BANDO 2018(fondo 2016-2017)Classifica e Finanziamento Progetti GR Change Promoting

(1)

N. Code ch type ^Title FINALE ^IRG ^MDC DESTINATARIO MOH (euro) Finanziato Finanziamento NOTE

1

GR-2018-

12366385 CP

Myocarditis Therapy with IL-1 inhibitor (MYTH- 1): a double-blind, phase IIa, placebo- controlled, randomized clinical trial to evaluate the efficacy and safety of anakinra in addition to standard of care for the treatment of virus-

negative myocarditis 11 Immunology Cardiologia-Pneumologia SAN RAFFAELE MILANO € 450.000,00 € 450.000,00 € 21.955.376,10

2

GR-2018-

12368369 CP

The Role of Imaging Guided Surgery to Improve the Detection of Lymph Node Metastases in Prostate Cancer Patients Treated with Radical Prostatectomy and Extended Pelvic Lymph

Node Dissection 11,5 Oncology 2 - Translational Clinical Nefrologia e Urologia SAN RAFFAELE MILANO € 435.000,00 € 435.000,00 € 21.520.376,10

3

GR-2018-

12368106 CP

Fecal microbiota transplantation for treatment of steroid-refractory gastro-intestinal acute Graft-versus-Host Disease after allogeneic hematopoietic stem cell transplantation

11,5 Immunology Ematologia e Immunologia OSPEDALE BAMBINO GESU' € 450.000,00 € 450.000,00 € 21.070.376,10

4

GR-2018-

12367602 CP

Efficacy and safety of fecal microbiota transplantation by oral capsules in patients with liver cirrhosis and hepatic encephalopathy refractory to conventional treatment

12 Digestive, Kidney and Urological

Systems Gastroenterologia FONDAZIONE GEMELLI € 408.000,00 € 408.000,00 € 20.662.376,10

5

GR-2018-

12365438 CP

Efficacy and Cost Analysis of a Minimalistic Approach for Transcatheter Aortic Valve

implantation Therapy 12 Healthcare Delivery and

Methodologies Cardiologia-Pneumologia Sicilia € 400.000,00 € 400.000,00 € 20.262.376,10

6

GR-2018-

12366240 CP

Diagnostic performance and clinical impact of PSMA PET/CT vs. mpMRI in patients with a high suspicion of prostate cancer and previously negative biopsy: a head to head, parallel,

prospective trial (PROSPET-BX). 12 Surgical Sciences, Biomedical

Imaging, and Bioengineering Diagnostica HUMANITAS € 450.000,00 € 450.000,00 € 19.812.376,10

7

GR-2018-

12368086 CP

Diagnostic and antibiotic stewardship for control of high endemicity of MDR Gram- negatives and Clostridium difficile in a Long

Term Acute Care Rehabilitation Setting 13 Infectious Diseases and

Microbiology Malattie Infettive DON GNOCCHI € 328.000,00 € 328.000,00 € 19.484.376,10

8

GR-2018-

12365670 CP

Decoding malignant glioma heterogeneity by fully hybrid PET/MR for HYpoxia, PERfusion and DIffusion spatial habitat imaging: the

HYPERDIrect study 13,5 Oncology 2 - Translational Clinical Diagnostica SAN RAFFAELE MILANO € 450.000,00 € 450.000,00 € 19.034.376,10

9

GR-2018-

12365105 CP The effects of a multimodal approach for the

treatment of Primary Progressive Aphasia 14 Brain Disorders and Clinical

Neuroscience Geriatria FATEBENEFRATELLI € 421.743,00 € 421.743,00 € 18.612.633,10

10

GR-2018-

12366092 CP

Assessment and treatment of communicative pragmatic abilities in neurological and psychiatric disorders: feasibility and clinical

efficacy 14,5 Biobehavioral and Behavioral

Processes Riabilitazione S.CAMILLO € 449.938,53 € 449.938,53 € 18.162.694,57

11

GR-2018-

12366756 CP

Novel determinants and potential therapeutic targets in extraskeletal calcification and ossification: focus on the PTH and FGF23

network". 14,5

Endocrinology, Metabolism, Nutrition and Reproductive

Sciences Endocrinologia MAGGIORE € 448.900,00 € 448.900,00 € 17.713.794,57

12

GR-2018-

12365477 CP Diagnostic Reference Levels for Pediatric heart

catheterizations: setup of a national platform 14,5 Healthcare Delivery and

Methodologies Diagnostica Veneto € 284.234,50 € 284.234,50 € 17.429.560,07

1

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13

GR-2018-

12367809 CP

LUNCH - Lung Ultrasound for early detection of silent and apparent aspiratioN in infants and young CHildren with cerebral palsy and other developmental disabilities: a new, fast, safe, cost-effective infant-friendly imaging tool to

easily monitor feeding, 14,5 Biobehavioral and Behavioral

Processes Pediatria STELLA MARIS € 406.000,00 € 406.000,00 € 17.023.560,07

14

GR-2018-

12368250 CP

Targeting default mode network dysfunction in persons at risk of Alzheimer's disease with non-

invasive techniques 15 Brain Disorders and Clinical

Neuroscience Neurologia FATEBENEFRATELLI € 450.000,00 € 450.000,00 € 16.573.560,07

