BANDO 2018 (fondo 2016-2017) Classifica e Finanziamento Progetti RF Change Promoting

(1)

N. Code (VS+CV) Destinatario MOH FINANZIAMENTO Finanziamento

1

RF-2018-

12367807 CP

A case-control study on the association of dipeptidyl peptidase IV inhibitor (gliptin) treatment in type 2 diabetes and

bullous pemphigoid 8,50 Musculoskeletal, Oral and Skin

Sciences Dermatologia

ISTITUTO DERMOPATICO

DELL'IMMACOLATA € 364.650,00 € 364.650,00 € 17.119.484,40

2 RF-2018-

12366314 CP

Whole Genome Sequencing into the diagnostic workflow of rare diseases: a cost-effectiveness evaluation in a heterogeneous population of patients with inconclusive Whole Exome

Sequencing 9,50 Genes, Genomes and Genetics Pediatria GASLINI € 450.000,00 € 450.000,00 € 16.669.484,40

3 RF-2018-

12366868 CP

Phase II, multicenter, double blind, randomized controlled trial on "off the shelf" allogeneic Platelet Rich Plasma (PRP) to

treat diabetic foot ulcers 10,50 Musculoskeletal, Oral and Skin

Sciences Dermatologia

Ospedale Policlinico San

Martino € 445.000,00 € 445.000,00 € 16.224.484,40

4 RF-2018-

12368274 CP

Impact of high tibial osteotomy in preventing disease progression in medial knee osteoarthritis:

quantifying the effects on cartilage and subchondral bone by using a combined biomechanical and medical

imaging approach 11,50 Musculoskeletal, Oral and Skin

Sciences Ortopedia RIZZOLI € 449.900,00 € 449.900,00 € 15.774.584,40

5 RF-2018-

12365514 CP

DAILY TIME USE, PHYSICAL ACTIVITY, QUALITY OF CARE AND INTERPERSONAL RELATIONSHIPS IN PSYCHIATRIC RESIDENTIAL FACILITIES: AN ITALIAN

MULTICENTRE STUDY 11,50 Healthcare Delivery and

Methodologies Malattie Psichiatriche FATEBENEFRATELLI € 449.450,10 € 449.450,10 € 15.325.134,30

6 RF-2018-

12365527 CP

Ventral Tegmental Area dopaminergic midbrain: new therapeutic target in early

Alzheimer's Disease. 11,50 Brain Disorders and Clinical

Neuroscience Neurologia SANTA LUCIA € 449.667,00 € 449.667,00 € 14.875.467,30

7 RF-2018-

12366604 CP

'PRoSPECT': Predicting Salmonella Pathogenic Potential to Enhance

Targeted Control Strategies 11,50 Veterinary Malattie Infettive IZSVE € 400.950,00 € 400.950,00 € 14.474.517,30

8 RF-2018-

12367534 CP

Prevalence and spatial distribution of endometriosis in Italy: administrative data and active search through a

multistage screening survey 11,50 Healthcare Delivery and

Methodologies Ostetricia e Ginecologia BURLO GAROFOLO € 444.200,00 € 444.200,00 € 14.030.317,30

(2)

9 RF-2018-

12367150 CP

Development of a new diagnostic tool based on tumor-associated macrophages to refine the prognosis of patients undergoing hepatic resection for colorectal liver metastases: a prospective

study. 12,00 Oncology 2 - Translational

Clinical Oncologia HUMANITAS € 440.000,00 € 440.000,00 € 13.590.317,30

10 RF-2018-

12368399 CP

Development of a Novel Signature Integrating Clinical, Imaging And Epigenetic Information to Tailor Pelvic Nodal

Treatment in Prostate Cancer 12,00 Oncology 2 - Translational

Clinical Nefrologia e Urologia SAN RAFFAELE MILANO € 430.000,00 € 430.000,00 € 13.160.317,30

11 RF-2018-

12367080 CP

Liquid biopsy of semen for early detection and characterization of prostate cancer - Semen ProstatE Cancer TumoR Elements

(SPECTRE) project 12,50 Oncology 2 - Translational

Clinical Nefrologia e Urologia HUMANITAS € 450.000,00 € 450.000,00 € 12.710.317,30

12 RF-2018-

12366976 CP

Markers of oxidative stress in Inflammatory Bowel Disease in children and adults: risk factors and implications for a dietetic

approach 12,50 Digestive, Kidney and Urological

Systems Gastroenterologia Marche € 330.000,00 € 330.000,00 € 12.380.317,30

13 RF-2018-

12367090 CP

Cardiac Arrhythmia catheter ablation procedures guided by x- Ray imaging: N-Acetylcisteine Protection Against radiation induced Cellular damagE

(CARAPACE Study). 12,50 Cardiovascular and Respiratory

Sciences Cardiologia-Pneumologia MONZINO € 348.920,00 € 348.920,00 € 12.031.397,30

