bologna Sant'Orsola-
Malpighi TRS-2018-00001599 2 - Pediatric Diseases SAFETY OF ALBUTEROL IN CHILDREN UNDER TWO YEARS OF AGE WITH WHEEZING: A
SYSTEMATIC REVIEW WITH META-ANALYSIS 15,00
Gentile Ivan
Azienda Ospedaliera Universitaria - Università degli Studi di Napoli Federico II
TRS-2018-00001588 5 - AMR Correlation between Pk/Pd parameters and clinical response in ICU patients undergoing
therapy with echinocandins: a real-life multicentre study 15,00
Indolfi Giuseppe Azienda Ospedaliero Universitaria
Meyer TRS-2017-00001204 2 - Pediatric Diseases A Real World, Observational, Retro-Prospective, Cohort Study on the Use of Direct-Acting
Antivirals for Italian Children with Chronic Hepatitis C 15,00
D'Ascenzo Fabrizio Division of Cardiology, Città Della
Salute e della Scienza, Turin TRS-2018-00001572 3 - Gender Medicine 6 vs. 24 months of antiplatelet therapy with new p2Y12 inhinitor in fEmale patieNTs presenting with ACS and treated with coronary stent impLantation: the YENTL a randomized controlled trial.
15,00 Del Sette Massimo Ente Ospedaliero Ospedali
Galliera TRS-2018-00001483 1 - Rare Diseases Cognitive Impairment and depression in Pediatric and Juvenile Stroke: CIPJS study 15,00 Ardissino Gianluigi
Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico - Centro SEU
TRS-2018-00001729 2 - Pediatric Diseases Tailored eculizumab treatment for aHUS in children 15,00 Bilo Grzegorz Istituto Auxologico Italiano, IRCCS;
Ospedale San Luca TRS-2018-00001449 3 - Gender Medicine Hypertension treatment with aldosterone antagonist in obese female and male individuals. 15,00 Roti Giovanni
Ospedale Maggiore : Azienda Ospedaliero-Universitaria di
Parma TRS-2018-00001307 1 - Rare Diseases OVVERIDE CHEMORESISTANCE IN T CELL ACUTE LYMPHOBLASTIC LEUKEMIA 15,00
Russo Giuseppina Policlinico universitario G.
Martino di Messina TRS-2018-00001423 3 - Gender Medicine Gender Differences in Effectiveness and Safety of New Drugs for Treatment of type 2
diabetes. Non-interventional prospective multicenter study 15,00
Pedone Claudio Università Campus Bio-Medico di
Roma TRS-2018-00001253 4- Safety Elderly Effectiveness and safety of deprescribing in older people: a randomized clinical trial 15,00 Barone Adesi Francesco Università del Piemonte Orientale TRS-2018-00001475 4- Safety Elderly Risk of type 2 diabetes mellitus in antidepressant users: employing a pharmacodynamic
approach in a multiregional population-based cohort study. 15,00
Santucci Annalisa Università di Siena TRS-2018-00001371 1 - Rare Diseases A monocentric, double-blind, crossover clinical study to assess the efficacy of weekly
administration of low-dose methotrexate in patients with alkaptonuria 15,00 Raia Valeria University "Federico II" of Naples TRS-2018-00001633 1 - Rare Diseases
A phase 2 randomized, double blind, multi-center, placebo-controlled study to explore clinical effects of combined repurposed drugs in Cystic Fibrosis subjects with rare genotypes not responsive to current CFTR-targeted therapies.
