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Subject Index 341

Subject Index

A

Acute toxicity – cystitis 295 – esophagitis 318 – gastrointestinal 325 – lung 318

Additivity 6 Akt, see PKB Alpha/beta ratio 327 Amifostine 323 Anal cancer 279 – in elderly patients 337 Anastrozole 254 Anemia 308

Angiogenesis 45, 103, 117 Angiostatin 103 Anticonvulsants 167 Antiemetics 325 Antimetabolites 19 Apoptosis 12, 37, 312 AQ4N 79

Astrocytoma 166 – anaplastic 166 – high grade 166 – low grade 166 – pilocytic 166

Ataxia telangiectasia mutated (ATM) 128 Auger electron 151

B Bax 39 Bcl-2 39

Bevacizumab 110, 220, 278 Bladder cancer 285 – in elderly patients 338 Blood-brain barrier 165 Bortezomib 312 Brain metastases 141, 180 – and motexafi n-gadolinium 141 – and temozolomide 144, 181 Brain tumors, see CNS tumors Breast cancer 251

– locally advanced breast cancer 260 – neoadjuvant chemotherapy 260 5-Bromo-2’-deoxyuridine (BrdU) 24

C

Camptothecins 54 Capecitabine 29, 220

– in breast cancer 262 – in rectal cancer 274 Carboxylesterase 29 Carboplatin 96 Carmustine 168 Cell cycle 11, 25, 131

Central nervous system (CNS) tumors 60, 139, 165 – recurrent CNS tumors 176

Cervical cancer 303

Cetuximab 118, 221, 243, 277, 321 Chemosensitivity testing 14 Chitosan 157

Cisplatin 93 Comorbidity 334

Complications, see acute and late toxicity Consequential late effects 326

Convection-enhanced delivery 169 Cytidine deaminase 29

Cytochrome P450 enzymes 166

D

Dendrimer 159

Deoxyribonucleicacid (DNA) 10 – DNA array 153

– DNA damage 10

– DNA-dependent protein kinase 128 – DNA repair 10, 117

– DNA topoisomerase 53 Dihydrofolate reductase 22 Docetaxel 36

Dose density of chemotherapy 276 Doxorubicin 257

Ductal carcinoma in situ of the breast 252

E

4EBP1 130 Endostatin 103

Endothelial cells 108, 131, 152, 326 Ependymoma 178

Epidermal growth factor (EGF) 115 – EGF receptors (EGFR) 115 – EGFR inhibitors 115

– EGFR inhibitors and mTOR inhibitors 134 – EGFR inhibitors in cervical cancer 311 – EGFR inhibitors in colorectal cancer 277 Epipodophyllotoxin 56

ErbB, see EGFR ERCC1 93

Erlotinib 118, 221, 243, 312

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342 Subject Index

Endometrial cancer 306 Erythropoietin 308 Esophageal cancer 58, 197

– esophagogastric junction adenocarcinoma 197, 207 – in elderly patients 335

Etanidazole 69 Etoposide 54 Everolimus 127

Excision repair cross-complementing 1, see ERCC1 Exemestane 254

F

Fibroblast collagen system 326 Fibroblast growth factor (FGF) 103 5-Fluorouracil (5-FU) 19, 26 – in rectal cancer 267 – continuous infusion 269 Fractionation sensitivity 6, 327 Ftorafur 28

G

Gadolinium-neutron capture therapy 143 Gastric cancer 207

Gastrointestinal toxicity 325 Gefi tinib 118, 242

Gemcitabine 21, 29, 218, 305

Gene-directed enzyme-prodrug therapy 74 Gene therapy 151, 176

Glioblastoma multiforme (GBM) 143, 166 – and motexafi n-gadolinium 143 – and temozolomide 145 – in elderly patients 338 Gluthatione S-transferase 174

Granulocyte colony-stimulating factor (G-CSF) 322 Granulocyte macrophage colony-stimulating factor

(GM-CSF) 322

H

Head and neck tumors 61, 187 – in elderly patients 324 HER2 in breast cancer 259 Hormonal ablation 14 – in breast cancer 254 – with mTOR inhibitors 133 – with radiation therapy 14 Hydroxyurea 24, 168 Hypopharynx cancer 189 Hypoxia 9, 44, 67, 108, 130, 306 – acute 67