14 RF-2018-

12367604 CP

Circulating biomarkers as predictors of gender-specific response to Immune Checkpoint Inhibitors in melanoma and non-

small-cell lung cancer patients 12,50 Oncology 2 - Translational

Clinical Oncologia I. O. V. € 448.800,00 € 448.800,00 € 11.582.597,30

15 RF-2018-

12365682 CP

STAND-ALONE: "STand AND wALk". OptimiziNg the Embodiment and agency of the exoskeleton (EXO) in spinal cord

injury patients (SCIp) 12,50 Integrative, Functional, and

Cognitive Neuroscience Riabilitazione SANTA LUCIA € 450.000,00 € 450.000,00 € 11.132.597,30

(3)

16 RF-2018-

12365210 CP

The PROMOTOER: a Brain Computer Interface-based intervention that promotes upper limb functional motor recovery in subacute stroke patients. A randomized controlled trial protocol to test long-term efficacy and to identify

determinants of response to inte 13,00 Brain Disorders and Clinical

Neuroscience Riabilitazione SANTA LUCIA € 332.445,00 € 332.445,00 € 10.800.152,30

17 RF-2018-

12366931 CP

Emergency genomics: an informative tool to guide advanced precision medicine in

Intensive Care Units 13,00 Genes, Genomes and Genetics Pediatria

OSPEDALE BAMBINO

GESU' € 450.000,00 € 450.000,00 € 10.350.152,30

18 RF-2018-

12366746 CP

Tracking and predicting neurodegeneration along the Parkinson's Disease continuum using clinical, cognitive and

advanced MRI data 13,00 Brain Disorders and Clinical

Neuroscience Neurologia SAN RAFFAELE MILANO € 450.000,00 € 450.000,00 € 9.900.152,30

19 RF-2018-

12367391 CP

Integrated multidisciplinary approach for personalized management of patients with Spondyloarthritis and

Inflammatory Bowel Disease. 13,50 ^Immunology Ematologia e Immunologia FONDAZIONE GEMELLI € 450.000,00 € 450.000,00 € 9.450.152,30 20 RF-2018-

12366098 CP Liver Screening in the population

of Veneto Region 13,50 Digestive, Kidney and Urological

Systems Gastroenterologia Veneto € 450.000,00 € 450.000,00 € 9.000.152,30

21 RF-2018-

12366749 CP

Acute normovolemic hemodilution in high-risk cardiac surgery patients. A multicenter,

randomized trial. 13,50 Surgical Sciences, Biomedical

Imaging, and Bioengineering Cardiologia-Pneumologia SAN RAFFAELE MILANO € 450.000,00 € 450.000,00 € 8.550.152,30

22 RF-2018-

12365425 CP

Development of a biomarker to predict the efficacy of anti- angiogenic therapy in ovarian

cancer. 13,50 Oncology 1 - Basic Translational Oncologia C.R.O. AVIANO € 450.000,00 € 450.000,00 € 8.100.152,30

23 RF-2018-

12365790 CP

Novel predictive biomarkers in the clinical management of ibrutinib-treated chronic lymphocytic leukemia patients:

results form an observational

prospective clinical trial 14,00 Oncology 2 - Translational

Clinical Oncologia C.R.O. AVIANO € 450.000,00 € 450.000,00 € 7.650.152,30

24 RF-2018-

12367311 CP

PERSONALIZED MOLECULAR DRIVEN SURGERY ACCORDING TO BRCA MUTATIONAL STATUS IN ADVANCED EPITHELIAL OVARIAN CANCER PATIENTS WITH HIGH

TUMOR LOAD 14,00 Oncology 2 - Translational

Clinical Oncologia FONDAZIONE GEMELLI € 449.936,65 € 449.936,65 € 7.200.215,65

(4)

25

RF-2018-

12365371 CP

Ablation of the maladaptive ER stress response restores diaphragm function and insulin resistance in SEPN1-related

myopathies 14,00 Musculoskeletal, Oral and Skin

Sciences Neurologia MARIO NEGRI € 450.000,00 € 450.000,00 € 6.750.215,65

26 RF-2018-

12367026 CP

Preclinical and Clinical Development of a 68Ga-NOTA- AHX-R54, a CXCR4-PET tracer targeting tumoral and stromal cells in human solid cancers. First

in Man Clinical Trial 14,00 Oncology 2 - Translational

Clinical Oncologia PASCALE € 450.000,00 € 450.000,00 € 6.300.215,65

27

RF-2018-

12368001 CP

PROPHYBIOM TRIAL:

PROPHYlactic Implantation of

BIOlogic Mesh in peritonitis 14,00 Surgical Sciences, Biomedical

Imaging, and Bioengineering Gastroenterologia Emilia-Romagna € 360.528,65 € 360.528,65 € 5.939.687,00

28 RF-2018-

12368096 CP

Targeting the future of axillary staging in early breast cancer. A prospective study comparing

sentinel node biopsy vs PET/MRI 14,00 Surgical Sciences, Biomedical

Imaging, and Bioengineering Oncologia SAN RAFFAELE MILANO € 450.000,00 € 450.000,00 € 5.489.687,00

