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Ashton AC, Dolly JO (1988) “Characterization of the inhibitory action of botulinum neurotoxin type A on the release of several transmitters from rat cerebrocortical synaptosomes”. J Neurochem 50:1808-1816.

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Angaut-Petit D, Molgo J, Comella JX, Faille L, Tabti N (1990) “Terminal sprouting in mouse neuromuscular junctions poisoned with botulinum type A toxin: morphological and electrophysiological features”. Neuroscience 37:799-808.

Ashton AC, Dolly JO (1988) “Characterization of the inhibitory action of botulinum neurotoxin type A on the release of several transmitters from rat cerebrocortical synaptosomes”. J Neurochem 50:1808-1816.

Ashton AC, Dolly JO (1991) “Microtubule-dissociating drugs and A23187 reveal differences in the inhibition of synaptosomal transmitter release by botulinum neurotoxins types A and B”. J Neurochem 56:827-835.

Baethmann A (1979) [Brain edema due to mechanical, circulatory, osmotic, metabolic and toxic causes]. Klin Anasthesiol Intensivther 19:56-75.

Bajjalieh SM, Peterson K, Shinghal R, Scheller RH (1992) “SV2, a brain synaptic vesicle protein homologous to bacterial transporters”. Science 257:1271-1273

Bajjalieh SM, Peterson K, Linial M, Scheller RH (1993) “Brain contains two forms of synaptic vesicle protein 2”. Proc Natl Acad Sci U S A 90:2150-2154.

Bajjalieh SM, Frantz GD, Weimann JM, McConnell SK, Scheller RH (1994)

“Differential expression of synaptic vesicle protein 2 (SV2) isoforms”. J Neurosci 14:5223-5235.

Banerjee A, Kowalchyk JA, DasGupta BR, Martin TF (1996) “SNAP-25 is required for a late postdocking step in Ca2+-dependent exocytosis”. J Biol Chem 271:20227-20230.

Beise J, Hahnen J, Andersen-Beckh B, Dreyer F (1994) “Pore formation by tetanus

toxin, its chain and fragments in neuronal membranes and evaluation of the underlying

motifs in the structure of the toxin molecule”. Naunyn Schmiedebergs Arch Pharmacol

349:66-73.

(2)

Bennett MK, Calakos N, Scheller RH (1992) “Syntaxin: a synaptic protein implicated in docking of synaptic vesicles at presynaptic active zones”. Science 257:255-259.

Bennett MK, Garcia-Arraras JE, Elferink LA, Peterson K, Fleming AM, Hazuka CD, Scheller RH (1993) “The syntaxin family of vesicular transport receptors”. Cell 74:863- 873.

Bergquist F, Niazi HS, Nissbrandt H (2002) Evidence for different exocytosis pathways in dendritic and terminal dopamine release in vivo. Brain Res 950:245-253.

Bezprozvanny I, Scheller RH, Tsien RW (1995) “Functional impact of syntaxin on gating of N-type and Q-type calcium channels”. Nature 378:623-626.

Bigalke H, Ahnert-Hilger G, Habermann E (1981) “Tetanus toxin and botulinum A toxin inhibit acetylcholine release from but not calcium uptake into brain tissue”.

Naunyn Schmiedebergs Arch Pharmacol 316:143-148.

Bigalke H, Heller I, Bizzini B, Habermann E (1981) “Tetanus toxin and botulinum A toxin inhibit release and uptake of various transmitters, as studied with particulate preparations from rat brain and spinal cord”. Naunyn Schmiedebergs Arch Pharmacol 316:244-251.

Bigalke H, Dreyer F, Bergey G (1985) “Botulinum A neurotoxin inhibits non- cholinergic synaptic transmission in mouse spinal cord neurons in culture”. Brain Res 360:318-324.

Black JD, Dolly JO (1986) “Interaction of 125I-labeled botulinum neurotoxins with nerve terminals. II. Autoradiographic evidence for its uptake into motor nerves by acceptor-mediated endocytosis”. J Cell Biol 103:535-544.