15,00
Carta Mauro Giovanni
University of Cagliari, Depatment of Medical Sciences and Public
Health TRS-2018-00001566 4- Safety Elderly Exercise in Elderly people with Major depressive disorder and Metabolic or Cardiovascular
Disease 15,00
Coppini Raffaele University of Florence TRS-2018-00001737 2 - Pediatric Diseases Pharmacological treatment of pediatric heart failure and cardiomypathies in Italy 15,00 Galli Luisa University of Florence, Meyer
Children's Hospital TRS-2018-00001547 2 - Pediatric Diseases Paediatric drug resistant tuberculosis: a multi-centre observational study on efficacy and
safety of second line off-label drugs in HIV-negative children 15,00 Consolo Filippo IRCCS Ospedale San Raffaele TRS-2018-00001581 4- Safety Elderly Is it safe to reduce intensity of antiplatelet therapy in elderly patients? 15,25 Picci Piero Istituto Ortopedico Rizzoli TRS-2018-00001655 1 - Rare Diseases
An Open-label, Multi-center, Phase 2 Study of Denosumab in selected patient with Aneurysmal Bone Cyst (ABC), difficult to treat due to site or relapsed after conventional treatments.
15,25
Maiorana Arianna Ospedale Pediatrico Bambino
Gesù TRS-2018-00001484 1 - Rare Diseases Efficacy and Safety of Somatostatin-Analogues in Hyperinsulinism Hypoglycemia: an
interventional, prospective randomized, open-label trial controlled with diazoxide 15,25 Casale Maddalena Università degli studi della
Campania "Luigi Vanvitelli" TRS-2018-00001648 1 - Rare Diseases National Survey on the prevalence of morbidity and mortality due to Asplenia or
Splenectomy in Rare Diseases through the Italian Network on Asplenia. 15,25 Marrocco Trischitta MassimI.R.C.C.S. Policlinico San Donato TRS-2018-00001246 3 - Gender Medicine EFFECT OF SODIUM NITRITE ON AORTIC STIFFNESS AND WAVE REFLECTIONS
AFTERENDOVASCULAR ABDOMINAL AORTIC REPAIR 15,50
Provini Federica IRCCS-ISNB TRS-2018-00001602 4- Safety Elderly Long-term efficacy of a specific training program for general practitioners to discontinue
benzodiazepines in the elderly: a cluster randomized controlled trial 15,50 Colafati Giovanna Stefania Ospedale Pediatrico Bambino
Gesu TRS-2018-00001796 1 - Rare Diseases Finding noninvasive MRI biomarkers in pediatric gliomas: clinical impact of diffusion
kurtosis imaging, multiparametric MRI, radiomics and radiogenomics. 15,50 Serra Giulia Ospedale Pediatrico Bambino
Gesù TRS-2018-00001778 2 - Pediatric Diseases Efficacy and safety of memantine as antimanic and mood-stabilizing medication for children and adolescents with Bipolar Disorder: a multi-center, randomized, double-blind, placebo-controlled clinical trial.
15,50
Saponara Maristella Policlinico Sant'Orsola-Malpighi,
University of Bologna TRS-2018-00001224 1 - Rare Diseases A phase 2 study of temozolomide in advanced rare tumors with MGMT promoter
methylation after failure of standard therapies 15,50
De Giacomo Andrea Università degli Studi di Bari "Aldo
Moro" TRS-2018-00001742 2 - Pediatric Diseases Oxytocin targeted therapies to address Autism Spectrum Disorders¿ core symptoms 15,50
Tagliaferri Pierosandro Università Magna Graecia TRS-2018-00001288 3 - Gender Medicine Gender based pharmacogenomic analysis of tyrosine kinase inhibitors in lung cancer and of
proteosome inhibitors in multiple myeloma 15,50
De Benedetti Fabrizio IRCCS Ospedale Pediatrico
Bambino Gesù TRS-2018-00001451 1 - Rare Diseases
