In conclusione, possiamo dire che l’analisi morfologica da noi condotta conferma e arricchisce di ulteriori informazioni dati già noti, che permettono la diagnosi differenziale, seppur attualmente ancora difficoltosa, tra le neoplasie paratiroidee.
Dal punto di vista molecolare i nostri obiettivi futuri sono di approfondire lo studio dell’espressione genica all’interno dei gruppi di adenomi, adenomi atipici e dei carcinomi (metastatici e non), anche se già risulta chiaro che il gruppo degli adenomi atipici sembra presentare una più stretta somiglianza con i carcinomi non metastatici che con gli adenomi.
Per una migliore caratterizzazione di questi tumori, sicuramente è da porsi come obiettivo anche una più approfondita analisi delle possibilità dell’immunoistochimica, in quanto risulta chiaro dalla letteratura che, al momento, marcatori utili non sono standardizzabili nei vari laboratori, e comunque non esistono marcatori che possano discriminare con sicurezza una neoplasia dell’altra.
Bibliografia
Abboud, B: Anatomie topographique et vascularisation artérielle des glandes parathyroïdes. Application pratique. Presse Med. 1996;25:1156–1161.
Adimonye A, Stankiewicz E, Touche S, Kudahetti S, Tinwell B, Corbishley C, Lu YJ, Watkin N, Berney D. The Prognostic Value of PIK3CA Copy Number Gain in Penile Cancer. Urology. 2018 Jul 19. pii: S0090-4295(18)30560-0. doi: 10.1016/j.urology.2018.03.056. PMID: 30031830
Agarwal SK, Mateo CM, Marx SJ. Rare germline mutations in cyclin-dependent kinase inhibitor genes in multiple endocrine neoplasia type 1 and related states. J Clin Endocrinol Metab. 2009 May;94(5):1826-34. doi: 10.1210/jc.2008-2083. Epub 2009 Jan 13. Erratum in: J Clin Endocrinol Metab. 2009 Jul;94(7):2674.
Agha A, Carpenter R, Bhattacharya S, Edmonson SJ, Carlsen E, Monson JP. Parathyroid carcinoma in multiple endocrine neoplasia type 1 (MEN1) syndrome: two case reports of an unrecognised entity. J Endocrinol Invest. 2007 Feb;30(2):145-9.
Agarwal A, Pradhan R, Kumari N, Krishnani N, Shukla P, Gupta SK, Chand G, Mishra A, Agarwal G, Verma AK, Mishra SK. Molecular Characteristics of Large Parathyroid Adenomas. World J Surg. 2016 Mar;40(3):607-14. doi: 10.1007/s00268-015-3380-2.
Agarwal N, Tochigi Y, Adhikari AS, Cui S, Cui Y, Iwakuma T. MTBP plays a crucial role in mitotic progression and chromosome segregation. Cell Death Differ. 2011 Jul;18(7):1208-19. doi: 10.1038/cdd.2010.189. Epub 2011 Jan 28. PMID: 21274008
Aitken RE, Bartley PC, Bryant SJ, Lloyd HM. The effect of multiphasic biochemical screening on the diagnosis of primary hyperparathyroidism. Aust N Z J Med. 1975 Jun;5(3):224-6.
Altenähr E, Arps H, Montz R, Dorn G. Quantitative ultrastructural and radioimmunologic assessment of parathyroid gland activity in primary hyperparathyroidism. Lab Invest. 1979 Oct;41(4):303-12.
Anastasi G et al. Trattato di Anatomia Umana. Volume II. Edi-Ermes ed., IV edizione. 2007.
Asare EA, Sturgeon C, Winchester DJ, Liu L, Palis B, Perrier ND, Evans DB, Winchester DP, Wang TS. Parathyroid Carcinoma: An Update on Treatment Outcomes and Prognostic Factors from the National Cancer Data Base (NCDB). Ann Surg Oncol. 2015 Nov;22(12):3990-5. doi: 10.1245/s10434-015-4672-3. Epub 2015 Jun 16.
Awad SS, Miskulin J, Thompson N. Parathyroid adenomas versus four-gland hyperplasia as the cause of primary hyperparathyroidism in patients with prolonged lithium therapy. World J Surg. 2003 Apr;27(4):486-8.
Bagatella F, Gaio E, Caroggio A. Anatomia. In: XXXI Convegno Nazionale di Aggiornamento AOOI-Le paratiroidi: aspetti clinici e terapeutici. Cernobbio (Como), 12-13 ottobre 2007.