Blaustein RO, Germann WJ, Finkelstein A, DasGupta BR (1987) “The N-terminal half

of the heavy chain of botulinum type A neurotoxin forms channels in planar

phospholipid bilayers”. FEBS Lett 226:115-120.

(3)

Boquet P, Duflot E (1982) “Tetanus toxin fragment forms channels in lipid vesicles at low pH”. Proc Natl Acad Sci U S A 79:7614-7618.

Bozzi Y, Costantin L, Antonucci F, Caleo M (2006) “Action of botulinum neurotoxins in the central nervous system: antiepileptic effects”. Neurotox Res 9:197-203.

Brierley JB (1979) “Ischemic necrosis along brain arterial boundary zones: some aspects of its etiology”. Adv Neurol 26:155-162.

Burgen AS, Dickens F, Zatman LJ (1949) “The action of botulinum toxin on the neuro- muscular junction”. J Physiol 109:10-24.

Cabiaux V, Lorge P, Vandenbranden M, Falmagne P, Ruysschaert JM (1985) “Tetanus toxin induces fusion and aggregation of lipid vesicles containing phosphatidylinositol at low pH”. Biochem Biophys Res Commun 128:840-849.

Calakos N, Scheller RH (1994) “Vesicle-associated membrane protein and synaptophysin are associated on the synaptic vesicle”. J Biol Chem 269:24534-24537.

Caleo M, Medini P, von Bartheld CS, Maffei L (2003) “Provision of brain-derived neurotrophic factor via anterograde transport from the eye preserves the physiological responses of axotomized geniculate neurons”. J Neurosci 23:287-296.

Capogna M, McKinney RA, O'Connor V, Gahwiler BH, Thompson SM (1997) “Ca2+

or Sr2+ partially rescues synaptic transmission in hippocampal cultures treated with botulinum toxin A and C, but not tetanus toxin”. J Neurosci 17:7190-7202.

Charvin N, L'Eveque C, Walker D, Berton F, Raymond C, Kataoka M, Shoji-Kasai Y,

Takahashi M, De Waard M, Seagar MJ (1997) “Direct interaction of the calcium sensor

protein synaptotagmin I with a cytoplasmic domain of the alpha1A subunit of the P/Q-

type calcium channel”. Embo J 16:4591-4596.

(4)

Chen ST, Hsu CY, Hogan EL, Maricq H, Balentine JD (1986) “A model of focal ischemic stroke in the rat: reproducible extensive cortical infarction”. Stroke 17:738- 743.

Choi DW (1996) “Ischemia-induced neuronal apoptosis”. Curr Opin Neurobiol 6:667- 672.

Colbourne F, Li H, Buchan AM, Clemens JA (1999) “Continuing postischemic neuronal death in CA1: influence of ischemia duration and cytoprotective doses of NBQX and SNX-111 in rats”. Stroke 30:662-668.

Costantin L, Bozzi Y, Richichi C, Viegi A, Antonucci F, Funicello M, Gobbi M, Mennini T, Rossetto O, Montecucco C, Maffei L, Vezzani A, Caleo M (2005)

“Antiepileptic effects of botulinum neurotoxin E”. J Neurosci 25:1943-1951.

Critchley DR, Nelson PG, Habig WH, Fishman PH (1985) “Fate of tetanus toxin bound to the surface of primary neurons in culture: evidence for rapid internalization”. J Cell Biol 100:1499-1507.

de Paiva A, Meunier FA, Molgo J, Aoki KR, Dolly JO (1999) “Functional repair of motor endplates after botulinum neurotoxin type A poisoning: biphasic switch of synaptic activity between nerve sprouts and their parent terminals”. Proc Natl Acad Sci U S A 96:3200-3205.

Dirnagl U, Iadecola C, Moskowitz MA (1999) “Pathobiology of ischaemic stroke: an integrated view”. Trends Neurosci 22:391-397.

