Bibliografia
1. Andreazzoli M, Gestri G, Angeloni D, Menna E, Barsacchi G: Role of Xrx1 in Xenopus eye and anterior brain development. Development 1999, 126: 2451-2460.
2. Andreazzoli M, Gestri G, Cremisi F, Casarosa S, Dawid I, Barsacchi G. Xrx1 controls proliferation and neurogenesis in Xenopus anterior neural plate. Development 2003
3. Besharse JC, Iuvone PM: Circadian clock in Xenopus eye controlling retinal serotonin N-Acetyltransferase. Nature 1983, 305: 133-135. 4. Borjigin J, Wang MM, Snyder SH: Diurnal varation in mRNA encoding
serotonin N-acetyltrasferase in pineal gland. Nature 1995, 378: 783-785.
5. Cahill GM, Besharse JC: Circadian Clock function localized in
Xenopus retinal photoreceptors. Neuron 1993, 10: 573-577.
6. Casarosa S, Andreazzoli M, Simeone A, Barsacchi G: Xrx1, a novel
Xenopus homeobox gene expressed during eye and pineal gland
development. Mechanisms of Development 1997, 61: 187-198.
7. Casarosa S, Amato M., Andreazzoli M, Gestri G, Barsacchi G, Cremisi F: Xrx1 controls proliferation and multipotency of retinal progenitors.
Molecular and Cellular Neuroscience 2003, 22: 25-36.
8. Cau E, Wilson SW: Ash1a and Neurogenin1 function downstream of Floating Head to regulate epiphysial neurogenesis. Development 2003, 130: 2455-2466.
9. Charlton HM: The pineal gland of Xenopus laevis, Daudin : a histological, histochemical, and electron microscopic study.
General and Comparative Endocrinology 1968, 11: 465-480.
10. Chitnis A, Henrique D, Lewis J, Ish-Horowicz D, Kintner C: Primary neurogenesis in Xenopus embryos regulated by a homologue of the
Drosophila neurogenic gene Delta .Nature 1995, 375: 761-766
11. Concha ML, Wilson SW: Asymmetry in the epithalamus of vertebrates. J Anat 2001, 199: 63-84.
12. Coon SL, Roseboom PH, Baler R, Weller JL, Namboodiri MAA, Koonin EV, Klein DC: Pineal serotonin N-acetyltransferase: expression cloning and molecular analysis. Science 1995, 270: 1681-1683.
13. Cremona M, Colombo S,Andreazzoli M, Cossu G, Broccoli V: Bsx, an evolutionary conserved Brain Specific homeoboX expressed in the septum, epyphysis, mammillary bodies and arcuate nucleus. Gene
Expression Patterns 2004
14. Dale L,Jones C.M. BMP signalling in early Xenopus development.
BioEassays 1999 21, 751-760
15. Dale L, Slack J.M. Fate map for the 32-cell stage of Xenopus laevis.
Development 1987. 99:527-551
16. Eagleson G, Ferreiro B, Harris WA: Fate of anterior neural ridge and the morphogenesis of the Xenopus forebrain. Journal of
Neurobiology 1995, 28: 146-158.
17. Eagleson GW, Harris WA: Mapping of the presuntive brain regions in the neural plate of Xenopus laevis. Journal of Neurobiology 1990, 21: 427-440.
18. Falcon J, Gothilf Y, Coon SL, Boeuf G, Klein DC: Genetic, temporal and developmental differences between melatonin rhythm generating system in the teleost fish pineal organ and retina. Journal of
Neuroendocrinology 2003, 15: 378-382.
19. Foster RG, Roberts A: The pineal eye in Xenopus laevis embryos and larvae: a photoreceptor with a direct excitatory effect on behaviour.
J Comp Phisiol 1982, 145: 413-419.
20. Gamse JT, Shen Y-C, Thisse C, Thisse B, Raymond P, Halpern M.E, Liang J.O Otx5 regulates genes that show circadian expression in the Zebrafish pineal complex. Nature genetics 2002, 30:117-121
21. Gamse JT, Thisse C, Thisse B, Halpern ME: The parapineal mediates left-right asymmetry in the diencephalons. Development 2003, 130: 1059-1068.
22. Gilbert S: Biologia dello sviluppo. Zanichelli 2000
23. Garidou ML, Diaz E, Calgari C, Pévet P, Simonneaux V: Transcription factors may frame Aa-nat gene expression and melatonin synthesis at night in the syrian hamster pineal gland. Endocrinology 2003, 144: 2461-2472.
24. Gont LK, Fainsod A, Kim SH, De Robertis EM: Overexpression of the homeobox Xnot-2 leads to notochord formation in Xenopus.
Development Biology 1996, 174: 174-178.