Bagatella F, Gaio E, Caroggio A. Embriologia. In: XXXI Convegno Nazionale di Aggiornamento AOOI-Le paratiroidi: aspetti clinici e terapeutici. Cernobbio (Como), 12-13 ottobre 2007.
Bai S, LiVolsi VA, Fraker DL, Bing Z. Water-clear parathyroid adenoma: report of two cases and literature review. Endocr Pathol. 2012 Sep;23(3):196-200. doi: 10.1007/s12022-012-9211-1. Review. No abstract available.
Barnes L. Metastases to the Head and Neck: An Overview. Head Neck Pathol. 2009 Sep;3(3):217-24. doi: 10.1007/s12105-009-0123-4. Epub 2009 Jul 5. Review.
Baser H., Ali Karagoz, Ahmet Okus, Mustafa Cayci, Meryem Ilkay Eren Karanis, Ferda Sevimli Burnik, Salih Baser, Differential Diagnosis of Atypical Parathyroid Adenoma and Parathyroid Carcinoma in a Case With Severe Hypercalcemia., Journal of Medical Cases, ISSN 1923-4155 print, 1923-4163 online, Volume 4, Number 6, June 2013, pages 357-361, doi: https://doi.org/10.4021/jmc1198w
Behrens K, Maul K, Tekin N, Kriebitzsch N, Indenbirken D, Prassolov V, Müller U, Serve H, Cammenga J, Stocking C. RUNX1 cooperates with FLT3-ITD to induce leukemia. J Exp Med. 2017 Mar 6;214(3):737-752. doi: 10.1084/jem.20160927. Epub 2017 Feb 17. PMID: 28213513
Bergero N, De Pompa R, Sacerdote C, Gasparri G, Volante M, Bussolati G, Papotti M. Galectin-3 expression in parathyroid carcinoma: immunohistochemical study of 26 cases. Hum Pathol. 2005 Aug;36(8):908-14.
Bi Q, Ranjan A, Fan R, Agarwal N, Welch DR, Weinman SA, Ding J, Iwakuma T. MTBP inhibits migration and metastasis of hepatocellular carcinoma. Clin Exp
Metastasis. 2015 Apr;32(4):301-11. doi: 10.1007/s10585-015-9706-5. Epub 2015 Mar 11. PMID: 25759210
Black WC, Haff RC. The surgical pathology of parathyroid chief cell hyperplasia. Am J Clin Pathol. 1970 May;53(5):565-79. No abstract available.
Boehm BO, Rosinger S, Belyi D, Dietrich JW. The parathyroid as a target for radiation damage. N Engl J Med. 2011 Aug 18;365(7):676-8. doi: 10.1056/NEJMc1104982. No abstract available
Bondeson L, Sandelin K, Grimelius L. Histopathological variables and DNA cytometry in parathyroid carcinoma. Am J Surg Pathol. 1993 Aug;17(8):820-9.
Boyd JD. Development of the Thyroid and Parathyroid Glands and the Thymus Lecture delivered at the Royal College of Surgeons of England on 30th June, 1950 Ann R Coll Surg Engl. 1950 Dec;7(6):455-71. No abstract available.
Bringhurst FR, Demay MB, Kronenberg HM. Hormones and Disorders of. Mineral Metabolism. In: Larsen, P.R., Kronenberg, H.M., Melmed, S., et al., Eds., Williams Textbook of Endocrinology, 10th Edition, Elsevier, Philadelphia, 1323-1324.
Brown S, O'Neill C., Suliburk J et al. Parathyroid carcinoma: increasing incidence and changing presentation. ANZ J Surg. 2011 Jul-Aug;81(7-8):528-32.
Callender GG, Udelsman R. Surgery for primary hyperparathyroidism. Cancer. 2014 Dec 1;120(23):3602-16. doi: 10.1002/cncr.28891. Epub 2014 Jul 9. Review
Canaff L, Vanbellinghen JF, Kanazawa I, Kwak H, Garfield N, Vautour L, Hendy GN. Menin missense mutants encoded by the MEN1 gene that are targeted to the proteasome: restoration of expression and activity by CHIP siRNA. J Clin Endocrinol Metab. 2012 Feb;97(2):E282-91. doi: 10.1210/jc.2011-0241. Epub 2011 Nov 16. PMID: 22090276
Carlson D. Parathyroid pathology: hyperparathyroidism and parathyroid tumors. Arch Pathol Lab Med. 2010 Nov;134(11):1639-44. doi: 10.1043/2009-0578-CCR.1. Review. PMID: 21043817
Carney JA. The glandulae parathyroideae of Ivar Sandström. Contributions from two continents. Am J Surg Pathol. 1996 Sep;20(9):1123-44.