Dong M, Richards DA, Goodnough MC, Tepp WH, Johnson EA, Chapman ER (2003)

“Synaptotagmins I and II mediate entry of botulinum neurotoxin B into cells”. J Cell

Biol 162:1293-1303.

(5)

Dong M, Yeh F, Tepp WH, Dean C, Johnson EA, Janz R, Chapman ER (2006) “SV2 is the protein receptor for botulinum neurotoxin A”. Science 312:592-596.

Donovan JJ, Middlebrook JL (1986) “Ion-conducting channels produced by botulinum toxin in planar lipid membranes”. Biochemistry 25:2872-2876.

Eleopra R, Tugnoli V, Rossetto O, Montecucco C, De Grandis D (1997) “Botulinum neurotoxin serotype C: a novel effective botulinum toxin therapy in human”. Neurosci Lett 224:91-94.

Eleopra R, Tugnoli V, Rossetto O, De Grandis D, Montecucco C (1998) “Different time courses of recovery after poisoning with botulinum neurotoxin serotypes A and E in humans”. Neurosci Lett 256:135-138.

Fassio A, Sala R, Bonanno G, Marchi M, Raiteri M (1999) “Evidence for calcium- dependent vesicular transmitter release insensitive to tetanus toxin and botulinum toxin type F”. Neuroscience 90:893-902.

Fernandez-Salas E, Steward LE, Ho H, Garay PE, Sun SW, Gilmore MA, Ordas JV, Wang J, Francis J, Aoki KR (2004) “Plasma membrane localization signals in the light chain of botulinum neurotoxin”. Proc Natl Acad Sci U S A 101:3208-3213.

Fisher A, Montal M (2006) “Characterization of Clostridial botulinum neurotoxin channels in neuroblastoma cells”. Neurotox Res 9:93-100.

Foran P, Shone CC, Dolly JO (1994) “Differences in the protease activities of tetanus and botulinum B toxins revealed by the cleavage of vesicle-associated membrane protein and various sized fragments”. Biochemistry 33:15365-15374.

Foran P, Lawrence GW, Shone CC, Foster KA, Dolly JO (1996) “Botulinum neurotoxin C1 cleaves both syntaxin and SNAP-25 in intact and permeabilized chromaffin cells:

correlation with its blockade of catecholamine release”. Biochemistry 35:2630-2636.

(6)

Foran PG, Mohammed N, Lisk GO, Nagwaney S, Lawrence GW, Johnson E, Smith L, Aoki KR, Dolly JO (2003) “Evaluation of the therapeutic usefulness of botulinum neurotoxin B, C1, E, and F compared with the long lasting type A. Basis for distinct durations of inhibition of exocytosis in central neurons”. J Biol Chem 278:1363-1371.

Gambale F, Montal M (1988) “Characterization of the channel properties of tetanus toxin in planar lipid bilayers”. Biophys J 53:771-783.

Genoud S, Pralong W, Riederer BM, Eder L, Catsicas S, Muller D (1999) “Activity- dependent phosphorylation of SNAP-25 in hippocampal organotypic cultures”. J Neurochem 72:1699-1706.

Gill R, Nordholm L, Lodge D (1992) “The neuroprotective actions of 2,3-dihydroxy-6- nitro-7-sulfamoyl-benzo(F)quinoxaline (NBQX) in a rat focal ischaemia model”. Brain Res 580:35-43.

Grosse G, Grosse J, Tapp R, Kuchinke J, Gorsleben M, Fetter I, Hohne-Zell B, Gratzl M, Bergmann M (1999) “SNAP-25 requirement for dendritic growth of hippocampal neurons”. J Neurosci Res 56:539-546.

Hayashi T, McMahon H, Yamasaki S, Binz T, Hata Y, Sudhof TC, Niemann H (1994)

“Synaptic vesicle membrane fusion complex: action of clostridial neurotoxins on assembly”. Embo J 13:5051-5061.

Heckmann M, Ceballos-Baumann AO, Plewig G (2001)” Botulinum toxin A for axillary hyperhidrosis (excessive sweating)”. N Engl J Med 344:488-493.

