0 2 4 6 8 10 12 14 16 18 20
Time
0 5 10 15 20 25 30
Concentration
Plasma
0 2 4 6 8 10 12 14 16 18 20
Time
0 2 4 6 8 10 12
Concentration
Liver
0 2 4 6 8 10 12 14 16 18 20
Time
0 2 4 6 8 10 12 14 16 18 20
Concentration
Highly Perfused Organs
0 2 4 6 8 10 12 14 16 18 20
Time
0 0.05 0.1 0.15 0.2 0.25
Concentration
Poorly Perfused Tissues
Stratum Corneum Viable epidermis Dermis
Small Intestinal Lumen
Liver Plasma
Highly perfused Organs Poorly perfused
Tissues Pineal gland
Salivary glands
TD
Gastro Intestinal Circulatory System
Large Intestinal Lumen
�𝑑𝑑𝑑𝑑(𝑡𝑡)
𝑑𝑑𝑡𝑡 = 𝑓𝑓(𝑑𝑑, 𝑡𝑡, 𝑑𝑑𝑑𝑑𝑑𝑑𝑑𝑑) 𝑑𝑑 𝑡𝑡 = 0 = 𝑑𝑑𝑖𝑖𝑖𝑖𝑖𝑖
𝜕𝜕𝑑𝑑𝑖𝑖(𝑡𝑡, 𝑥𝑥)
𝜕𝜕𝑡𝑡 = 𝐷𝐷𝑖𝑖 𝜕𝜕2𝑑𝑑𝑖𝑖(𝑡𝑡, 𝑥𝑥)
𝜕𝜕𝑥𝑥2 𝑑𝑑𝑖𝑖 𝑥𝑥 = ℎ𝑖𝑖𝑑𝑑= 𝑘𝑘𝑖𝑖𝑑𝑑𝑖𝑖+1
0 ≤ 𝑥𝑥 < ℎ𝑖𝑖