Caron NR, Sturgeon C, Clark OH. Persistent and recurrent hyperparathyroidism. Curr Treat Options Oncol. 2004 Aug;5(4):335-45. Review.
Caron NR, Sturgeon C, Clark OH. Persistent and recurrent hyperparathyroidism. Curr Treat Options Oncol. 2004 Aug;5(4):335-45. Review. PMID: 15233910
Carpten JD, Robbins CM, Villablanca A, Forsberg L, Presciuttini S, Bailey- Wilson J, Simonds WF, Gillanders EM, Kennedy AM, Chen JD, Agarwal SK, Sood R, Jones MP, Moses TY, Haven C, Petillo D, Leotlela PD, Harding B, Cameron D, Pannett AA, Höög A, Heath H 3rd, James-Newton LA, Robinson B, Zarbo RJ, Cavaco BM, Wassif W, Perrier ND, Rosen IB, Kristoffersson U, Turnpenny PD, Farnebo LO, Besser GM, Jackson CE, Morreau H, Trent JM, Thakker RV, Marx SJ, Teh BT, Larsson C, Hobbs MR. HRPT2, encoding parafibromin, is mutated in hyperparathyroidism-jaw tumor syndrome. Nat Genet. 2002 Dec;32(4):676-80. Epub 2002 Nov 18.
Cascón A, Huarte-Mendicoa CV, Javier Leandro-García L, Letón R, Suela J, Santana A, Costa MB, Comino-Méndez I, Landa I, Sánchez L, Rodríguez-Antona C, Cigudosa JC, Robledo M. Detection of the first gross CDC73 germline deletion in an HPT-JT syndrome family. Genes Chromosomes Cancer. 2011 Nov;50(11):922-9. doi: 10.1002/gcc.20911. Epub 2011 Aug 11.
Cetani F, Pardi E, Borsari S, Viacava P, Dipollina G, Cianferotti L, Ambrogini E, Gazzerro E, Colussi G, Berti P, Miccoli P, Pinchera A, Marcocci C. Genetic analyses of the HRPT2 gene in primary hyperparathyroidism: germline and somatic mutations in familial and sporadic parathyroid tumors. J Clin Endocrinol Metab. 2004 Nov;89(11):5583-91.
Cetani F, Pardi E, Viacava P, Pollina GD, Fanelli G, Picone A, Borsari S, Gazzerro E, Miccoli P, Berti P, Pinchera A, Marcocci C. A reappraisal of the Rb1 gene abnormalities in the diagnosis of parathyroid cancer. Clin Endocrinol (Oxf). 2004 Jan;60(1):99-106.
Cetani F, Pardi E, Viacava P et al. A reappraisal of the Rb1 gene abnormalities in the diagnosis of parathyroid cancer. Clin Endocrinol (Oxf). 2004 Jan;60(1):99-106.
Chang CW, Hsu WB, Tsai JJ, Tang CJ, Tang TK. CEP295 interacts with microtubules and is required for centriole elongation. J Cell Sci. 2016 Jul 1;129(13):2501-13. doi: 10.1242/jcs.186338. Epub 2016 May 16. PMID: 27185865
Chandrasekharappa SC, Guru SC, Manickam P, Olufemi SE, Collins FS, Emmert-Buck MR, Debelenko LV, Zhuang Z, Lubensky IA, Liotta LA, Crabtree JS, Wang Y, Roe BA, Weisemann J, Boguski MS, Agarwal SK, Kester MB, Kim YS, Heppner C, Dong Q, Spiegel AM, Burns AL, Marx SJ. Positional cloning of the gene for multiple endocrine neoplasia-type 1. Science. 1997 Apr 18;276(5311):404-7.
Chevalier JM, Martelli H, Wind P. La découverte chirurgicale des glandes parathyroides et du nerf laryngé recurrent. Ann Chir. 1995;49(4):296–304
Chow LS, Erickson LA, Abu-Lebdeh HS, Wermers RA. Parathyroid lipoadenomas: a rare cause of primary hyperparathyroidism. Endocr Pract. 2006 Mar- Apr;12(2):131-6.