29

RF-2018-

12366594 CP

Nerve growth factor in pediatric severe traumatic brain injury:

translational and clinical studies on a candidate biomarker and

therapeutic drug 14,00 Brain Disorders and Clinical

Neuroscience Pediatria FONDAZIONE GEMELLI € 392.500,00 € 392.500,00 € 5.097.187,00

30 RF-2018-

12366235 CP

Novel approaches of advanced neuroimaging based on MRI fiber tracking to detect early signs of vascular cognitive impairment in

hypertensive patients. 14,50 Brain Disorders and Clinical

Neuroscience Cardiologia-Pneumologia NEUROMED € 408.000,00 € 408.000,00 € 4.689.187,00

31

RF-2018-

12367272 CP

Multimodal prehabilitation in colorectal cancer patients to improve functional capacity and lower postoperative complications: A randomized

clinical trial. 14,50 Surgical Sciences, Biomedical

Imaging, and Bioengineering Oncologia Emilia-Romagna € 360.000,00 € 360.000,00 € 4.329.187,00

32 RF-2018-

12366111 CP

multidimensional assessment of neurological and immunological patterns to test the efficacy and response to a novel therapy in

multiple sclerosis 14,50 Brain Disorders and Clinical

33

RF-2018-

12366631 CP Safety and efficacy of a possible

FSHD treatment 14,50 Genes, Genomes and Genetics Neurologia SAN RAFFAELE MILANO € 450.000,00 € 450.000,00 € 3.429.465,00

(5)

34

RF-2018-

12368164 CP

Identifying ageing TRajEctories towards chronic

Neurodegenerative Diseases through Marche regional

administrative databases - TREND 14,50 Healthcare Delivery and

Methodologies Neurologia Marche € 400.000,00 € 400.000,00 € 3.029.465,00

35 RF-2018-

12365985 CP

SynErg. Synergies anchoring to gravity: A novel test to diagnose risk of falls in type 2 diabetes

patients 14,50 Biobehavioral and Behavioral

Processes Diagnostica SANTA LUCIA € 450.000,00 € 450.000,00 € 2.579.465,00

36

RF-2018-

12365530 CP

Epidemiological profiles and cost patterns of cancer patients

(EpiCost2) 15,00 Healthcare Delivery and

Methodologies Oncologia

Istituto Superiore di

Sanita' € 308.000,00 € 308.000,00 € 2.271.465,00

37 RF-2018-

12365391 CP

Effects of long-term oral administration of palmitoylethanolamide on subjects with mild cognitive

impairment 15,00 Brain Disorders and Clinical

38

RF-2018-

12367340 CP

Haploidentical Bone Marrow Transplantation with or without NK cell Infusion in refractory/

relapsed Acute Myeloid Leukemia

and Myelodysplastic Syndrome 15,00 Vascular and Hematology Ematologia e Immunologia FONDAZIONE GEMELLI € 447.500,00 € 447.500,00 € 1.373.965,00

39 RF-2018-

12365824 CP

Fasting mimicking diet as intervention tool to improve endogenous insulin secretion and reduce autoimmune process in children and adolescents with newly-diagnosed type 1 diabetes

mellitus 15,00

Endocrinology, Metabolism, Nutrition and Reproductive

Sciences Pediatria GASLINI € 449.978,26 € 449.978,26 € 923.986,74

40

RF-2018-

12365308 CP

Targeting inflammation in depression using minocycline: a patient stratification approach using peripheral inflammatory

biomarkers, PET and MRI 15,00 Brain Disorders and Clinical

Neuroscience Malattie Psichiatriche FATEBENEFRATELLI € 448.400,00 € 448.400,00 € 475.586,74 41 RF-2018-

12367835 CP

What is the best interval to screen women 45-49 and 70-74

for breast cancer? 15,00 Oncology 2 - Translational

Clinical Oncologia

Istituto Scientifico

Romagnolo € 450.000,00 € 450.000,00 € 25.586,74

42

RF-2018-

12365207 CP

NEW REHABILITATION APPROACH FOR MOVEMENT DISORDER, COMBINING NON INVASIVE STIMULATION, COMPUTER- BASED PLATFORM TRAINING AND

TELEMONITORING 15,50 Emerging Technologies and

Training in Neurosciences Neurologia MAGGIORE € 447.940,00 € -

(6)

