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Developmental dyslexia and its complex genetic puzzle

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(1)

TSPC

2015

November, 13th – P01

Developmental dyslexia and its complex genetic puzzle

Athanasakis E1*, Faletra F2*, Licastro D3, Gerbino W1, Lonciari I2, Faletra F2

1

University of Trieste, Trieste, Italy; 2Institute for Maternal and Child Health IRCCS “Burlo Garofolo”, Trieste, Italy; 3Cluster in Biomedicine, CBM S.c.r.l., Bioinformatic Services, Trieste, Italy.

*These authors contributed equally to this work.

Keywords: developmental dyslexia, genetics, linkage, sequencing, genes

(2)

TSPC

2015

November, 13th – P01

1. Finucci JM, Guthrie JT, Childs AL, Abbey H, Childs B. (1976). The genetics of specific reading disability. Annals of Human Genetics 40:1-23.

2. DeFries JC, Fulker DW, LaBuda MC. (1987). Evidence for a genetic aetiology in reading disability of twins. Nature 329:537-9.

3. Schulte-Körne G, Grimm T, Nöthen MM, Müller-Myhsok B, Cichon S, Vogt IR, Propping P, Remschmidt H. (1998). Evidence for linkage of spelling disability to chromosome 15. American Society of Human Genetics 63:279-82.

4. Deffenbacher KE, Kenyon JB, Hoover DM, Olson RK, Pennington BF, DeFries JC, Smith SD. (2004). Refinement of the 6p21.3 quantitative trait locus influencing dyslexia: linkage and association analyses. Human Genetics 115:128-38.

5. Francks C, Paracchini S, Smith SD, Richardson AJ, Scerri TS, Cardon LR, Marlow AJ, MacPhie IL, Walter J, Pennington BF, Fisher SE, Olson RK, DeFries JC, Stein JF, Monaco AP. (2004). A 77-kilobase region of chromosome 6p22.2 is associated with dyslexia in families from the United Kingdom and from the United States. American

Journal of Human Genetics 75:1046-58.

6. Meng H, Smith SD, Hager K, Held M, Liu J, Olson RK, Pennington BF, DeFries JC, Gelernter J, O'Reilly-Pol T, Somlo S, Skudlarski P, Shaywitz SE, Shaywitz BA, Marchione K, Wang Y, Paramasivam M, LoTurco JJ, Page GP, Gruen JR. (2005). DCDC2 is associated with reading disability and modulates neuronal development in the brain. Proceedings of the National Academy of Sciences of the United States of America

102:17053-8.

7. Kere J. (2011). Molecular genetics and molecular biology of dyslexia. Wiley

Interdisciplinary Reviews. Cognitive Science. 2:441-8.

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