Novel genetic and immune biomarkers of diagnosis, risk, severity and response to treatment of macrophage activation syndrome (MAS) and secondary haemophagocytic lymphohistiocytosis (sHLH): a prospective observational study
16,00
Di Meco Francesco Foundation I.R.C.C.S Neurological
Institute Carlo Besta, Milan TRS-2018-00001731 1 - Rare Diseases Blood-brain barrier opening for mitoxantrone delivery in recurrent glioblastoma with Magnetic Resonance guided Focused Ultrasound and ultrasound contrast agents: a single center pilot study to assess safety and feasibility
16,00
Menichetti Francesco Azienda Ospedaliera Universitaria
Pisana TRS-2018-00001498 5 - AMR Clinical impact of an educational intervention on antibiotic prescribing in patients with
Gram-negative bacilli bacteremia: a multicenter cluster randomized controlled trial 16,00 Carugati Manuela Ospedale San Gerardo TRS-2018-00001266 5 - AMR Antimicrobial stewardship among solid organ transplant recipients (ASSOT): a multicenter
quasi-experimental study. 16,00
Giustozzi Michela Department of Internal and
Emergency Medicine-Stroke Unit TRS-2018-00001707 4- Safety Elderly Clinical benefit of anticoagulant Vs no anticoagulant treatment in patients aged 90 or older
with atrial fibrillation in real-world clinical practice. 16,00
Giaquinto Carlo Department of women and Child
Health University of Padova TRS-2018-00001473 5 - AMR
DEVELOPMENT AND IMPLEMENTATION OF PEDIATRIC IN-HOSPITAL ANTIMICROBIAL STEWARDSHIP PROGRAM THROUGH PEDIATRIC CLINICAL PATHWAYS AND PERIODICAL
PRESCRIPTION FEEDBACK 16,00
Vinciguerra Paolo Humanitas Research Hospital TRS-2018-00001736 1 - Rare Diseases New Riboflavin applications in CXL (CORNEAL CROSSLINKING). 16,00 Stocchi Fabrizio IRCCS San Raffaele Pisana TRS-2018-00001364 4- Safety Elderly Efficacy and safety study of use Quetiapine for patients with Parkinson¿s disease psychosis:
a randomised, double-blind, placebo-controlled trial. 16,00
Bonati Maurizio
Laboratory for Mother and Child Health, Department of Public Health, IRCCS - Istituto di Ricerche Farmacologiche "Mario Negri"
TRS-2018-00001710 2 - Pediatric Diseases Safety and Efficacy of on-Label and Off-label Psychotropic drugs in children and
adolescents with mental disorders. (SELOPsy study) 16,00
Ciceri Fabio Ospedale San Raffaele TRS-2018-00001631 5 - AMR
Impact of microbiome characterization and fecal transplant on the risk of infections by multi-drug-resistant (MDR) bacteria after allogeneic hematopoietic stem cell transplantation (HSCT).
16,00
Scuteri Angelo Policlinico Tor Vergata TRS-2018-00001429 3 - Gender Medicine Gender-specific efficacy of canrenone on arterial aging and metabolic parameters in a
cohort of obese middle-age subjects with elevated blood pressure 16,00 Talora Claudio Sapienza University of Rome TRS-2018-00001241 1 - Rare Diseases Antioxidant therapy as an effective therapeutic strategy for Hailey-Hailey-Disease 16,00
Blandizzi Corrado
Sezione di Farmacologia e Farmacovigilanza - Dipartimento di Medicina Clinica e
Sperimentale - Università di Pisa
TRS-2018-00001741 3 - Gender Medicine
The risk of perinatal events in newborn after antidepressant exposure during pregnancy, experiencing the ¿AMALTEA¿ app from data collection to pharmacological consultation ¿
the AMALTEA study 16,00
De Santis Marco Università Cattolica del Sacro
Cuore TRS-2018-00001555 1 - Rare Diseases
Primary Cytomegalovirus infection in the first and second trimester of pregnancy and therapy with Valacyclovir: prevention of vertical transmission and of fetal-neonatal injury.
The VALCYPRE Study.