Hess DT, Slater TM, Wilson MC, Skene JH (1992) “The 25 kDa synaptosomal-

associated protein SNAP-25 is the major methionine-rich polypeptide in rapid axonal

transport and a major substrate for palmitoylation in adult CNS”. J Neurosci 12:4634-

4641.

(7)

Hickenbottom SL, Grotta J (1998) “Neuroprotective therapy. Semin Neurol 18:485-492.

Hicks A, Davis S, Rodger J, Helme-Guizon A, Laroche S, Mallet J (1997) Synapsin I and syntaxin 1B: key elements in the control of neurotransmitter release are regulated by neuronal activation and long-term potentiation in vivo”. Neuroscience 79:329-340.

Hoch DH, Romero-Mira M, Ehrlich BE, Finkelstein A, DasGupta BR, Simpson LL (1985) “Channels formed by botulinum, tetanus, and diphtheria toxins in planar lipid bilayers: relevance to translocation of proteins across membranes”. Proc Natl Acad Sci U S A 82:1692-1696.

Hossmann KA, Sakaki S, Zimmermann V (1977) “Ion activities in reversible ischemia of the cat brain”. Acta Neurol Scand Suppl 64:108-109.

Hossmann KA (1994) “Viability thresholds and the penumbra of focal ischemia”. Ann Neurol 36:557-565.

Iezzi M, Theander S, Janz R, Loze C, Wollheim CB (2005)”SV2A and SV2C are not vesicular Ca2+ transporters but control glucose-evoked granule recruitment”. J Cell Sci 118:5647-5660.

Ito U, Spatz M, Walker JT, Jr., Klatzo I (1975) “Experimental cerebral ischemia in mongolian gerbils. I. Light microscopic observations”. Acta Neuropathol (Berl) 32:209- 223.

Jankovic J (1994) “Botulinum toxin in the treatment of dystonic tics”. Mov Disord 9:347-349.

Janz R, Sudhof TC (1999) “SV2C is a synaptic vesicle protein with an unusually

restricted localization: anatomy of a synaptic vesicle protein family”. Neuroscience

94:1279-1290.

(8)

Karpiak SE, Tagliavia A, Wakade CG (1989) “Animal models for the study of drugs in ischemic stroke”. Annu Rev Pharmacol Toxicol 29:403-414.

Keller JE, Neale EA, Oyler G, Adler M (1999) “Persistence of botulinum neurotoxin action in cultured spinal cord cells”. FEBS Lett 456:137-142.

Keller JE, Neale EA (2001) “The role of the synaptic protein snap-25 in the potency of botulinum neurotoxin type A”. J Biol Chem 276:13476-13482.

Kirino T (1982) “Delayed neuronal death in the gerbil hippocampus following ischemia”. Brain Res 239:57-69.

Kirino T, Sano K (1984) “Selective vulnerability in the gerbil hippocampus following transient ischemia”. Acta Neuropathol (Berl) 62:201-208.

Kitamura M, Iwamori M, Nagai Y (1980) “Interaction between Clostridium botulinum neurotoxin and gangliosides”. Biochim Biophys Acta 628:328-335.

Lacy DB, Tepp W, Cohen AC, DasGupta BR, Stevens RC (1998) “Crystal structure of botulinum neurotoxin type A and implications for toxicity”. Nat Struct Biol 5:898-902.

Lalli G, Herreros J, Osborne SL, Montecucco C, Rossetto O, Schiavo G (1999)

“Functional characterisation of tetanus and botulinum neurotoxins binding domains”. J Cell Sci 112 ( Pt 16):2715-2724.

Ledeen RW (1978) “Ganglioside structures and distribution: are they localized at the nerve ending?” J Supramol Struct 8:1-17.

Lee JM, Zipfel GJ, Choi DW (1999) “The changing landscape of ischaemic brain injury

mechanisms”. Nature 399:A7-14.