43

RF-2018-

12366553 CP

Exploiting circulating levels of epithelial-to-mesenchymal transition transcription factors (EMT-TF) mRNAs for the diagnosis of colorectal and pancreatic

cancer 15,50 Oncology 2 - Translational

Clinical Oncologia HUMANITAS € 450.000,00 € -

44 RF-2018-

12365810 CP

Plasma cell free tumor DNA genotyping as a tool for the clinical management of diffuse large B-cell lymphoma: results from a prospective observational

clinical trial 15,50 Oncology 2 - Translational

Clinical Oncologia C.R.O. AVIANO € 450.000,00 € -

45 RF-2018-

12366802 CP

Reducing adverse effects after hospital discharge in multichronic patients: a randomized trial on

transition of care intervention 15,50 Healthcare Delivery and

Methodologies Geriatria Lazio € 450.000,00 € -

46 RF-2018-

12367938 CP

Liquid biopsy - Digging deep into tumor and host biology to refine

breast cancer management 15,50 Oncology 2 - Translational

Clinical Oncologia

ISTITUTO TUMORI

MILANO € 408.265,00 € - 47

RF-2018-

12368170 CP Normothermic machine perfusion

in split liver transplantation 15,50 Surgical Sciences, Biomedical

Imaging, and Bioengineering Trapiantologia

OSPEDALE BAMBINO

GESU' € 450.000,00 € -

48 RF-2018-

12366485 CP

Clinical and Neurobiological correlates of changes after Dialectical Behavioral Therapy in adolescents with Borderline Personality Disorder. A

randomized clinical trial. 16,00 Brain Disorders and Clinical

Neuroscience Malattie Psichiatriche FATEBENEFRATELLI € 448.525,00 € -

49

RF-2018-

12367899 CP

Whole Genome Sequencing- based tool to clinically patients with Nontuberculous

mycobacteria pulmonary disease. 16,00 Infectious Diseases and

Microbiology Malattie Infettive SAN RAFFAELE MILANO € 450.000,00 € -

50 RF-2018-

12367627 CP

IT'S TIME FOR ACTION: LOW- INFLAMMATORY DIET TO REDUCE INFLAMMATION AND IMPROVE

QUALITY OF LIFE IN FAP PATIENTS 16,00 Risk, Prevention and Health

Behavior Oncologia

ISTITUTO TUMORI

MILANO € 449.735,00 € -

51

RF-2018-

12367651 CP

A novel therapeutic option for disorders of consciousness: noninvasive thalamic

neuromodulation using MRI- guided low-intensity focused

ultrasound 16,00 Brain Disorders and Clinical

Neuroscience Neurologia CARLO BESTA € 450.000,00 € -

(7)

52 RF-2018-

12365673 CP

Optimizing the management of lymphoma patients in the era of precision medicine: a prospective study using the liquid biopsy for disease outcome prediction and monitoring by quantitative assessment of clonotypic IGH rearrangement and circulating

tumor DNA 16,00 Oncology 2 - Translational

Clinical Ematologia e Immunologia HUMANITAS € 450.000,00 € -

53

RF-2018-

12365482 CP

The proactive role of Community- Hospital Platform in the Assessment and response to frailty in older subjects: the In (INRCA)PAR (PARma) CHO

(CommunityHOspital) Study 16,00 Healthcare Delivery and

Methodologies Geriatria Emilia-Romagna € 409.333,00 € -

54 RF-2018-

12366752 CP

Identification of a behavioral and fMRI predictive biomarker of clinical response to deep brain stimulation in drug-refractory obsessive compulsive tic disorder.

16,00 Brain Disorders and Clinical

Neuroscience Neurologia GALEAZZI € 247.800,00 € -

55

RF-2018-

12366929 CP

Adalimumab with and without Methotrexate in second step therapy for Juvenile Idiopathic Arthritis Uveitis: evidence of efficacy, safety and outcome predictors from a multi-centric

observational prospective study 16,00 Musculoskeletal, Oral and Skin

Sciences Pediatria Toscana € 445.221,00 € -

56 RF-2018-

12367832 CP

Inflammation and radiotherapy:

friend or foe? A translational research to explain relationship

and a possible way to optimize it. 16,50 Oncology 2 - Translational

Clinical Oncologia Emilia-Romagna € 425.150,00 € -

57

RF-2018-

12366637 CP

A personalized translational approach for the PREvention and treatment of Surgical Site infections in patients Undergoing

pancreatic REsection (PRESSURE) 16,50 Surgical Sciences, Biomedical

Imaging, and Bioengineering Gastroenterologia HUMANITAS € 450.000,00 € -

58 RF-2018-

12367683 CP

Effects of aerobic training on motor and cognitive performances in patients with multiple sclerosis: a structural and

functional MRI study 16,50 Brain Disorders and Clinical

Neuroscience Neurologia SAN RAFFAELE MILANO € 450.000,00 € -

(8)

59 RF-2018-

12365494 CP

VIDEOMICROSCOPY VERSUS VIDEODERMATOSCOPY: A NON- INFERIORITY EVALUATION OF 2 SIMPLE NON-INVASIVE METHODS FOR THE DIAGNOSIS OF SCABIES.