– chronic 67

– hypoxia-inducible factor-1 (HIF-1) 82, 83, 130, 307

I

Imatinib 134, 310 Immune response 46 Immunotherapy 176

Insulin-like growth factor receptor 128 Integrins 152, 155, 307

Intercellular adhesion molecule (ICAM)-1 152, 155 Interstitial fl uid pressure 306

Irinotecan 54, 277 Isobologram 6

K

Keratinocyte growth factor (KGF) 321, 322

L

Lapatinib 118 Larynx cancer 188 Late toxicity 326 – bladder 295 Letrozole 254 Leucovorin 269 Levamisol 269

Linear quadratic model 327 Liposomes 157

Liver metastases from rectal cancer 276 Lung cancer, see NSCLC and SCLC Lung toxicity 318

Lymphangiogenesis 104

M

Mammalian target of rapamycin (mTOR) 127 – mTOR inhibitors 127

Matrix metalloproteinase inhibitor 103 Medulloblastoma 179

Meningioma 180 Methotrexate 22

Methyl-guanine methyl transferase (MGMT) 143, 146, 174 Metronomic chemotherapy 5

Micelles 157 Microenvironment – in cervical cancer 306 Microtubules 37 Misonidazole 69, 309 Mitomycin C 75, 309 Mitotic spindle 37 Motexafi n-gadolinium 139

N

Nanoparticles 157 Nasopharynx cancer 190 Neoantigens 152 Neovascularization 152 Nimorazole 69 Nitroimidazoles 69 Nitrosoureas 168

Non-small cell lung cancer (NSCLC) 56, 231 – in elderly patients 335

Normal tissues 317 Nucleoside 24

O

O-6 benzylguanine 144 Oligoastrocytoma 166 Oligodendroglioma 166, 178 Oropharynx cancer 187 Oxaliplatin 97, 276

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Subject Index 343

Oxidative damage 72 Oxygenation 44 Oxygen diffusion 67

P

Paclitaxel 36, 219 – in breast cancer 257 – in cervical cancer 305 Pancreatic cancer 215 PCV 339

Pemetrexed 30, 110 Pentoxifylline 328 P-glycoprotein 169 Pimonidazole 69

Phosphatidyl-inositol 3-kinase (PI3K) 128 Platelet-derived growth factor (PDGF) 103, 307 Poly-ADP-ribose polymerase 1 (PARP-1) 146, 174 Polyethylene glycol (PEG) 158

Polyglycolic acid (PGA) 158 Polylactic acid (PLA) 158 Polylacticglycolic acid (PLGA) 158 Polymers 159

– synthetic polymers 159 Porfi romycin 75

Positron emission tomography (PET) – in lung cancer 232

Procarbazine 168 Prodrug 28, 79

– gene-directed enzyme-prodrug therapy 74 Programmed cell death, see apoptosis Protein kinase B (PKB, Akt) 128 Proteomics 154

Proteosome 312

Protracted drug exposure 13, 27 Protracted venous infusion 27 PTEN 129

Pyrimidine analogs 19 P21 39

P53 25, 39 PR-104 74

R

Radiation-induced neoantigens 152 Radiation-inducible gene therapy 151 Radiation sensitivity 6

Radical scavenging agents 323 Radiolysis of water 79 Radiosensitization 6 Rapamycin 127, 133 Rectal cancer 59, 267 – in elderly patients 337 Redox cycling 72 Repopulation 8, 320

S

Selenium 323

Serial analysis of gene expression (SAGE) 153 Side effects, see acute and late toxicity Single nucleotide polymorphisms 15 Small cell lung cancer (SCLC) 57, 243 – in elderly patients 336

Sorafenib 312 Spatial interaction 8 Stem cells 319 – hematopoietic 322 Sub-additivity 6 Suicide genes 176 Superoxide dismutase 324 Supportive measures 324, 328 Supra-additivity 6