(9)

Luvisetto S, Rossetto O, Montecucco C, Pavone F (2003) “Toxicity of botulinum neurotoxins in central nervous system of mice”. Toxicon 41:475-481.

Luvisetto S, Marinelli S, Rossetto O, Montecucco C, Pavone F (2004) “Central injection of botulinum neurotoxins: behavioural effects in mice”. Behav Pharmacol 15:233-240.

Mahrhold S, Rummel A, Bigalke H, Davletov B, Binz T (2006) “The synaptic vesicle protein 2C mediates the uptake of botulinum neurotoxin A into phrenic nerves”. FEBS Lett 580:2011-2014.

Matteoli M, Verderio C, Rossetto O, Iezzi N, Coco S, Schiavo G, Montecucco C (1996)

“Synaptic vesicle endocytosis mediates the entry of tetanus neurotoxin into hippocampal neurons”. Proc Natl Acad Sci U S A 93:13310-13315.

McMahon HT, Foran P, Dolly JO, Verhage M, Wiegant VM, Nicholls DG (1992)

“Tetanus toxin and botulinum toxins type A and B inhibit glutamate, gamma- aminobutyric acid, aspartate, and met-enkephalin release from synaptosomes. Clues to the locus of action”. J Biol Chem 267:21338-21343.

Menestrina G, Forti S, Gambale F (1989) “Interaction of tetanus toxin with lipid vesicles. Effects of pH, surface charge, and transmembrane potential on the kinetics of channel formation”. Biophys J 55:393-405.

Minton NP (1995) “Molecular genetics of clostridial neurotoxins”. Curr Top Microbiol Immunol 195:161-194.

Montecucco C, Schiavo G, Brunner J, Duflot E, Boquet P, Roa M (1986) “Tetanus

toxin is labeled with photoactivatable phospholipids at low pH”. Biochemistry 25:919-

924.

(10)

Montecucco C, Schiavo G, Gao Z, Bauerlein E, Boquet P, DasGupta BR (1988)

“Interaction of botulinum and tetanus toxins with the lipid bilayer surface”. Biochem J 251:379-383.

Montecucco C, Rossetto O, Schiavo G (2004) “Presynaptic receptor arrays for clostridial neurotoxins”. Trends Microbiol 12:442-446.

Montecucco C, Schiavo G, Pantano S (2005) “SNARE complexes and neuroexocytosis:

how many, how close?” Trends Biochem Sci 30:367-372.

Murakami T, Okada M, Kawata Y, Zhu G, Kamata A, Kaneko S (2001) “Determination of effects of antiepileptic drugs on SNAREs-mediated hippocampal monoamine release using in vivo microdialysis”. Br J Pharmacol 134:507-520.

Nagasawa H, Kogure K (1989) “Correlation between cerebral blood flow and histologic changes in a new rat model of middle cerebral artery occlusion”. Stroke 20:1037-1043.

Neale EA, Bowers LM, Jia M, Bateman KE, Williamson LC (1999) “Botulinum neurotoxin A blocks synaptic vesicle exocytosis but not endocytosis at the nerve terminal”. J Cell Biol 147:1249-1260.

Nishiki T, Kamata Y, Nemoto Y, Omori A, Ito T, Takahashi M, Kozaki S (1994)

“Identification of protein receptor for Clostridium botulinum type B neurotoxin in rat brain synaptosomes”. J Biol Chem 269:10498-10503.

Okada M, Nutt DJ, Murakami T, Zhu G, Kamata A, Kawata Y, Kaneko S (2001)

“Adenosine receptor subtypes modulate two major functional pathways for hippocampal serotonin release”. J Neurosci 21:628-640.

Osen-Sand A, Catsicas M, Staple JK, Jones KA, Ayala G, Knowles J, Grenningloh G,

Catsicas S (1993) “Inhibition of axonal growth by SNAP-25 antisense oligonucleotides

in vitro and in vivo”. Nature 364:445-448.

