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Skin transportADME Processes

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(1)

0 2 4 6 8 10 12 14 16 18 20

Time

0 5 10 15 20 25 30

Concentration

Plasma

0 2 4 6 8 10 12 14 16 18 20

Time

0 2 4 6 8 10 12

Concentration

Liver

0 2 4 6 8 10 12 14 16 18 20

Time

0 2 4 6 8 10 12 14 16 18 20

Concentration

Highly Perfused Organs

0 2 4 6 8 10 12 14 16 18 20

Time

0 0.05 0.1 0.15 0.2 0.25

Concentration

Poorly Perfused Tissues

Stratum Corneum Viable epidermis Dermis

Small Intestinal Lumen

Liver Plasma

Highly perfused Organs Poorly perfused

Tissues Pineal gland

Salivary glands

TD

Gastro Intestinal Circulatory System

Large Intestinal Lumen

𝑑𝑑𝑑𝑑(𝑡𝑡)

𝑑𝑑𝑡𝑡 = 𝑓𝑓(𝑑𝑑, 𝑡𝑡, 𝑑𝑑𝑑𝑑𝑑𝑑𝑑𝑑) 𝑑𝑑 𝑡𝑡 = 0 = 𝑑𝑑𝑖𝑖𝑖𝑖𝑖𝑖

𝜕𝜕𝑑𝑑𝑖𝑖(𝑡𝑡, 𝑥𝑥)

𝜕𝜕𝑡𝑡 = 𝐷𝐷𝑖𝑖 𝜕𝜕2𝑑𝑑𝑖𝑖(𝑡𝑡, 𝑥𝑥)

𝜕𝜕𝑥𝑥2 𝑑𝑑𝑖𝑖 𝑥𝑥 = ℎ𝑖𝑖𝑑𝑑= 𝑘𝑘𝑖𝑖𝑑𝑑𝑖𝑖+1

0 ≤ 𝑥𝑥 < ℎ𝑖𝑖

Skin transport

ADME Processes

Riferimenti

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