15

GR-2018-

12367485 CP

A randomized controlled trial on rehabilitation training with a robotic anthropomorphic exoskeleton in patients with motor incomplete spinal cord injury: clinical outcomes and

cortical plasticity 15,5 Brain Disorders and Clinical

Neuroscience Neurologia Istituto Scienze Neurologiche € 450.000,00 € 450.000,00 € 16.123.560,07 16

GR-2018-

12367794 CP

Biocompatible nanoassemblies to increase the safety and the efficacy of steroid treatment

against liver inflammation 15,5 Digestive, Kidney and Urological

Systems Gastroenterologia Lombardia € 403.800,00 € 403.800,00 € 15.719.760,07

17

GR-2018-

12368292 CP

Phase II Multicentric Randomized Clinical Trials Comparing First line Checkpoint Blockade Immunotherapy versus Immunotherapy Combined with Stereotactic Radiation Therapy

for stage IV Non Small Cell Lung Cancer 15,5 Oncology 2 - Translational Clinical Oncologia

AUSL RE Ist. Tecnologie

Avanzate € 450.000,00 € 450.000,00 € 15.269.760,07 18

GR-2018-

12365398 CP

Effect of metyrapone on cardiovascular risk factors in patients with adrenal incidentalomas and subclinical/mild Cushing's syndrome. 15,5

Sciences Endocrinologia Emilia-Romagna € 450.000,00 € 450.000,00 € 14.819.760,07

19

GR-2018-

12366771 CP

Ambroxol as a disease-modifying treatment to reduce the risk of cognitive impairment in GBA- associated Parkinson's disease. A multicenter, randomized, double-blind, placebo-controlled,

phase 2 trial. 16 Brain Disorders and Clinical

Neuroscience Neurologia Lombardia € 449.200,00 € 449.200,00 € 14.370.560,07

20

GR-2018-

12365485 CP

B7-H3 chimeric antigen receptor redirected-T lymphocytes in relapsed/refractory acute

myeloid leukemia. 16,5 Oncology 2 - Translational Clinical Ematologia e Immunologia OSPEDALE BAMBINO GESU' € 449.990,00 € 449.990,00 € 13.920.570,07 21

GR-2018-

12367431 CP

EXPLORING OPTIMAL SEQUENCE TREATMENT IN HER2+ PERTUZUMAB PRE-TREATED ADVANCED BREAST CANCER PATIENTS. THE

STEP TRIAL. 16,5 Oncology 2 - Translational Clinical Oncologia REGINA ELENA € 450.000,00 € 450.000,00 € 13.470.570,07

22

GR-2018-

12366005 CP

Clinical and brain functional MRI effects of a rehabilitative training of upper limb using immersive virtual reality in people with

Parkinson's Disease 16,5 Brain Disorders and Clinical

Neuroscience Riabilitazione SAN RAFFAELE MILANO € 450.000,00 € 450.000,00 € 13.020.570,07

23

GR-2018-

12366862 CP

Preoperative identification of the histologically

"vulnerable" plaque using non-invasive imaging, biomechanical assessment and baroreflex evaluation in patients with severe

carotid stenosis 17 Vascular and Hematology Cardiologia-Pneumologia SAN DONATO € 324.100,00 € 324.100,00 € 12.696.470,07

24

GR-2018-

12366425 CP

The utilization of home-made videos to differentiate psychogenic non-ES from other

paroxysmal events. Assessment and validation. 17 Brain Disorders and Clinical

Neuroscience Neurologia Calabria € 427.200,00 € 427.200,00 € 12.269.270,07

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25

GR-2018-

12366002 CP

Effectiveness of attention/executive functions training on prospective memory abilities of Parkinson's disease subjects with Mild Cognitive Impairment and healthy aged individuals: a placebo-controlled study with a

combined immersive Virtual Reality and T 17 Brain Disorders and Clinical

Neuroscience Riabilitazione SANTA LUCIA € 450.000,00 € 450.000,00 € 11.819.270,07

26

GR-2018-

12367275 CP

Identification of early predictors of hip and knee arthroplasty failure by developing an innovative software for the automated analysis

of radiographic examinations. 17 Musculoskeletal, Oral and Skin

Sciences Ortopedia HUMANITAS € 450.000,00 € 450.000,00 € 11.369.270,07

27

GR-2018-

12365874 CP

RECOMmENceR: RE-establishing COrtico Muscolar COMunication to ENhance Recovery.

Clinical validation of BCI-controlled Functional Electrical Stimulation for upper limb rehabilitation after stroke.