(11)

Osen-Sand A, Staple JK, Naldi E, Schiavo G, Rossetto O, Petitpierre S, Malgaroli A, Montecucco C, Catsicas S (1996)”Common and distinct fusion proteins in axonal growth and transmitter release”. J Comp Neurol 367:222-234.

Porta M (2000) “A comparative trial of botulinum toxin type A and methylprednisolone for the treatment of myofascial pain syndrome and pain from chronic muscle spasm”.

Pain 85:101-105

Poulain B, Mochida S, Weller U, Hogy B, Habermann E, Wadsworth JD, Shone CC, Dolly JO, Tauc L (1991) “Heterologous combinations of heavy and light chains from botulinum neurotoxin A and tetanus toxin inhibit neurotransmitter release in Aplysia”. J Biol Chem 266:9580-9585.

Pulsinelli WA, Brierley JB, Plum F (1982) “Temporal profile of neuronal damage in a model of transient forebrain ischemia”. Ann Neurol 11:491-498

Pulsinelli WA, Levy DE, Duffy TE (1982) “Regional cerebral blood flow and glucose metabolism following transient forebrain ischemia”. Ann Neurol 11:499-502.

Rauch G, Gambale F, Montal M (1990) “Tetanus toxin channel in phosphatidylserine planar bilayers: conductance states and pH dependence”. Eur Biophys J 18:79-83.

Rizo J, Sudhof TC (1998) “Mechanics of membrane fusion”. Nat Struct Biol 5:839-842.

Roa M, Boquet P (1985) “Interaction of tetanus toxin with lipid vesicles at low pH.

Protection of specific polypeptides against proteolysis”. J Biol Chem 260:6827-6835.

Roberts E (1974) “Disinhibition as an organizing principle in the nervous system. The

role of gamma-aminobutyric acid”. Adv Neurol 5:127-143.

(12)

Roberts LA, Morris BJ, O'Shaughnessy CT (1998) “Involvement of two isoforms of SNAP-25 in the expression of long-term potentiation in the rat hippocampus”.

Neuroreport 9:33-36.

Rossetto O, Schiavo G, Montecucco C, Poulain B, Deloye F, Lozzi L, Shone CC (1994)

“SNARE motif and neurotoxins”. Nature 372:415-416.

Sadoul K, Berger A, Niemann H, Regazzi R, Catsicas S, Halban PA (1997) “SNAP-25 can self-associate to form a disulfide-linked complex”. Biol Chem 378:1171-1176.

Schiavo G, Papini E, Genna G, Montecucco C (1990) “An intact interchain disulfide bond is required for the neurotoxicity of tetanus toxin”. Infect Immun 58:4136-4141.

Schiavo G, Ferrari G, Rossetto O, Montecucco C (1991) “Tetanus toxin receptor.

Specific cross-linking of tetanus toxin to a protein of NGF-differentiated PC 12 cells”.

FEBS Lett 290:227-230.

Schiavo G, Benfenati F, Poulain B, Rossetto O, Polverino de Laureto P, DasGupta BR, Montecucco C (1992) “Tetanus and botulinum-B neurotoxins block neurotransmitter release by proteolytic cleavage of synaptobrevin”. Nature 359:832-835.

Schiavo G, Shone CC, Rossetto O, Alexander FC, Montecucco C (1993) “Botulinum neurotoxin serotype F is a zinc endopeptidase specific for VAMP/synaptobrevin”. J Biol Chem 268:11516-11519.

Schiavo G, Rossetto O, Catsicas S, Polverino de Laureto P, DasGupta BR, Benfenati F, Montecucco C (1993) “Identification of the nerve terminal targets of botulinum neurotoxin serotypes A, D, and E”. J Biol Chem 268:23784-23787.

Schiavo G, Malizio C, Trimble WS, Polverino de Laureto P, Milan G, Sugiyama H,

Johnson EA, Montecucco C (1994) “Botulinum G neurotoxin cleaves

VAMP/synaptobrevin at a single Ala-Ala peptide bond”. J Biol Chem 269:20213-20216.