16,00 Carbone Marco Università di Milano-Bicocca TRS-2018-00001257 1 - Rare Diseases A Precision Medicine approach to understand the basis of treatment failure in Primary
Biliary Cholangitis (PBC) 16,00
Chieffo Alaide San Raffaele Hospital TRS-2018-00001223 3 - Gender Medicine Diagnosis and treatment of chronic ischemic syndromes in patients with non-obstructive
coronary artery disease 16,25
Meocci Patrizia Meyer Children's University
Hospital - Florence TRS-2018-00001445 4- Safety Elderly EFFICACY AND SAFETY OF CARDIOVASCULAR DRUGS IN OLDER PEOPLE WITH DEMENTIA
RECEIVING HOME CARE ASSISTANCE 16,50
Barcellini Wilma Fondazione IRCCS Ca' Granda
Ospedale Maggiore Policlinico TRS-2018-00001698 1 - Rare Diseases Comparison of the efficacy and safety of standard versus low-dose rituximab in warm
autoimmune hemolyticanemia and cold agglutinin disease 16,50
Napoleone Ettore FP-MCRN (Family Pediatricians- Medicines for Children Research Network)
TRS-2018-00001260 2 - Pediatric Diseases Diagnostic tools and training strategies for improving the appropriate use of Antibiotics among childhood population in extra hospital settings to reduce both the Ab resistance and ADRs: a RCT.
16,50
Belardelli Filippo Istituto di Farmacologia
Traslazionale (CNR) TRS-2018-00001763 3 - Gender Medicine
Combining peptide vaccination with discontinuous interferon-alpha alone or together with a single dose of cyclophosphamide to prevent recurrence and identify gender-specific biomarkers in resected stage III melanoma patients
16,50
Hollander Lital Istituto di ricerche farmacologiche
Mario Negri TRS-2018-00001267 1 - Rare Diseases Pembrolizumab and Trabectedin in advanced pretreated malignant pleural mesothelioma ¿
PETRA Study 16,50
Sangiorgi Luca Rizzoli Orthopaedic Institute TRS-2018-00001328 1 - Rare Diseases Finding New Evidence on Multiple Osteochondromas 16,50 Vania Andrea Sapienza Università di Roma TRS-2018-00001565 2 - Pediatric Diseases
A multicenter controlled clinical Study to Evaluate efficacy and safety of CHOLecalciferol supplementation with diet and physical activity in improving cardio-metabolic and skeletal profile in female and male pediatric prepubertal subjects affected by overweight and/or Obesity.
16,50
Arca Marcello Sapienza University of Rome Dept of Internal Medicine and Allied Sciences
TRS-2018-00001398 1 - Rare Diseases Efficacy of lomitapide in reducing cardiovascular outcomes in patients with homozygous
familial hypercholesterolemia (HoFH): data from a real-world analysis 16,50 Di Zazzo Antonio Università Campus Bio-Medico di
ROma TRS-2018-00001723 2 - Pediatric Diseases New Topical administration of 1mg/mL Acetylsalicylic acid in management of allergic
Vernal keratoconjunctivitis 16,50
Cardile Venera University of Catania TRS-2018-00001542 1 - Rare Diseases CORRELATION BETWEEN GENOTYPE, PHENOTYPE AND BIOMARKERS IN KRABBE DISEASE:
ISTITUTION OF AN ITALIAN REGISTER 16,50
Zignego Anna Linda University of Florence TRS-2018-00001447 1 - Rare Diseases Use of rituximab to improve the outcome of antiviral therapy for HCV-associated mixed
cryoglobulinemia vasculitis 16,50
Ferrante Pasquale University of Milano TRS-2018-00001352 1 - Rare Diseases The role of cytotoxic T lymphocytes function against Merkel Cell Carcinoma: an
observational study 16,50
Marchese Cinzia Sapienza University of Rome -
Umberto I Polyclinic TRS-2018-00001418 1 - Rare Diseases
