0 0.1 0.2 0.3 0.4 0.5 D en si to m et ric a na ly si s of T G F-β1/ β-actin (arbitrary units) Wild-type R6/2 Wild-type R6/2 < 15 kD < 45 kD
A
β-actin > TGF-β1 > Saline LY379268 WT R6/2Cerebral cortex
Striatum
Cerebral cortex D en si to m et ric a na ly si s of m G lu 2/ 3 re ce pt or s/
β-actin (arbitrary unit)
0 0.3 0.6 0.9 Cerebral cortex Striatum β-actin > mGlu2/3 > Cerebral cortex Striatum WT R6/2 WT R6/2
*
Wild-type mice R6/2 miceB
Saline LY379268, 10 mg/kg StriatumC
D en si to m et ric a na ly si s of T G F-β1/ β-actin (arbitrary units) Wild-type Saline Riluzole, 10 mg/kg R6/2*
Cerebral cortex
Striatum
β-actin > TGF-β1 >
Wild-type R6/2
Cerebral cortex Striatum
*
< 45 kD < 210 kD*
*
WT R6/2 Saline LY379268 WT R6/2 WT R6/2 # # Saline Riluzole WT R6/2 WT R6/2 Saline Riluzole WT R6/2 WT R6/2 < 15 kD < 45 kD # # Serum levels of TG F-β1 ( ng /m l)D
* 0 20 40 60 80 100 120 140*
0.9 0.3 0.6 04-week old mice 12-week old mice
160 Wild-type mice R6/2 mice