(13)

Schiavo G, Montecucco C (1995) “Tetanus and botulism neurotoxins: isolation and assay”. Methods Enzymol 248:643-652.

Schiavo G, Matteoli M, Montecucco C (2000) “Neurotoxins affecting neuroexocytosis”.

Physiol Rev 80:717-766.

Schmid MF, Robinson JP, DasGupta BR (1993) “Direct visualization of botulinum neurotoxin-induced channels in phospholipid vesicles”. Nature 364:827-830.

Scott AB, Rosenbaum A, Collins CC (1973) “Pharmacologic weakening of extraocular muscles”. Invest Ophthalmol 12:924-927.

Sheng ZH, Yokoyama CT, Catterall WA (1997) “Interaction of the synprint site of N- type Ca2+ channels with the C2B domain of synaptotagmin I”. Proc Natl Acad Sci U S A 94:5405-5410.

Shimazaki Y, Nishiki T, Omori A, Sekiguchi M, Kamata Y, Kozaki S, Takahashi M (1996) “Phosphorylation of 25-kDa synaptosome-associated protein. Possible involvement in protein kinase C-mediated regulation of neurotransmitter release”. J Biol Chem 271:14548-14553.

Shone CC, Hambleton P, Melling J (1985) “Inactivation of Clostridium botulinum type A neurotoxin by trypsin and purification of two tryptic fragments. Proteolytic action near the COOH-terminus of the heavy subunit destroys toxin-binding activity”. Eur J Biochem 151:75-82.

Shone CC, Hambleton P, Melling J (1987) “A 50-kDa fragment from the NH2-terminus

of the heavy subunit of Clostridium botulinum type A neurotoxin forms channels in

lipid vesicles”. Eur J Biochem 167:175-180.

(14)

Shone CC, Quinn CP, Wait R, Hallis B, Fooks SG, Hambleton P (1993) “Proteolytic cleavage of synthetic fragments of vesicle-associated membrane protein, isoform-2 by botulinum type B neurotoxin”. Eur J Biochem 217:965-971.

Siesjo BK, Bengtsson F (1989) “Calcium fluxes, calcium antagonists, and calcium- related pathology in brain ischemia, hypoglycemia, and spreading depression: a unifying hypothesis”. J Cereb Blood Flow Metab 9:127-140.

Silberstein S, Mathew N, Saper J, Jenkins S (2000) “Botulinum toxin type A as a migraine preventive treatment”. For the BOTOX Migraine Clinical Research Group.

Headache 40:445-450.

Simons K, Ikonen E (1997) “Functional rafts in cell membranes. Nature 387:569-572.

Simpson LL (1980) Kinetic studies on the interaction between botulinum toxin type A and the cholinergic neuromuscular junction”. J Pharmacol Exp Ther 212:16-21.

Smith ML, Bendek G, Dahlgren N, Rosen I, Wieloch T, Siesjo BK (1984) “Models for studying long-term recovery following forebrain ischemia in the rat. 2. A 2-vessel occlusion model”. Acta Neurol Scand 69:385-401.

Sudhof TC (1995) “The synaptic vesicle cycle: a cascade of protein-protein interactions”. Nature 375:645-653.

Sutton MA, Wall NR, Aakalu GN, Schuman EM (2004) Regulation of dendritic protein synthesis by miniature synaptic events. Science 304:1979-1983.

Takei N, Numakawa T, Kozaki S, Sakai N, Endo Y, Takahashi M, Hatanaka H (1998)

“Brain-derived neurotrophic factor induces rapid and transient release of glutamate

through the non-exocytotic pathway from cortical neurons”. J Biol Chem 273:27620-

27624.

(15)

Tamura A, Graham DI, McCulloch J, Teasdale GM (1981) “Focal cerebral ischaemia in the rat: 1. Description of technique and early neuropathological consequences following middle cerebral artery occlusion”. J Cereb Blood Flow Metab 1:53-60.

