Subject Index

(1)

Subject Index 513

Subject Index

CMYK

3D 78, 80, 84–86, 88–90, 93, 97, 99, 101, 102, 304, 355, 357, 358, 378, 379, 424, 428, 431, 435–437, 439, 443

4D 102–105, 435, 437, 438, 440, 443

A

Acceleration 69, 208, 281, 282, 339, 415 ACE 130, 131

Akt 5, 6, 9

Anemia 149, 339–344, 346, 347, 353, 375, 383, 388 Angiogenesis 13–23, 161, 162, 201, 384, 414, 453–455 Anorexia 150, 248, 250, 271, 498

Apoptosis 14, 21, 22, 40, 61, 62, 129, 158, 159, 161–163, 384, 414, 417, 453–455, 482, 484, 485

B

Bcl-2 4, 5, 8, 9, 150, 159, 385, 414, 455 BED 387, 441, 443

BEV 85, 86, 88

Biopsy 31, 34, 36–40, 48, 50, 61, 112, 225, 227, 229, 230, 235, 237–240, 242, 255, 260, 323, 328, 340, 467, 487

Brachytherapy 269–273, 297, 298, 304, 305, 325, 389, 404, 406, 407, 509

Brain toxicity 383, 386, 387

Bronchial stump recurrence 298–301

C

CALGB 139, 143, 195, 209, 210, 224–229, 232–234, 453, 454, 486

Carbon ions 478, 479

Carboplatin 19, 21, 126, 128, 136–141, 143, 146, 148, 157–159, 163, 183, 196, 211, 212, 214–217, 227, 229, 239, 240, 242, 260, 278, 279, 281, 313–315, 317, 341, 342, 344, 357, 376, 378, 380, 450, 452, 464, 478, 497

Carcinogenesis 4, 6, 7, 40, 162, 201 Cardiotoxicity 358, 360

CAV 148–150, 316, 341 Cell kill 159, 174, 207, 211, 213 Chemoradiation, concurrent 452, 482 Chemotherapy

8, 9, 13, 15, 19–22, 50, 55, 61, 69–73, 89, 99, 101, 106, 111–113, 115–120, 123, 124, 126–128, 132, 135, 137–147, 149, 150, 155–157, 159–161, 163, 182, 183, 191, 196, 207–217, 223–227, 229, 230, 232–243, 247, 252, 253, 260–262, 265, 266, 272, 278–283, 287, 288, 290–292, 297–300, 302, 304, 305, 310, 312, 314–317, 340–348, 356, 359, 368, 373, 374, 376–380, 387, 388, 390, 395, 396, 398, 402, 403, 413, 415, 416, 418, 423, 424, 432, 447–453, 456, 457, 464–466, 469, 475, 478, 482, 483, 487, 488, 490, 496–500, 502, 505, 506, 509, 511, 512

– induction 20, 69, 71, 72, 99, 113, 117, 119, 126, 155, 159, 182,

209, 210, 211, 213, 215–217, 226, 227, 229, 230, 233–240, 24, 243, 266, 278, 282, 283, 312, 345, 356, 376, 380, 403, 415, 416, 450, 451, 466, 475, 478

– preoperative 196, 218, 225,234, 236, 239

Cisplatin 9, 19, 23, 70–73, 111, 112, 115–117, 123, 126–128, 136–141, 143, 145–149, 158, 160, 209–216, 225–227, 229, 233, 235–240, 242, 252, 260, 266, 278–283, 313, 314, 316, 340–342, 344–347, 356, 371, 376, 390, 415, 424, 452, 457, 475, 482, 497, 505, 511

c-Kit 5, 6, 9, 19, 150 CODE 149

Comorbidity 51, 169, 173, 180, 240, 347, 463 Consolidation chemotherapy 214, 215, 238, 345 Continuous infusion 17, 225, 226, 340, 341, 487

Cough 47, 112, 248, 251, 269–271, 273, 277, 303, 330, 331, 351, 352, 397, 398, 404–406, 442

COX-2 5, 8, 128, 129, 162, 163, 452, 454, 457 Cryotherapy 200–203, 327

Cyclophosphamide 72, 115–117, 137, 147, 148, 210, 225, 235, 278–281, 315, 316, 341, 344, 356

Cytokines 354, 356, 384, 385, 481, 488, 489

D DF 61–63

DNA 3, 4, 6–8, 64, 123, 124, 126, 155, 157–159, 161, 340, 379, 448, 449, 453, 456, 467, 481, 484

Docetaxel 20, 136, 138–142, 150, 157, 159, 209, 214, 239, 242, 341, 342, 449, 497

Dose response 136, 173, 255, 272, 290, 301, 469, 490 Doxorubicin 72, 115, 137, 149, 225, 278–281, 315, 316, 356 DRR 79, 84, 88, 114

DVH 86, 89, 102, 355, 358

Dyspnea 47, 150, 182, 201, 248, 250, 277, 303, 321, 322, 327–

330, 352, 357, 396

E

EGFR 5, 6, 9, 20, 144, 145, 161, 452, 453, 455, 457, 491 Elderly 54, 143, 147, 149, 169, 170, 171, 179, 180, 309–317, 340,