Phase-II monocentric open-label study on a novel vaginoplasty technique using autologous vaginal mucosal layers in patients with Mayer-Rokitansky-Küster-Hauser (MRKH) syndrome: anatomical and functional outcomes
16,75
Iacoviello Licia Fondazione Neuromed TRS-2018-00001553 4- Safety Elderly The COmbined MEditerranean diet and STAtins for secondary cardiovascular risk
prevention TRIAL 17,00
Papi Massimiliano Fondazione Policlinico Gemelli- Università Cattolica del Sacro Cuore
TRS-2018-00001784 4- Safety Elderly GRAphene detector of CIrculating microRNAs as a Leading high-sensitive tool for fracture
prevention and therapy follow up in osteoporosis 17,00
Greco Massimiliano Humanitas Research Hospital TRS-2018-00001630 4- Safety Elderly SAFEty of anesthesia and Ancillary perioperative druG in the Elderly patient: A Network
Meta-analysis of Mixed Treatment Comparisons (SAFE-AGE study) 17,00 Maselli Roberta Humanitas Research Hospital TRS-2018-00001463 1 - Rare Diseases Risk of Microbial Translocation in patients undergoing Per-Oral Endoscopic Myotomy
(POEM) for Achalasia: Antibiotic Prophylaxis vs Short-therapy 17,00 Stefanini Giulio Giuseppe IRCCS Istituto Clinico Humanitas TRS-2018-00001525 4- Safety Elderly
Tailoring Antithrombotic ReGimEns in ocTogenarians with atrial fibrillation and coronary artery disease treated with percutaneous revascularization: a randomized comparison of low-dose ticagrelor versus dual antiplatelet therapy with aspirin and clopidogrel on top of oral anticoagulation
17,00
Sciuto Rosa IRCCS Regina Elena National
Cancer Institute TRS-2018-00001717 1 - Rare Diseases In vivo biological characterization of NET using 64CU -DOTATOC PET /CT: a novel potential
theranostic agent. 17,00
Raponi Massimiliano Ospedale Pediatrico Bambino
Gesù TRS-2018-00001685 5 - AMR Promoting appropriateness of antibiotic prescriptions in children's hospitals: a
collaborative multisite prospective study 17,00
Vaccaro Olga "Federico II" University of Naples TRS-2018-00001301 3 - Gender Medicine
Gender differences in the response and the benefit/risk profile of two antihyperglycemic drugs with different mechanisms of action: enhancement of insulin secretion
(sulfonylureas) vs improvement of insulin action (pioglitazone) Protocol version 1 - January 30, 2018
17,50
Garavelli Livia AUSL IRCCS Reggio Emilia TRS-2018-00001691 1 - Rare Diseases Clinical Management of Mowat-Wilson Syndrome: Creation of a Disease Registry and of
Specific Growth Charts for Affected Children and Youths 17,50
Caproni Marzia Azienda USL Toscana Centro TRS-2018-00001494 1 - Rare Diseases Long-term treatment effectiveness and safety in patients with bullous pemphigoid through
the development of the Bullous Pemphigoid patient-Registry (BPReg) 17,50 Fisher Alessandra Daphne
Department of Experimental, Clinical and Biomedical Sciences,
University of Florence TRS-2018-00001272 2 - Pediatric Diseases Safety Study of Triptorelin in Adolescents with Gender Dysphoria/ Gender Incongruence. 17,50 Milito Cinzia
Department of Molecular Medicine Sapienza University of Rome
TRS-2018-00001708 5 - AMR
Observational cohort prospective multicenter study on antibiotic use and on antibiotic resistance of S. pneumoniae and H. influenzae strains colonizing nasopharyngeal mucosa in patients with Primary Immune Defects
17,50
Ardizzone Sandro Fatebenefratelli e Oftalmico Hospital ASST Fatebenefratelli Sacco
TRS-2018-00001783 4- Safety Elderly Deprescribing chronic proton pump inhibitor (PPI) use in elderly patients 17,50
Seregni Ettore Fondazione IRCCS Istituto