Trudeau LE, Fang Y, Haydon PG (1998) “Modulation of an early step in the secretory machinery in hippocampal nerve terminals”. Proc Natl Acad Sci U S A 95:7163-7168.

Tugnoli V, Eleopra R, Montecucco C, De Grandis D (1997) “The therapeutic use of botulinum toxin”. Expert Opin Investig Drugs 6:1383-1394.

Turton K, Chaddock JA, Acharya KR (2002) “Botulinum and tetanus neurotoxins:

structure, function and therapeutic utility”. Trends Biochem Sci 27:552-558.

Tyson GW, Teasdale GM, Graham DI, McCulloch J (1984) “Focal cerebral ischemia in the rat: topography of hemodynamic and histopathological changes”. Ann Neurol 15:559-567.

Umland TC, Wingert LM, Swaminathan S, Furey WF, Schmidt JJ, Sax M (1997)

“Structure of the receptor binding fragment HC of tetanus neurotoxin”. Nat Struct Biol 4:788-792.

Valtysson J, Hillered L, Andine P, Hagberg H, Persson L (1994) “Neuropathological endpoints in experimental stroke pharmacotherapy: the importance of both early and late evaluation”. Acta Neurochir (Wien) 129:58-63.

Verderio C, Coco S, Rossetto O, Montecucco C, Matteoli M (1999) “Internalization and proteolytic action of botulinum toxins in CNS neurons and astrocytes”. J Neurochem 73:372-379.

Verderio C, Pozzi D, Pravettoni E, Inverardi F, Schenk U, Coco S, Proux-Gillardeaux V,

Galli T, Rossetto O, Frassoni C, Matteoli M (2004) “SNAP-25 modulation of calcium

(16)

dynamics underlies differences in GABAergic and glutamatergic responsiveness to depolarization”. Neuron 41:599-610.

Vezzani A, Conti M, De Luigi A, Ravizza T, Moneta D, Marchesi F, De Simoni MG (1999) “Interleukin-1beta immunoreactivity and microglia are enhanced in the rat hippocampus by focal kainate application: functional evidence for enhancement of electrographic seizures”. J Neurosci 19:5054-5065.

Viegi A, Cotrufo T, Berardi N, Mascia L, Maffei L (2002) “Effects of dark rearing on phosphorylation of neurotrophin Trk receptors”. Eur J Neurosci 16:1925-1930.

Vyas AA, Patel HV, Fromholt SE, Heffer-Lauc M, Vyas KA, Dang J, Schachner M, Schnaar RL (2002) “Gangliosides are functional nerve cell ligands for myelin- associated glycoprotein (MAG), an inhibitor of nerve regeneration”. Proc Natl Acad Sci U S A 99:8412-8417.

Washbourne P, Pellizzari R, Rossetto O, Bortoletto N, Tugnoli V, De Grandis D, Eleopra R, Montecucco C (1998) “On the action of botulinum neurotoxins A and E at cholinergic terminals”. J Physiol Paris 92:135-139.

Williamson LC, Halpern JL, Montecucco C, Brown JE, Neale EA (1996) “Clostridial neurotoxins and substrate proteolysis in intact neurons: botulinum neurotoxin C acts on synaptosomal-associated protein of 25 kDa”. J Biol Chem 271:7694-7699.

Wood PL (1995) “Microglia as a unique cellular target in the treatment of stroke:

potential neurotoxic mediators produced by activated microglia”. Neurol Res 17:242- 248.

Xu NJ, Yu YX, Zhu JM, Liu H, Shen L, Zeng R, Zhang X, Pei G (2004) “Inhibition of

SNAP-25 phosphorylation at Ser187 is involved in chronic morphine-induced down-

regulation of SNARE complex formation”. J Biol Chem 279:40601-40608.

(17)

Xue JY, Liu GT, Wei HL, Pan Y (1992) “Antioxidant activity of two

dibenzocyclooctene lignans on the aged and ischemic brain in rats”. Free Radic Biol

Med12:127-13

(18)

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