342, 347 ENI 85, 101, 102

EORTC 140, 239, 240, 242, 289, 343, 346, 375, 386, 387, 395, 397, 398, 401, 403–407, 486

EP 148, 149, 225, 227, 229, 235 Erythropoietin 163, 390, 340, 346

Etoposide 19, 71–73, 112, 126, 128, 136–138, 145–150, 158, 160, 212–215, 225, 227, 229, 235, 237, 238, 278–283, 313–317, 341, 342, 344

EUS-NA 36

(2)

514 Subject Index

F

FEV1 51, 353, 476, 479

G

Gating, respiratory 104, 197, 357, 431, 437, 468, 469 Gemcitabine 19, 128, 136–141, 143, 150, 157–159, 163, 209,

211, 233, 239, 240, 341, 342, 345, 371, 376, 390, 449, 497 Gene 4, 6, 7–9, 14, 28, 59, 60, 131, 144, 161, 232, 277, 384, 413,

414, 453, 487, 491

Growth factors 4–6, 14, 18, 21, 129, 132, 156, 162, 339, 346, 347, 384, 389

– signals 3, 5, 6

GTV 79, 81–85, 87, 89, 90, 91, 97, 98, 101, 103, 112, 124, 424–

429, 432, 435–437, 440, 441, 443, 469

H

Hemoptysis 19, 47, 192, 201, 248, 269–272, 303, 321, 322, 331, 332

Her2/Neu 5, 6, 9

Hyperfractionation 68, 215, 229, 230, 281, 282, 343, 368, 415 Hypofractionation 68, 402, 442

I

Ifosfamide 137, 139, 140, 142, 146, 147, 210, 229, 235, 497 IGF 5, 6, 389

Immobilization 70, 78, 82, 442

IMRT 70, 74, 88, 347, 357, 358, 370, 371, 379, 423–432, 440 IOERT 255–263, 265–267

Irradiation, prophylactic cranial 71, 111, 228–231, 278, 281, 287, 314, 316,

383, 403, 404, 424, 506, 508

Irinotecan 19, 136, 138, 139, 148, 209, 279, 456 ITV 97, 102, 103, 104

K KGF 130

L

Lobectomy 51–55, 176, 192, 195, 241, 2651, 311, 415, 505

M

Mediastinoscopy 37–40, 50, 100, 229, 230, 232–234 Meta-analysis 5, 8, 34, 36, 38, 50, 71, 106, 145, 191, 192, 214,

252, 278, 280, 288– 292, 314, 359, 360, 497, 507, 508 Mitomycin 140, 141, 146, 210, 213, 225, 226, 235–237, 240,

260, 340, 345, 356, 475 MLC 85, 423, 429, 430 MN 60–63

Motion, respiratory 82, 97, 104, 357, 437, 438, 4490, 442, 468, 476

MVD 15, 16, 18, 52

MVP 225, 226, 236, 237, 260, 261 Myc 5, 6, 7, 9, 277, 417

Myelotoxicity 340, 341, 343, 483

N

Neutrons 124, 473–475, 479

Neutropenia 214, 279, 313, 340–344, 346, 483, 486, 487

Non-small cell lung cancer, early stage 23, 169, 170, 173, 179–183, 311, 435

– locally advanced 182, 207–211, 214–217, 310, 312, 313, 380, 481

NSCLC 5–9, 13, 15–17, 19–23, 31–33, 38, 39, 62, 63, 67–69, 71, 77, 80–82, 91, 97, 98, 100–102, 105, 106, 116, 119, 123, 126–

128, 130, 135–147, 157, 158, 163, 170, 189, 190, 191–196, 206, 208, 214, 223, 231, 233, 235–240, 242, 243, 247, 248, 250–253, 255, 256, 258, 259, 266, 267, 297, 305, 310, 341, 342, 344, 345, 376, 378, 387, 388, 401, 403, 405, 406, 412, 415–417, 424, 428, 432, 435, 436, 441–443, 447, 448, 450, 456, 461–469, 475, 476, 478, 481, 482, 485–487, 490, 491, 497, 499, 505–507, 509, 511 NTCP 77, 89, 101, 124

P

p53 5, 7, 8, 40, 144, 157, 159, 232, 277

Paclitaxel 19, 21, 112, 126, 128, 136–143, 146, 157, 159, 160, 163, 196, 209, 211, 214, 215–217, 227, 239, 240, 242, 279, 341, 342, 345, 357, 360, 378, 380, 390, 449, 450, 452, 481–487, 490, 497, 498

Pain 22, 47, 55, 68, 112, 192, 241, 248, 251, 252, 271, 303, 352, 368, 373–375, 396–399, 401, 404–406, 414, 441, 442 PDGF 14, 15, 20, 354, 454, 488

PDT 200–202, 326, 327

Performance status 139, 142, 143, 179, 182, 183, 209, 210, 238, 240, 249, 250, 252, 260, 264, 300, 302, 303, 309, 311, 312, 315, 329

PET 37, 39, 41, 48–50, 63, 80–82, 98, 100, 101, 106, 195, 199, 201, 232, 242, 357, 386, 395, 428, 461–469, 476, 485 PGE2 128, 129

Photofrin 200, 202, 327

Pleural efﬁ sion 31, 32, 35, 38, 39, 48, 54, 207, 277, 328–330, 341, 413, 416

Pneumonectomy 51–54, 169, 191, 192, 224, 236, 238, 241, 242, 256, 258, 298, 415, 505