Chrisoulidou A, Mandanas S, Mitsakis P, Iliadou PK, Manafis K, Flaris N, Boudina M, Mathiopoulou L, Pazaitou-Panayiotou K. Parathyroid involvement in thyroid cancer: an unforeseen event. World J Surg Oncol. 2012 Jun 28;10:121. doi: 10.1186/1477-7819-10-121.
Christakis I, Busaidy NL, Cote GJ, Williams MD, Hyde SM, Silva Figueroa AM, Kwatampora LJ, Clarke CN, Qiu W, Lee JE, Perrier ND. Parathyroid carcinoma and atypical parathyroid neoplasms in MEN1 patients; A clinico-pathologic challenge. The MD Anderson case series and review of the literature. Int J Surg. 2016 Jul;31:10-6. doi: 10.1016/j.ijsu.2016.05.035. Epub 2016 May 19. Review.
Clayman GL, Gonzalez HE, El-Naggar A, Vassilopoulou-Sellin R. Parathyroid carcinoma: evaluation and interdisciplinary management. Cancer. 2004 Mar 1;100(5):900-5.
Cohen J, Gierlowski TC, Schneider AB. A prospective study of hyperparathyroidism in individuals exposed to radiation in childhood. JAMA. 1990 Aug 1;264(5):581-4.
Cohn KH, Silen W. Lessons of parathyroid reoperations. Am J Surg. 1982 Nov;144(5):511–517
Collins FS, Liotta LA. Allelic deletions on chromosome 11q13 in multiple tumors from individual MEN1 patients. Cancer Res. 1996 Nov 15;56(22):5272-8.
Costa-Guda J, Arnold A. Genetic and epigenetic changes in sporadic endocrine tumors: parathyroid tumors. Mol Cell Endocrinol. 2014 Apr 5;386(1-2):46-54. doi: 10.1016/j.mce.2013.09.005. Epub 2013 Sep 11. Review.
Costa-Guda J, Arnold A. Genetic and epigenetic changes in sporadic endocrine tumors: parathyroid tumors. Mol Cell Endocrinol. 2014 Apr 5;386(1-2):46-54. doi: 10.1016/j.mce.2013.09.005. Epub 2013 Sep 11. Review.
Costa-Guda J, Imanishi Y, Palanisamy N, Kawamata N, Phillip Koeffler H, Chaganti RS, Arnold A. Allelic imbalance in sporadic parathyroid carcinoma and evidence for its de novo origins. Endocrine. 2013 Oct;44(2):489-95. doi: 10.1007/s12020-013-9903-4. Epub 2013 Feb 24.
Costa-Guda J, Marinoni I, Molatore S, Pellegata NS, Arnold A. Somatic Mutation and Germline Sequence Abnormalities in CDKN1B, Encoding p27Kip1, in Sporadic Parathyroid Adenomas. J Clin Endocrinol Metab. 2011 Apr;96(4):E701-6. doi: 10.1210/jc.2010-1338. Epub 2011 Feb 2.
Costa-Guda J, Soong CP, Parekh VI, Agarwal SK, Arnold A. Germline and somatic mutations in cyclin-dependent kinase inhibitor genes CDKN1A, CDKN2B, and CDKN2C in sporadic parathyroid adenomas. Horm Cancer. 2013 Oct;4(5):301-7. doi: 10.1007/s12672-013-0147-9. Epub 2013 May 29.
Crabtree JS, Scacheri PC, Ward JM, Garrett-Beal L, Emmert-Buck MR, Edgemon KA, Lorang D, Libutti SK, Chandrasekharappa SC, Marx SJ, Spiegel AM, Collins FS. A mouse model of multiple endocrine neoplasia, type 1, develops multiple endocrine tumors. Proc Natl Acad Sci U S A. 2001 Jan 30;98(3):1118-23.
Cromer MK, Starker LF, Choi M, Udelsman R, Nelson-Williams C, Lifton RP, Carling T. Identification of somatic mutations in parathyroid tumors using whole- exome sequencing. J Clin Endocrinol Metab. 2012 Sep;97(9):E1774-81. doi: 10.1210/jc.2012-1743. Epub 2012 Jun 27.