Nazionale dei Tumori Milano TRS-2018-00001646 1 - Rare Diseases Phase II Study of 177Lu-DOTATATE therapy in recurrent or progressive meningioma
patients. 17,50
Fattorini Annalisa IRCCS Ospedale San Raffaele TRS-2018-00001706 4- Safety Elderly Management Of Dabigatran Etexilate Under LAboratory TEsting in Atrial Fibrillation 17,50 ridolfi laura IRST IRCCS TRS-2018-00001251 4- Safety Elderly Combination Immunotherapy of a dendritic cell based vaccine and nivolumab in elderly
metastatic melanoma patient: a phase 1 study. 17,50
Harari Sergio Ospedale San Giuseppe TRS-2018-00001428 1 - Rare Diseases Is it Possible to Predict the Evolution of Lymphangioleomyomatosis? A Prospective
Radiological, Functional and Biomolecular Study 17,50
Azzari Chiara Università degli Studi di Firenze TRS-2018-00001455 2 - Pediatric Diseases
Three or four dose schedule for hexavalent (DTP-HBV-IPV-Hib) vaccination in preterm babies? Risk of pertussis and Haemophilus influenzae type b in preterm babies vaccinated
with 3 doses of hexavalent vaccines. 17,50
Procino Giuseppe University of Bari TRS-2018-00001281 1 - Rare Diseases Novel Off-label Application of Mirabegron (Betmiga) to cure X-linked Nephrogenic Diabetes
Insipidus 17,50
Giacomelli Roberto University of L'Aquila TRS-2018-00001556 1 - Rare Diseases Short-term anakinra as first-line disease-modifying therapy in adult onset Still¿s disease: a
proof-of-concept multicenter double blind randomized controlled trial 17,50 Merli Francesco
Azienda Ospedaliera Arcispedale Santa Maria Nuova - IRCCS - Ematologia
TRS-2018-00001541 4- Safety Elderly
Prephase treatment with prednisone +/- Vitamin D supplementation followed by reduced- dose immunochemotherapy in Elderly non-FIT patients with Diffuse Large B-Cell Lymphoma (DLBCL). A randomized, open label, phase III study by Fondazione Italiana Linfomi.
18,00
Davoli Marina Department of Epidemiology Regional Health Service, Regione Lazio, ASL Roma 1
TRS-2018-00001789 3 - Gender Medicine SAFETY AND RISKS ASSOCIATED WITH NEW AND OLD PHARMACOLOGICAL TREATMENTS
FOR PSORIASIS IN PREGNANCY AND LACTATION: A SYSTEMATIC REVIEW 18,00
Di Martino Mirko
Department of Epidemiology, ASL Roma 1, Lazio Region, Italy.
Division of Outcome Research TRS-2018-00001329 5 - AMR Improving the rational use of antibiotics in pediatric outpatients: the impact of a
multidimensional, public health intervention. 18,00
De Martino Maria Cristina
Dipartimento di Medicina Clinica e Chirurgia, Università degli Studi di Napoli "Federico II"
TRS-2018-00001432 1 - Rare Diseases
Brain morpho-functional MRI, neurological and neuromuscular function, psychological profile, and cognitive function correlates in hypogonadal men with rare hypothalamus- pituitary-testis axis disorders: a comparative study on the effects of different testosterone formulations
18,00
Belleudi Valeria
Dipartimento Epidemiologia del S.S.R. - ASL Roma 1 - Regione
Lazio TRS-2018-00001587 2 - Pediatric Diseases Utilization, effectiveness, safety and costs of Palivizumab in infants according to gestational
age: a record-linkage, multi-database, multi-regional, observational cohort study. 18,00 Federici Augusto
Divisione Ematologia e Medicina Trasfusionale ASST-
Fatebenefratelli-Sacco TRS-2018-00001391 1 - Rare Diseases "MAnagement of Gastro-Intestinal bleeds (GIB) with VWF Concentrates in von Willebrand
Inherited and Acquired patients: retrospective and prospective study '18." 18,00