EFFICACY AND COST EFFECTIVENESS IN A MIGRANT POPULATION IN EASTERN SICILY

17,00 Surgical Sciences, Biomedical

Imaging, and Bioengineering Dermatologia Sicilia € 274.800,00 € -

60 RF-2018-

12365556 CP

BOTULINUM TOXINS HARBOURED BY NON-CLOSTRIDIAL

ORGANISMS: RISK ASSESSMENT

AND MITIGATION STRATEGIES 17,00 ^Veterinary Diagnostica

Sanita' € 450.000,00 € -

61 RF-2018-

12365672 CP

Selective laser trabeculoplasty (SLT) for deprescribing maximal tolerated medical therapy in elderly and ultra-elderly glaucoma patients: evaluation of the rate of progression of visual field damage

and quality of life 17,00 Brain Disorders and Clinical

Neuroscience Oculistica BIETTI € 447.700,00 € -

62

RF-2018-

12366404 CP

Clinical impact of susceptibility mapping in brain MRI: from quantification to disease follow-

up 17,00 Surgical Sciences, Biomedical

Imaging, and Bioengineering Diagnostica STELLA MARIS € 450.000,00 € -

63 RF-2018-

12365250 CP

Prophylaxis of viral infections after haploidentical hematopoietic stem cell transplantation by adoptive T cell therapy with donor multivirus-

specific T cells 17,00 Infectious Diseases and

Microbiology Trapiantologia SAN MATTEO € 450.000,00 € -

64

RF-2018-

12365409 CP

Primary prevention of Neural Tube Defects by supplementation with folate plus inositol and genetic and metabolic profiling in

high risk population 17,00 Risk, Prevention and Health

Behavior Pediatria GASLINI € 437.000,00 € -

65 RF-2018-

12367951 CP

Effects of weight loss on cardiac remodelling: bariatric surgery versus intensive lifestyle

modification. 17,00

Sciences Cardiologia-Pneumologia Friuli-Venezia Giulia € 450.000,00 € -

(9)

66 RF-2018-

12367937 CP

Unsolved challenges in congenital thyroid dysfunctions: definition of clinical and molecular predictors of cardiovascular risk.

17,00

Sciences Endocrinologia AUXOLOGICO € 383.500,00 € -

67 RF-2018-

12366380 CP

BI-UPCAT: BIlateral UPper-limb Children Action observation Training for children with diplegic

cerebral palsy 17,00 Brain Disorders and Clinical

Neuroscience Riabilitazione STELLA MARIS € 450.000,00 € -

68 RF-2018-

12366738 CP

Cardiac autonomic regulation over 24 hours, sleep homeostasis and systemic inflammation relationships in individuals following a three-shift schedule of

work. 17,00 Cardiovascular and Respiratory

Sciences Cardiologia-Pneumologia HUMANITAS € 450.000,00 € -

69 RF-2018-

12366277 CP

Novel biomarkers of

thromboinflammation to stratify patients and guide treatments in

systemic sclerosis. 17,00 ^Immunology Ematologia e Immunologia SAN RAFFAELE MILANO € 450.000,00 € -

70

RF-2018-

12367404 CP

CARDIOVASCULAR PREVENTION IN INFLAMMATORY SYSTEMIC DISORDERS: 'CUPID IS CALLING'

PROGRAM 17,00 Musculoskeletal, Oral and Skin

Sciences Ematologia e Immunologia Emilia-Romagna € 441.200,00 € -

71 RF-2018-

12366274 CP

Assessment of overuse and underuse of health care interventions in cancer care, and evaluation of the impact of delivering care through an innovative organisational model

(clinical network) 17,00 Healthcare Delivery and

Methodologies Oncologia

AUSL RE Ist. Tecnologie

Avanzate € 420.000,00 € - 72

RF-2018-

12367373 CP Evaluation of telemedicine for

rare ocular and heart diseases 17,00 Genes, Genomes and Genetics Oculistica Campania € 438.000,00 € -

73 RF-2018-

12366074 CP

Impact of Mineralocorticoid Receptor pharmacological antagonism on arterial aging and metabolic parameters in overweight/obese middle age women women across menopausal transition: efficacy and pathophysiological mechanisms

17,50

Sciences Endocrinologia SAN RAFFAELE PISANA € 449.999,00 € -

(10)

74 RF-2018-

12365609 CP

Role of Vitamin K2 in association with local intraoperative therapy with diphosphonates to improve Bone Mineral Density (BMD) and femoral neck fracture healing in elderly Italian osteoporotic

patients. 17,50 Musculoskeletal, Oral and Skin

Sciences Ortopedia Abruzzo € 303.050,00 € -

75 RF-2018-

12367630 CP

Reducing the burden of radiologic contrast media-induced hypersensitivity reactions and the use of "anti-allergic"

premedications: the COntrast MEdia CHAllenge (COMECHA)

trial. 19,00 ^Immunology Ematologia e Immunologia Toscana € 409.000,00 € -

76 RF-2018-

12365770 CP

Safety and efficacy of dantrolene therapy in patients with acute

ischemic stroke 19,00 Brain Disorders and Clinical

77 RF-2018-

12366598 CP

Malaria detection in transfusion medicine: clinical and molecular strategies to optimise donors management and transfusion