Sustained drug release 159 Synergism 6

S-1 28

T

Tamoxifen 254, 258 Taxanes 35

Temozolomide 143, 169 Temsirolimus 127 Texaphyrins 140 Therapeutic gain 5 Thioredoxin reductase 140 Thymidylate synthase (TS) 21 Tirapazamine 76, 309 Topoisomerases 53 Topoisomerase inhibitors 54 Topotecan 54

Toxicity, see acute and late toxicity TRAIL 312

Transforming growth factor (TGF) beta 326 Trastuzumab 259, 262

Treatment monitoring 14 Tumor cell kill 3 Tumor vasculature 68

U UFT 28

Uterine cancer, see cervical and endometrial cancer

V

Vascular-disrupting agents 153

Vascular endothelial growth factor (VEGF) 68, 103, 131, 307 – VEGF inhibitors 105

– VEGF receptors 105 Vasculature 131 Vulvar cancer 306 – in elderly patients 338

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List of Contributors 345

List of Contributors

G-One Ahn, PhD

Division of Radiation and Cancer Biology Department of Radiation Oncology Stanford School of Medicine 269 Campus Drive

Center for Clinical Science and Research, Rm 1255 Stanford, CA 94305-5152

USA

K. K. Ang, MD PhD

Professor, Departments of Experimental Radiation Oncology

and Radiation Oncology

The University of Texas M. D. Anderson Cancer Center 1515 Holcombe Blvd.

Houston, TX 77030-4009 USA

Nicolaus H. Andratschke, MD Department of Radiation Oncology Klinikum rechts der Isar der Technischen Universität München Ismaninger Straße 22

81675 München Germany

Michael Bastasch, MD

Department of Radiation Oncology The University of Texas Southwestern Medical Center at Dallas

5801 Forest Park Rd.

Dallas, TX 75390-9183 USA

Claus Belka, MD

Department of Radiation Oncology University Hospital

Eberhard-Karls Universität Tübingen Hoppe-Seyler-Strasse 3

72076 Tübingen Germany

Jean Bourhis, MD

Professor, Head of Radiation Oncology Department Institut Gustave Roussy

39, rue Camille Desmoulins 94805 Villejuif Cedex France

J. Martin Brown, PhD

Division of Radiation and Cancer Biology Department of Radiation Oncology Stanford School of Medicine 269 Campus Drive

Center for Clinical Science and Research, Rm 1255 Stanford, CA 94305-5152

USA

Björn L. D. M. Brücher, MD Department of Surgery Klinikum rechts der Isar der Technischen Universität München Ismaninger Straße 22

81675 München Germany

Thomas A. Buchholz, MD Department of Radiation Oncology

The University of Texas M. D. Anderson Cancer Center 1515 Holcombe Blvd.

Houston, TX 77030 USA

Seungtaek Choi, MD

Department of Radiation Oncology

The University of Texas M.D. Anderson Center 1515 Holcombe Blvd.

Dallas, Texas 77030 USA

Hak Choy, MD Professor and Chairman

Nancy B. and Jake L. Hamon distinguished Chair in Therapeutic Oncology Research

Department of Radiation Oncology The University of Texas

Southwestern Medical Center at Dallas 5801 Forest Park Rd.

Dallas, TX 75390-9183 USA

Christopher H. Crane, MD

Department of Radiation Oncology, Box 97

The University of Texas M. D. Anderson Cancer Center 1515 Holcombe Blvd.

Houston, TX 77030 USA

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346 List of Contributors

Wolfgang Dörr, DVM PhD

Professor, Medical Faculty Carl Gustav Carus University of Technology Dresden

Fetscherstrasse 74, PF 58 01307 Dresden

Germany

Jürgen Dunst, MD

Professor, Department of Radiation Oncology University Hospital Schleswig-Holstein Campus Lübeck

Ratzeburger Allee 160 23538 Lübeck Germany

Douglas B. Evans, MD

Department of Surgical Oncology

The University of Texas M. D. Anderson Cancer Center 1515 Holcombe Blvd.

Houston, TX 77030 USA

Jochen Fleckenstein, MD

Department of Radiotherapy and Radiation Oncology Saarland University Medical School

66421 Homburg Germany

Anthony Fyles, MD

Department of Radiation Oncology Princess Margaret Hospital 610 University Ave.

