SPOTLIGHTS ON IMMUNONCOLOGY
Andrea Botticelli
A.O. Sant’Andrea, Sapienza Università di Roma
LE 5 W DELL’IMMUNO-BREAST WHY ?
WHEN ? WHERE ? WHO ?
WHAT ?
LE 5 W DELL’IMMUNO-BREAST WHY ?
WHEN ? WHERE ? WHO ?
WHAT ?
DENKERT SABCS 2016
LE 5 W DELL’IMMUNO-BREAST WHY ?
WHEN ? WHERE ? WHO ?
WHAT ?
LE 5 W DELL’IMMUNO-BREAST WHY ?
WHEN ? WHERE ? WHO ?
WHAT ?
I TNBC SONO TUTTI UGUALI ?
DIFFERENTE DISTRIBUZIONE : DIFFERENTI PROFILI
LE 5 W DELL’IMMUNO-BREAST WHY ?
WHEN ? WHERE ? WHO ?
WHAT ?
BIOMARKERS ?
•PD-L1
•TILs
•TML/MSI
•NUOVI BIOMARKERS : CD73
LE 5 W DELL’IMMUNO-BREAST WHY ?
WHEN ? WHERE ? WHO ?
WHAT ?
AACR 2017
SABCS 2017
COHORT A COHORT B
QUALE BIOMARKER?
LE 5 W DELL’IMMUNO-BREAST WHY ?
WHEN ? WHERE ? WHO ?
WHAT ?
HOW ?
Immune effects of Chemotherapy, Radiation Therapy and Targeted Therapies
Presented By Sandra Demaria at 2017 ASCO Annual Meeting
ANTIGENICITY ADJUVANTICITY
COME AUMENTARE L’ ANTIGENICITY ?
COME AUMENTARE L’ ADJUVANTICITY ?
KEYNOTE 173
ASCO 2017
ANTI PD-L1 + CT
SABCS 2017
SABCS 2017
SABCS 2017
QUALE BIOMARKER?
Savas et al, Nat Rev Oncol, 2015
INFILTRATO ?
Salgado R, et al. Ann Oncol 2015
In conclusione…
WHY ? Forte componente immunitaria nel BC
WHEN ? 1L e NEOADJ
WHERE ? TNBC .. Non solo
WHO ? PD-L1 + TILs… Non solo
WHAT ? Anti PD-1/PD-L1
HOW ? Le associazioni