25. Gonzales-Fernandez F, Kittredge KL, Rayborn ME, Hollyfield JG, Landers RA, Saha M, Grainger RM: Interphotoreceptor retinoid-binding protein (IRBP), a major 124 kDa glycoprotein in the
interphotoreceptor matrix of Xenopus laevis. Journal of Cell Science 1993, 105: 7-21.
26. Gonzales-Fernandez F: Interphotoreceptor retinoid-binding protein: an old gene for new eyes. Vision Reseach 2003, 43: 3021-3036.
27. Gothilf Y, Coon SL, Toyama R, Chitnis A, Namboodiri MAA, Klein DC:
Zebrafish Serotonin N-Acetyltransferase-2: marker for development
of pineal photoreceptor and circadian clock function. Endocrinology 1999, 140: 4895-4903.
28. Green CB: Molecular control of Xenopus retinal circadian rhythms.
Journal of Neuroendocrinology 2003, 15: 350-354.
29. Green CB, Besharse JC: Tryptophan hidroxylase expression is regulated by a circadian clock in Xenopus laevis retina. Journal of
Neurochemistry 1994, 62: 2420-2428.
30. Green CB, Liang MY, Steenhard BM, Besharse: Ontogeny of circadian and light regulatin of melatonin release in Xenopus laevis embryos.
Development Brain Research 1999, 117: 109-116.
31. Green P, Hartenstein AY, Hartenstein V: The embryonic development of the Drosophila visual system. Cell Tissue Res. 1993, 273: 583-598. 32. Guglielmotti V, Cristino L, Sada E, Bentivoglio M: The epithalamus of
the developing and adult frog: calretinin expression and habenular asymmetry in Rana esculenta. Brian Research 2004, 999: 9-19.
33. Heasman J: Morpholino oligos: marking sense of antisense?
34. Huang H, Brown D. Overexpression of Xenopus laevis growth hormone stimulates growth of tadpoles and frogs. PNAS 2000, 97:190-194
35. Jamieson D, Roberts A: Responses of young Xenopus laevis tadpoles to light dimming: possible roles for the pineal eye. The
journal of Experimental biology 2000, 203: 1857-1867.
36. Jones B, McGinnis W: A new Drosophila homeobox gene, bsh, is expressed in a subset of brain cells during embryogenesis.
Development 1993, 117: 793-806.
37. Kemali M, De Santis A:The extraretinal Portion of the pineal complex of the frog (Frontal Organ) is connected to the pineal, the Hypothalamus, the brain stem and the retina. Exp. Brain. Res. 1983, 53:193-196
38. Korf HW, Liesner R, Meissl H, Kirk A: Pineal complex of the clawed toad, Xenopus laevis daud : Structure and function. Cell Tissue Res. 1981, 216: 113-130.
39. Kuruda H, Hayata T, Akira E, Asashima M: Cloning a novel developmental regulating gene Xotx5: its potential role in anterior formation in Xenopus laevis. Develop. Growth Differ. 2000, 42: 87-93. 40. Learchl A.: Biological rhythms in the context of light at night (LAN).
Neuroendocrinol Letter. 2002, 23 Suppl 2: 23-7
41. Lupo G, Andreazzoli M, Gestri G, Liu Y, He RQ, Barsacchi G: Homeobox genes in the genetic control of eye development. Int. J.
42. Malpel S, Klarsfeld A, Rouyer F: Larval optic nerve and adult extra-retinal photoreceptors sequentially associate with clock neurons during Drosophila brain development. Development 2002, 129:1443-1453
43. Masai I, Heisenberg CP, Barth KA, Macdonald, Amadek S, Wilson SW:
floating head and masterblind Regulate Neuronal Pattering in the
Roof of the Forebrain. Neuron 1997, 18: 43-57.
44. Murtha MT, Leckman JF, Ruddle FH: Detection of homeobox genes in development and evolution. Proc. Natl. Acad. Sci. 1991, 88: 10711-10715.
45. Nieuwkoop P.D., Faber J: Normal table of Xenopus laevis (Daudin) 46. Otto C, SchUtz G, Niehrs C, Glinka A: Dissecting GHRH and pituitary
adenylate cyclase activating polypeptide-mediated signalling in Xenopus. Mechanism of Development 2000, 94:111-116
47. Padoa E.: Manuale di Anatomia Comparata. Edizione Feltrinelli, 1993 48. Preitner N, Damiola F, Zakany J, Duboule D, Albrecht U, Schibler U: The
orphan nuclear receptor REV-ERBα controls circadian transcription within the positive limb of the mammalian circadian oscillator. Cell 2002, 110:251-260.
49. Rajendran RR, Van Niel EE, Stenkamp DL, Cunningham L, Raymond PA, Gonzalez-Fernandez F. Zebrafish interphotoreceptor retinoid-binding protein: differential circadian expressiong among cone subtypes. Journal Experiment Biology 1996; 199: 2775-87.