Castagnola Elio Istituto Giannina Gaslini TRS-2018-00001709 2 - Pediatric Diseases Evaluation pharmacokinetics/pharmacodinamics (PK/PD)of antibiotics in critically ill
children 18,00
Parri Niccolò Meyer University Children's
Hospital TRS-2018-00001786 2 - Pediatric Diseases A prospective clinical trial to evaluate the safety and efficacy of Contrast Enhanced
UltraSound (CEUS) in pediatric blunt abdominal trauma 18,00
Martinelli Diego Ospedale Pediatrico Bambino
Gesu', IRCCS TRS-2018-00001794 1 - Rare Diseases Safety and Efficacy of EPI-743 for the Treatment of Patients with RARS2 defect syndrome
(Pontocerebellar Hypoplasia Type 6) 18,00
Pieri Marina Ospedale San Raffaele TRS-2018-00001343 4- Safety Elderly Anesthesia depth levels and postoperative DeliRium in agEd pAtients: a prospective double-
blinded Multicenter Study 18,00
Mercuri Eugenio Maria Università Cattolica TRS-2018-00001703 1 - Rare Diseases
Clinical follow up of children and adults with Spinal muscular atrophy treated with
Nusinersen 18,00
Andreoli Laura University of Brescia TRS-2018-00001727 3 - Gender Medicine Implementing Knowledge and Communication about the Use of Drugs during Pregnancy in Women with Autoimmune Rheumatic Diseases: a multicenter, national-based, prospective cohort study.
18,00 D'amico Emanuele University of Catania TRS-2018-00001616 1 - Rare Diseases Hypermetabolism status in persons with Primary Progressive Form of Multiple Sclerosis: a
case control study 18,00
Giuliano Mario AOU Federico II TRS-2018-00001574 1 - Rare Diseases Mulitcenter open label, phase II trial of oral Vinorelbine and Anakinra as second-line
treatment for L-group Histiocytoses. 18,50
Tronci Enrico Computer Science Department -
Sapienza University of Rome TRS-2017-00001203 1 - Rare Diseases A complete set of in-vivo validated patient computational models to support in-silico drug
re-purposingfor rare diseases: the NLSDM case. 18,50
Savastano Silvia
Federico II University,
Dipartimento di Medicina Clinica e Chirurgia, Unità di
Endocrinologia
TRS-2018-00001419 3 - Gender Medicine
GEN.I.O.
GENder-difference In Obesity.
A multicenter study to evaluate differences in efficacy and safety of Saxenda and Mysimba in a female and male population.
18,50
Leone Francesco FPO IRCCS Candiolo TRS-2018-00001345 4- Safety Elderly Fluoropyrimidine Induced cardioToxicity in colorectal cancer: a multidimensioNal Elderly
patient Safety aSsessment 18,50
Sarzani Riccardo
Internal Medicine and Geriatrics,
"Hypertension Excellence Centre"
of the European Society of Hypertension, IRCCS-INRCA, University "Politecnica delle Marche"
TRS-2018-00001642 4- Safety Elderly
HYpertension in the Very Elderly: longitudinal evaluation of the 24-hour blood pressure profile, drug therapy, comorbidities and individual performance status ¿ The Italian
Registry 18,50
Banzi Rita IRCCS Mario Negri Institute for
Pharmacological Research TRS-2018-00001270 2 - Pediatric Diseases Efficacy and safety of pharmacological interventions for the treatment of multiple sclerosis
in children and adolescents: a systematic review of published and unpublished studies 18,50 Pietrangelo Antonello Azienda Ospedaliero Universitaria
Policlinico di Modena TRS-2017-00001188 1 - Rare Diseases Efficacy and safety of the association of the oral iron chelating agents deferasirox and defer
iprone in beta thalassemic patients: a multicenter open label trial. 18,50
Becattini Cecilia Medicina Interna e
Cardiovascolare - Università di Perugia