Toronto, ON M5G 2M9 Canada

Hans Geinitz, MD

Department of Radiation Oncology Klinikum rechts der Isar der Technischen Universität München Ismaninger Straße 22

81675 München Germany

Mark R. Gilbert, MD

Department of Neuro-Oncology

The University of Texas M.D. Anderson Cancer Center 1515 Holcombe Blvd.

Houston, TX 77030 USA

Dennis E. Hallahan, MD B-902 Vanderbilt Clinic Vanderbilt University 1301 22nd Ave South Nashville, TN 37232-5671 USA

Zhaozhong Han, PhD

Department of Radiation Oncology Vanderbilt University School of Medicine 11611 21st Ave. South

Nashville, TN 37232 USA

Paul Harari, MD

Jack Fowler Professor, Department of Human Oncology University of Wisconsin Hospital Medical School 600 Highland Avenue, K4 312-3684

Madison, WI 53792 USA

Hiroshi Harada, MD

Department of Radiation Oncology and Image-Applied Therapy

Kyoto University

Graduate School of Medicine Kyoto 606-8507

Japan

Ghazal Hariri

Department of Radiation Oncology School of Medicine

Vanderbilt University 11611 21st Ave. South Nashville, TN 37232 USA

Masahiro Hiraoka, MD PhD Department of Radiation Oncology and Image-Applied Therapy

Kyoto University

Graduate School of Medicine Kyoto 606-8507

Japan

Deepak Khuntia, MD Assistant Professor

Department of Human Oncology University of Wisconsin

600 Highland Avenue, K4 312-3684 Madison, WI 53792

USA

Guido Lammering, MD PhD Department of Radiation Oncology and Laboratory of Experimental Radiation Oncology (Maastro Clinic and Lab), University Maastricht Postbus 4446

6401 CX Heerlen The Netherlands

Zhongxing Liao, MD

Associate Professor, Department of Experimental Radiation Oncology

The University of Texas M. D. Anderson Cancer Center 1515 Holcombe Blvd.

Houston, TX 77030-4009 USA

Florian Lordick, MD

3rd Department of Internal Medicine (Hematology/Medical Oncology)

Klinikum rechts der Isar der Technischen Universität München

Ismaninger Str. 22 81675 Munich Germany

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List of Contributors 347

Kathryn A. Mason, MS

Department of Experimental Radiation Oncology The University of Texas M. D. Anderson Cancer Center 1515 Holcombe Blvd., Box 066

Houston, TX 77030-4009 USA

Luka Milas, MD PhD Professor, Department of Experimental Radiation Oncology

The University of Texas M. D. Anderson Cancer Center 1515 Holcombe Blvd., Box 066

Houston, TX 77030-4009 USA

Michael Milosevic, MD Department of Radiation Oncology Princess Margaret Hospital 610 University Ave.

Toronto, ON M5G 2M9 Canada

Minesh P. Mehta, MD Department of Human Oncology

University of Wisconsin Hospital Medical School 600 Highland Avenue, K4 312-3684

Madison, WI 53792 USA

Michael Molls, MD Professor and Chairman,

Department of Radiation Oncology Klinikum rechts der Isar der Technischen Universität München Ismaninger Straße 22

81675 München Germany

Carsten Nieder, MD

Department of Radiation Oncology Klinikum rechts der Isar der Technischen Universität München Ismaninger Straße 22

81675 München Germany

Amit Oza, MD

Department of Medical Oncology and Haematology Princess Margaret Hospital

610 University Ave.

Toronto, ON M5G 2M9 Canada

Peter W. T. Pisters, MD Department of Surgical Oncology

The University of Texas M. D. Anderson Cancer Center 1515 Holcombe Blvd.