50. Roberts A: Pineal eye and behaviour in Xenopus tadpoles. Nature 1978, 273: 774-775.
51. Rubenstein JLR, Shimamura K, Martinez S, Puelles L: Regionalization of the prosencephalic neural plate. Annu. Rev. Neurosci 1998, 21: 445-477.
52. Sasai Y, Lu B, Steinbeisser H, Geissert D, Gont LK, De Robertis EM:
Xenopus chordin: a novel dorsalizing factor activated by
organizer-specific homeobox genes. Cell 1994, 79: 779-790.
53. Sassone-Corsi P: Rhythmic transcription and autoregulatoryloops: winding up the biological clock. Cell 1994, 78: 361-364.
54. Schmucker D, Su AL, Beermann A, Jackle H, Jay DG: Chromophore-assisted laser inactivation of patched protein switches cell fate in the larval visual system of Drosophila. Proc. Natl. Acad. Sci. 1994, 91: 2664-2668.
55. Valenciano AI, Alonso-Gòmes, Iuvone PM: Regulation of Tryptophan hidroxylase activity in Xenopus laevis photoreceptor cells by cyclic AMP. Journal of Neurochemistry 2000, 74: 1961-1967.
56. Vignali R, Colombetti S, Lupo G, Zhang W, Stachel S, Harland RM, Barsacchi G: Xotx5, a new member of the Otx gene family, may be involved in anterior and eye development in Xenopus laevis.
Mechanisms of Development 2000, 96: 3-13.
57. Von Dassow G, Schmidt JE, Kimelman D: Induction of the Xenopus organizer: expression and regulation of Xnot, a novel FGF and activin-regulated homeobox gene. Gene and Development 1993, 7: 355-366.
58. Whitemore D, Foulkes NS, Sassone-Corsi P: Light acts directly on organs and cell in culture to set the vertebrate circadian clock.
Nature 2000, 404: 87-91.
59. Wiechmann AF, Smith AR: Melatonin receptor RNA is expressed in photoreceptors and displays a diurnal rhythm in Xenopus retina.
Molecular Brian Research 2001, 91: 104-111.
60. Wilson SW, Hourt C: Early steps in the development of the forebrain.
Developmental Cell 2004, 6: 167-181.
61. Wilson SW, Rubenstein JLR: Induction and dorsoventral pattering of the telencephalon. Neuron 2000, 28: 641-651.
62. Wolpert L, Beddington R, Brockes J, Jessel T, Lawrance P, Meyerowitz E: Biologia dello sviluppo, Zanichelli 2000.
63. Yasuo H, Lemaire P: Role of Goosecoid, Xnot and Wnt antagonists in the maintenance of the notochord genetic programme in Xenopus gastrulae. Development 2001, 128: 3783-3793.
64. Zhang Y, Coleman JE, Fuchs GE, Semple-Rowland SL: Circadian oscillator function in embryonic retina and retinal explant cultures.
Ringraziamenti
I primi ringraziamenti vanno ai miei genitori che in questi anni mi sono sempre stati accanto, aiutandomi a superare qualsiasi difficoltà abbia incontrato.
Vorrei ringraziare la Prof.ssa Giuseppina Barsacchi che mi ha permesso di entrare nel suo gruppo di ricerca, un gruppo speciale da cui ogni giorno ho imparato sempre di più.
Ringrazio Massimiliano che mi ha seguito passo passo in questo lungo e faticoso percorso sempre con estrema pazienza.
Un ringraziamento speciale a Marzia e Donatella, tecniche davvero insostituibili sempre pronte ad aiutarti e consigliarti.
Grazie a tutti i ragazzi della Fontina che in questo periodo di tesi mi hanno fatto compagnia rendendo tutti i giorni speciali e indimenticabili.
Soprattutto ringrazio tutti i “tesisti fontiniani” ed in particolare Paola, Riccardo, Devid, Roberta, Marco e Luca, che con me hanno vissuto quest’avventura. Ringrazio Guido, un compagno di lavoro sempre presente e pronto a darmi preziosi consigli, e Sarah, un’amica sincera, con la quale ho condiviso tutti i momenti belli e che ha saputo aiutarmi in quelli più difficili.
Grazie alle “bimbe” di casa, Federica e Claudia, per l’ amicizia e la pazienza che in questo periodo mi hanno saputo dimostrare.
Infinite grazie a Cristina, una persona e un’amica insostituibile che mi ha accompagnato in tutti questi anni di “vita pisana”, aiutandomi a crescere e a superare con serenità tutti gli ostacoli.
Grazie inoltre a tutte le persone che durante questi anni ho conosciuto e che mi hanno fatto trascorrere momenti unici, vi ricorderò sempre tutti con immenso affetto!