17 Brain Disorders and Clinical

Neuroscience Riabilitazione SANTA LUCIA € 290.555,00 € 290.555,00 € 11.078.715,07

28

GR-2018-

12368336 CP

New treatment perspectives in adolescents with Anorexia Nervosa: the efficacy of non-

invasive brain-directed treatment 17 Biobehavioral and Behavioral

Processes Malattie Psichiatriche OSPEDALE BAMBINO GESU' € 420.800,00 € 420.800,00 € 10.657.915,07 29

GR-2018-

12366779 CP

Integrated PET/MR scanner as reference imaging tool in the study of dementia:

technological and clinical assessment (PM-D) 17 Brain Disorders and Clinical

Neuroscience Neurologia SDN € 300.000,00 € 300.000,00 € 10.357.915,07

30

GR-2018-

12367517 CP Pharmacological targeting of CtBP1/BARS in

cancer 17,5 Oncology 1 - Basic Translational Oncologia PASCALE € 450.000,00 € 450.000,00 € 9.907.915,07

31

GR-2018-

12367636 CP

Neurovisceral mechanisms of blood pressure regulation: novel therapeutic targets for

borderline hypertension 17,5 Biobehavioral and Behavioral

Processes Cardiologia-Pneumologia SANTA LUCIA € 298.900,00 € 298.900,00 € 9.609.015,07 32

GR-2018-

12365706 CP

SMN circular RNAs as potential biomarkers for the therapeutic response to Nusinersen in

Spinal Muscular Atrophy patients 18 Brain Disorders and Clinical

Neuroscience Pediatria FONDAZIONE GEMELLI € 393.000,00 € 393.000,00 € 9.216.015,07

33

GR-2018-

12366992 CP

Synovial tissue and blood signature to personalize the management of Rheumatoid Arthritis patients with disease flare after biological DMARDs discontinuation for

sustained remission. 18 Musculoskeletal, Oral and Skin

Sciences Ematologia e Immunologia FONDAZIONE GEMELLI € 450.000,00 € 450.000,00 € 8.766.015,07

34

GR-2018-

12366897 CP

Definition of radiological and endocrine/metabolic/inflammatory biomarker(s) to identify high-grade dysplasia/invasive carcinoma in patients with intraductal papillary mucinous neoplasms of

the pancreas 18 Digestive, Kidney and Urological

Systems Gastroenterologia SAN RAFFAELE MILANO € 450.000,00 € 450.000,00 € 8.316.015,07

35

GR-2018-

12367235 CP

Inherited thrombocytopenias: discovering the

"new" forms that affect half of patients and developing an in vitro tool for testing the ability of new drugs to increase platelet production and predicting the response to treatment in

the individual patient 18 Genes, Genomes and Genetics Ematologia e Immunologia SAN MATTEO € 450.000,00 € 450.000,00 € 7.866.015,07

36

GR-2018-

12368395 CP

Clinical-instrumental definition of the phenotypic spectrum, response to treatment and natural history in Pearson and Kearns-

Sayre syndrome. 18 Brain Disorders and Clinical

Neuroscience Neurologia OSPEDALE BAMBINO GESU' € 243.980,00 € 243.980,00 € 7.622.035,07

3

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N. Code ch type ^Title FINALE ^IRG ^MDC DESTINATARIO MOH (euro) Finanziato Finanziamento NOTE 37

GR-2018-

12367064 CP

New Strategies for the evaluation of safety and quality of X-ray irradiated soft dairy products

18,5 Veterinary Diagnostica IZSPB € 450.000,00 € 450.000,00 € 7.172.035,07

38

GR-2018-

12365981 CP Antimicrobial Stewardship in solid organ

TRAsplant recipients (ASTRA) 18,5 Infectious Diseases and

Microbiology Malattie Infettive MAGGIORE € 450.000,00 € 450.000,00 € 6.722.035,07

39

GR-2018-

12366312 CP

Long non-coding RNAs as predictive biomarkers and therapeutic targets in BRAF-mutated

cutaneous melanoma 18,5 Oncology 2 - Translational Clinical Oncologia C.R.O. AVIANO € 450.000,00 € 450.000,00 € 6.272.035,07

40

GR-2018-

12367476 CP

Efficacy and safety of memantine as antimanic and mood-stabilizing medication for children and adolescents with Bipolar Disorder: a multicenter, randomized, double-blind, placebo-

controlled clinical trial. 18,5 Biobehavioral and Behavioral

Processes Malattie Psichiatriche OSPEDALE BAMBINO GESU' € 395.850,00 € 395.850,00 € 5.876.185,07

41

GR-2018-

12365475 CP

TELEMEDICINE WITH MOBILE INTERNET DEVICES FOR INNOVATIVE CARE OF PATIENTS WITH EPILEPSY.

Short title: TELE-EPIC (TELEmedicine - for

EPIlepsy Care) 18,5 Brain Disorders and Clinical

Neuroscience Neurologia Istituto Scienze Neurologiche € 450.000,00 € 450.000,00 € 5.426.185,07 42

GR-2018-

12367944 CP Evaluating funtional ultrasonography to predict

and fight multiorgan failure in sepsis and shock 18,5 Bioengineering Sciences and

Technologies Diagnostica SAN RAFFAELE MILANO € 450.000,00 € 450.000,00 € 4.976.185,07

43

GR-2018-

12365991 CP

Mesocorticolimbic dopamine modulation by using prefrontal transcranial direct current stimulation (tDCS) to improve neuropsychiatric symptoms and memory deficits in Mild