Cryns VL, Thor A, Xu HJ, Hu SX et al. Loss of the retinoblastoma tumor- suppressor gene in parathyroid carcinoma. N Engl J Med. 1994 Mar 17;330(11):757- 61.
Cryns VL, Thor A, Xu HJ, Hu SX, Wierman ME, Vickery AL Jr, Benedict WF, Arnold A. Loss of the retinoblastoma tumor-suppressor gene in parathyroid carcinoma. N Engl J Med. 1994 Mar 17;330(11):757-61.
da Silva WC, Oshiro TM, de Sá DC, Franco DD, Festa Neto C, Pontillo A. Genotyping and differential expression analysis of inflammasome genes in sporadic malignant melanoma reveal novel contribution of CARD8, IL1B and IL18 in melanoma susceptibility and progression. Cancer Genet. 2016 Oct;209(10):474-480. doi: 10.1016/j.cancergen.2016.09.004. Epub 2016 Sep 16. PMID: 27810076
de la Monte SM, Hutchins GM, Moore GW. Endocrine organ metastases from breast carcinoma. Am J Pathol. 1984 Jan;114(1):131-6.
DeKelver RC, Lewin B, Weng S, Yan M, Biggs J, Zhang DE. RUNX1-ETO induces a type I interferon response which negatively effects t(8;21)-induced increased self-renewal and leukemia development. Leuk Lymphoma. 2014 Apr;55(4):884-91. doi: 10.3109/10428194.2013.815351. Epub 2013 Jul 25. PMID: 23772668
DeLellis RA, Lloyd RV, Heitz PU, Eng C, editors (2004): World Health Organization Classification of Tumours. Pathology and Genetics of Tumours of Endocrine Organs. 3rd ed. Lyon: Iarc Press.
DeLellis RA. Parathyroid tumors and related disorders. Mod Pathol. 2011 Apr;24 Suppl 2:S78-93. doi: 10.1038/modpathol.2010.132.
Digonnet A, Carlier A, Willemse E, Quiriny M, Dekeyser C, de Saint Aubain N, Lemort M, Andry G., Parathyroid carcinoma: a review with three illustrative cases. J Cancer. 2011;2:532-7. Epub 2011 Oct 27. PMID:22043238
Du L, Chen X, Cao Y, Lu L, Zhang F, Bornstein S, Li Y, Owens P, Malkoski S, Said S, Jin F, Kulesz-Martin M, Gross N, Wang XJ, Lu SL. Overexpression of PIK3CA in murine head and neck epithelium drives tumor invasion and metastasis through PDK1 and enhanced TGFβ signaling. Oncogene. 2016 Sep 1;35(35):4641-52. doi: 10.1038/onc.2016.1. Epub 2016 Feb 15. PMID: 26876212
Edis AJ. Surgical anatomy and technique of neck exploration for primary hyperparathyroidism. Surg Clin North Am. 1977 Jun;57(3):495-504. No abstract available
Ejerblad S, Grimelius L, Johansson H, Werner I. Studies on the non-adenomatous glands in patients with a solitary parathyroid adenoma. Ups J Med Sci. 1976;81(1):31- 6.
El Hour M, Moncada-Pazos A, Blacher S, Masset A, Cal S, Berndt S, Detilleux J, Host L, Obaya AJ, Maillard C, Foidart JM, Ectors F, Noel A, Lopez-Otin C. Higher sensitivity of Adamts12-deficient mice to tumor growth and angiogenesis. Oncogene. 2010 May 20;29(20):3025-32. doi: 10.1038/onc.2010.49. Epub 2010 Mar 8. PMID: 20208563
Elgoweini M, Chetty R. Hyalinizing parathyroid adenoma and hyperplasia: report of 3 cases of an unusual histologic variant. Ann Diagn Pathol. 2011 Oct;15(5):329-32. doi: 10.1016/j.anndiagpath.2011.03.001. Epub 2011 Apr 17. PMID: 21498097
Eng C. Mendelian genetics of rare--and not so rare--cancers. Ann N Y Acad Sci. 2010 Dec;1214:70-82. doi: 10.1111/j.1749-6632.2010.05789.x. Epub 2010 Sep 28. Review. PMID: 20946573
Erickson LA, Jin L, Papotti M, et al. Oxyphil parathyroid carcinomas: a clinicopathologic and immunohistochemical study of 10 cases. Am J Surg Pathol. 2002 26:344-9 PMID:11859206
Erovic BM, Harris L, Jamali M, Goldstein DP, Irish JC, Asa SL, Mete O. Biomarkers of parathyroid carcinoma. Endocr Pathol. 2012 Dec;23(4):221-31. doi: 10.1007/s12022-012-9222-y.