TRS-2018-00001379 4- Safety Elderly Benefit-risk profile of direct oral anticoagulants and vitamin K antagonists in patients with
atrial fibrillation and cancer 18,50
Drago Lorenzo
Università degli Studi di Milano - Dipartimento di Scienze Biomediche per la Salute
TRS-2018-00001611 5 - AMR prOactive surveillanCe data gatheRing and analysis to sensitize about Antibiotic
prescription inappropriateness and resulting resistance in local General Practice setting 18,50
Scotti Lorenza University of Milano-Bicocca TRS-2018-00001694 4- Safety Elderly Prevention of dementia by antihypertensive drug use: a meta-analysis 18,50 Sorio Claudio University of Verona TRS-2018-00001562 1 - Rare Diseases Intestinal organoids and optical imaging technology for the prediction and follow-up of the
functional response to CFTR potentiators and correctors 18,50
Mandala Mario ASST Papa Giovanni XXIII TRS-2018-00001469 4- Safety Elderly Anti pneumococcal and anti influenza vaccine prophylaxis in elderly cancer patients
receiving anti-PD-1 antibodies: a prospective phase 2 randomized study 19,00
Leoni Olivia ATS Insubria TRS-2018-00001795 4- Safety Elderly
Polypharmacy and the risk of Potentially Inappropriate Prescriptions (PIPs) in community dwelling older
patients 19,00
Bignami Elena Azienda Ospedaliero-Universitaria
di Parma TRS-2018-00001657 4- Safety Elderly Sevoflurane for the prevention of post-operative cognitive dysfunction in elderly patients
undergoing cardiac surgery 19,00
Poggio Paolo Centro Cardiologio Monzino IRCCS TRS-2018-00001390 3 - Gender Medicine A multicentre prospective study on subclinical aortic valve disease: effects of statins on oxidative stress and inflammation in aortic valve sclerosis patients requiring surgical myocardial revascularization.
19,00 Arrigo Alessandro Department of Ophthalmology,
University Vita-Salute San Raffaele
TRS-2018-00001772 1 - Rare Diseases Multimodal and functional assessment in Choroideremia. 19,00
Messori Andrea ESTAR Toscana TRS-2018-00001284 1 - Rare Diseases Prophylaxis of bleeding in patients with hemophilia A and high-titer inhibitors: systematic
review of the published evidence and determination of cost-effectiveness (EMI-HEMO) 19,00 Perricone Roberto Fondazione Policlinico Tor Vargata TRS-2018-00001544 1 - Rare Diseases
The registry of patients with hereditary angioedema to derive real life data for determining the cost/efficacy ratio of therapies for treatment or prevention of disease epsiodes in
patients with genetic and acquired C1 inhibitor deficiency. 19,00 Pisani Antonio Fondazione Santa Lucia, IRCCS TRS-2018-00001294 1 - Rare Diseases Mobile Health Technology for Genomics-Based Personalized Therapy in Young-Onset
Parkinson's Disease 19,00
Capra Valeria Istituto G.Gaslini, U.O.C.
Neurochirurgia TRS-2018-00001327 3 - Gender Medicine Prevention of Neural Tube Defects by Inositol: a pilot randomised controlled study 19,00 Gattorno Marco Istituto Giannina Gaslini TRS-2018-00001645 2 - Pediatric Diseases ANAKINRA IN DIFFICULT TO TREAT CHIDREN WITH RECURRENT PERICARDITIS 19,00 Pace Andrea Istituto Regina Elena TRS-2018-00001323 1 - Rare Diseases Repurposing the energy blocker Lonidamine as a therapeutic agent in the combined
treatment of newly diagnosed Glioblastoma Multiforme 19,00
Picardo Sergio Giuseppe Opedale Pediatrico Bambino
Gesù, Roma TRS-2018-00001604 2 - Pediatric Diseases OPIOID MANAGEMENT by PHARMACOGENETICS and POPULATION PHARMACOKINETICS for
ANALGESIA with LEAST OPTIMAL SCALING 19,00