safety 19,00 Infectious Diseases and

Microbiology Malattie Infettive Veneto € 398.410,00 € -

78

RF-2018-

12366386 CP

EFFICACY AND SAFETY OF LONG- TERM TREATMENT WITH ANTIRESORPTIVE AGENTS FOR

OSTEOPOROSIS 20,50 Biology of Development and

Aging Endocrinologia Sicilia € 448.400,00 € -

79 RF-2018-

12365595 CP

Environmental factors in the development and progression of essential tremor: new therapeutic approaches in a multidisciplinary

study 20,50 Population Sciences and

Epidemiology Neurologia SANTA LUCIA € 450.000,00 € -

80 RF-2018-

12367371 CP

HElmet NonInVasive ventilation versus high-flow Oxygen Therapy in acute hypoxemic respiratory failure: an open-label, multicentre randomized trial. The HENIVOT

study 20,50 Cardiovascular and Respiratory

Sciences Cardiologia-Pneumologia FONDAZIONE GEMELLI € 450.000,00 € -

81 RF-2018-

12366840 CP

Inflammatory profile of patients with severe asthma and chronic rhinosinusitis. Impact on disease control of inflammatory and

metabolomic profiling. 17,50 Cardiovascular and Respiratory

Sciences Cardiologia-Pneumologia MAUGERI € 333.400,00 € -

82

RF-2018-

12365694 CP

Diabetic Retinopathy screening by using an easy, portable and

expert system smartphone-based 17,50 Emerging Technologies and

Training in Neurosciences Oculistica BIETTI € 448.500,00 € -

(11)

83

RF-2018-

12365493 CP

Personalizing Care Using Routine Patient-Reported Symptom Monitoring During Cancer Treatment: a multicenter cluster

randomized trial (CoSMo) 17,50 Risk, Prevention and Health

Behavior Oncologia Emilia-Romagna € 446.510,00 € -

84 RF-2018-

12367215 CP

Integrated genomic and PET/MRI procedures for the

characterization of breast cancer subtype: standardization of radiogenomic protocols and creation of an integrated open-

access infrastructure 17,50 Surgical Sciences, Biomedical

Imaging, and Bioengineering Diagnostica SDN € 400.000,00 € -

85 RF-2018-

12366871 CP

Development of Motor and Cognitive Reserve Index Tool for appropriateness and efficiency in Neurorehabilitation (DeMoCRIT

Rehab) 17,50 Brain Disorders and Clinical

Neuroscience Riabilitazione DON GNOCCHI € 303.240,00 € -

86

RF-2018-

12367730 CP

Immunological predictors of Healthy Aging: The observed progressive delay of frailty in adults living with HIV informs immunopathogenetic mechanism associated with Healthy Aging in the general population and allows to draw successful patient care

models i 17,50 AIDS and Related Research Malattie Infettive Emilia-Romagna € 450.000,00 € -

87 RF-2018-

12367402 CP

Activity pacing monitoring in patients with fatigue symptoms through the combined use of portable electronic device and

smartphone application 17,50 Risk, Prevention and Health

Behavior Ematologia e Immunologia SAN RAFFAELE MILANO € 450.000,00 € -

88

RF-2018-

12367953 CP

Novel imaging and molecular biomarkers for assessing response to chemotherapy in advanced Gastric Cancer:

development and validation of a multi-parametric predictive model to improve and optimize

the patient management 17,50 Surgical Sciences, Biomedical

Imaging, and Bioengineering Diagnostica Toscana € 390.000,00 € -

89 RF-2018-

12366760 CP

Biological age and work ability in the aging working force: effects of strenuous occupational conditions and of delayed

retirement. 17,50 Population Sciences and

Epidemiology Riabilitazione MAGGIORE € 439.000,00 € -

(12)

90

RF-2018-

12367702 CP

Definition of new key parameters for personalized care in Bone

Fragility scenario 17,75 Musculoskeletal, Oral and Skin

Sciences Riabilitazione RIZZOLI € 449.485,00 € -

91 RF-2018-

12368325 CP

Driving motor cortical oscillations for functional recovery in stroke patients: a tailored neuro-

stimulation treatment 18,00 Brain Disorders and Clinical

Neuroscience Neurologia SANTA LUCIA € 450.000,00 € -

92

RF-2018-

12367958 CP

Persistent Organic Pollutant (ß- HCH) contamination in Central Italy: biomonitoring, exposure assessment using Bayesian model and health effects evaluation in a

large cohort of residents 18,00 Population Sciences and

Epidemiology Diagnostica Lazio € 450.000,00 € -

93 RF-2018-

12366331 CP

Early albumin administration in patients with decompensated cirrhosis hospitalized for non-SBP infections: a factor VIII-guided approach to improve the intra-

hospital outcome. 18,00 Digestive, Kidney and Urological

Systems Gastroenterologia MAGGIORE € 445.000,00 € -

94

RF-2018-

12365792 CP Validation of sarcolipin as an early

biomarker in ALS patients 18,00 Brain Disorders and Clinical

95 RF-2018-

12365106 CP

Behavioral and neural effects of repeated noninvasive brain stimulation in older adults with

subjective memory complaints 18,00 Biobehavioral and Behavioral

Processes Geriatria FATEBENEFRATELLI € 440.265,00 € -

96

RF-2018-

12365127 CP

The role of vitamin D binding protein in multiple sclerosis: a prospective longitudinal study in

newly diagnosed patients 18,00 Immunology Neurologia

Sanita' € 408.800,00 € -

97 RF-2018-

12365873 CP

An integromic approach based on genotype-related inflammatory and oxidative profiling and wearable-health technology for personalized therapy in