PORT 105, 106, 116, 189–196, 507 Protons 124, 370, 456, 474–476, 478

PTV 79–87, 90, 91, 97, 98, 101, 103, 112, 424–429, 432, 435–

437, 440, 441, 443, 469

Q

Quality of life 31, 39, 124, 135, 138, 143, 147, 169, 181–183, 192, 199, 202, 243, 248, 251, 270, 287, 292, 315, 321, 322, 341, 342, 347, 376, 388, 390, 395–399, 402, 404, 413, 414, 417, 495, 496, 498, 501, 506, 509, 511

R

Radiation myelopathy 251, 303, 367–371

– pneumonitis 59, 60, 64, 89, 115, 131, 180, 192, 195, 241, 242, 251, 303, 360, 424, 425, 428, 465, 476, 478, 481, 487–490 – therapy 21, 55, 60, 63, 64, 67–73, 77, 78, 88, 90, 123, 124, 126,

128, 147, 160, 169–176, 178–183, 189, 197, 207–217, 223, 237, 241, 243, 260, 261, 266, 278–283, 287, 290, 297–305, 310–317, 351–353, 357, 358, 370, 371, 375–377, 379, 380, 423, 424, 450, 465, 466, 468, 473–475, 479, 481, 482, 487

Radiochemotherapy, concurrent 182, 209, 211, 213–217, 312, 313

Radionecrosis 386, 387, 389, 390 Radioprotection 125, 127, 129–132

Radiosensitivity 59, 60, 63, 64, 67, 157, 163, 369, 449, 454, 455

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Subject Index 515

CMYK

Radiosurgery 182, 216, 217, 383, 386 Radiotherapy

8, 13, 15, 20, 22, 23, 55, 60, 63, 64, 72, 77, 78, 97, 98, 100–102, 105, 106, 111, 112, 113, 115–119, 123–132, 135, 145, 146, 163, 176, 182, 183, 189–197, 208, 212, 213, 215–217, 223–227, 229, 230, 235–238, 240–243, 247–251, 253, 255, 257–261, 266, 269–273, 277, 281, 287, 291, 292, 310, 312–314, 325, 339, 341–

348, 353, 358, 359, 374–378, 380, 383–390, 396, 398, 401–406, 414, 416, 418, 424, 435–440, 443, 444, 447–457, 461–469, 474, 478, 479, 481, 485–487, 490, 498, 499

– conformal 78, 97, 176, 242, 378, 435, 466 – gated 105, 435, 439, 440, 443 – intraluminal 269, 271, 273

– palliative 208, 247–249, 251–253, 272, 314, 403–406, 509 – preoperative 55, 224, 226, 236, 260

– stereotactic 78

– tumor-tracking 105, 437, 438, 440 Rb 5–7, 40, 277

Reason for not undergoing surgery 171, 181

Recurrence 10, 40, 50, 52–54, 62, 63, 71, 101, 105, 106, 111, 116–118 , 145, 146, 174–176, 178, 181, 189–191, 194–196, 199, 228, 231, 243, 255, 258–260, 262, 265, 278, 280, 282, 283, 297, 298–305, 311, 324, 329, 414, 415, 418, 443

Re-irradiation 303, 304, 384

Relapse 21, 62, 130, 142, 147, 149, 150, 175, 179, 182, 183, 192, 214, 223, 224, 228, 230, 231, 233, 235, 238, 255, 259, 262, 265–257, 270, 273, 283, 287, 288, 290, 299, 310, 313, 386, 441, 443, 473, 486

Resection 31, 36, 39, 40, 47, 48, 50–55, 105, 135, 145, 146, 178, 189, 192, 195, 196, 200–202, 217, 223–233, 235–243, 255, 257, 259–262, 264, 266, 302, 303, 305, 321, 327, 330–332, 383, 387, 390, 412–416, 418, 463, 487, 509

RNA 3, 18, 379, 489

RTOG 68, 69, 71–73, 77, 90, 101, 126, 131, 159, 163, 194, 196, 237, 238, 255, 266, 267, 290, 292, 345, 347, 352, 374–378, 380, 386, 387, 455, 482

S

SCLC 5–9, 13, 15, 16, 19–22, 67, 71–73, 135, 147–149, 153, 158, 277, 279, 287, 288, 291, 310, 342–344, 346, 347, 383, 387, 388, 403, 417, 423, 424, 432, 506, 508, 509, 511

Segmentectomy 51, 52, 195, 201, 261

Simulation 79, 82, 83, 85, 114, 117, 258, 436, 437, 475 Small-cell lung cancer, extensive disease 279, 283, 304, 317 Small-cell lung cancer, limited disease 277–283, 314–316 Small-cell lung cancer, limited stage 111, 280–282 SOD 131

SPECT 353, 355, 356, 359, 386, 387, 467

Staging 31–40, 48–50, 55, 67, 100, 106, 112, 116, 119, 169–171, 173, 174, 176–178, 183, 199, 201–203, 207, 208, 217, 224, 225, 232–234, 260, 304, 332, 395, 412, 461–464, 466–469 Stent 199, 200, 321, 322, 324, 325, 328

Superior sulcus tumors 47, 55, 260, 261

Surgery 15, 34, 36–38, 43, 48, 49, 51, 53, 54, 62, 81, 101, 145–

147, 169–171, 176, 178, 181, 189, 190, 194–196, 199–202, 208, 223–243, 257–262, 266, 297, 298, 301, 302, 310, 311, 329, 331, 332, 341, 388, 415, 462–466, 478, 496–499, 505, 506, 509 SUV 64, 81, 82, 465–467