Houston, TX 77030 USA

Dorothea Riesenbeck, MD

Klinik für Strahlentherapie und Radioonkologie Marienhospital Herne, Ruhr-Universität Bochum Hölkeskampring 40

44625 Herne Germany

Claus Rödel, MD

Klinik und Poliklinik für Strahlentherapie Universitätsklinikum Erlangen

Postfach 2306 Universitätsstrasse 27 91054 Erlangen Germany

Christian Rübe, MD PhD

Head of the Department of Radiotherapy and Radiation Oncology

Saarland University Medical School 66421 Homburg

Germany

Jann N. Sarkaria, MD Assistant Professor Department of Oncology Mayo Clinic College of Medicine 200 First Street SW

Rochester, MN 55905 USA

Rolf Sauer, MD

Professor, Direktor der Strahlenklinik Universitätsklinikum Erlangen Postfach 2306

Universitätsstrasse 27 91054 Erlangen Germany

Keiko Shibuya, MD

Department of Radiation Oncology and Image-Applied Therapy

Kyoto University

Graduate School of Medicine Kyoto 606-8507

Japan

Howard D. Thames, PhD

Department of Biomathematics/Biostatistics

The University of Texas M. D. Anderson Cancer Center 1515 Holcombe Blvd.

Houston, TX 77030 USA

Anne M. Traynor, MD Assistant Professor Department of Medicine University of Wisconsin

600 Highland Avenue, K4 312-3684 Madison, WI 53792

USA

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348 List of Contributors

Gauri Varadhachary, MD

Gastrointestinal Medical Oncology, Box 426 The University of Texas

M. D. Anderson Cancer Center 1515 Holcombe Blvd.

Houston, TX 77030 USA

Robert A. Wolff, MD

Gastrointestinal Medical Oncology, Box 426 The University of Texas

M. D. Anderson Cancer Center 1515 Holcombe Blvd.

Houston, TX 77030 USA

Anthony Zietman, MD

Department of Radiation Oncology Massachusetts General Hospital Harvard Medical School 101 Blossom Street Boston, MA 02114 USA

Frank Zimmermann, MD Department of Radiation Oncology Klinikum rechts der Isar der Technischen Universität München Ismaninger Str. 22

81675 München Germany

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List of Contributors 349

M e d i c a l R ad i o l o g y Diagnostic Imaging and Radiation Oncology

Titles in the series already published

R ad i at i o n O n c o l o g y

Lung Cancer

Edited by C.W. Scarantino Innovations in Radiation Oncology Edited by H. R. Withers and L. J. Peters

Radiation Therapy of Head and Neck Cancer Edited by G. E. Laramore Gastrointestinal Cancer – Radiation Therapy

Edited by R.R. Dobelbower, Jr.

Radiation Exposure and Occupational Risks

Edited by E. Scherer, C. Streffer, and K.-R. Trott

Radiation Therapy of Benign Diseases A Clinical Guide

S. E. Order and S. S. Donaldson Interventional Radiation

Therapy Techniques – Brachytherapy Edited by R. Sauer

Radiopathology of Organs and Tissues Edited by E. Scherer, C. Streffer, and K.-R. Trott

Concomitant Continuous Infusion Chemotherapy and Radiation Edited by M. Rotman and C. J. Rosenthal Intraoperative Radiotherapy – Clinical Experiences and Results Edited by F. A. Calvo, M. Santos, and L.W. Brady

Radiotherapy of Intraocular and Orbital Tumors

Edited by W. E. Alberti and R. H. Sagerman

Interstitial and Intracavitary Thermoradiotherapy

Edited by M. H. Seegenschmiedt and R. Sauer

Non-Disseminated Breast Cancer Controversial Issues in Management Edited by G. H. Fletcher and S.H. Levitt

Current Topics in

Clinical Radiobiology of Tumors Edited by H.-P. Beck-Bornholdt

Practical Approaches to Cancer Invasion and Metastases A Compendium of Radiation

Oncologists’ Responses to 40 Histories Edited by A. R. Kagan with the Assistance of R. J. Steckel

Radiation Therapy in Pediatric Oncology Edited by J. R. Cassady

Radiation Therapy Physics Edited by A. R. Smith Late Sequelae in Oncology Edited by J. Dunst and R. Sauer Mediastinal Tumors. Update 1995 Edited by D. E. Wood

and C. R. Thomas, Jr.