Parkinson's disease 18,00 Brain Disorders and Clinical

98

RF-2018-

12365153 CP

Red orange juice daily

consumption and human health: a pilot study in high cardio- metabolic

risk subjects and Type 2 Diabetic

patients 18,00

Sciences Endocrinologia

Sanita' € 450.000,00 € -

(13)

99 RF-2018-

12367863 CP

Predicting multiple organ specific autoimmunity in childhood:

development and optimization of a screening strategy for autoimmune co-morbidities in

pediatric patients. 18,00 Immunology Pediatria SAN RAFFAELE MILANO € 450.000,00 € -

100 RF-2018-

12367443 CP

Magnetic Resonance guided Focused UltraSound (MRgFUS) versus Levodopa/Carbidopa Intestinal Gel (LCIG) in patients with asymmetric Parkinson's

disease 18,50 Brain Disorders and Clinical

101 RF-2018-

12365732 CP

Validating the histaminergic receptors and enzymes as biomarkers in relapsing-remitting and progressive multiple sclerosis and testing the anti-inflammatory power of histamine in innate

immune cells from patients 18,50 Brain Disorders and Clinical

102 RF-2018-

12367418 CP

Searching for morpho-functional and genetic biomarkers of the clinical disability related to the visual disturbances of migraine

with aura patients 18,50 Brain Disorders and Clinical

Neuroscience Neurologia BIETTI € 450.000,00 € -

103 RF-2018-

12367270 CP

The bovine biological signature: a holistic approach to strengthen

steroid abuse monitoring 18,50 Veterinary Diagnostica IZSPLV € 450.000,00 € -

104 RF-2018-

12368261 CP

Applying REal-time Sequencing for foodborne pathogens in Italy - Acronym - ARES

18,50 ^Veterinary Malattie Infettive IZSAM € 411.115,00 € - 105 RF-2018-

12367428 CP

Kinematic assessment of cervical dystonia: phenomenology and

response to treatment 18,50 Brain Disorders and Clinical

Neuroscience Neurologia HUMANITAS € 447.500,00 € -

106 RF-2018-

12366978 CP

Focus on HIV-1 subjects with a multidrug resistant virus and limited antiretroviral options

(Prestigio Registry) 18,50 AIDS and Related Research Malattie Infettive SAN RAFFAELE MILANO € 450.000,00 € -

(14)

107 RF-2018-

12367152 CP

Advanced therapy medicinal product based on mutated NPM1- specific cytotoxic T cells for the treatment of patients with relapsed/refractory NPM1-

mutated acute myeloid leukemia 18,50 Oncology 2 - Translational

Clinical Ematologia e Immunologia SAN MATTEO € 450.000,00 € -

108 RF-2018-

12368075 CP

Tackling UnderRecognized Mood disOrders to Improve Long-term Chronic Coronary Care (TURMOIL-

CCC) 18,50 Risk, Prevention and Health

Behavior Riabilitazione DON GNOCCHI € 279.942,00 € -

109 RF-2018-

12368224 CP

Addressing challenges in the chronic Hepatitis C Infection cascade of care to achieve the WHO elimination goals.

Identification of possible strategies able to increase the diagnosis, linkage to care and access to antiviral therapy.

Translation of modellin 18,50 Healthcare Delivery and

Methodologies Malattie Infettive

Sanita' € 450.000,00 € -

110 RF-2018-

12367194 CP

The role of circulating Micro- RNAs profile in patients with severe aortic stenosis following transcatheter aortic valve

intervention. MIRN TAVI Study 18,50 Cardiovascular and Respiratory

Sciences Cardiologia-Pneumologia SAN RAFFAELE MILANO € 450.000,00 € -

111 RF-2018-

12366936 CP

Extensive molecular profiling of radically resected colon cancer patients enrolled in the phase 3 randomized TOSCA trial on adjuvant treatment duration - The TATA (TOSCA Adjuvant