SWOG 115, 138, 145, 146, 227–229, 231–234, 453, 454 Symptom palliation 247, 250, 323, 401

T

Target volume 70, 77–85, 88, 93, 97, 99, 102, 105, 106, 112, 118–120, 176, 193, 194, 216, 242, 358, 378, 383, 389, 427, 435, 436, 461, 463, 466

TBNA 36

Telomerase 4, 5, 8, 9

TGF 60, 354–357, 452, 454, 488–490

Thoractotomy 50, 53–55, 224, 227, 230, 233, 238–240, 256, 258, 415, 463, 466

Thrombocytopenia 20, 136, 139, 140, 146, 149, 240, 313, 315, 316, 340, 341, 343–345, 486, 489

Tirapazamine 137, 157, 160, 450

TNF 14, 15, 20, 23, 128, 130, 354, 384, 385, 389, 488 Topotecan 112, 149, 150, 209, 279, 281, 456 Toxicity

– bone marrow 343, 345–348, 483 – CNS 383, 385, 390

– esophagus 69, 126, 127, 377, 378 – haematological 137, 142, 143, 148

– lung 69, 77, 89, 101, 180, 278, 351, 354–357, 360 Tpot 61–63

Trial, clinical 116, 124, 127, 130, 131, 137, 139–141, 143, 145, 146, 148, 150, 163, 243, 256, 259, 342, 360, 370, 399, 403, 415, 436, 476, 484, 485, 506

TTNA 36

Tumor hypoxia 15, 129, 157, 159, 160, 163, 450 – motion 70, 82, 83, 438

– volume 70, 71, 79–81, 84, 85, 97–99, 111, 112, 117–119, 225, 379, 436, 440, 450, 455, 476

V

V20 69, 70, 89–91, 101, 113, 118, 194, 241, 355, 424, 426 VATS 38, 39, 54, 55

VEGF 5, 8, 10, 14–20, 22, 144, 161, 162, 386, 454 VEGFR 19, 20, 162

Vinblastine 137, 141, 146, 209–211, 225–227, 229, 233, 235–

237, 266, 344, 356, 371, 376, 475

Vincristine 71, 72, 115, 117, 147–149, 278–281, 315, 316, 341 Vindesine 136–138, 145, 146, 208, 210, 213, 225, 229, 235, 260,

344, 345, 356

Vinorelbine 136–140, 142, 143, 146, 150, 157, 209, 211, 242, 341, 342, 345, 497

(4)

List of Contributors 517

List of Contributors

Neil K. Aaronson, PhD

Division of Psychosocial Research and Epidemiology The Netherlands Cancer Institute

Plesmanlaan 121 1066 CX Amsterdam The Netherlands Kathy S. Albain, MD

Loyola University Medical Center Cardinal Bernardin Cancer Center Department of Medical Oncology 2160 s 1st Avenue, Room 109 Maywood, IL 60153 USA

Mitchell Anscher, MD Department of Radiation Oncology Duke University Medical Center PO Box 3085

Durham, NC 27710 USA

Javier Aristu, MD, PhD Department of Oncology Clinica Universitaria Avenida Pio XII s/n 31008 Pamplona Spain

Leire Arbea, MD Department of Oncology Clinica Universitaria Avenida Pio XII s/n 31008 Pamplona Spain

Michael Bamberg, MD Professor and Director

Department of Radiation Oncology University Hospital

Hoppe-Seyler-Str. 3 72076 Tübingen Germany

Philip V. Barber, MD

Department of Clinical Oncology Christie Hospital NHS Trust Wilmslow Road

Withington

Manchester, M20 4BX UK

Chandra P. Belani, MD Professor of Medicine

University of Pittsburgh School of Medicine Co-Director, Lung and Thoracic Cancer Program University of Pittsburgh Cancer Institute UPMC Cancer Pavillion

5150 Centre Avenue, 5th Floor Pittsburgh, PA 15232 USA

A. William Blackstock, MD

Department of Radiation Oncology / Radiation Biology Comprehensive Cancer Center of Wake Forest University Winston Salem, NC 27157

USA

James A. Bonner, MD

Merle M. Salter Professor and Chairman The University of Alabama at Birmingham Department of Radiation Oncology Wallace Tumor Institute - Suite 105 1824 6th Avenue, South

Birmingham, AL 35233 USA

Paul A. Burt, MD

Department of Clinical Oncology Christie Hospital NHS Trust Wilmslow Road, Withington Manchester, M20 4BX UK

David Bush, MD Associate Professor

Department of Radiation Medicine Loma Linda University Medical Center 11234 Anderson Street

Loma Linda, CA 92354 USA

Felipe A. Calvo, MD, PhD Professor, Department of Oncology University Hospital Gregorio Marañón DR Esquerdo 46

Madrid, 28007 Spain

Francesc Casas, MD

Department of Radiation Oncology Hospital Clinic i Universitari de Barcelona Villarroel 170

08036 Barcelona Spain

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518 List of Contributors

CMYK

Marie Chaltin, MD Department of Radiotherapy Ghent University Hospital De Pintelaan 185 9000 Ghent Belgium