Thermoradiotherapy and Thermochemotherapy Volume 1:

Biology, Physiology, and Physics Volume 2:

Clinical Applications

Edited by M.H. Seegenschmiedt, P. Fessenden, and C.C. Vernon Carcinoma of the Prostate Innovations in Management Edited by Z. Petrovich, L. Baert, and L.W. Brady

Radiation Oncology of Gynecological Cancers Edited by H.W. Vahrson Carcinoma of the Bladder Innovations in Management Edited by Z. Petrovich, L. Baert, and L.W. Brady

Blood Perfusion and

Microenvironment of Human Tumors Implications for

Clinical Radiooncology

Edited by M. Molls and P. Vaupel Radiation Therapy of Benign Diseases A Clinical Guide

2nd Revised Edition

S. E. Order and S. S. Donaldson Carcinoma of the Kidney and Testis, and Rare Urologic Malignancies Innovations in Management Edited by Z. Petrovich, L. Baert, and L.W. Brady

Progress and Perspectives in the Treatment of Lung Cancer Edited by P. Van Houtte, J. Klastersky, and P. Rocmans Combined Modality Therapy of Central Nervous System Tumors Edited by Z. Petrovich, L. W. Brady, M. L. Apuzzo, and M. Bamberg Age-Related Macular Degeneration Current Treatment Concepts Edited by W. A. Alberti, G. Richard, and R. H. Sagerman

Radiotherapy of Intraocular and Orbital Tumors 2nd Revised Edition Edited by R. H. Sagerman, and W. E. Alberti

Modifi cation of Radiation Response Cytokines, Growth Factors, and Other Biolgical Targets Edited by C. Nieder, L. Milas, and K. K. Ang

Radiation Oncology for Cure and Palliation R. G. Parker, N. A. Janjan,

and M. T. Selch

Clinical Target Volumes in Conformal and Intensity Modulated Radiation Therapy A Clinical Guide to Cancer Treatment Edited by V. Grégoire, P. Scalliet, and K. K. Ang

Advances in Radiation Oncology in Lung Cancer

Edited by Branislav Jeremi´c New Technologies in Radiation Oncology Edited by W. Schlegel, T. Bortfeld, and A.-L. Grosu

Technical Basis of Radiation Therapy Practical Clinical Applications 4th Revised Edition

Edited by S. H. Levitt, J. A. Purdy, C. A. Perez, and S. Vijayakumar Multimodal Concepts for Integration of Cytotoxic Drugs

Edited by J. M. Brown, M. P. Mehta, and C. Nieder

123

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350 Subject Index

M e d i c a l R ad i o l o g y Diagnostic Imaging and Radiation Oncology

Titles in the series already published

D i ag n o st i c Im ag i n g

Innovations in Diagnostic Imaging Edited by J. H. Anderson Radiology of the Upper Urinary Tract Edited by E. K. Lang

The Thymus - Diagnostic Imaging, Functions, and Pathologic Anatomy Edited by E. Walter, E. Willich, and W. R. Webb

Interventional Neuroradiology Edited by A. Valavanis Radiology of the Pancreas Edited by A. L. Baert, co-edited by G. Delorme Radiology of the Lower Urinary Tract Edited by E. K. Lang

Magnetic Resonance Angiography Edited by I. P. Arlart, G. M. Bongartz, and G. Marchal

Contrast-Enhanced MRI of the Breast S. Heywang-Köbrunner and R. Beck Spiral CT of the Chest

Edited by M. Rémy-Jardin and J. Rémy Radiological Diagnosis of Breast Diseases Edited by M. Friedrich

and E.A. Sickles Radiology of the Trauma

Edited by M. Heller and A. Fink Biliary Tract Radiology

Edited by P. Rossi, co-edited by M. Brezi

Radiological Imaging of Sports Injuries Edited by C. Masciocchi

Modern Imaging of the Alimentary Tube Edited by A. R. Margulis

Diagnosis and Therapy of Spinal Tumors Edited by P. R. Algra, J. Valk, and J. J. Heimans

Interventional Magnetic Resonance Imaging

Edited by J.F. Debatin and G. Adam Abdominal and Pelvic MRI

Edited by A. Heuck and M. Reiser

Radiology of Blunt Trauma of the Chest P. Schnyder and M. Wintermark Portal Hypertension