Cognitive impairment and Alzheimer's disease 18,5 Brain Disorders and Clinical

Neuroscience Neurologia SANTA LUCIA € 450.000,00 € 450.000,00 € 4.526.185,07

44

GR-2018-

12367588 CP

Adipose-derived vesicles: immunomodulators and biomarkers during anti-inflammatory

therapy in multiple sclerosis 19

Sciences Endocrinologia SANTA LUCIA € 430.000,00 € 430.000,00 € 4.096.185,07

45

GR-2018-

12365529 CP

Monitoring of therapy-resistant Leukemic Stem Cells and regulatory T-cells in refractory Acute Myeloid Leukemia and Acute Promyelocytic

Leukemia 19 Oncology 2 - Translational Clinical Ematologia e Immunologia SANTA LUCIA € 450.000,00 € 450.000,00 € 3.646.185,07

46

GR-2018-

12365733 CP

Therapeutic treatments by transcranial magnetic stimulation and optogenetic manipulation promote anxiety modulation needed for emotional processing and fear

extinction in trauma-related pathologies 19 Brain Disorders and Clinical

Neuroscience Malattie Psichiatriche SANTA LUCIA € 450.000,00 € 450.000,00 € 3.196.185,07 47

GR-2018-

12367927 CP

Financial Abilities in neurological diseases.

Development of a telerehabilitation program:

FINAGE 19 Brain Disorders and Clinical

Neuroscience Riabilitazione S.CAMILLO € 445.653,00 € 445.653,00 € 2.750.532,07

48

GR-2018-

12366091 CP

Unravelling the role of KCTD protein family in the clinical management of childhood acute

lymphoblastic leukemias 19 Vascular and Hematology Ematologia e Immunologia SDN € 370.500,00 € 370.500,00 € 2.380.032,07

49

GR-2018-

12367117 CP

The upper-limb functional rehabilitation in chronic stroke patients: From neuroimaging and bio-humoral biomarkers of a personalized Action Observation Treatment based on virtual reality to a maximized and predictable

rehabilitative outcome. 19,5 Brain Disorders and Clinical

Neuroscience Neurologia HUMANITAS € 450.000,00 € 450.000,00 € 1.930.032,07

(5)

50

GR-2018-

12368376 CP

Impact of peripheral endovascular repair on femoral-popliteal artery kinematic: from clinical experience to in vivo biomechanical

modeling (PERFEKT study) 19,5 Surgical Sciences, Biomedical

Imaging, and Bioengineering Cardiologia-Pneumologia

Ospedale Policlinico San

Martino € 262.300,00 € 262.300,00 € 1.667.732,07 51

GR-2018-

12368031 CP

Understanding molecular mechanisms of resistance to immune check-point inhibitors in

advanced non-small cell lung cancer (NSCLC) 19,5 Oncology 2 - Translational Clinical Oncologia Emilia-Romagna € 450.000,00 € 450.000,00 € 1.217.732,07

52

GR-2018-

12367789 CP

Classifying unipolar versus bipolar depression:

an innovative diagnostic support system based on clinical features and genetic, inflammatory

and neuroimaging biomarkers 20 Brain Disorders and Clinical

Neuroscience Malattie Psichiatriche SAN RAFFAELE MILANO € 450.000,00 € 434.904,31 € 782.827,76

Subranking List posizione 1 score: validità scientifica 2, Rilevanza2,

53

GR-2018-

12367076 CP

Therapeutic vaccination : A Phase I/II Randomized, Placebo-Controlled Trial of ChAdOx1.tHIVconsvX prime-MVA.tHIVconsvX Boost Vaccination Regimen in Early-treated

durably-controlling HIV-1 positive Adults. 20 AIDS and Related Research Malattie Infettive SAN RAFFAELE MILANO € 450.000,00 € 434.904,31 € 347.923,45

Subranking List posizione 2 score: validità scientifica 2,5, Rilevanza3,

54

GR-2018-

12367114 CP

Effectiveness and feasibility of an early, tailored, physical activity program including supervised sessions and home-based exercises for patients with myocardial infarction aged 70 years and older. The Physical Intervention in

ELderly after myocardial IN 20 Cardiovascular and Respiratory

Sciences Cardiologia-Pneumologia Emilia-Romagna € 360.000,00 € 347.923,45 € -

Subranking List posizione 3 score: validità scientifica 3,5, Rilevanza2,5,

55

GR-2018-

12366891 CP

A phase 3 randomized study of regorafenib versus trifluridine/tipiracil in metastatic

colorectal cancer patients: the REGATTA study 20 Oncology 2 - Translational Clinical Oncologia I. O. V. € 254.750,00 € -

Subranking List posizione 4 score: validità scientifica 3,5, Rilevanza 4,

56

GR-2018-

12367700 CP

The role of diet in low-grade chronic inflammation and risk of cancer and major chronic-degenerative disease: a prospective

study 20 Population Sciences and

Epidemiology Oncologia ISTITUTO TUMORI MILANO € 415.985,00 € -

Subranking List posizione 5 score: validità scientifica 4, Rilevanza 3,

57

GR-2018-

12365804 CP

Early detection of Cerebral Palsy in preterm neonates: development and validation of an

innovative and non-invasive screening method 20 Brain Disorders and Clinical

Neuroscience Pediatria SANTA LUCIA € 450.000,00 € -

Subranking List posizione 6 score: validità scientifica 4, Rilevanza 3,5

58

GR-2018-

12365778 CP

Use of integrative tools for clinical impact in neurodegenerative diseases: improving the care management of patients and developing a combined therapy for the treatment of