Joe Chang, MD, PhD

Department of Radiation Oncology The University of Texas

M. D. Anderson Cancer Center 1515 Holcombe Boulevard, Box 96 Houston, TX 77030-4009

USA

Yuhchyau Chen, PhD, MD Associate Professor

Department of Radiation Oncology University of Rochester School of Medicine 601 Elmwood Avenue, Box 647

Rochester, NY 14642 USA

L. Chinsoo Cho, MD Associate Professor

Department of Radiation Oncology University of Texas

Southwestern Medical Center at Dallas 5801 Forest Park

Dallas, TX 75390 USA

Hak Choy, MD Professor and Chairman

Department of Radiation Oncology University of Texas

Southwestern Medical Center at Dallas 5801 Forest Park

Dallas, TX 75390 USA

James D. Cox, MD Professor and Chairman

USA

Aleksandar Dagovi ´c, MD, MSc Department of Oncology University Hospital Zmaj Jovina 30 34000 Kragujevac Serbia

Werner De Gersem, Ir Department of Radiotherapy Ghent University Hospital De Pintelaan 185 9000 Ghent Belgium

Wilfried De Neve, MD, PhD Professor, Department of Radiotherapy Ghent University Hospital

De Pintelaan 185 9000 Ghent Belgium

Masaharu Fujino, MD Department of Radiology

Hokkaido University School of Medicine North-15 West-7, Kita-ku

Sapporo, 060-8638 Japan

Susan M. Galbraith, MD Medical Director

Clinical Discovery Bristol-Myers Squibb

Pharmaceutical Research Institute Princeton, NJ 08543-4000 USA

Sidhu P. Gangadharan, MD Chief Resident in Thoracic Surgery Brigham & Women‘s Hospital 75 Francis Street

Boston, MA 02115-6195 USA

Yolanda Garces, MD Mayo Clinic

Department of Radiation Oncology Charlton Building

200 1st Street, S.W.

Rochester, MN 55905 USA

Anca Ligia Grosu, MD

Department of Radiation Oncology Klinikum rechts der Isar

Technische Universität München Ismaninger Str. 22

81675 München Germany

Stephen M. Hahn, MD

Associate Professor, Department of Radiation Oncology University of Pennsylvania

School of Medicine 3400 Spruce Street 2 Donner

Philadelphia, PA 19104 USA

Masaki Hara, MD, PhD Associate Professor Department of Radiology Nagoya City University

Graduate School of Medical Sciences 1 Kawasumi, Mizuho-cho, Mizuho-ku Nagoya, 467-8601

Japan

(6)

Jeffrey C. Haynes, BA, MD Department of Radiation Oncology

The University of Pennsylvania Medical Center 3400 Spruce Street

2 Donner

Philadelphia PA 19104-4174 USA

Rodney J. Hicks, MB, BS (Hons), MD, FRACP Associate Professor of Medicine and Radiology The University of Melbourne

Director, Centre for Molecular Imaging Head, Nuclear Medicine and P.E.T.

The Peter MacCallum Cancer Institute 12 Cathedral Place

East Melbourne, VIC 3002 Australia

Branislav Jeremi ´c, MD, PhD Department of Radiation Oncology Klinikum rechts der Isar

Melenda Jeter, MD, MPH Assistant Professor

Department of Radiation Oncology, Box 97 The University of Texas

M. D. Anderson Cancer Center 1515 Holcombe Boulevard Houston, TX 77030 USA

Ritsuko Komaki, MD, FACR

Professor of Radiation Oncology, Gloria Lupton Tennison Endowed Professor for Lung Cancer Research

USA

Paul A. Kvale, MD Professor of Medicine

Pulmonary and Critical CareMedicine Henry Ford Medical Center

2799 West Grand Boulevard Detroit, MI 48202

USA

Frank J. Lagerwaard, MD Department of Radiation Oncology VU University Medical Center de Boelelaan 1117

1007 MB Amsterdam The Netherlands

Hans Langendijk, MD, PhD Department of Radiation Oncology VU University Medical Center De Boelelaan 1117

Cécile Le Péchoux, MD Institut Gustave Roussy Department of Radiotherapy 39, Rue Camille Deesmoulins 94805 Villejuif

France

Jason Lester, MD Velindre NHS Trust Whitchurch

Cardiff, CF14 2TL, Wales UK

Zhongxing Liao, MD

USA

Philip A. Linden, MD

Instructor in Surgery, Harvard Medical School and Associate Surgeon, Brigham & Women’s Hospital 75 Francis Street

Fergus R. Macbeth, MD, FRCR Velindre NHS Trust Whitchurch Cardiff CF14 2TL, Wales UK

Mitchell Machtay, MD, FACR Associate Professor and Vice-Chair Department of Radiation Oncology Kimmel Cancer Center

Thomas Jefferson University Hospital 111 Sourn 11th Street

Michael P. MacManus, MD

Associate Professor, Department of Radiation Oncology Peter MacCallum Cancer Centre

St Andrew’s Place

East Melbourne, Victoria 3002 Australia

Lawrence B. Marks, MD Associate Professor

Department of Radiation Oncology Duke University Medical Center P.O.Box 3085

Durham, ND 27710 USA

Mary K. Martel, PhD Associate Professor

Department of Radiation and Cellular Oncology University of Chicago Medical Center

5758 C South Maryland Avenue Chicago, IL 60637

USA

(7)

520 Subject Index

CMYKCMYK

Neil E. Martin, MD

Department of Radiation Oncology,

University of Pennsylvania School of Medicine 3400 Spruce St.