Translational Analysis) project 18,50 Oncology 2 - Translational

Clinical Oncologia I. O. V. € 450.000,00 € -

112

RF-2018-

12365727 CP

An integrated and

multidisciplinary approach for the treatment of substance use

disorder 19,00 Biobehavioral and Behavioral

Processes Malattie Psichiatriche SANTA LUCIA € 449.700,00 € -

113 RF-2018-

12368360 CP

Hazards and risks of heart disease related to epilepsy and anti- epileptic drugs, unmasked by exhaustive neurophysiologic and cardiologic investigations: a prospective, advanced diagnostic evaluation that can identify early

potentially fatal cardiac abnorm 19,00 Brain Disorders and Clinical

Neuroscience Neurologia Calabria € 220.000,00 € -

(15)

114

RF-2018-

12368158 CP

Whole exome sequencing to decipher the basis of insulin- dependent diabetes mellitus and rheumatoid arthritis in

autoantibody-negative patients 19,00 Genes, Genomes and Genetics Ematologia e Immunologia SAN RAFFAELE MILANO € 450.000,00 € -

115 RF-2018-

12367763 CP

Intra-cardiac fluid-dynamic pattern and morphofunctional characteristics in patients with post-ischemic and primitive dilated cardiomyopathy to predict clinical outcome and left ventricle

remodeling. MICROPHONE_study 19,00 Cardiovascular and Respiratory

Sciences Cardiologia-Pneumologia SAN DONATO € 420.100,00 € -

116 RF-2018-

12367535 CP

Reliable biomarkers, pathogenic mechanisms and effects of

therapy in Fabry Disease 19,50 Brain Disorders and Clinical

Neuroscience Neurologia

Istituto Scienze

Neurologiche € 450.000,00 € -

117 RF-2018-

12368006 CP

Identification of noninvasive biomarkers in H3-K27M mutant midline gliomas such as diffuse

intrinsic pontine glioma 19,50 Oncology 2 - Translational

Clinical Pediatria

ISTITUTO TUMORI

MILANO € 449.240,00 € -

118 RF-2018-

12367246 CP

Providing effective treatment and overcoming Resistance with tailOred Treatment of sEvere baCterial infections in hospiTalised patients PROTECT

19,50 Infectious Diseases and

Microbiology Malattie Infettive Veneto € 450.000,00 € -

119 RF-2018-

12365757 CP

Spinal Cord Injury: study of the activation of the innate immune system for the identification of patients with good or low

recovery. 19,50 Brain Disorders and Clinical

120 RF-2018-

12367105 CP

ATTENTION AND PERFORMANCE:

AN ICT NEUROPSYCHOLOGICAL ASSESSMENT ACROSS THE LIFE

SPAN 19,50 Integrative, Functional, and

Cognitive Neuroscience Neurologia AUXOLOGICO € 450.000,00 € -

121 RF-2018-

12366276 CP

Perioperative steroids schema for the prevention of major complications after pancreaticoduodenectomy in patients at high-risk for pancreatic fistula: a randomized controlled trial

19,50 Surgical Sciences, Biomedical

Imaging, and Bioengineering Oncologia Veneto € 150.000,00 € -

(16)

122

RF-2018-

12368227 CP

Clinical impact and

neurophysiological implications of a goal-based exercise in Parkinson Disease: a randomized controlled

trial. 20,00 Biobehavioral and Behavioral

Processes Riabilitazione Toscana € 440.000,00 € -

123 RF-2018-

12365582 CP

Identification of somatic mosaicism in patients with epileptogenic developmental disorders (EDD): implementing the diagnostic workflow in the

next-generation sequencing era 20,00 Brain Disorders and Clinical

Neuroscience Neurologia Toscana € 301.365,00 € -

124 RF-2018-

12368188 CP

Sequential targeted therapy and immunotherapy in symptomatic melanoma brain metastases: a

phase 2 randomised trial 20,00 Oncology 2 - Translational

Clinical Oncologia Toscana € 448.500,00 € -

125

RF-2018-

12365572 CP

Improving predictors of global outcome and treatment response in mild cognitive impairment subjects with Parkinson's Disease:

A single-blind case-control randomized longitudinal study comparing cognitive stimulation alone to an augmented

experimental mul 20,00 Brain Disorders and Clinical

Neuroscience Neurologia SANTA LUCIA € 434.000,00 € - 126 RF-2018-

12367836 CP

PLASMA-LYTE VS NORMAL SALINE TRIAL IN INTENSIVE CARE

(PlaSTIC Study) 20,00 Surgical Sciences, Biomedical

Imaging, and Bioengineering Cardiologia-Pneumologia HUMANITAS € 450.000,00 € -

127

RF-2018-

12367379 CP

Post-surgical scars: a clinical and objective diagnostic criteria for pathologic adherent scars, and effectiveness of manual treatment on patient-reported, clinical, and functional outcome

measures 20,25 Musculoskeletal, Oral and Skin

Sciences Riabilitazione MAUGERI € 365.280,00 € -

128 RF-2018-

12367982 CP

Cerebrospinal fluid HIV-1 viral escape: clinical consequences, nature of viral persistence and characterization of neuroinflammatory profile in a longitudinally studied HIV-

infected ART-treated population 20,25 AIDS and Related Research Malattie Infettive SPALLANZANI € 440.000,00 € -