Riboflavin Transporter Deficiency. 20 Brain Disorders and Clinical

Neuroscience Neurologia OSPEDALE BAMBINO GESU' € 449.687,00 € -

Subranking List posizione 7 score: validità scientifica 4, Rilevanza 4

59

GR-2018-

12365528 CP

Development of survival-based synthetic indicators of route to diagnosis, adherence to guidelines and patient reported outcomes in patients with breast and colon cancer, and evaluation of their relationship with socio-

economic characteristics, investigat 20,5 Healthcare Delivery and

Methodologies Oncologia Lombardia € 430.000,00 € -

60

GR-2018-

12366914 CP Assessing cancer outcome on the go: liquid

biopsy and tissue re-biopsy 20,5 Oncology 2 - Translational Clinical Oncologia REGINA ELENA € 420.000,00 € -

61

GR-2018-

12366502 CP

Advanced Therapy Medicinal Product based on interferon alpha conditioned dendritic cells loaded with universal lung cancer stem cell

antigens for Lung Cancer patients 20,5 Oncology 2 - Translational Clinical Oncologia Istituto Superiore di Sanita' € 450.000,00 € -

5

(6)

GR-2018-

12366693 CP

Cognitive profile after severe acquired brain injury: impact of clinical, genetic and epigenetic

pattern 20,5 Brain Disorders and Clinical

Neuroscience Neurologia DON GNOCCHI € 445.444,00 € -

63

GR-2018-

12368183 CP

Slimming Mood: the impact of weight reduction on neurobiological mechanisms

underpinning Bipolar Disorder 20,5 Brain Disorders and Clinical

Neuroscience Malattie Psichiatriche SAN RAFFAELE MILANO € 215.000,00 € - 64

GR-2018-

12365168 CP Pharmacological restoring of Caveolin in

Diabetic cardiomyopathy 21 Cardiovascular and Respiratory

Sciences Cardiologia-Pneumologia SAN RAFFAELE PISANA € 450.000,00 € - 65

GR-2018-

12365601 CP

Early detection and treatment of developmental dyslexia: a multilevel and

multimodal approach 21 Biobehavioral and Behavioral

Processes Riabilitazione MEDEA € 450.000,00 € -

66

GR-2018-

12366327 CP

Myocardial blood flow derived from CT perfusion imaging: a new imaging biomarker

for the detection of myocardial ischaemia 21 Cardiovascular and Respiratory

Sciences Diagnostica HUMANITAS € 361.500,00 € -

67

GR-2018-

12368185 CP Transcranial magnetic stimulation-based

biomarkers in prodromal Alzheimer's disease 21 Brain Disorders and Clinical

Neuroscience Neurologia SANTA LUCIA € 450.000,00 € -

68

GR-2018-

12367948 CP

Strategies to improve cognition in healthy elderly at risk for cognitive decline by coupling

tES and cognitive training. 21 Brain Disorders and Clinical

Neuroscience Neurologia FATEBENEFRATELLI € 448.830,00 € -

69

GR-2018-

12367247 CP

Computational analysis and quantitative MRI at ultra-high field: an integrated decisional framework for the diagnosis of focal cortical

dysplasia 21 Surgical Sciences, Biomedical

Imaging, and Bioengineering Neurologia Toscana € 400.050,00 € - 70

GR-2018-

12365421 CP Multidisciplinary management of upper limb

spasticity after stroke and spinal cord injury 21 Surgical Sciences, Biomedical

Imaging, and Bioengineering Neurologia Sicilia € 449.000,00 € - 71

GR-2018-

12366859 CP

GRASP THE AUTISM: testing the effectiveness of a new pathway for early detection of Autism

Spectrum Disorder 21,5 Biobehavioral and Behavioral

Processes Malattie Psichiatriche MEDEA € 450.000,00 € -

72

GR-2018-

12368207 CP RESOLVINg SCI: Resolution pathways in spinal

cord injury. 21,5 Molecular, Cellular, and

Developmental Neuroscience Neurologia SANTA LUCIA € 449.000,00 € -

73

GR-2018-

12365413 CP

Continuous versus intermittent ßeta-lactam infusiOn in PaTients with cIrrhosis and sepsis:

an open label randoMIZEd controlled clinical

trial (ß-OPTIMIZE) 21,5 Infectious Diseases and

Microbiology Gastroenterologia Veneto € 408.179,10 € -

74

GR-2018-

12366532 CP HDAC2-Mediated ImmunoTherapy In

Colorectal cancer (MITIC) 21,5 Genes, Genomes and Genetics Oncologia SDN € 427.500,00 € -

75

GR-2018-

12365806 CP Desmopressin for reducing postoperative

bleeding and transfusions in cardiac surgery 21,5 Cardiovascular and Respiratory

Sciences Cardiologia-Pneumologia SAN DONATO € 188.400,00 € - 76

GR-2018-

12366363 CP

Fanconi anemia: towards a personalized medicine approach through bioenergetics-

based therapies 21,5 Genes, Genomes and Genetics Ematologia e Immunologia BURLO GAROFOLO € 420.000,00 € -