2 Donner

K.A. Mason, MSc

USA

W. Gillies McKenna, MD, PhD Chairman and Professor

Department of Radiation Oncology

University of Pennsylvania School of Medicine 3400 Spruce Street

2 Donner

Philadelphia, PA 19104-4274 USA

Kevin P. McMullen, MD Department of Radiation Oncology

Comprehensive Cancer Center of Wake Forest University Winston Salem, North Carolina 27157

USA

Luka Milas, MD, PhD

Department of Experimental Radiation Oncolog The University of Texas

M.D. Anderson Cancer Center 1515 Holcombe Boulevard, Box 66 Houston, TX 77030-4009

USA

Keith Miller, MD

Department of Radiation Oncology Duke University Medical Center PO Box 3085

Nena Mirkovic, MD

Assistant Professor on Radiation Oncology Department of Radiation Oncology Loyola University Medical Center Cardinal Bernardin Cancer Center 2160 S 1st Avenue

Maywood, IL 60153 USA

Michael Molls, MD Professor and Chairman

Carsten Nieder, MD

Rikiya Onimaru, MD Department of Radiology

Hiroki Onishi, MD Department of Radiology

Yamanashi University School of Medicine Yamanashi, 409-3898

Japan

Robert Prosnitz, MD

Suresh Ramalingam, MD Assistant Professor of Medicine

University of Pittsburgh School of Medicine UPMC Cancer Pavillion

5150 Centre Avenue, 5th Floor Pittsburgh, PA 15232 USA

Timothy E. Schultheiss, PhD, FACR Professor, Beckman Research Institute

Director, Radiation Physics, Radiation Oncology City of Hope Medical Center

1500 East Duarte Road Duarte, CA 91010-3000 USA

Suresh Senan, MRCP,FRCR,PhD Department of Radiation Oncology VU University Medical Center de Boelelaan 1117

Timothy D. Shafman, MD Department of Radiation Oncology Duke University Medical Center PO Box 3085

Wenyin Shi, MD, PhD

Department of Radiation Oncology Shands Cancer Center

University of Florida Gainesville, FL 32610 USA

(8)

Subject Index 521

Yuta Shibamoto, MD, DMSc Professor and Chairman Department of Radiology Nagoya City University

Graduate School of Medical Sciences 1 Kawasumi, Mizuho-cho, Mizuho-ku, Nagoya, 467-8601

Japan

Hiroki Shirato, MD Associate Professor Department of Radiology

Dietmar W. Siemann, PhD

Professor and Associate Chair for Research Department of Radiation Oncology University of Florida

Shands Cancer Center P.O.Box 100385 2000 SW Archer Road Gainsville, FL 32610 USA

Michael J. Simoff, MD Assistant Professor of Medicine Pulmonary and Critical Care Medicine Henry Ford Hospital & Medical Centers 2799 West Grand Boulevard

Detroit, MI 48202-2689 USA

Richard Stephens Research Scientist Cancer Division MRC Clinical Trials Unit 222 Euston Road London, NW1 2DA UK

Ron Stout, MD

Department of Clinical Oncology Christie Hospital NHS Trust Wilmslow Road

Withington

Manchester, M20 4BX UK

David J. Sugarbaker, MD Professor of Surgical Oncology, Harvard Medical School Brigham & Women’s Hospital Department of Thoracic Surgery 75 Francis Street

Tom G. Sutedja, MD

Department of Pulmonary Medicine Vrije Universiteit Medical Center P.O.Box 7057,

Elinor Thompson, MD Iberoamerican Cochrane Centre Hospital de la Santa Creu I Sant Pau Casa de Convalescencia

Sant Antoni M. Claret 171 08041 Barcelona Spain

K. Vandecasteele, MD Department of Radiotherapy Ghent University Hospital De Pintelaan 185 9000 Ghent Belgium

Núria Viñolas, MD

Hospital Clinic i Universitari de Barcelona Department of Medical Oncology Villarroel 170

08036 Barcelona Spain

Zjelko Vujaskovic, MD

Maria Werner-Wasik, MD, FACR Associate Professor

Department of Radiation Oncology

Kimmel Cancer Center of Jefferson Medical College 11 South 11th Street

Xiaoli Yu, MD

Frank B. Zimmermann, MD Department of Radiation Oncology Klinikum rechts der Isar

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Subject Index 523

CMYKCMYK

R ad i at i o n O n c o l o g y

Lung Cancer

Edited by C.W. Scarantino

Innovations in Radiation Oncology Edited by H. R. Withers and L. J. Peters

Radiation Therapy of Head and Neck Cancer Edited by G. E. Laramore

Gastrointestinal Cancer – Radiation Therapy

Edited by R.R. Dobelbower, Jr.

