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INSIDE TRACK CONFERENCE

MOLECULAR DIAGNOSTICS, GENOMICS AND EPIGENETICS IN CLINICAL ONCOLOGY

25-26 November 2016 Rome, Italy

Chairs:

M.S. Aapro, CH J. Gligorov, FR

WWW.ESO.NET

#MOLDIAconf16

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FOREWORD

The main common feature of cancer cells is their ability to escape to homeostatic regulation mechanisms of living. In a sense giving them immortality, causing in the absence of treatment the death of the

organism, which is their origin. The exponential knowledge of the biology of cancer and the phenomenal capacity of synthesis of new treatments and diagnostic tools have opened up the prospect of a precision medicine in oncology that requires regular and frequent updating of our

knowledge.

This knowledge concerns both the intrinsic prognosis of the disease, as the prediction value of therapeutic approaches that in fact becomes increasingly “personalized”. This conference, organized for several years, aims to take stock of current and future tools that help us optimize the care of patients with cancer.

LEARNING OBJECTIVES

• Update the knowledge of the implications for practice and clinical research (tools to be used, tools still in research, areas where no tools are yet available)

• Understanding epigenetics and genomics research and their impact on cancer prognosis and therapy response (prediction)

CME ACCREDITATION AND CERTIFICATES

Participants will be entitled to receive a certificate of attendance at the close of the Masterclass by completing the online evaluation

questionnaire.

The event has been accredited by the European Accreditation Council for Continuing Medical Education (EACCME) to provide the following CME activity for medical specialists. The EACCME is an institution of the

European Union of Medical Specialists (UEMS). The evaluation of the event has been performed by the Accreditation Council of Oncology in Europe (ACOE) that acknowledged the quality of the scientific programme and its educational value. The event is designated for a maximum of 9 European CME credits (ECMEC). Through an agreement between UEMS and the American Medical Association, physicians may convert EACCME credits to an equivalent number of AMA PRA Category 1 Credits™.

Furthermore, for Italian participants, a maximum of 10 ECM credits have been granted by Commissione Nazionale per la Formazione Continua.

More information can be obtained from the organizing secretariat.

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FACULTY (as of September)

M.S. Aapro

IMO Clinique de Genolier, CH D. Arnold

CUF Hospitals Cancer Center, Lisbon, PT L. Crinò

University of Perugia, Perugia, IT G. Curigliano

European Institute of Oncology, Milan, IT R. Danesi

University of Pisa, Pisa, IT L. Del Mastro

Istituto Nazionale per la Ricerca sul Cancro, Genoa, IT V. Dieras

Institut Curie, Paris, FR E. Felip

Vall d'Hebron University Hospital, Barcelona, ES J. Gligorov

Hopitaux Universitaires Paris Est Tenon, Paris, FR N. Mottet

Hopital Nord, Saint Etienne, FR N. Normanno

INT-Fondazione Pascale, Naples, IT F. Penault-Llorca

Centre Jean Perrin, Clermon-Ferrand, FR J. Remon

Institut Gustave Roussy, Le Plessis Robinson, FR J. Robert

Universitè Bordeaux Segalen, Bordeux, FR E. Rouleau

Institut Gustave Roussy, Villejuif, FR C. Sotiriu

Université Libre de Bruxelles, Brussels, BE A. Stathis

Oncology Institute of Southern Switzerland, Bellinzona, CH D. Tilki

University Hospital Hamburg-Eppendorf - Martini Klinik, Hamburg, DE G. Viale

European Institute of Oncology, Milan, IT

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PRELIMINARY PROGRAMME

FRIDAY, 25 NOVEMBER

9:45 Welcome and introduction M.S. Aapro, CH and J. Gligorov, FR INTRODUCTORY SESSION

10:00 Understanding drivers of cancer cell development 10:20 Discussion

C. Sotiriu, BE

10:30 Understanding next generation sequencing 10:50 Discussion

R. Rouleau, FR

11:00 Understanding liquid biopsies 11:20 Discussion

R. Danesi, IT

11:30 Understanding pharmacogenetics in cancer treatment and clinical trials

11:50 Discussion J. Robert, FR

12:00 Round table and discussion Chairs and faculty

12:30 Lunch

WHERE DO WE STAND ON LUNG CANCER?

13:30 Lung cancer as a model for the development of personalized medicine: What should you ask from your pathologist in order to apply specific treatments

13:50 Discussion E. Felip, ES

14:00 Future developments in medical lung cancer therapy 14:20 Discussion

L. Crinò, IT

14:30 Clinical case discussion J. Remon, FR

15:00 Coffee break

WHERE DO WE STAND IN PROSTATE CANCER?

15:30 Genomic tools in prostate cancer 15:50 Discussion

D. Tilki, DE

16:00 How to decide the medical treatment of prostate cancer?

16:20 Discussion based on a clinical case N. Mottet, FR

16:30 Genomics: An essential aspect for haemato-oncologists 16:50 Discussion

A. Stathis, CH

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17:00 Day’s closure

M. Aapro, CH and J. Gligorov, FR

SATURDAY, 26 NOVEMBER

WHERE DO WE STAND IN COLORECTAL CANCER?

8:30 Genomic tools in colorectal cancer 8:50 Discussion

N. Normanno, IT

9:00 How does the clinician use these data to best treat colon and rectal cancer?

9:20 Discussion based on a clinical case D. Arnold, DE

10:00 Coffee break

WHERE DO WE STAND IN BREAST CANCER?

10:00 Pathological characterisation of breast cancer: Bridges between molecular and pathological definitions (triple negative, liminal, lobular…)

10:20 Discussion G. Viale, IT

10:30 Molecular characterisation of breast cancer: When is it needed?

Is lobular an unrecognized special case?