Diagnostic Imaging-Guided Therapy Edited by P. Rossi

Co-edited by P. Ricci and L. Broglia Recent Advances in

Diagnostic Neuroradiology Edited by Ph. Demaerel Virtual Endoscopy

and Related 3D Techniques Edited by P. Rogalla, J. Terwisscha Van Scheltinga, and B. Hamm Multislice CT

Edited by M. F. Reiser, M. Takahashi, M. Modic, and R. Bruening

Pediatric Uroradiology Edited by R. Fotter

Transfontanellar Doppler Imaging in Neonates

A. Couture and C. Veyrac Radiology of AIDS

A Practical Approach Edited by J.W.A.J. Reeders and P.C. Goodman CT of the Peritoneum

Armando Rossi and Giorgio Rossi Magnetic Resonance Angiography 2nd Revised Edition

Edited by I. P. Arlart,

G. M. Bongratz, and G. Marchal Pediatric Chest Imaging

Edited by Javier Lucaya and Janet L. Strife Applications of Sonography in Head and Neck Pathology Edited by J. N. Bruneton in collaboration with C. Raffaelli and O. Dassonville

Imaging of the Larynx Edited by R. Hermans 3D Image Processing

Techniques and Clinical Applications Edited by D. Caramella

and C. Bartolozzi Imaging of Orbital and Visual Pathway Pathology Edited by W. S. Müller-Forell Orthopedic Imaging

Techniques and Applications Edited by A. M. Davies and H. Pettersson Radiology of the Female Pelvic Organs Edited by E. K.Lang

Magnetic Resonance of the Heart and Great Vessels

Clinical Applications

Edited by J. Bogaert, A.J. Duerinckx, and F. E. Rademakers

Modern Head and Neck Imaging Edited by S. K. Mukherji and J. A. Castelijns Radiological Imaging of Endocrine Diseases Edited by J. N. Bruneton

in collaboration with B. Padovani and M.-Y. Mourou

Trends in Contrast Media Edited by H. S. Thomsen, R. N. Muller, and R. F. Mattrey Functional MRI

Edited by C. T. W. Moonen and P. A. Bandettini Radiology of the Pancreas 2nd Revised Edition Edited by A. L. Baert Co-edited by G. Delorme and L. Van Hoe

Emergency Pediatric Radiology Edited by H. Carty Spiral CT of the Abdomen

Edited by F. Terrier, M. Grossholz, and C. D. Becker

Liver Malignancies Diagnostic and Interventional Radiology Edited by C. Bartolozzi and R. Lencioni

Medical Imaging of the Spleen Edited by A. M. De Schepper and F. Vanhoenacker

Radiology of Peripheral Vascular Diseases Edited by E. Zeitler

Diagnostic Nuclear Medicine Edited by C. Schiepers

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Subject Index 351

123

M e d i c a l R ad i o l o g y Diagnostic Imaging and Radiation Oncology

Titles in the series already published

Pediatric ENT Radiology Edited by S. J. King and A. E. Boothroyd Radiological Imaging of the Small Intestine

Edited by N. C. Gourtsoyiannis Imaging of the Knee

Techniques and Applications Edited by A. M. Davies and V. N. Cassar-Pullicino Perinatal Imaging

From Ultrasound to MR Imaging Edited by Fred E. Avni

Radiological Imaging of the Neonatal Chest Edited by V. Donoghue

Diagnostic and Interventional Radiology in Liver Transplantation Edited by E. Bücheler, V. Nicolas, C. E. Broelsch, X. Rogiers, and G. Krupski

Radiology of Osteoporosis Edited by S. Grampp Imaging Pelvic Floor Disorders Edited by C. I. Bartram and J. O. L. DeLancey

Associate Editors: S. Halligan, F. M. Kelvin, and J. Stoker Imaging of the Pancreas Cystic and Rare Tumors Edited by C. Procacci and A. J. Megibow High Resolution Sonography of the Peripheral Nervous System Edited by S. Peer and G. Bodner Imaging of the Foot and Ankle Techniques and Applications Edited by A. M. Davies, R. W. Whitehouse, and J. P. R. Jenkins