Radiation Exposure and Occupational Risks

Edited by E. Scherer, C. Streffer, and K.-R. Trott

Radiation Therapy of Benign Diseases A Clinical Guide

S. E. Order and S. S. Donaldson

Interventional Radiation

Therapy Techniques – Brachytherapy Edited by R. Sauer

Radiopathology of Organs and Tissues Edited by E. Scherer, C. Streffer, and K.-R. Trott

Concomitant Continuous Infusion Chemotherapy and Radiation Edited by M. Rotman and C. J. Rosenthal

Intraoperative Radiotherapy – Clinical Experiences and Results Edited by F. A. Calvo, M. Santos, and L.W. Brady

Radiotherapy of Intraocular and Orbital Tumors

Edited by W. E. Alberti and R. H. Sagerman

Interstitial and Intracavitary Thermoradiotherapy

Edited by M. H. Seegenschmiedt and R. Sauer

Non-Disseminated Breast Cancer Controversial Issues in Management Edited by G. H. Fletcher and S.H. Levitt

Current Topics in

Clinical Radiobiology of Tumors Edited by H.-P. Beck-Bornholdt Practical Approaches to

Cancer Invasion and Metastases A Compendium of Radiation

Oncologists’ Responses to 40 Histories Edited by A. R. Kagan with the Assistance of R. J. Steckel

Radiation Therapy in Pediatric Oncology Edited by J. R. Cassady

Radiation Therapy Physics Edited by A. R. Smith Late Sequelae in Oncology Edited by J. Dunst and R. Sauer Mediastinal Tumors. Update 1995 Edited by D. E. Wood

and C. R. Thomas, Jr.

Thermoradiotherapy and Thermochemotherapy Volume 1:

Biology, Physiology, and Physics Volume 2:

Clinical Applications

Edited by M.H. Seegenschmiedt, P. Fessenden, and C.C. Vernon Carcinoma of the Prostate Innovations in Management Edited by Z. Petrovich, L. Baert, and L.W. Brady

Radiation Oncology of Gynecological Cancers Edited by H.W. Vahrson Carcinoma of the Bladder Innovations in Management Edited by Z. Petrovich, L. Baert, and L.W. Brady

Blood Perfusion and

Microenvironment of Human Tumors Implications for

Clinical Radiooncology Edited by M. Molls and P. Vaupel

Radiation Therapy of Benign Diseases A Clinical Guide

2nd Revised Edition

S. E. Order and S. S. Donaldson Carcinoma of the Kidney and Testis, and Rare Urologic Malignancies

Innovations in Management Edited by Z. Petrovich, L. Baert, and L.W. Brady

Progress and Perspectives in the Treatment of Lung Cancer Edited by P. Van Houtte, J. Klastersky, and P. Rocmans Combined Modality Therapy of Central Nervous System Tumors Edited by Z. Petrovich, L. W. Brady, M. L. Apuzzo, and M. Bamberg Age-Related Macular Degeneration Current Treatment Concepts Edited by W. A. Alberti, G. Richard, and R. H. Sagerman

Radiotherapy of Intraocular and Orbital Tumors 2nd Revised Edition Edited by R. H. Sagerman, and W. E. Alberti

Modiﬁ cation of Radiation Response Cytokines, Growth Factors, and Other Biolgical Targets Edited by C. Nieder, L. Milas, and K. K. Ang

Radiation Oncology for Cure and Palliation R. G. Parker, N. A. Janjan,

and M. T. Selch Clinical Target Volumes in

Conformal and Intensity Modulated Radiation Therapy

A Clinical Guide to Cancer Treatment

Edited by V. Grégoire, P. Scalliet, and K. K. Ang

Advances in Radiation Oncology in Lung Cancer

Edited by Branislav Jeremi´c

M e d i c a l R ad i o l o g y Diagnostic Imaging and Radiation Oncology

Titles in the series already published

123

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524 Subject Index

D i ag n o st i c Im ag i n g

Innovations in Diagnostic Imaging Edited by J. H. Anderson

Radiology of the Upper Urinary Tract Edited by E. K. Lang

The Thymus - Diagnostic Imaging, Functions, and Pathologic Anatomy Edited by E. Walter, E. Willich, and W. R. Webb

Interventional Neuroradiology Edited by A. Valavanis

Radiology of the Pancreas Edited by A. L. Baert, co-edited by G. Delorme

Radiology of the Lower Urinary Tract Edited by E. K. Lang

Magnetic Resonance Angiography Edited by I. P. Arlart, G. M. Bongartz, and G. Marchal

Contrast-Enhanced MRI of the Breast S. Heywang-Köbrunner and R. Beck Spiral CT of the Chest

Edited by M. Rémy-Jardin and J. Rémy Radiological Diagnosis of Breast Diseases Edited by M. Friedrich

and E.A. Sickles Radiology of the Trauma Edited by M. Heller and A. Fink Biliary Tract Radiology

Edited by P. Rossi, co-edited by M. Brezi

Radiological Imaging of Sports Injuries Edited by C. Masciocchi

Modern Imaging of the Alimentary Tube Edited by A. R. Margulis

Diagnosis and Therapy of Spinal Tumors Edited by P. R. Algra, J. Valk, and J. J. Heimans

Liver Malignancies Diagnostic and

Interventional Radiology Edited by C. Bartolozzi and R. Lencioni

Medical Imaging of the Spleen Edited by A. M. De Schepper and F. Vanhoenacker

Radiology of Peripheral Vascular Diseases Edited by E. Zeitler

Diagnostic Nuclear Medicine Edited by C. Schiepers

Radiology of Blunt Trauma of the Chest P. Schnyder and M. Wintermark Portal Hypertension