Farley AM, Morris LX, Vroegindeweij E, Depreter ML, Vaidya H, Stenhouse FH, Tomlinson SR, Anderson RA, Cupedo T, Cornelissen JJ, Blackburn CC. Dynamics of thymus organogenesis and colonization in early human development. Development. 2013 May;140(9):2015-26. doi: 10.1242/dev.087320.
Farndon JR, Leight GS, Dilley WG, Baylin SB, Smallridge RC, Harrison TS, Wells SA Jr. Familial medullary thyroid carcinoma without associated endocrinopathies: a distinct clinical entity. Br J Surg. 1986 Apr;73(4):278-81.
Farnebo F, Auer G, Farnebo LO et al. Evaluation of retinoblastoma and Ki-67 immunostaining as diagnostic markers of benign and malignant parathyroid disease. World J Surg. 1999 Jan;23(1):68-74.
Favia G, Lumachi F, Polistina F et al. Parathyroid carcinoma: sixteen new cases and suggestions for correct management. World J Surg. 1998 Dec;22(12):1225-30.
Favere AM, Tsukumo DM, Matos PS, Santos SL, Lalli CA., Association between atypical parathyroid adenoma and neurofibromatosis., Arch Endocrinol Metab. 2015 Oct;59(5):460-6. doi: 10.1590/2359-3997000000092. Epub 2015 Sep 25.
Fernandez-Ranvier GG, Khanafshar E, Jensen K, Zarnegar R, Lee J, Kebebew E, Duh QY, Clark OH. Parathyroid carcinoma, atypical parathyroid adenoma, or parathyromatosis? Cancer. 2007 Jul 15;110(2):255-64.
Fernandez-Ranvier GG, Khanafshar E, Tacha D, Wong M, Kebebew E, Duh QY, Clark OH. Defining a molecular phenotype for benign and malignant parathyroid tumors. Cancer. 2009 Jan 15;115(2):334-44. doi: 10.1002/cncr.24037.
Fitko R, Roth SI, Hines JR, Roxe DM, Cahill E. Parathyromatosis in hyperparathyroidism. Hum Pathol. 1990 Feb;21(2):234-7.
Flavia G., Iacobone M., La Chirurgia delle paratiroidi. CLEUP ed. 2004
Foglio illustrativo Prosigna® Breast Cancer Prognostic Gene Signature Assay (Saggio prognostico della firma genica del cancro al seno Prosigna®),
https://www.nanostring.com/download_file/view/1019/7506
Fontanil T, Rúa S, Llamazares M, Moncada-Pazos A, Quirós PM, García- Suárez O, Vega JA, Sasaki T, Mohamedi Y, Esteban MM, Obaya AJ, Cal S. Interaction between the ADAMTS-12 metalloprotease and fibulin-2 induces tumor-
suppressive effects in breast cancer cells. Oncotarget. 2014 Mar 15;5(5):1253-64. PMID: 24457941
Fraker DL, Travis WD, Merendino JJ Jr, Zimering MB, Streeten EA, Weinstein LS, Marx SJ, Spiegel AM, Aurbach GD, Doppman JL, et al. Locally recurrent parathyroid neoplasms as a cause for recurrent and persistent primary hyperparathyroidism. Ann Surg. 1991 Jan;213(1):58-65.
Frank-Raue K, Rybicki LA, Erlic Z, Schweizer H, Winter A, Milos I, Toledo SP, Toledo RA, Tavares MR, Alevizaki M, Mian C, Siggelkow H, Hüfner M, Wohllk N, Opocher G, Dvořáková S, Bendlova B, Czetwertynska M, Skasko E, Barontini M, Sanso G, Vorländer C, Maia AL, Patocs A, Links TP, de Groot JW, Kerstens MN, Valk GD, Miehle K, Musholt TJ, Biarnes J, Damjanovic S, Muresan M, Wüster C, Fassnacht M, Peczkowska M, Fauth C, Golcher H, Walter MA, Pichl J, Raue F, Eng C, Neumann HP; International RET Exon 10 Consortium. Risk profiles and penetrance estimations in multiple endocrine neoplasia type 2A caused by germline RET mutations located in exon 10. Hum Mutat. 2011 Jan;32(1):51- 8. doi: 10.1002/humu.21385.