77

GR-2018-

12365450 CP

Tenecteplase before endovascular treatment for stroke up to 16 hours with tissue based

selection. A phase IIb, proof-of-concept study. 22 Brain Disorders and Clinical

Neuroscience Neurologia Toscana € 413.000,00 € -

78

GR-2018-

12367397 CP

Refining criteria for early diagnosis of heart failure with preserved ejection fraction:

invasive hemodynamics versus noninvasive

approaches (REFINE-HFpEF) 22 Cardiovascular and Respiratory

Sciences Cardiologia-Pneumologia AUXOLOGICO € 295.500,00 € -

(7)

GR-2018-

12366800 CP

Predicting early treatment response to anti-PD- 1 immune checkpoint inhibitor in metastatic

melanoma patients using CT texture analysis. 22 Surgical Sciences, Biomedical

Imaging, and Bioengineering Diagnostica SAN GALLICANO € 430.000,00 € -

80

GR-2018-

12366660 CP

Diagnostic scan radiomic to predict the outcomes of effectively cured high risk head and neck cancer patients accrued in an ongoing

prospective study with two follow up strategies 22 Surgical Sciences, Biomedical

Imaging, and Bioengineering Oncologia ISTITUTO TUMORI MILANO € - € - 81

GR-2018-

12367892 CP

Towards "precision surgery" in pancreatic neuroendocrine tumours: genetic and imaging

biomarkers for surgical treatment tailoring. 22 Oncology 2 - Translational Clinical Oncologia SAN RAFFAELE MILANO € 450.000,00 € -

82

GR-2018-

12368241 CP

Rheumapill Project: a polypill to improve disease activity and prevent associated cardiovascalur risk in rheumatoid arthritis and

systemic lupus erythematosus 22 Immunology Ematologia e Immunologia Piemonte € 226.615,00 € -

83

GR-2018-

12366952 CP

Systematic Left Ventricular Assist Device Implant Eligibility with Non-Invasive Assessment: the SIENA score, a new project for the prediction of right ventricular failure after

LVAD in patients with end-stage heart failure 22 Cardiovascular and Respiratory

Sciences Cardiologia-Pneumologia Toscana € 259.785,00 € -

84

GR-2018-

12366499 CP

Biomarkers in autism spectrum disorders early diagnosis: the role of maternal immune activation in an at risk population

22,5 Brain Disorders and Clinical

Neuroscience Neurologia Istituto Scienze Neurologiche € 447.700,00 € -

85

GR-2018-

12367864 CP

Clinical utility of serum Thymidine Kinase 1 and inflammation biomarkers in presurgical- window of opportunity trials with exemestane.

Assessing their role as predictive and prognostic biomarkers in postmenopausal

breast cancer. 22,5 Oncology 2 - Translational Clinical Oncologia I.E.O. € 445.000,00 € -

86

GR-2018-

12367407 CP

CMV IMPACT (CMV IMmunoglobulin Preemption plus Antiviral for Children after liver Transplantation)

Phase III randomized controlled trial on the efficacy of anti-Cytomegalovirus (CMV) Immunoglobulins (Megalotect®) in addition to

Ganciclovir in the preempti 22,5 Digestive, Kidney and Urological

Systems Pediatria Lombardia € 450.000,00 € -

87

GR-2018-

12365286 CP

PATTERN OF USE, SAFETY AND EFFECTIVENESS OF BIOLOGIC TREATMENTS IN RHEUMATOID ARTHRITIS: COMPARATIVE EVALUATION BY

REAL WORLD DATA 22,5 Healthcare Delivery and

Methodologies Ematologia e Immunologia Lazio € 447.400,00 € -

88

GR-2018-

12367496 CP

Pediatric Onset Multiple Sclerosis: correlations between clinical, neurophysiological, cognitive features and lesion burden defined with Ultra

High-Field MRI 23 Brain Disorders and Clinical

Neuroscience Neurologia Toscana € 447.640,00 € -

89

GR-2018-

12366991 CP

Exploiting the metabolic vulnerability of triple- negative BREAst cancer by combining metformin and a diet mimicKing FASTing: the

BREAKFAST study 23 Oncology 2 - Translational Clinical Oncologia ISTITUTO TUMORI MILANO € 448.500,00 € -

90

GR-2018-

12367308 CP

Effects of sacubitril/valsartan (LCZ696) on myocardial fibrosis in patients affected by

chronic heart failure. 23 Cardiovascular and Respiratory

Sciences Cardiologia-Pneumologia SDN € 440.000,00 € -

7

(8)

GR-2018-

12367416 CP

Mothers exposed to Intimate Partner Violence:

Examining the efficacy of the Moms'

Empowerment Program in an Italian Sample 23 Risk, Prevention and Health

Behavior Malattie Psichiatriche MAGGIORE € 382.920,00 € -

92

GR-2018-

12366328 CP

Randomized controlled trial to assess the efficacy of intravenous steroids to treat patients with acute myocarditis with left ventricular systolic dysfunction and the efficacy of ramipril in patients with acute myocarditis

with preserved left ventricular 23 Cardiovascular and Respiratory

Sciences Cardiologia-Pneumologia Lombardia € 450.000,00 € -

93

GR-2018-

12366876 CP

The secretory signature of adipocytes under nutrient overload-induced stress: the exploitation of circulating factors as diagnostic and prognostic biomarkers of bariatric surgery 23,5