10:50 Discussion

F. Penault-Llorca, FR

11:00 Neoadjuvant/adjuvant therapy: How to manage early triple- negative tumours with and without BRCA mutations

11:20 Discussion based on a clinical case L. Del Mastro, IT

11:30 Treatment of HER-2 positive disease in the (neo-) adjuvant settings: What alternatives?

11:50 Discussion based on a clinical case V. Dieras, FR

12:00 What is or is not special about invasive lobular tumour adjuvant treatment

12:20 Discussion based on a clinical case G. Curigliano, IT

12:30 Close

M. Aapro, CH and J. Gligorov, FR 12:45 Lunch and departures

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REGISTRATION

Register online at www.eso.net.

Registration grants participantion in all sessions, a copy of the Programme Book, coffee breaks and lunches as indicated in the programme.

All rates are quoted in Euro and include VAT.

GENERAL INFORMATION

Early (by 28 August) Late (by 23 October) On-site (from 24 October)

Registration fee EUR 240 EUR 360 EUR 480

Club ESO Members EUR 220 EUR 360 EUR 480

CANCELLATION OF REGISTRATION OR REPLACEMENT

Cancellation should be notified to ESO in writing. In case of cancellation without replacement, the fee less handling charges of EUR 100 will be refunded after the event, provided that the cancellation is recived by ESO before 16 October.

Replacements will be possible till 16 October.

CONFIRMATION OF REGISTRATION

Registration will be confirmed preferably by e-mail, by fax or by mail.

MEDIA REGISTRATION

The Conference is open to representatives of print and electronic media.

Registration is free of charge to journalists who are in possession of a valid, recognised press card. Freelance journalists must present a commissioning letter on headed paper from a recognised news organisation or publication.

Representatives of advertising, marketing and public relations companies are not eligible for free media registration.

A copy of the Press Card or the commissioning letter should be sent, together with the media registration form, to [email protected].

ORGANISING SECRETARIAT European School of Oncology (ESO) Bellinzona Office

Piazza Indipendenza, 2 6500 Bellinzona - Switzerland Fax: +41 91 820 09 53 - www.eso.net

VENUE

Radisson Blu ES. Hotel Via Turati, 171

Rome, Italy

Tel: +39 06 444 841- www.radissonblu.com/eshotel-rome Programme and organisation

Luis Carvalho - [email protected] Tel: +41 91 820 09 58

Programme and registrations Laura Richetti - [email protected] Tel: +41 91 820 09 51

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GENERAL INFORMATION

BADGE

The badge is the only official evidence of registration and should be worn at all times during the event. Loss of badge causes loss of registration.

INSURANCE

The organisers bear no responsibility for untoward events in relation to the participation in the Conference. Participants are advised to take out their own personal and travel insurance.

TRAVEL GRANTS

Travel grants were made available on a competitive basis. The application deadline is passed (28 August).

OFFICIAL LANGUAGE

The official language will be English. No translation will be provided.

HOTEL ACCOMMODATION

The following are recommended hotels located close to the conference venue.

Hotel Category Walking distance to the venue

Radisson Blu Hotel

www.radissonblu.com/eshotel-rom Conference venue

Royal Santina Hotel

www.hotelroyalsantina.com 12 minutes

Una Hotel

www.unahotels.it/en/una_hotel_roma/roma_hotels.htm 7 minutes Hotel Caracciolo

www.hotelcaracciolo.com 5 minutes

Amalfi Hotel

www.hotelamalfiroma.it 10 minutes

More information is available at www.eso.net.

ACKNOWLEDGEMENTS

ESO wishes to extend its appreciation to Genomic Health for having granted its support to the conference through an unrestricted grant.

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MOLECULAR DIAGNOSTICS, GENOMICS AND EPIGENETICS IN CLINICAL ONCOLOGY 25-26 NOVEMBER 2016 - Rome, Italy

Please fill in this form in BLOCK LETTERS and send by the deadline to:

European School of Oncology (ESO) - Piazza Indipendenza, 2, 6500 Bellinzona - Switzerland, Fax: +41 91 820 09 53 - E mail: [email protected]

ONLINE REGISTRATION IS AVAILABLE AT: WWW.ESO.NET PARTICIPANT'S DETAILS

Dr. Prof. Mrs. Mr.

Surname Name

Institute Department Street

Zip Code Town Country

Phone Fax Mobile

Email

Date of birth Birth date (town and country)

Profession

Specialisation Main field

VAT number (compulsory for self-employed persons) Fiscal code (Italian residents only)

If your invoice details are different to those above, please complete the following section:

Invoice contact details Address

Phone email

VAT number (compulsory for self-employed persons) Fiscal Code (Italian residents only)

REGISTRATION

All rates are quoted in Euro and include VAT.

PAYMENT DETAILS:

The registration is processed when payment accompanies the form (credit card details or copy of bank transfer) Visa/Mastercard Card Number / / /

Expire date / CV2 code

Holder’s name (in CAPITAL LETTERS): and signature

BANK TRANSFER with no cost to the beneficiary (please provide a copy of the bank transfer):

Bank: Banca Popolare di Milano, Agenzia 24 - Milan, Italy Account holder: European School of Oncology

Number: No. 16333

IBAN: IT96G0558401624 0000000 16333 - BIC: BPMIITMMXXX Reference: "Molecolar Diagnostics" + your name

I authorize the European School of Oncology to use my personal data according to what is specified in Article 13 DLGS 196, available at www.eso.net or on request at fax number +39 02 8546 4545.

Signature Date

REGISTRATION FORM

Early (by 28 August) Late (by 23 October) On-site (from 24 October)

Registration fee EUR 240 EUR 360 EUR 480

Club ESO Members EUR 220 EUR 360 EUR 480

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