Fraser WD. Hyperparathyroidism. Lancet. 2009 Jul 11;374(9684):145-58. doi: 10.1016/S0140-6736(09)60507-9. Review.
Fregni G, Quinodoz M, Möller E, Vuille J, Galland S, Fusco C, Martin P, Letovanec I, Provero P, Rivolta C, Riggi N, Stamenkovic I. Reciprocal modulation of mesenchymal stem cells and tumor cells promotes lung cancer metastasis. EBioMedicine. 2018 Mar;29:128-145. doi: 10.1016/j.ebiom.2018.02.017. Epub 2018 Feb 23. PMID: 29503225
Friedman E, Sakaguchi K, Bale AE, Falchetti A, Streeten E, Zimering MB, Weinstein LS, McBride WO, Nakamura Y, Brandi ML, et al. Clonality of parathyroid tumors in familial multiple endocrine neoplasia type 1. N Engl J Med. 1989 Jul 27;321(4):213-8. Erratum in: N Engl J Med 1989 Oct 12;321(15):1057.
Fu L, Fu H, Tian L, Xu K, Hu K, Wang J, Wang J, Jing H, Shi J, Ke X. High expression of RUNX1 is associated with poorer outcomes in cytogenetically normal acute myeloid leukemia. Oncotarget. 2016 Mar 29;7(13):15828-39. doi: 10.18632/oncotarget.7489. PMID: 26910834
Fujiwara S, Sposto R, Ezaki H, Akiba S, Neriishi K, Kodama K, Hosoda Y, Shimaoka K. Hyperparathyroidism among atomic bomb survivors in Hiroshima. Radiat Res. 1992 Jun;130(3):372-8.
Gattenloehner S, Chuvpilo S, Langebrake C, Reinhardt D, Müller-Hermelink HK, Serfling E, Vincent A, Marx A. Novel RUNX1 isoforms determine the fate of acute myeloid leukemia cells by controlling CD56 expression. Blood. 2007 Sep 15;110(6):2027-33. Epub 2007 Apr 12. PMID: 17431130
Gill AJ, Clarkson A, Gimm O, Keil J, Dralle H, Howell VM, Marsh DJ. Loss of nuclear expression of parafibromin distinguishes parathyroid carcinomas and hyperparathyroidism-jaw tumor (HPT-JT) syndrome-related adenomas from sporadic parathyroid adenomas and hyperplasias. Am J Surg Pathol. 2006 Sep;30(9):1140-9.
Gill AJ. Understanding the genetic basis of parathyroid carcinoma. Endocr Pathol. 2014 Mar;25(1):30-4.
Giusti F, Marini F, Brandi ML. Multiple Endocrine Neoplasia Type 1.In: Pagon RA, Adam MP, Ardinger HH, et al., editors. GeneReviews®. Seattle (WA): University of Washington, Seattle. PMID: 20301710
Givens DJ, Hunt JP, Bentz BG. Uncommon presentations of parathyroid adenoma. Head Neck. 2013 Sep;35(9):E265-8. doi: 10.1002/hed.23124. Epub 2012 Aug 21. PMID: 22907766
Gnepp D.R., Diagnostic Surgical Pathology of the Head and Neck, 2nd Edition, Saunders; 2 edizione (31 marzo 2009)
Goasguen N, Chirica M, Roger N, Munoz-Bongrand N, Zohar S, Noullet S, de Roquancourt A, Cattan P, Sarfati E. Primary hyperparathyroidism from parathyroid microadenoma: specific features and implications for a surgical strategy in the era of minimally invasive parathyroidectomy. J Am Coll Surg. 2010 Apr;210(4):456-62. doi: 10.1016/j.jamcollsurg.2009.12.017.
Gorlin RJ, Vickers RA. Multiple mucosal neuromas, pheochromocytoma, medullary carcinoma of the thyroid and marfanoid body build with muscle wasting: reexamination of a syndrome of neural crest malmigration. Birth Defects Orig Artic Ser. 1971 May;7(6):69-72. Review.