Sciences Endocrinologia Istituto Superiore di Sanita' € 450.000,00 € - 94

GR-2018-

12366798 CP

Neurovascular quantitative magnetic resonance and molecular measures in Multiple Sclerosis: relationships with the effect of

rehabilitation 24 Brain Disorders and Clinical

Neuroscience Riabilitazione DON GNOCCHI € 450.000,00 € -

95

GR-2018-

12367748 CP

Role of the Maternal Gut Microbiota in Immune Activation at the Maternal-Foetal Interface: Impact on Preeclampsia and

Offspring's Immune Development 24 ^Immunology Ostetricia e Ginecologia HUMANITAS € 450.000,00 € -

96

GR-2018-

12366773 CP

Accelerating the route to diagnosis of rare pediatric disorders in highly inbred

communities 24 Genes, Genomes and Genetics Pediatria Emilia-Romagna € 449.998,00 € -

97

GR-2018-

12368245 CP

Characterisation of voluntary motor behaviour by muscle synergies, in neurological diseases:

clinical applications for biomarking and

tailoring of rehabilitation therapies. 24,25 Musculoskeletal, Oral and Skin

Sciences Riabilitazione S.CAMILLO € 449.900,00 € -

98

GR-2018-

12367966 CP

Anti-VEGFs for macular degeneration: pattern of use, safety, appropriate use and economic

burden for the National Health Service 24,5 Healthcare Delivery and

Methodologies Oculistica Lazio € 450.000,00 € -

99

GR-2018-

12366599 CP

Dendritic cell vaccination after curative resection for stage IV colorectal cancer: a phase

2 study. 24,5 Oncology 2 - Translational Clinical Oncologia Istituto Scientifico Romagnolo € 350.000,00 € -

100

GR-2018-

12366625 CP FONTINA: FOod NanoparTicles ImmuNe

impAct 24,5 Bioengineering Sciences and

Technologies Pediatria Veneto € 430.000,00 € -

101

GR-2018-

12367847 CP

SPRING

RadiomicS and PRediction models IN Glioblastoma:

multidisciplinary management for personalized medicine challenge

24,5 Brain Disorders and Clinical

Neuroscience Oncologia FONDAZIONE GEMELLI € 350.000,00 € -

102

GR-2018-

12368382 CP Technologies' Economic and CLinical real world

Assessment in Diabetes (TECLA-D) 24,5

Sciences Endocrinologia Lombardia € 447.670,00 € -

103

GR-2018-

12368144 CP

Identification and validation of a TRF2-driven miRNA signature with therapeutic and

prognostic value in colorectal cancer. 24,5 Oncology 2 - Translational Clinical Oncologia REGINA ELENA € 450.000,00 € - 104

GR-2018-

12368314 CP

Soccer and possible risk of neurodegenerative disease: a cohort study on Italian professional

players 24,5 Population Sciences and

Epidemiology Neurologia MARIO NEGRI € 330.000,00 € -

(9)

105

GR-2018-

12367799 CP

Noninvasive prediction of nonalcoholic fatty liver disease by imaging and circulating biomarkers in high risk individuals with HIV, previous HCV infection and type 2 diabetes, and correlation with the evolution of liver

damage, development of sarcopenia a 25 Biology of Development and Aging Malattie Infettive Emilia-Romagna € 450.000,00 € - 106

GR-2018-

12365196 CP Pharmacogenomics of immune checkpoint

inhibitors 25 Genes, Genomes and Genetics Oncologia ISTITUTO TUMORI MILANO € 449.921,33 € -

107

GR-2018-

12365583 CP

Molecular profiling of metastatic colorectal cancer response to anti-VEGF therapy: from tumor metabolic adaptation to identification of

new predictive and therapeutic tools 25,5 Oncology 2 - Translational Clinical Oncologia I. O. V. € 449.000,00 € -

108

GR-2018-

12367459 CP

Searching for an Operational definition and molecular signature of Multimorbidity in the

Elderly (SOME) 25,5 Healthcare Delivery and

Methodologies Geriatria I.N.R.C.A. € 450.000,00 € -

109

GR-2018-

12367834 CP

New targets for veno-venous Extracorporeal Membrane Oxygenation support in Acute Respiratory Distress Syndrome: deep knowledge of inflammatory/coagulation patterns, miRNAs and progenitor cells to guide

the next increase in survival 26 Cardiovascular and Respiratory

Sciences Cardiologia-Pneumologia ISMETT € 237.700,00 € -

110

GR-2018-

12366776 CP

Are genetic, brain connectivity and robotic measures biomarkers of motor recovery after robotic rehabilitation in stroke patients? From

Gene and NEuRon to Action (GENERA project). 26 Brain Disorders and Clinical

Neuroscience Riabilitazione DON GNOCCHI € 322.390,00 € -

111

GR-2018-

12368192 CP

Development and validation of a screening instrument and inflammatory biomarkers for Subjective Cognitive Decline in a rural cohort:

18-year follow-up data from the The Zabut

Aging Project population-based study 26,5 Population Sciences and

Epidemiology Neurologia Sicilia € 405.500,00 € -

112

GR-2018-

12366610 CP

The DIRECT signature derived from circulating tumor Dna and Image-based biomarkers for the baseline identification of REfraCTory Hodgkin