Diagnostic Imaging-Guided Therapy Edited by P. Rossi

Co-edited by P. Ricci and L. Broglia Recent Advances in

Diagnostic Neuroradiology Edited by Ph. Demaerel Virtual Endoscopy and Related 3D Techniques

Edited by P. Rogalla, J. Terwisscha Van Scheltinga, and B. Hamm Multislice CT

Edited by M. F. Reiser, M. Takahashi, M. Modic, and R. Bruening

Pediatric Uroradiology Edited by R. Fotter

Transfontanellar Doppler Imaging in Neonates

A. Couture and C. Veyrac Radiology of AIDS A Practical Approach Edited by J.W.A.J. Reeders and P.C. Goodman

CT of the Peritoneum

Armando Rossi and Giorgio Rossi

Magnetic Resonance Angiography 2nd Revised Edition

Edited by I. P. Arlart,

G. M. Bongratz, and G. Marchal Interventional Magnetic

Resonance Imaging

Edited by J.F. Debatin and G. Adam

Abdominal and Pelvic MRI

Edited by A. Heuck and M. Reiser

Orthopedic Imaging

Techniques and Applications Edited by A. M. Davies and H. Pettersson

Radiology of the Female Pelvic Organs Edited by E. K.Lang

Magnetic Resonance of the Heart and Great Vessels

Clinical Applications

Edited by J. Bogaert, A.J. Duerinckx, and F. E. Rademakers

Modern Head and Neck Imaging Edited by S. K. Mukherji and J. A. Castelijns

Radiological Imaging of Endocrine Diseases Edited by J. N. Bruneton

in collaboration with B. Padovani and M.-Y. Mourou

Trends in Contrast Media Edited by H. S. Thomsen, R. N. Muller, and R. F. Mattrey

Functional MRI

Edited by C. T. W. Moonen and P. A. Bandettini

Radiology of the Pancreas 2nd Revised Edition Edited by A. L. Baert Co-edited by G. Delorme and L. Van Hoe

Emergency Pediatric Radiology Edited by H. Carty

Spiral CT of the Abdomen

Edited by F. Terrier, M. Grossholz, and C. D. Becker

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CMYK

Pediatric Chest Imaging Edited by Javier Lucaya and Janet L. Strife

Applications of Sonography in Head and Neck Pathology Edited by J. N. Bruneton in collaboration with C. Raffaelli and O. Dassonville

Imaging of the Larynx Edited by R. Hermans

3D Image Processing Techniques and Clinical Applications Edited by D. Caramella and C. Bartolozzi

Imaging of Orbital and Visual Pathway Pathology Edited by W. S. Müller-Forell

Pediatric ENT Radiology Edited by S. J. King and A. E. Boothroyd

Radiological Imaging of the Small Intestine

Edited by N. C. Gourtsoyiannis

Imaging of the Knee

Techniques and Applications Edited by A. M. Davies and V. N. Cassar-Pullicino

Perinatal Imaging From Ultrasound to MR Imaging Edited by Fred E. Avni

Radiological Imaging of the Neonatal Chest Edited by V. Donoghue

Diagnostic and Interventional Radiology in Liver Transplantation Edited by E. Bücheler, V. Nicolas, C. E. Broelsch, X. Rogiers, and G. Krupski

Radiology of Osteoporosis Edited by S. Grampp

Imaging Pelvic Floor Disorders Edited by C. I. Bartram and J. O. L. DeLancey

Associate Editors: S. Halligan, F. M. Kelvin, and J. Stoker

Imaging of the Pancreas Cystic and Rare Tumors Edited by C. Procacci and A. J. Megibow

High Resolution Sonography of the Peripheral Nervous System Edited by S. Peer and G. Bodner

Imaging of the Foot and Ankle Techniques and Applications Edited by A. M. Davies, R. W. Whitehouse, and J. P. R. Jenkins

Radiology Imaging of the Ureter Edited by F. Joffre, Ph. Otal, and M. Soulie

Imaging of the Shoulder Techniques and Applications Edited by A. M. Davies and J. Hodler

Radiology of the Petrous Bone Edited by M. Lemmerling and S. S. Kollias

Interventional Radiology in Cancer Edited by A. Adam, R. F. Dondelinger, and P. R. Mueller

Duplex and Color Doppler Imaging of the Venous System

Edited by G. H. Mostbeck

Multidetector-Row CT of the Thorax Edited by U. J. Schoepf

Functional Imaging of the Chest Edited by H.-U. Kauczor

Radiology of the Pharynx and the Esophagus Edited by O. Ekberg

Radiological Imaging in Hematological Malignancies Edited by A. Guermazi

Imaging and Intervention in Abdominal Trauma

Edited by R. F. Dondelinger

Multislice CT 2nd Revised Edition

Edited by M. F. Reiser, M. Takahashi, M. Modic, and C. R. Becker

Intracranial Vascular Malformations and Aneurysms

From Diagnostic Work-Up to Endovascular Therapy Edited by M. Forsting

Radiology and Imaing of the Colon Edited by A. H. Chapman

Coronary Radiology Edited by M. Oudkerk

Dynamic Contrast-Enhanced Magnetic Resonance Imaging in Oncology Edited by A. Jackson, D. L. Buckley, and G. J. M. Parker

Imaging in Treatment Planing for Sinonasal Diseases

Edited by R. Maroldi and P. Nicolai

123