Radiology Imaging of the Ureter Edited by F. Joffre, Ph. Otal, and M. Soulie

Imaging of the Shoulder Techniques and Applications Edited by A. M. Davies and J. Hodler Radiology of the Petrous Bone Edited by M. Lemmerling and S. S. Kollias

Interventional Radiology in Cancer Edited by A. Adam, R. F. Dondelinger, and P. R. Mueller

Duplex and Color Doppler Imaging of the Venous System

Edited by G. H. Mostbeck Multidetector-Row CT of the Thorax Edited by U. J. Schoepf Functional Imaging of the Chest Edited by H.-U. Kauczor Radiology of the Pharynx and the Esophagus Edited by O. Ekberg Radiological Imaging in Hematological Malignancies Edited by A. Guermazi Imaging and Intervention in Abdominal Trauma

Edited by R. F. Dondelinger Multislice CT

2nd Revised Edition

Edited by M. F. Reiser, M. Takahashi, M. Modic, and C. R. Becker

Intracranial Vascular Malformations and Aneurysms

From Diagnostic Work-Up to Endovascular Therapy Edited by M. Forsting Radiology and Imaing of the Colon Edited by A. H. Chapman Coronary Radiology Edited by M. Oudkerk

Dynamic Contrast-Enhanced Magnetic Resonance Imaging in Oncology Edited by A. Jackson, D. L. Buckley, and G. J. M. Parker

Imaging in Treatment Planning for Sinonasal Diseases

Edited by R. Maroldi and P. Nicolai Clinical Cardiac MRI

With Interactive CD-ROM Edited by J. Bogaert,

S. Dymarkowski, and A. M. Taylor Focal Liver Lesions

Detection, Characterization, Ablation

Edited by R. Lencioni, D. Cioni, and C. Bartolozzi

Multidetector-Row CT Angiography Edited by C. Catalano and R. Passariello

Paediatric Musculoskeletal Diseases With an Emphasis on Ultrasound Edited by D. Wilson

Contrast Media in Ultrasonography Basic Principles and Clinical Applications Edited by Emilio Quaia

MR Imaging in White Matter Diseases of the Brain and Spinal Cord

Edited by M. Filippi, N. De Stefano, V. Dousset, and J. C. McGowan Diagnostic Nuclear Medicine 2nd Revised Edition Edited by C. Schiepers Imaging of the Kidney Cancer Edited by A. Guermazi Magnetic Resonance Imaging in Ischemic Stroke

Edited by R. von Kummer and T. Back Imaging of the Hip & Bony Pelvis

Techniques and Applications

Edited by A. M. Davies, K. J. Johnson, and R. W. Whitehouse

Imaging of Occupational and Environmental Disorders of the Chest Edited by P. A. Gevenois and P. De Vuyst

Contrast Media

Safety Issues and ESUR Guidelines Edited by H. S. Thomsen Virtual Colonoscopy A Practical Guide

Edited by P. Lefere and S. Gryspeerdt Vascular Embolotherapy

A Comprehensive Approach Volume 1

Edited by J. Golzarian. Co-edited by S. Sun and M. J. Sharafuddin Vascular Embolotherapy A Comprehensive Approach Volume 2

Edited by J. Golzarian. Co-edited by S. Sun and M. J. Sharafuddin

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Louros”, president of the Greek National Ethics Council (1993), honorary president of the International Society of Humanistic Neo-Hippocratic Medicine (1993), vice president

As a result of the physics of brachytherapy, the dose falls off rapidly away from the source dwell positions, decreasing normal tissue exposure to radiation, potentially

Large tertiary or quarternary centers might have multiple divisions in the Department (e.g., Emergency Medicine Division, Critical Care Medicine Division, Hospitalist

Clinical Professor, Department of Radiology, Co-Director of Nuclear Cardiology, Division of Nuclear Medicine, Duke University Medical Center, Durham, NC, USA.

Assistant Professor on Radiation Oncology Department of Radiation Oncology Loyola University Medical Center Cardinal Bernardin Cancer Center 2160 S 1st Avenue. Maywood, IL