Lymphoma 26,5 Oncology 2 - Translational Clinical Diagnostica HUMANITAS € 433.000,00 € -

113

GR-2018-

12367463 CP

Cost-effectiveness of lung cancer screening, tobacco control policies and electronic

cigarettes 26,5 Healthcare Delivery and

Methodologies Oncologia Toscana € 319.250,00 € -

114

GR-2018-

12368094 CP

Effective strategies to prevent and treat delirium in intensive care unit patients: a review of the literature and a network meta-

analysis. 26,5 Surgical Sciences, Biomedical

Imaging, and Bioengineering Neurologia SAN RAFFAELE MILANO € 228.000,00 € -

115

GR-2018-

12365449 CP

Salicylic Acid Inflammatory Bowel Disease (SA- IBD): the effect of a naturally salicylic acid rich diet in patients with Ulcerative Colitis: a pilot

study. 26,5 Digestive, Kidney and Urological

Systems Gastroenterologia HUMANITAS € 438.000,00 € -

116

GR-2018-

12367786 CP

The possible role of metabolic factors in the onset and progression of ALS: opportunities for

the redefinition of care models. 27 Population Sciences and

Epidemiology Neurologia Istituto Superiore di Sanita' € 430.000,00 € -

9

(10)

117

GR-2018-

12365975 CP

Genetic profiling and tumor microenvironment characterization in advanced Non-small cell lung cancers treated with immunotherapy: a

model for patients' selection 27 Oncology 2 - Translational Clinical Oncologia I. O. V. € 445.550,00 € -

118

GR-2018-

12366043 CP The role of anti-oxidants on idiopathic male

infertility 27

Sciences Endocrinologia Emilia-Romagna € 440.000,00 € -

119

GR-2018-

12366383 CP

A new PSMA-based radiopharmaceutical for imaging and therapy of prostate cancer: from molecule to man

27,5 Oncology 2 - Translational Clinical Oncologia I. O. V. € 448.850,00 € - 120

GR-2018-

12366178 CP

Platelet inhibition with ticagrelor 60 mg versus ticagrelor 90 mg twice daily in elderly patients

with acute coronary syndrome (ACS) 27,5 Cardiovascular and Respiratory

Sciences Cardiologia-Pneumologia Campania € 445.730,00 € -

121

GR-2018-

12366998 CP

Effect of Mediterranean diet versus low-fat diet for improving knee osteoarthritis outcomes: a

randomized, cross-over, clinical trial 28,5 Musculoskeletal, Oral and Skin

Sciences Geriatria DE BELLIS € 450.000,00 € -

122

GR-2018-

12366007 CP

A new approach in cancer prevention:

randomized intervention trial of physical activity and metformin to improve sleep and

metabolic syndrome. 28,5 Risk, Prevention and Health

Behavior Oncologia ISTITUTO TUMORI MILANO € 433.810,08 € -

123

GR-2018-

12365393 CP

Safety and efficacy of a novel, simplified technique for bone augmentation around

dental implants 28,5 Musculoskeletal, Oral and Skin

Sciences Otorinolaringoiatria e Odontoiatria Emilia-Romagna € 404.360,00 € - 124

GR-2018-

12367530 CP Gambling, Information Communications

Technology and eHealth (GAM-E) 29,5 Risk, Prevention and Health

Behavior Malattie Psichiatriche Lazio € 300.000,00 € -

125

GR-2018-

12367478 CP

The dynamic relationship between temporary employment and stress-related disorders in Italy: investigating the "Which came first?" in a

causal inference approach 30 Population Sciences and

Epidemiology Malattie Psichiatriche Lazio € 450.000,00 € -

126

GR-2018-

12365839 CP Malignant pleural mesothelioma: the need to

move from research to secondary prevention 30,5 Population Sciences and

Epidemiology Diagnostica Sicilia € 330.000,00 € -

127

GR-2018-

12366975 CP

An open-label, randomized, controlled clinical trial on the effects of endoscopic sleeve gastroplasty on weight, metabolic risk factors, quality of life, satiety, gastrointestinal motility

and gut microbiota 30,5

Sciences Gastroenterologia FONDAZIONE GEMELLI € 374.180,00 € -

128

GR-2018-

12365139 CP

Validation of molecular markers expression on eosinophils membrane as diagnostic and prognostic tools in patients with COPD

undergoing rehabilitation therapy. 31,5 Cardiovascular and Respiratory

Sciences Cardiologia-Pneumologia SAN RAFFAELE PISANA € 432.080,00 € - 129

GR-2018-

12367600 CP

Social and Economic impact of Early DIagnosis and REhabilitation in Complicated Traumas

with nerve injuries (SEE DIRECTly) 32 Musculoskeletal, Oral and Skin

Sciences Riabilitazione DON GNOCCHI € 185.330,00 € -

130

GR-2018-

12367584 CP

Prospective study of clozapine-associated left ventricular dysfunction in patients with

treatment resistant schizophrenia. 32,25 Emerging Technologies and

Training in Neurosciences Malattie Psichiatriche Lazio € 441.950,00 € -