Greene AB, Butler RS, McIntyre S, Barbosa GF, Mitchell J, Berber E, Siperstein A, Milas M. National trends in parathyroid surgery from 1998 to 2008: a decade of change. J Am Coll Surg. 2009 Sep;209(3):332-43. doi: 10.1016/j.jamcollsurg.2009.05.029.
Greif PA, Konstandin NP, Metzeler KH, Herold T, Pasalic Z, Ksienzyk B, Dufour A, Schneider F, Schneider S, Kakadia PM, Braess J, Sauerland MC, Berdel WE, Büchner T, Woermann BJ, Hiddemann W, Spiekermann K,
Bohlander SK. RUNX1 mutations in cytogenetically normal acute myeloid leukemia are associated with a poor prognosis and up-regulation of lymphoid genes. Haematologica. 2012 Dec;97(12):1909-15. doi: 10.3324/haematol.2012.064667. Epub 2012 Jun 11. PMID: 22689681
Grieb BC, Gramling MW, Arrate MP, Chen X, Beauparlant SL, Haines DS, Xiao H, Eischen CM. Oncogenic protein MTBP interacts with MYC to promote tumorigenesis. Cancer Res. 2014 Jul 1;74(13):3591-602. doi: 10.1158/0008-5472.CAN- 13-2149. Epub 2014 May 1. PMID: 24786788
Grieb BC, Chen X, Eischen CM. MTBP is overexpressed in triple-negative breast cancer and contributes to its growth and survival. Mol Cancer Res. 2014 Sep;12(9):1216-24. doi: 10.1158/1541-7786.MCR-14-0069. Epub 2014 May 27. PMID: 24866769
Grimelius L, Akerstrom G, Johansson H, Juhlin C, Rastad J.. The Parathyroid glands. In: Kovacs K. Asa S, eds. Functional endocrine pathology. Vol.1. Boston:. Blackwell Scientific; 1991;375-95.
Guiter GE, DeLellis RA (2002). Risk of recurrence or metastasis in atypical parathyroid adenomas. Mod. Pathol. 15:115A
Harari A, Waring A, Fernandez-Ranvier G, Hwang J, Suh I, Mitmaker E, Shen W, Gosnell J, Duh QY, Clark O. Parathyroid carcinoma: a 43-year outcome and survival analysis. J Clin Endocrinol Metab. 2011 Dec;96(12):3679-86. doi: 10.1210/jc.2011-1571. Epub 2011 Sep 21.
Haven CJ, van Puijenbroek M, Tan MH, Teh BT, Fleuren GJ, van Wezel T, Morreau H. Identification of MEN1 and HRPT2 somatic mutations in paraffin- embedded (sporadic) parathyroid carcinomas. Clin Endocrinol (Oxf). 2007 Sep;67(3):370-6. Epub 2007 Jun 6.
Hendy GN, Cole DE. Genetic defects associated with familial and sporadic hyperparathyroidism. Front Horm Res. 2013;41:149-65. doi: 10.1159/000345675. Epub 2013 Mar 19.
Hillary S., Balasubramanian S., Anatomy of the thyroid, parathyroid, pituitary and adrenal glands. In Surgery (Oxford) 35(10) 537-541, September 2017 DOI: 10.1016/j.mpsur.2017.06.016
Hill, M.A. (2018, September 19) Embryology Endocrine - Parathyroid
https://embryology.med.unsw.edu.au/embryology/index.php/Endocrine_- _Parathyroid_Development
Hirade T, Abe M, Onishi C, Taketani T, Yamaguchi S, Fukuda S. Internal tandem duplication of FLT3 deregulates proliferation and differentiation and confers resistance to the FLT3 inhibitor AC220 by Up-regulating RUNX1 expression in hematopoietic cells. Int J Hematol. 2016 Jan;103(1):95-106. doi: 10.1007/s12185-015- 1908-8. Epub 2015 Nov 21. PMID: 26590920
Ho TH, Serie DJ, Parasramka M, Cheville JC, Bot BM, Tan W, Wang L, Joseph RW, Hilton T, Leibovich BC, Parker AS, Eckel-Passow JE. Differential gene expression profiling of matched primary renal cell carcinoma and metastases reveals upregulation of extracellular matrix genes. Ann Oncol. 2017 Mar 1;28(3):604- 610. doi: 10.1093/annonc/mdw652. PMID: 27993815
Horwitz CA, Myers WP, Foote FW Jr. Secondary malignant tumors of the parathyroid glands. Report of two cases with associated hypoparathyroidism. Am J